HK1218512A1 - 雜環化合物和其用途 - Google Patents

雜環化合物和其用途

Info

Publication number
HK1218512A1
HK1218512A1 HK16106548.6A HK16106548A HK1218512A1 HK 1218512 A1 HK1218512 A1 HK 1218512A1 HK 16106548 A HK16106548 A HK 16106548A HK 1218512 A1 HK1218512 A1 HK 1218512A1
Authority
HK
Hong Kong
Prior art keywords
heterocyclic compounds
heterocyclic
compounds
Prior art date
Application number
HK16106548.6A
Other languages
English (en)
Inventor
Mingda Bi
Robert Kuehl
Original Assignee
Amgen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50549466&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1218512(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Amgen Inc filed Critical Amgen Inc
Publication of HK1218512A1 publication Critical patent/HK1218512A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs
HK16106548.6A 2013-03-14 2016-06-07 雜環化合物和其用途 HK1218512A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361785763P 2013-03-14 2013-03-14
PCT/US2014/027104 WO2014152236A1 (en) 2013-03-14 2014-03-14 Heterocyclic compounds and their uses

Publications (1)

Publication Number Publication Date
HK1218512A1 true HK1218512A1 (zh) 2017-02-24

Family

ID=50549466

Family Applications (4)

Application Number Title Priority Date Filing Date
HK16106250.4A HK1218080A1 (zh) 2013-03-14 2016-06-02 雜環化合物和其用途
HK16106547.7A HK1218544A1 (zh) 2013-03-14 2016-06-07 奧美卡替莫卡必爾的鹽和製備鹽的方法
HK16106548.6A HK1218512A1 (zh) 2013-03-14 2016-06-07 雜環化合物和其用途
HK16107606.3A HK1219484A1 (zh) 2013-03-14 2016-06-30 心肌肌球蛋白激動劑的鹽和製備鹽的方法

Family Applications Before (2)

Application Number Title Priority Date Filing Date
HK16106250.4A HK1218080A1 (zh) 2013-03-14 2016-06-02 雜環化合物和其用途
HK16106547.7A HK1218544A1 (zh) 2013-03-14 2016-06-07 奧美卡替莫卡必爾的鹽和製備鹽的方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK16107606.3A HK1219484A1 (zh) 2013-03-14 2016-06-30 心肌肌球蛋白激動劑的鹽和製備鹽的方法

Country Status (41)

Country Link
US (12) US9988354B2 (zh)
EP (3) EP2968173B1 (zh)
JP (5) JP6498658B2 (zh)
KR (2) KR102474467B1 (zh)
CN (3) CN108785265A (zh)
AP (1) AP2015008789A0 (zh)
AR (1) AR095542A1 (zh)
AU (2) AU2014239995B2 (zh)
BR (2) BR112015022857B1 (zh)
CA (3) CA3147180A1 (zh)
CL (1) CL2015002708A1 (zh)
CR (1) CR20150549A (zh)
CY (2) CY1122695T1 (zh)
DK (2) DK2968173T3 (zh)
EA (1) EA031185B1 (zh)
ES (2) ES2837038T3 (zh)
HK (4) HK1218080A1 (zh)
HR (2) HRP20191728T1 (zh)
HU (2) HUE052355T2 (zh)
IL (2) IL240788B (zh)
JO (1) JOP20140114B1 (zh)
LT (2) LT2968173T (zh)
MA (2) MA44637B1 (zh)
ME (1) ME03566B (zh)
MX (3) MX363347B (zh)
MY (1) MY186048A (zh)
NZ (1) NZ711225A (zh)
PE (1) PE20151786A1 (zh)
PH (2) PH12015501998A1 (zh)
PL (2) PL2970123T3 (zh)
PT (2) PT2970123T (zh)
RS (2) RS59536B1 (zh)
RU (1) RU2663663C2 (zh)
SA (1) SA515361088B1 (zh)
SG (2) SG10201706656RA (zh)
SI (2) SI2970123T1 (zh)
TN (1) TN2015000380A1 (zh)
TW (1) TWI667026B (zh)
UA (1) UA117011C2 (zh)
UY (1) UY35449A (zh)
WO (2) WO2014152236A1 (zh)

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EP4243825A1 (en) 2020-11-12 2023-09-20 Amgen Inc. Methods of treating heart failure by administering omecamtiv mecarbil
WO2022177927A1 (en) 2021-02-16 2022-08-25 Assia Chemical Industries Ltd Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt
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Also Published As

Publication number Publication date
EP3821882A1 (en) 2021-05-19
MX2021001231A (es) 2021-04-12
US11884630B2 (en) 2024-01-30
JP2020125307A (ja) 2020-08-20
BR112015022857B1 (pt) 2022-10-25
US11384053B2 (en) 2022-07-12
CN105209437A (zh) 2015-12-30
TN2015000380A1 (en) 2017-01-03
CN105120844A (zh) 2015-12-02
US10421726B2 (en) 2019-09-24
CN105209437B (zh) 2018-09-18
AP2015008789A0 (en) 2015-10-31
US9951015B2 (en) 2018-04-24
LT2970123T (lt) 2019-11-11
JOP20140114B1 (ar) 2021-08-17
KR20220045014A (ko) 2022-04-12
JP2022023891A (ja) 2022-02-08
PT2968173T (pt) 2020-12-18
AU2014240049C1 (en) 2019-03-07
CN108785265A (zh) 2018-11-13
US20200331859A1 (en) 2020-10-22
BR112015023417A2 (pt) 2017-07-18
AU2014240049B2 (en) 2018-07-19
HRP20191728T1 (hr) 2019-12-13
US11472773B2 (en) 2022-10-18
ME03566B (me) 2020-07-20
MX2015012429A (es) 2016-04-07
US20140309235A1 (en) 2014-10-16
US20220153700A1 (en) 2022-05-19
JP2016513683A (ja) 2016-05-16
AU2014240049A1 (en) 2015-09-10
PH12019500176A1 (en) 2020-11-04
US20230044617A1 (en) 2023-02-09
JP7174132B2 (ja) 2022-11-17
JP2016519071A (ja) 2016-06-30
ES2750676T3 (es) 2020-03-26
CY1122695T1 (el) 2021-03-12
HRP20201967T1 (hr) 2021-03-05
KR102374159B1 (ko) 2022-03-15
MA38399A1 (fr) 2017-01-31
WO2014152270A1 (en) 2014-09-25
JP6783138B2 (ja) 2020-11-11
US11958809B2 (en) 2024-04-16
PH12015501998B1 (en) 2016-01-11
KR102474467B1 (ko) 2022-12-05
PE20151786A1 (es) 2015-12-11
RS61215B1 (sr) 2021-01-29
DK2970123T3 (da) 2019-10-21
SG11201507258PA (en) 2015-10-29
US20200079736A1 (en) 2020-03-12
EA031185B1 (ru) 2018-11-30
US20180312469A1 (en) 2018-11-01
NZ711225A (en) 2020-06-26
CL2015002708A1 (es) 2016-03-11
IL240788B (en) 2020-09-30
TWI667026B (zh) 2019-08-01
CR20150549A (es) 2016-01-04
MA38399B2 (fr) 2020-12-31
EP2968173A1 (en) 2016-01-20
RU2015143643A (ru) 2017-04-18
CA2902646C (en) 2022-08-16
CA3147180A1 (en) 2014-09-25
BR112015023417B1 (pt) 2023-10-17
WO2014152236A1 (en) 2014-09-25
MA44637A1 (fr) 2019-08-30
LT2968173T (lt) 2021-03-25
SI2968173T1 (sl) 2021-04-30
IL241089B (en) 2019-10-31
EP2970123A1 (en) 2016-01-20
AU2014239995A1 (en) 2015-09-10
PH12015501998A1 (en) 2016-01-11
IL241089A0 (en) 2015-11-30
MX2015012414A (es) 2016-04-25
CA2902436A1 (en) 2014-09-25
PT2970123T (pt) 2019-10-28
DK2968173T3 (da) 2020-12-21
KR20150136063A (ko) 2015-12-04
JP6689942B2 (ja) 2020-04-28
SI2970123T1 (sl) 2019-12-31
AR095542A1 (es) 2015-10-21
US20240101517A1 (en) 2024-03-28
MA44637B1 (fr) 2021-04-30
MX363347B (es) 2019-03-20
HK1218080A1 (zh) 2017-02-03
ES2837038T3 (es) 2021-06-29
US20200277261A1 (en) 2020-09-03
CY1123633T1 (el) 2022-03-24
PL2970123T3 (pl) 2020-03-31
HK1219484A1 (zh) 2017-04-07
PL2968173T3 (pl) 2021-03-08
CA2902646A1 (en) 2014-09-25
HUE046285T2 (hu) 2020-02-28
RS59536B1 (sr) 2019-12-31
IL240788A0 (en) 2015-10-29
SG10201706656RA (en) 2017-09-28
JP6966590B2 (ja) 2021-11-17
MY186048A (en) 2021-06-17
HUE052355T2 (hu) 2021-04-28
EP2970123B1 (en) 2019-08-14
US20220298114A1 (en) 2022-09-22
AU2014239995B2 (en) 2018-07-26
EP2968173B1 (en) 2020-10-14
JP6498658B2 (ja) 2019-04-10
UY35449A (es) 2014-09-30
JP2019059746A (ja) 2019-04-18
US20160016906A1 (en) 2016-01-21
UA117011C2 (uk) 2018-06-11
SA515361088B1 (ar) 2018-07-22
NZ750950A (en) 2020-09-25
US20180273479A1 (en) 2018-09-27
BR112015022857A2 (pt) 2017-07-18
EA201591728A1 (ru) 2016-01-29
US9988354B2 (en) 2018-06-05
US20200399221A1 (en) 2020-12-24
TW201524507A (zh) 2015-07-01
RU2663663C2 (ru) 2018-08-08
HK1218544A1 (zh) 2017-02-24

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