HK1214820A1 - 雜芳基吡啶酮和氮雜-吡啶酮酰胺化合物 - Google Patents
雜芳基吡啶酮和氮雜-吡啶酮酰胺化合物Info
- Publication number
- HK1214820A1 HK1214820A1 HK16102768.8A HK16102768A HK1214820A1 HK 1214820 A1 HK1214820 A1 HK 1214820A1 HK 16102768 A HK16102768 A HK 16102768A HK 1214820 A1 HK1214820 A1 HK 1214820A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- pyridone
- aza
- heteroaryl
- amide compounds
- compounds
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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- A61K31/47—Quinolines; Isoquinolines
- A61K31/472—Non-condensed isoquinolines, e.g. papaverine
- A61K31/4725—Non-condensed isoquinolines, e.g. papaverine containing further heterocyclic rings
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- A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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- A61K31/50—Pyridazines; Hydrogenated pyridazines
- A61K31/502—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine
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- C07D487/04—Ortho-condensed systems
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- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- General Health & Medical Sciences (AREA)
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- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
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- Immunology (AREA)
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- Diabetes (AREA)
- Rheumatology (AREA)
- Oncology (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Heart & Thoracic Surgery (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Virology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Otolaryngology (AREA)
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- Communicable Diseases (AREA)
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Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361842648P | 2013-07-03 | 2013-07-03 | |
PCT/EP2014/064044 WO2015000949A1 (en) | 2013-07-03 | 2014-07-02 | Heteroaryl pyridone and aza-pyridone amide compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1214820A1 true HK1214820A1 (zh) | 2016-08-05 |
Family
ID=51059465
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16102768.8A HK1214820A1 (zh) | 2013-07-03 | 2016-03-10 | 雜芳基吡啶酮和氮雜-吡啶酮酰胺化合物 |
Country Status (11)
Country | Link |
---|---|
US (1) | US9326985B2 (zh) |
EP (1) | EP3016943B1 (zh) |
JP (1) | JP6165977B2 (zh) |
KR (1) | KR101815360B1 (zh) |
CN (2) | CN110698481B (zh) |
BR (1) | BR112015029972A2 (zh) |
CA (1) | CA2912359A1 (zh) |
HK (1) | HK1214820A1 (zh) |
MX (1) | MX2015018038A (zh) |
RU (1) | RU2016101548A (zh) |
WO (1) | WO2015000949A1 (zh) |
Families Citing this family (21)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
CN104812746B (zh) * | 2012-11-16 | 2017-03-08 | 弗·哈夫曼-拉罗切有限公司 | 布鲁顿氏酪氨酸激酶抑制剂 |
WO2015151006A1 (en) | 2014-03-29 | 2015-10-08 | Lupin Limited | Substituted purine compounds as btk inhibitors |
AU2015240465B2 (en) | 2014-04-04 | 2020-02-27 | Del Mar Pharmaceuticals | Use of dianhydrogalactitol and analogs or derivatives thereof to treat non-small-cell carcinoma of the lung and ovarian cancer |
WO2015170266A1 (en) | 2014-05-07 | 2015-11-12 | Lupin Limited | Substituted pyrimidine compounds as btk inhibitors |
US10077247B2 (en) | 2015-01-09 | 2018-09-18 | Ono Pharmaceutical Co., Ltd. | Tricyclic spiro compound |
US10208024B2 (en) | 2015-10-23 | 2019-02-19 | Array Biopharma Inc. | 2-aryl- and 2-heteroaryl-substituted 2-pyridazin-3(2H)-one compounds as inhibitors of FGFR tyrosine kinases |
CA3004448A1 (en) * | 2015-11-12 | 2017-05-18 | Afasci, Inc. | Ion channel inhibitory compounds, pharmaceutical formulations and uses |
CN109640997A (zh) * | 2016-06-30 | 2019-04-16 | W·西斯 | 通过抑制Bruton’s酪氨酸激酶(Btk)治疗和预防动脉粥样硬化血栓形成 |
CN109641892B (zh) * | 2016-08-16 | 2021-07-02 | 默克专利有限公司 | 用作可逆btk抑制剂的2-氧代-咪唑并吡啶及其用途 |
CN107033142A (zh) * | 2017-05-15 | 2017-08-11 | 杭州科耀医药科技有限公司 | 一种Venetoclax关键中间体的合成方法 |
EP3930717A1 (en) | 2019-02-25 | 2022-01-05 | Guangzhou Lupeng Pharmaceutical Company Ltd. | Inhibitor of btk and mutants thereof |
CN110590654A (zh) * | 2019-09-28 | 2019-12-20 | 成都睿智化学研究有限公司 | 一种4-氟-3-取代基-吡啶-2-甲酸酯类化合物的合成方法 |
WO2021066958A1 (en) | 2019-10-05 | 2021-04-08 | Newave Pharmaceutical Inc. | Inhibitor of btk and mutants thereof |
CN115151535A (zh) * | 2020-02-20 | 2022-10-04 | 和记黄埔医药(上海)有限公司 | 杂芳基杂环化合物及其用途 |
WO2022057894A1 (en) * | 2020-09-21 | 2022-03-24 | Hutchison Medipharma Limited | Heteroaryl heterocyclic compounds and uses thereof |
WO2022094172A2 (en) | 2020-10-30 | 2022-05-05 | Newave Pharmaceutical Inc. | Inhibitors of btk |
US20240058457A1 (en) | 2020-12-20 | 2024-02-22 | Newave Pharmaceutical Inc. | Btk degrader |
WO2022206924A1 (zh) * | 2021-04-02 | 2022-10-06 | 南京明德新药研发有限公司 | 含氮三并环双功能化合物及其制备方法和应用 |
WO2023143491A1 (zh) * | 2022-01-28 | 2023-08-03 | 和记黄埔医药(上海)有限公司 | 7,8-二氢-2h-环戊二烯并吡咯并吡嗪酮化合物的合成方法 |
CN115974868B (zh) * | 2022-11-07 | 2024-04-12 | 安徽理工大学 | 一种尿嘧啶衍生物的合成方法及其抗肺纤维化方面的潜在应用 |
Family Cites Families (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
US5583024A (en) | 1985-12-02 | 1996-12-10 | The Regents Of The University Of California | Recombinant expression of Coleoptera luciferase |
US5543523A (en) | 1994-11-15 | 1996-08-06 | Regents Of The University Of Minnesota | Method and intermediates for the synthesis of korupensamines |
JPH08336393A (ja) | 1995-04-13 | 1996-12-24 | Mitsubishi Chem Corp | 光学活性なγ−置換−β−ヒドロキシ酪酸エステルの製造法 |
US6602677B1 (en) | 1997-09-19 | 2003-08-05 | Promega Corporation | Thermostable luciferases and methods of production |
US6395916B1 (en) | 1998-07-10 | 2002-05-28 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
US7223879B2 (en) | 1998-07-10 | 2007-05-29 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
US6307087B1 (en) | 1998-07-10 | 2001-10-23 | Massachusetts Institute Of Technology | Ligands for metals and improved metal-catalyzed processes based thereon |
WO2003006151A1 (en) | 2001-07-12 | 2003-01-23 | Avecia Limited | Microencapsulated catalyst, methods of preparation and methods of use thereof |
WO2005014599A1 (en) | 2003-06-04 | 2005-02-17 | Cellular Genomics, Inc. | Imidazo[1,2-a]pyrazin-8-ylamines and method of inhibition of bruton’s tyrosine kinase by such compounds |
US7393848B2 (en) | 2003-06-30 | 2008-07-01 | Cgi Pharmaceuticals, Inc. | Certain heterocyclic substituted imidazo[1,2-A]pyrazin-8-ylamines and methods of inhibition of Bruton's tyrosine kinase by such compounds |
BRPI0517619A (pt) | 2004-11-10 | 2008-10-14 | Cgi Pharmaceuticals Inc | entidades quìmicas de imidazo[1,2-a] pirazin-8-ilaminas, suas composições farmacêuticas, uso dos referidos compostos na preparação de medicamento, processo de preparação de medicamento e métodos de utilização dos referidos compostos |
MX2007007330A (es) | 2004-12-16 | 2007-10-04 | Vertex Pharma | Piridonas de utilidad como inhibidores de quinasas . |
ZA200704971B (en) * | 2004-12-16 | 2008-09-25 | Vertex Pharma | Pyrid-2-ones useful as inhibitors of Tec family protein kinases for the treatment of inflammatory, proliferative and immunologically-mediated diseases |
KR101357524B1 (ko) | 2005-03-10 | 2014-02-03 | 질레드 코네티컷 인코포레이티드 | 특정 치환된 아미드, 그의 제조 방법, 및 사용 방법 |
DE602006021205D1 (de) | 2005-10-07 | 2011-05-19 | Exelixis Inc | Azetidine als mek-inhibitoren bei der behandlung proliferativer erkrankungen |
AR063706A1 (es) | 2006-09-11 | 2009-02-11 | Cgi Pharmaceuticals Inc | Determinadas amidas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
US7838523B2 (en) | 2006-09-11 | 2010-11-23 | Cgi Pharmaceuticals, Inc. | Certain substituted amides, method of making, and method of use thereof |
AR063946A1 (es) | 2006-09-11 | 2009-03-04 | Cgi Pharmaceuticals Inc | Determinadas pirimidinas sustituidas, el uso de las mismas para el tratamiento de enfermedades mediadas por la inhibicion de la actividad de btk y composiciones farmaceuticas que las comprenden. |
SI2530083T1 (sl) | 2006-09-22 | 2016-09-30 | Pharmacyclics Llc | Inhibitorji Bruton tirozin kinaze |
CL2008002793A1 (es) * | 2007-09-20 | 2009-09-04 | Cgi Pharmaceuticals Inc | Compuestos derivados de amidas sustituidas, inhibidores de la actividad de btk; composicion farmaceutica que los comprende; utiles en el tratamiento del cancer, trastornos oseos, enfermedades autoinmunes, entre otras |
JP5587193B2 (ja) * | 2007-10-23 | 2014-09-10 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なキナーゼ阻害剤 |
US8426441B2 (en) | 2007-12-14 | 2013-04-23 | Roche Palo Alto Llc | Inhibitors of bruton's tyrosine kinase |
US7683064B2 (en) | 2008-02-05 | 2010-03-23 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
DK2242749T3 (da) * | 2008-02-05 | 2013-06-17 | Hoffmann La Roche | Nye pyridinoner og pyridazinoner |
EP2297105B1 (en) | 2008-05-06 | 2015-09-02 | Gilead Connecticut, Inc. | Substituted amides, method of making, and use as btk inhibitors |
BRPI0914657A2 (pt) | 2008-06-24 | 2019-09-24 | F Hoffmann La Roche | piridin-2-onae piridazin-3-onas substituídas |
CN102083819B (zh) | 2008-07-02 | 2014-07-09 | 霍夫曼-拉罗奇有限公司 | 作为激酶抑制剂的新型苯基吡嗪酮 |
EP2307413B1 (en) | 2008-07-15 | 2015-09-09 | F. Hoffmann-La Roche AG | Novel phenyl-imidazopyridines and pyridazines |
WO2010056875A1 (en) | 2008-11-12 | 2010-05-20 | Cgi Pharmaceuticals, Inc. | Pyridazinones and their use as btk inhibitors |
US8299077B2 (en) * | 2009-03-02 | 2012-10-30 | Roche Palo Alto Llc | Inhibitors of Bruton's tyrosine kinase |
CN102292329B (zh) * | 2009-04-24 | 2014-09-03 | 霍夫曼-拉罗奇有限公司 | 布鲁顿酪氨酸激酶的抑制剂 |
CA2798634C (en) | 2010-05-07 | 2019-04-16 | Gilead Connecticut, Inc. | Pyridone and aza-pyridone compounds and methods of use |
AR082590A1 (es) * | 2010-08-12 | 2012-12-19 | Hoffmann La Roche | Inhibidores de la tirosina-quinasa de bruton |
WO2012031004A1 (en) | 2010-09-01 | 2012-03-08 | Gilead Connecticut, Inc. | Pyridinones/pyrazinones, method of making, and method of use thereof |
KR20180031823A (ko) | 2010-09-01 | 2018-03-28 | 질레드 코네티컷 인코포레이티드 | 피리다지논, 그의 제조 방법 및 사용 방법 |
JP5859640B2 (ja) | 2011-05-17 | 2016-02-10 | エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft | ブルトンチロシンキナーゼ阻害剤 |
TW201311669A (zh) | 2011-08-17 | 2013-03-16 | Hoffmann La Roche | 布魯頓氏酪胺酸激酶(bruton’s tyrosine kinase)之抑制劑 |
IN2014CN03265A (zh) | 2011-11-03 | 2015-07-03 | Hoffmann La Roche | |
US8722676B2 (en) | 2011-11-03 | 2014-05-13 | Genentech, Inc. | Bicyclic piperazine compounds |
JP5976826B2 (ja) | 2011-11-03 | 2016-08-24 | エフ・ホフマン−ラ・ロシュ・アクチェンゲゼルシャフト | Btk活性阻害剤としての8−フルオロフタラジン−1(2h)−オン化合物 |
UA111756C2 (uk) * | 2011-11-03 | 2016-06-10 | Ф. Хоффманн-Ля Рош Аг | Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона |
-
2014
- 2014-07-02 MX MX2015018038A patent/MX2015018038A/es unknown
- 2014-07-02 CA CA2912359A patent/CA2912359A1/en not_active Abandoned
- 2014-07-02 WO PCT/EP2014/064044 patent/WO2015000949A1/en active Application Filing
- 2014-07-02 EP EP14734486.5A patent/EP3016943B1/en active Active
- 2014-07-02 US US14/322,051 patent/US9326985B2/en active Active
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- 2014-07-02 CN CN201480037993.8A patent/CN105358545A/zh active Pending
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- 2016-03-10 HK HK16102768.8A patent/HK1214820A1/zh unknown
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KR101815360B1 (ko) | 2018-01-04 |
CA2912359A1 (en) | 2015-01-08 |
US20150011461A1 (en) | 2015-01-08 |
BR112015029972A2 (pt) | 2017-07-25 |
JP6165977B2 (ja) | 2017-07-19 |
EP3016943A1 (en) | 2016-05-11 |
RU2016101548A (ru) | 2017-08-08 |
WO2015000949A1 (en) | 2015-01-08 |
EP3016943B1 (en) | 2019-08-21 |
JP2016526551A (ja) | 2016-09-05 |
CN105358545A (zh) | 2016-02-24 |
CN110698481B (zh) | 2023-02-28 |
MX2015018038A (es) | 2016-03-16 |
US9326985B2 (en) | 2016-05-03 |
KR20160015294A (ko) | 2016-02-12 |
CN110698481A (zh) | 2020-01-17 |
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