DK0558258T3 - N-Isoxazol-naphthylsulfonamid-derivater og deres anvendelse som endothelin-antagonister - Google Patents

N-Isoxazol-naphthylsulfonamid-derivater og deres anvendelse som endothelin-antagonister

Info

Publication number
DK0558258T3
DK0558258T3 DK93301302.1T DK93301302T DK0558258T3 DK 0558258 T3 DK0558258 T3 DK 0558258T3 DK 93301302 T DK93301302 T DK 93301302T DK 0558258 T3 DK0558258 T3 DK 0558258T3
Authority
DK
Denmark
Prior art keywords
substituted
naphthylsulfonamide
isoxazole
derivatives
endothelin antagonists
Prior art date
Application number
DK93301302.1T
Other languages
English (en)
Inventor
Philip D Stein
John T Hunt
Natesan Murugesan
Original Assignee
Squibb & Sons Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Squibb & Sons Inc filed Critical Squibb & Sons Inc
Application granted granted Critical
Publication of DK0558258T3 publication Critical patent/DK0558258T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/08—Vasodilators for multiple indications
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D261/00—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings
    • C07D261/02—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings
    • C07D261/06—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members
    • C07D261/10—Heterocyclic compounds containing 1,2-oxazole or hydrogenated 1,2-oxazole rings not condensed with other rings having two or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D261/14—Nitrogen atoms

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Vascular Medicine (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Glass Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Steroid Compounds (AREA)
  • Peptides Or Proteins (AREA)
DK93301302.1T 1992-02-24 1993-02-23 N-Isoxazol-naphthylsulfonamid-derivater og deres anvendelse som endothelin-antagonister DK0558258T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US84049692A 1992-02-24 1992-02-24

Publications (1)

Publication Number Publication Date
DK0558258T3 true DK0558258T3 (da) 1997-05-26

Family

ID=25282528

Family Applications (1)

Application Number Title Priority Date Filing Date
DK93301302.1T DK0558258T3 (da) 1992-02-24 1993-02-23 N-Isoxazol-naphthylsulfonamid-derivater og deres anvendelse som endothelin-antagonister

Country Status (26)

Country Link
EP (1) EP0558258B1 (da)
JP (1) JP3273818B2 (da)
KR (1) KR100257134B1 (da)
CN (1) CN1044235C (da)
AT (1) ATE152713T1 (da)
AU (1) AU651922B2 (da)
CA (1) CA2089184A1 (da)
CY (1) CY2045B1 (da)
DE (1) DE69310414T2 (da)
DK (1) DK0558258T3 (da)
EG (1) EG20143A (da)
ES (1) ES2103061T3 (da)
FI (1) FI930774A (da)
GR (1) GR3024203T3 (da)
HK (1) HK121597A (da)
HU (1) HU219455B (da)
IL (1) IL104748A (da)
MX (1) MX9300842A (da)
MY (1) MY109004A (da)
NO (1) NO303012B1 (da)
NZ (1) NZ245905A (da)
PH (1) PH30795A (da)
PL (1) PL172035B1 (da)
RU (1) RU2116301C1 (da)
TW (1) TW224462B (da)
ZA (1) ZA93780B (da)

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US6541498B2 (en) 1993-05-20 2003-04-01 Texas Biotechnology Benzenesulfonamides and the use thereof to modulate the activity of endothelin
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US5939446A (en) * 1996-04-09 1999-08-17 Bristol-Myers Squibb Co. Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists
US5804585A (en) 1996-04-15 1998-09-08 Texas Biotechnology Corporation Thieno-pyridine sulfonamides derivatives thereof and related compounds that modulate the activity of endothelin
TW536540B (en) * 1997-01-30 2003-06-11 Bristol Myers Squibb Co Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe
AU6187898A (en) * 1997-01-30 1998-08-25 Bristol-Myers Squibb Company Method for preventing or treating low renin hypertension by administering an endothelin antagonist
US5783705A (en) * 1997-04-28 1998-07-21 Texas Biotechnology Corporation Process of preparing alkali metal salys of hydrophobic sulfonamides
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Also Published As

Publication number Publication date
NO303012B1 (no) 1998-05-18
GR3024203T3 (en) 1997-10-31
NO930633D0 (no) 1993-02-23
CA2089184A1 (en) 1993-08-25
ATE152713T1 (de) 1997-05-15
DE69310414T2 (de) 1997-12-11
NO930633L (no) 1993-08-25
JPH069585A (ja) 1994-01-18
PH30795A (en) 1997-10-17
CN1044235C (zh) 1999-07-21
HUT65762A (en) 1994-07-28
KR930017881A (ko) 1993-09-20
TW224462B (da) 1994-06-01
IL104748A (en) 1996-10-16
NZ245905A (en) 1995-07-26
IL104748A0 (en) 1993-06-10
PL297820A1 (en) 1993-09-06
CY2045B1 (en) 1998-04-30
ES2103061T3 (es) 1997-08-16
DE69310414D1 (de) 1997-06-12
EG20143A (en) 1997-07-31
MX9300842A (es) 1993-08-01
CN1079468A (zh) 1993-12-15
MY109004A (en) 1996-11-30
HU9300491D0 (en) 1993-05-28
AU651922B2 (en) 1994-08-04
ZA93780B (en) 1993-09-08
JP3273818B2 (ja) 2002-04-15
EP0558258B1 (en) 1997-05-07
HU219455B (hu) 2001-04-28
HK121597A (en) 1997-09-12
AU3319293A (en) 1993-08-26
FI930774A (fi) 1993-08-25
PL172035B1 (pl) 1997-07-31
RU2116301C1 (ru) 1998-07-27
KR100257134B1 (ko) 2000-05-15
EP0558258A1 (en) 1993-09-01
FI930774A0 (fi) 1993-02-22

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