HK121597A - N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists - Google Patents

N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists

Info

Publication number
HK121597A
HK121597A HK121597A HK121597A HK121597A HK 121597 A HK121597 A HK 121597A HK 121597 A HK121597 A HK 121597A HK 121597 A HK121597 A HK 121597A HK 121597 A HK121597 A HK 121597A
Authority
HK
Hong Kong
Prior art keywords
isoxazolyl
dimethyl
naphthalenesulfonamide
amino
compound
Prior art date
Application number
HK121597A
Other languages
German (de)
English (en)
French (fr)
Inventor
Philip D. Stein
John T. Hunt
Murugesan Natesan
Original Assignee
E.R. Squibb & Sons, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by E.R. Squibb & Sons, Inc. filed Critical E.R. Squibb & Sons, Inc.
Publication of HK121597A publication Critical patent/HK121597A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Immunology (AREA)
  • Vascular Medicine (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Steroid Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
HK121597A 1992-02-24 1997-06-26 N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists HK121597A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84049692A 1992-02-24 1992-02-24

Publications (1)

Publication Number Publication Date
HK121597A true HK121597A (en) 1997-09-12

Family

ID=25282528

Family Applications (1)

Application Number Title Priority Date Filing Date
HK121597A HK121597A (en) 1992-02-24 1997-06-26 N-isoxazole-naphthylsulfonamide derivatives and their use as endothelin antagonists

Country Status (26)

Country Link
EP (1) EP0558258B1 (OSRAM)
JP (1) JP3273818B2 (OSRAM)
KR (1) KR100257134B1 (OSRAM)
CN (1) CN1044235C (OSRAM)
AT (1) ATE152713T1 (OSRAM)
AU (1) AU651922B2 (OSRAM)
CA (1) CA2089184A1 (OSRAM)
CY (1) CY2045B1 (OSRAM)
DE (1) DE69310414T2 (OSRAM)
DK (1) DK0558258T3 (OSRAM)
EG (1) EG20143A (OSRAM)
ES (1) ES2103061T3 (OSRAM)
FI (1) FI930774A7 (OSRAM)
GR (1) GR3024203T3 (OSRAM)
HK (1) HK121597A (OSRAM)
HU (1) HU219455B (OSRAM)
IL (1) IL104748A (OSRAM)
MX (1) MX9300842A (OSRAM)
MY (1) MY109004A (OSRAM)
NO (1) NO303012B1 (OSRAM)
NZ (1) NZ245905A (OSRAM)
PH (1) PH30795A (OSRAM)
PL (1) PL172035B1 (OSRAM)
RU (1) RU2116301C1 (OSRAM)
TW (1) TW224462B (OSRAM)
ZA (1) ZA93780B (OSRAM)

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Also Published As

Publication number Publication date
AU651922B2 (en) 1994-08-04
CN1079468A (zh) 1993-12-15
FI930774L (fi) 1993-08-25
KR930017881A (ko) 1993-09-20
RU2116301C1 (ru) 1998-07-27
HU9300491D0 (en) 1993-05-28
PL297820A1 (en) 1993-09-06
TW224462B (OSRAM) 1994-06-01
HUT65762A (en) 1994-07-28
DK0558258T3 (da) 1997-05-26
ATE152713T1 (de) 1997-05-15
EP0558258B1 (en) 1997-05-07
MX9300842A (es) 1993-08-01
KR100257134B1 (ko) 2000-05-15
JP3273818B2 (ja) 2002-04-15
HU219455B (hu) 2001-04-28
MY109004A (en) 1996-11-30
NO303012B1 (no) 1998-05-18
NO930633D0 (no) 1993-02-23
DE69310414T2 (de) 1997-12-11
IL104748A0 (en) 1993-06-10
JPH069585A (ja) 1994-01-18
NO930633L (no) 1993-08-25
IL104748A (en) 1996-10-16
CN1044235C (zh) 1999-07-21
PH30795A (en) 1997-10-17
DE69310414D1 (de) 1997-06-12
ES2103061T3 (es) 1997-08-16
AU3319293A (en) 1993-08-26
CY2045B1 (en) 1998-04-30
EP0558258A1 (en) 1993-09-01
EG20143A (en) 1997-07-31
NZ245905A (en) 1995-07-26
CA2089184A1 (en) 1993-08-25
PL172035B1 (pl) 1997-07-31
GR3024203T3 (en) 1997-10-31
FI930774A7 (fi) 1993-08-25
FI930774A0 (fi) 1993-02-22
ZA93780B (en) 1993-09-08

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20040223

PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)