HUE046285T2 - Omecamtiv mecarbil sói és eljárás a só elõállítására - Google Patents
Omecamtiv mecarbil sói és eljárás a só elõállításáraInfo
- Publication number
- HUE046285T2 HUE046285T2 HUE14720369A HUE14720369A HUE046285T2 HU E046285 T2 HUE046285 T2 HU E046285T2 HU E14720369 A HUE14720369 A HU E14720369A HU E14720369 A HUE14720369 A HU E14720369A HU E046285 T2 HUE046285 T2 HU E046285T2
- Authority
- HU
- Hungary
- Prior art keywords
- salt
- preparing
- omecamtiv mecarbil
- mecarbil
- omecamtiv
- Prior art date
Links
- 150000003839 salts Chemical class 0.000 title 2
- 238000004519 manufacturing process Methods 0.000 title 1
- RFUBTTPMWSKEIW-UHFFFAOYSA-N omecamtiv mecarbil Chemical compound C1CN(C(=O)OC)CCN1CC1=CC=CC(NC(=O)NC=2C=NC(C)=CC=2)=C1F RFUBTTPMWSKEIW-UHFFFAOYSA-N 0.000 title 1
- 229950001617 omecamtiv mecarbil Drugs 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Cardiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Heart & Thoracic Surgery (AREA)
- Inorganic Chemistry (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201361785763P | 2013-03-14 | 2013-03-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HUE046285T2 true HUE046285T2 (hu) | 2020-02-28 |
Family
ID=50549466
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14719472A HUE052355T2 (hu) | 2013-03-14 | 2014-03-14 | Heterociklusos vegyületek és alkalmazásuk |
| HUE14720369A HUE046285T2 (hu) | 2013-03-14 | 2014-03-14 | Omecamtiv mecarbil sói és eljárás a só elõállítására |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HUE14719472A HUE052355T2 (hu) | 2013-03-14 | 2014-03-14 | Heterociklusos vegyületek és alkalmazásuk |
Country Status (41)
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK2970123T3 (da) | 2013-03-14 | 2019-10-21 | Amgen Inc | Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf |
| TWI829098B (zh) | 2015-01-02 | 2024-01-11 | 美商梅拉洛伊卡公司 | 細菌組成物 |
| US10543215B2 (en) | 2015-06-26 | 2020-01-28 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| PT3645518T (pt) * | 2017-06-30 | 2021-08-23 | Amgen Inc | Síntese de omecamtiv mecarbil |
| AU2018290983B2 (en) | 2017-06-30 | 2023-11-23 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
| EA039850B1 (ru) * | 2018-04-30 | 2022-03-21 | Эмджен Инк. | Синтез омекамтива мекарбила |
| ES2815899T3 (es) | 2018-07-09 | 2021-03-31 | Fis Fabbrica Italiana Sintetici Spa | 2-Fluoro-3-nitrotolueno cristalino y procedimiento para la preparación del mismo |
| WO2020014406A1 (en) * | 2018-07-12 | 2020-01-16 | Assia Chemical Industries Ltd. | Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl |
| US11465969B2 (en) | 2018-08-17 | 2022-10-11 | Cytokinetics, Inc. | Salts and crystal forms of omecamtiv mecarbil |
| WO2020185983A1 (en) * | 2019-03-12 | 2020-09-17 | Amgen Inc. | Polymorphs of a cardiac troponin activator |
| KR20220002885A (ko) * | 2019-03-12 | 2022-01-07 | 암젠 인크 | 심장 트로포닌 활성제의 다형체 및 공결정 |
| WO2021053175A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021053189A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021070123A1 (en) * | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| JP2023513249A (ja) | 2020-02-10 | 2023-03-30 | アムジェン インコーポレイテッド | オメカムチブメカルビル製剤 |
| AU2021380754A1 (en) | 2020-11-12 | 2023-06-22 | Amgen Inc. | Methods of treating heart failure by administering omecamtiv mecarbil |
| WO2022177927A1 (en) * | 2021-02-16 | 2022-08-25 | Assia Chemical Industries Ltd | Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt |
| CN117157274A (zh) | 2021-03-10 | 2023-12-01 | 安进股份有限公司 | 奥美卡替莫卡必尔的合成 |
| WO2024081611A1 (en) | 2022-10-11 | 2024-04-18 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
| US11986474B1 (en) | 2023-06-27 | 2024-05-21 | Cytokinetics, Incorporated | Methods for treating heart failure by administering cardiac sarcomere activators |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2788775B1 (fr) * | 1999-01-22 | 2001-04-13 | Pf Medicament | Nouvelles n-alcoyl-n-[1-(omega-(arylalcoyloxy)alcoyl] piperidin-4-yl]-4h-3,1-benzo(thia/oxa)zines-2-amines substituees, leur preparation et leur application en therapeutique |
| NZ518281A (en) | 1999-12-23 | 2005-01-28 | Pfizer Prod Inc | Controlled release drug dosage core comprising a drug-containing composition and a water-swellable composition |
| GB0124455D0 (en) * | 2001-10-11 | 2001-12-05 | Pfizer Ltd | Pharmaceutical formulations |
| WO2003032963A2 (en) | 2001-10-17 | 2003-04-24 | Aventis Pharma Deutschland Gmbh | Method of reducing type 2 diabetes in high risk patients |
| US20050096365A1 (en) | 2003-11-03 | 2005-05-05 | David Fikstad | Pharmaceutical compositions with synchronized solubilizer release |
| JP5080970B2 (ja) * | 2004-06-17 | 2012-11-21 | サイトキネティクス・インコーポレーテッド | 心疾患を治療するための置換尿素誘導体 |
| WO2007054975A1 (en) | 2005-11-08 | 2007-05-18 | Panacea Biotec Ltd | Pharmaceutical compositions for the treatment of cardiovascular and other associated disorders |
| PE20070823A1 (es) * | 2005-11-15 | 2007-08-09 | Glaxo Group Ltd | Sal tosilato de 8-(2,6-difluorofenil)-4-(4-fluoro-2-metilfenil)-2-{[2-hidroxi-1-(hidroximetil)etil]amino}pirido[2,3-]pirimidin-7(8h)-ona |
| EP1959960B1 (en) * | 2005-12-15 | 2013-04-10 | Cytokinetics, Inc. | Certain chemical entities, compositions and methods |
| US20070208000A1 (en) | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
| JP5178526B2 (ja) * | 2005-12-19 | 2013-04-10 | サイトキネティクス・インコーポレーテッド | 化合物、組成物および方法 |
| US7639112B2 (en) | 2007-04-25 | 2009-12-29 | Sony Corporation | Fuse device with integrated switch |
| US20090192168A1 (en) * | 2008-01-04 | 2009-07-30 | Alex Muci | Compounds, Compositions and Methods |
| TW201006816A (en) | 2008-05-15 | 2010-02-16 | Organon Nv | Hexafluoroisopropanol derivatives |
| EP3753565A1 (en) | 2008-10-03 | 2020-12-23 | ViCardia Therapeutics, Inc. | Aica riboside analogs for treatment of cardiac and other conditions |
| US9253433B2 (en) | 2012-11-27 | 2016-02-02 | International Business Machines Corporation | Method and apparatus for tagging media with identity of creator or scene |
| DK2970123T3 (da) | 2013-03-14 | 2019-10-21 | Amgen Inc | Salt af omecamtiv mecarbil og fremgangsmåde til fremstilling heraf |
| US9895308B2 (en) * | 2013-03-14 | 2018-02-20 | Amgen Inc. | Heterocyclic compounds and their uses |
| CA2975260C (en) | 2015-01-29 | 2024-05-21 | Signal Pharmaceuticals Llc | Isotopologues of 2-(tert-butylamino)-4-((1r,3r,4r)-3-hydroxy-4-methylcyclohexylamino)-pyrimidine-5-carboxamide |
| US10543215B2 (en) | 2015-06-26 | 2020-01-28 | Amgen Inc. | Combination therapy of cardiac myosin activator and sinus node if current inhibitor |
| PT3645518T (pt) | 2017-06-30 | 2021-08-23 | Amgen Inc | Síntese de omecamtiv mecarbil |
| AU2018290983B2 (en) | 2017-06-30 | 2023-11-23 | Amgen Inc. | Methods of treating heart failure with cardiac sarcomere activators |
| ES2815899T3 (es) | 2018-07-09 | 2021-03-31 | Fis Fabbrica Italiana Sintetici Spa | 2-Fluoro-3-nitrotolueno cristalino y procedimiento para la preparación del mismo |
| WO2020014406A1 (en) | 2018-07-12 | 2020-01-16 | Assia Chemical Industries Ltd. | Solid state forms of omecamtiv mecarbil & omecamtiv mecarbil dihcl |
| US11465969B2 (en) | 2018-08-17 | 2022-10-11 | Cytokinetics, Inc. | Salts and crystal forms of omecamtiv mecarbil |
| US20220042055A1 (en) | 2018-12-18 | 2022-02-10 | Amgen Inc. | Method of reducing aromatic nitro compounds |
| WO2021053175A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021053189A1 (en) | 2019-09-19 | 2021-03-25 | Synthon B.V. | Salts of omecamtiv mecarbil and solid forms thereof |
| WO2021070123A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Solid forms of omecamtiv mecarbil dihydrochloride and processes thereof |
| WO2021070124A1 (en) | 2019-10-09 | 2021-04-15 | Dr. Reddy’S Laboratories Limited | Alternate processes for the preparation of omecamtiv mecarbil |
| WO2021136477A1 (zh) | 2020-01-03 | 2021-07-08 | 苏州科睿思制药有限公司 | 化合物i二盐酸盐的共晶及其制备方法和用途 |
| JP2023513249A (ja) | 2020-02-10 | 2023-03-30 | アムジェン インコーポレイテッド | オメカムチブメカルビル製剤 |
| AU2021380754A1 (en) | 2020-11-12 | 2023-06-22 | Amgen Inc. | Methods of treating heart failure by administering omecamtiv mecarbil |
| WO2022177927A1 (en) | 2021-02-16 | 2022-08-25 | Assia Chemical Industries Ltd | Unhydrous crystalline form of omecamtiv mecarbil dihydrobromide salt |
| CN117157274A (zh) | 2021-03-10 | 2023-12-01 | 安进股份有限公司 | 奥美卡替莫卡必尔的合成 |
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2014
- 2014-03-14 DK DK14720369.9T patent/DK2970123T3/da active
- 2014-03-14 LT LTEP14719472.4T patent/LT2968173T/lt unknown
- 2014-03-14 JP JP2016502336A patent/JP6498658B2/ja active Active
- 2014-03-14 CA CA3147180A patent/CA3147180C/en active Active
- 2014-03-14 PE PE2015002000A patent/PE20151786A1/es unknown
- 2014-03-14 EP EP14720369.9A patent/EP2970123B1/en active Active
- 2014-03-14 SG SG10201706656RA patent/SG10201706656RA/en unknown
- 2014-03-14 MX MX2015012429A patent/MX2015012429A/es unknown
- 2014-03-14 ES ES14720369T patent/ES2750676T3/es active Active
- 2014-03-14 KR KR1020227007907A patent/KR102474467B1/ko active IP Right Grant
- 2014-03-14 RU RU2015143643A patent/RU2663663C2/ru active
- 2014-03-14 AP AP2015008789A patent/AP2015008789A0/xx unknown
- 2014-03-14 MA MA44637A patent/MA44637B1/fr unknown
- 2014-03-14 JP JP2016502348A patent/JP6783138B2/ja active Active
- 2014-03-14 ME MEP-2019-283A patent/ME03566B/me unknown
- 2014-03-14 SI SI201431724T patent/SI2968173T1/sl unknown
- 2014-03-14 HU HUE14719472A patent/HUE052355T2/hu unknown
- 2014-03-14 PL PL14720369T patent/PL2970123T3/pl unknown
- 2014-03-14 RS RS20191313A patent/RS59536B1/sr unknown
- 2014-03-14 EA EA201591728A patent/EA031185B1/ru unknown
- 2014-03-14 DK DK14719472.4T patent/DK2968173T3/da active
- 2014-03-14 SI SI201431358T patent/SI2970123T1/sl unknown
- 2014-03-14 AR ARP140101155A patent/AR095542A1/es not_active Application Discontinuation
- 2014-03-14 WO PCT/US2014/027146 patent/WO2014152270A1/en active Application Filing
- 2014-03-14 ES ES14719472T patent/ES2837038T3/es active Active
- 2014-03-14 MX MX2015012414A patent/MX363347B/es unknown
- 2014-03-14 BR BR112015023417-8A patent/BR112015023417B1/pt active IP Right Grant
- 2014-03-14 LT LT14720369T patent/LT2970123T/lt unknown
- 2014-03-14 US US14/773,436 patent/US9988354B2/en active Active
- 2014-03-14 RS RS20201513A patent/RS61215B1/sr unknown
- 2014-03-14 PL PL14719472T patent/PL2968173T3/pl unknown
- 2014-03-14 EP EP20201011.2A patent/EP3821882A1/en active Pending
- 2014-03-14 AU AU2014239995A patent/AU2014239995B2/en active Active
- 2014-03-14 PT PT147203699T patent/PT2970123T/pt unknown
- 2014-03-14 NZ NZ711225A patent/NZ711225A/en unknown
- 2014-03-14 AU AU2014240049A patent/AU2014240049C1/en active Active
- 2014-03-14 CA CA2902436A patent/CA2902436A1/en active Pending
- 2014-03-14 HU HUE14720369A patent/HUE046285T2/hu unknown
- 2014-03-14 UY UY0001035449A patent/UY35449A/es active IP Right Grant
- 2014-03-14 CN CN201480018405.6A patent/CN105209437B/zh active Active
- 2014-03-14 TW TW103109296A patent/TWI667026B/zh active
- 2014-03-14 WO PCT/US2014/027104 patent/WO2014152236A1/en active Application Filing
- 2014-03-14 KR KR1020157025283A patent/KR102374159B1/ko active IP Right Grant
- 2014-03-14 CN CN201810812212.8A patent/CN108785265A/zh active Pending
- 2014-03-14 SG SG11201507258PA patent/SG11201507258PA/en unknown
- 2014-03-14 MA MA38399A patent/MA38399B2/fr unknown
- 2014-03-14 UA UAA201509685A patent/UA117011C2/uk unknown
- 2014-03-14 CN CN201480014897.1A patent/CN105120844A/zh active Pending
- 2014-03-14 US US14/210,713 patent/US9951015B2/en active Active
- 2014-03-14 CA CA2902646A patent/CA2902646C/en active Active
- 2014-03-14 BR BR112015022857-7A patent/BR112015022857B1/pt active IP Right Grant
- 2014-03-14 PT PT147194724T patent/PT2968173T/pt unknown
- 2014-03-14 MY MYPI2015002299A patent/MY186048A/en unknown
- 2014-03-14 EP EP14719472.4A patent/EP2968173B1/en active Active
- 2014-03-16 JO JOP/2014/0114A patent/JOP20140114B1/ar active
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2015
- 2015-08-24 IL IL240788A patent/IL240788B/en active IP Right Grant
- 2015-08-31 TN TN2015000380A patent/TN2015000380A1/en unknown
- 2015-09-03 IL IL24108915A patent/IL241089B/en active IP Right Grant
- 2015-09-08 PH PH12015501998A patent/PH12015501998A1/en unknown
- 2015-09-11 MX MX2021001231A patent/MX2021001231A/es unknown
- 2015-09-14 CL CL2015002708A patent/CL2015002708A1/es unknown
- 2015-09-14 SA SA515361088A patent/SA515361088B1/ar unknown
- 2015-10-13 CR CR20150549A patent/CR20150549A/es unknown
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2016
- 2016-06-02 HK HK16106250.4A patent/HK1218080A1/zh unknown
- 2016-06-07 HK HK16106548.6A patent/HK1218512A1/zh unknown
- 2016-06-07 HK HK16106547.7A patent/HK1218544A1/zh unknown
- 2016-06-30 HK HK16107606.3A patent/HK1219484A1/zh unknown
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2018
- 2018-03-20 US US15/926,411 patent/US10421726B2/en active Active
- 2018-04-26 US US15/963,529 patent/US20180312469A1/en not_active Abandoned
- 2018-11-15 JP JP2018214801A patent/JP6689942B2/ja active Active
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2019
- 2019-01-24 PH PH12019500176A patent/PH12019500176A1/en unknown
- 2019-09-23 US US16/579,360 patent/US11384053B2/en active Active
- 2019-09-24 HR HRP20191728 patent/HRP20191728T1/hr unknown
- 2019-10-15 CY CY20191101080T patent/CY1122695T1/el unknown
- 2019-11-14 US US16/684,216 patent/US20200079736A1/en not_active Abandoned
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2020
- 2020-04-08 JP JP2020069487A patent/JP6966590B2/ja active Active
- 2020-07-02 US US16/920,155 patent/US20200331859A1/en not_active Abandoned
- 2020-07-02 US US16/920,144 patent/US11472773B2/en active Active
- 2020-12-08 HR HRP20201967TT patent/HRP20201967T1/hr unknown
- 2020-12-15 CY CY20201101184T patent/CY1123633T1/el unknown
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2021
- 2021-09-24 US US17/448,833 patent/US11958809B2/en active Active
- 2021-10-21 JP JP2021172324A patent/JP7174132B2/ja active Active
-
2022
- 2022-06-08 US US17/806,033 patent/US11884630B2/en active Active
- 2022-09-08 US US17/930,695 patent/US20230044617A1/en active Pending
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2023
- 2023-11-27 US US18/520,156 patent/US20240101517A1/en active Pending
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