HK1213581A1 - 抗- 抗體及其使用方法 - Google Patents
抗- 抗體及其使用方法Info
- Publication number
- HK1213581A1 HK1213581A1 HK16101574.4A HK16101574A HK1213581A1 HK 1213581 A1 HK1213581 A1 HK 1213581A1 HK 16101574 A HK16101574 A HK 16101574A HK 1213581 A1 HK1213581 A1 HK 1213581A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- antibodies
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K999/00—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS dummy group
- H05K999/99—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS dummy group dummy group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261720289P | 2012-10-30 | 2012-10-30 | |
PCT/US2013/067583 WO2014070934A1 (en) | 2012-10-30 | 2013-10-30 | Anti-cd40 antibodies and methods of use |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1213581A1 true HK1213581A1 (zh) | 2016-07-08 |
Family
ID=49551838
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK16101574.4A HK1213581A1 (zh) | 2012-10-30 | 2016-02-12 | 抗- 抗體及其使用方法 |
Country Status (12)
Country | Link |
---|---|
US (5) | US9676861B2 (zh) |
EP (2) | EP2914627B1 (zh) |
JP (4) | JP6693745B2 (zh) |
KR (1) | KR102270618B1 (zh) |
CN (3) | CN110066335B (zh) |
AU (2) | AU2013337903B2 (zh) |
CA (1) | CA2888763A1 (zh) |
DK (1) | DK2914627T3 (zh) |
ES (1) | ES2879552T3 (zh) |
HK (1) | HK1213581A1 (zh) |
NZ (1) | NZ707086A (zh) |
WO (1) | WO2014070934A1 (zh) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN102002104A (zh) | 2009-08-28 | 2011-04-06 | 江苏先声药物研究有限公司 | 一种抗vegf的单克隆抗体及含有该抗体的药物组合物 |
EP2625292B1 (en) | 2010-10-07 | 2018-12-05 | The General Hospital Corporation | Biomarkers of cancer |
KR20190122889A (ko) | 2011-04-29 | 2019-10-30 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
EP2914627B1 (en) | 2012-10-30 | 2021-04-07 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
CN105693845B (zh) * | 2014-11-24 | 2020-10-02 | 中国科学院上海营养与健康研究所 | 一种cd40胞外区的表达纯化及其用途 |
JP6518917B2 (ja) | 2015-05-29 | 2019-05-29 | アッヴィ・インコーポレイテッド | 抗cd40抗体およびその使用 |
US10682390B2 (en) | 2015-07-16 | 2020-06-16 | Biokine Therapeutics Ltd. | Compositions and methods for treating cancer |
BR112018006251A2 (pt) | 2015-09-30 | 2018-10-16 | Janssen Biotech Inc | anticorpos antagonistas que se ligam especificamente a cd40 humano e métodos de uso |
JP2019500892A (ja) | 2015-11-03 | 2019-01-17 | ヤンセン バイオテツク,インコーポレーテツド | Tim−3に特異的に結合する抗体及びその使用 |
MX2018010672A (es) * | 2016-03-04 | 2019-05-27 | Univ Rockefeller | Anticuerpos para cumulo de diferenciación 40 (cd40) con actividad agonista mejorada. |
SG11201808821WA (en) | 2016-04-18 | 2018-11-29 | Celldex Therapeutics Inc | Agonistic antibodies that bind human cd40 and uses thereof |
CN109476750B (zh) | 2016-05-27 | 2022-02-01 | 艾伯维生物制药股份有限公司 | 抗cd40抗体及其用途 |
BR112018074453A2 (pt) | 2016-05-27 | 2019-03-19 | Abbvie Biotherapeutics Inc. | proteínas de ligação biespecíficas ligando uma protéina imunomoduladora e um antígeno tumoral |
US20190263918A1 (en) * | 2016-06-08 | 2019-08-29 | Shanghai Jiao Tong University School Of Medicine | Sequence of antibody heavy chain constant region for enhancing agonistic antibody activity |
ES2963807T3 (es) | 2016-06-08 | 2024-04-02 | Xencor Inc | Tratamiento de enfermedades relacionadas con la IgG4 con anticuerpos anti-CD19 de reticulación a CD32B |
RU2769282C2 (ru) | 2016-06-20 | 2022-03-30 | Кимаб Лимитед | Анти-PD-L1 и IL-2 цитокины |
SG11201811431VA (en) | 2016-07-14 | 2019-01-30 | Genmab As | Multispecific antibodies against cd40 and cd137 |
CN109843916B (zh) | 2016-08-12 | 2023-10-31 | 詹森生物科技公司 | 具有增强的激动活性的Fc工程化抗TNFR超家族成员抗体及其使用方法 |
WO2018031258A1 (en) | 2016-08-12 | 2018-02-15 | Janssen Biotech, Inc. | Engineered antibodies and other fc-domain containing molecules with enhanced agonism and effector functions |
CN110114089A (zh) * | 2016-11-02 | 2019-08-09 | 埃派斯进有限公司 | 组合中的抗cd40抗体及其使用方法 |
WO2018089688A1 (en) | 2016-11-09 | 2018-05-17 | Jinjun Shi | Restoration of tumor suppression using mrna-based delivery system |
CN110382541A (zh) * | 2017-03-29 | 2019-10-25 | 葛莱高托普有限公司 | 人源化抗cd40抗体 |
TWI788340B (zh) * | 2017-04-07 | 2023-01-01 | 美商必治妥美雅史谷比公司 | 抗icos促效劑抗體及其用途 |
WO2018219327A1 (zh) | 2017-06-01 | 2018-12-06 | 江苏恒瑞医药股份有限公司 | 抗cd40抗体、其抗原结合片段及其医药用途 |
CN109136274B (zh) | 2017-06-19 | 2021-04-23 | 百奥赛图江苏基因生物技术有限公司 | 人源化cd40基因改造动物模型的制备方法及应用 |
WO2018233607A1 (en) * | 2017-06-19 | 2018-12-27 | Beijing Biocytogen Co., Ltd | NON-HUMAN ANIMAL GENETICALLY MODIFIED WITH HUMAN OR CHIMERIC CD40 |
CN109384845B (zh) * | 2017-08-14 | 2022-06-21 | 中国科学院上海营养与健康研究所 | 一种cd40单克隆抗体、其制备方法及其应用 |
EP3740509A4 (en) | 2018-01-17 | 2022-06-22 | Apexigen, Inc. | ANTI-PD-L1 ANTIBODIES AND METHODS OF USE |
EP4317972A3 (en) | 2018-02-06 | 2024-03-13 | The General Hospital Corporation | Repeat rna as biomarkers of tumor immune response |
CA3097007A1 (en) * | 2018-04-20 | 2019-10-24 | Lyvgen Biopharma Co., Ltd. | Anti-cd40 antibodies and uses thereof |
MA52889A (fr) | 2018-06-15 | 2021-04-21 | Flagship Pioneering Innovations V Inc | Augmentation de l'activité immunitaire par modulation de facteurs de signalisation post-cellulaires |
AR117091A1 (es) * | 2018-11-19 | 2021-07-07 | Bristol Myers Squibb Co | Anticuerpos monoclonales antagonistas contra cd40 y sus usos |
JP2022513624A (ja) | 2018-11-23 | 2022-02-09 | ストライク ファーマ アクティエボラーグ | 二重特異性コンジュゲート |
CN112839961B (zh) | 2018-11-30 | 2023-04-04 | 江苏恒瑞医药股份有限公司 | 一种cd40抗体药物组合物及其用途 |
MX2021005823A (es) | 2018-11-30 | 2021-07-15 | Jiangsu Hengrui Medicine Co | Anticuerpo anti-cd40, fragmento de union a antigeno y uso farmaceutico del mismo. |
CN109678959B (zh) * | 2019-02-22 | 2020-12-08 | 北京免疫方舟医药科技有限公司 | 抗cd40抗体及其应用 |
US10570210B1 (en) | 2019-03-04 | 2020-02-25 | Beijing Mabworks Biotech Co.Ltd | Antibodies binding CD40 and uses thereof |
CN111454363B (zh) * | 2019-03-04 | 2021-03-02 | 北京天广实生物技术股份有限公司 | Cd40抗体及其用途 |
CN113728008B (zh) * | 2019-04-10 | 2024-04-09 | 南开大学 | 抗cd40抗体及其用途 |
EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
US20220370418A1 (en) | 2019-09-09 | 2022-11-24 | Basilea Pharmaceutica International AG | Pharmaceutical combinations comprising a furazanobenzimidazoles and a cd40 agonist for use in the treatment of neoplastic diseases |
US20220332836A1 (en) * | 2019-09-11 | 2022-10-20 | Novartis Ag | A method for preventing human virus associated disorders in patients |
US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
GB202008003D0 (en) | 2020-05-28 | 2020-07-15 | Quine Medical Ab | Anti-CD40 antibody |
JP2023532339A (ja) | 2020-06-29 | 2023-07-27 | フラグシップ パイオニアリング イノベーションズ ブイ,インコーポレーテッド | サノトランスミッションを促進するためにエンジニアリングされたウイルス及び癌の処置におけるそれらの使用 |
WO2022002065A1 (zh) * | 2020-06-30 | 2022-01-06 | 百奥泰生物制药股份有限公司 | 抗cd40抗体或抗原结合片段及其应用 |
US20220325287A1 (en) | 2021-03-31 | 2022-10-13 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
WO2023278641A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
CA3232304A1 (en) * | 2021-09-26 | 2023-03-30 | Chen SHEN | Use of anti-cd40 antibody |
WO2024077191A1 (en) | 2022-10-05 | 2024-04-11 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additionalpolypeptides and their use in treating cancer |
Family Cites Families (114)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3896111A (en) | 1973-02-20 | 1975-07-22 | Research Corp | Ansa macrolides |
US4237224A (en) | 1974-11-04 | 1980-12-02 | Board Of Trustees Of The Leland Stanford Jr. University | Process for producing biologically functional molecular chimeras |
US4151042A (en) | 1977-03-31 | 1979-04-24 | Takeda Chemical Industries, Ltd. | Method for producing maytansinol and its derivatives |
US4137230A (en) | 1977-11-14 | 1979-01-30 | Takeda Chemical Industries, Ltd. | Method for the production of maytansinoids |
US4307016A (en) | 1978-03-24 | 1981-12-22 | Takeda Chemical Industries, Ltd. | Demethyl maytansinoids |
US4265814A (en) | 1978-03-24 | 1981-05-05 | Takeda Chemical Industries | Matansinol 3-n-hexadecanoate |
JPS5562090A (en) | 1978-10-27 | 1980-05-10 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS5566585A (en) | 1978-11-14 | 1980-05-20 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
US4256746A (en) | 1978-11-14 | 1981-03-17 | Takeda Chemical Industries | Dechloromaytansinoids, their pharmaceutical compositions and method of use |
JPS55164687A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS55102583A (en) | 1979-01-31 | 1980-08-05 | Takeda Chem Ind Ltd | 20-acyloxy-20-demethylmaytansinoid compound |
JPS55162791A (en) | 1979-06-05 | 1980-12-18 | Takeda Chem Ind Ltd | Antibiotic c-15003pnd and its preparation |
JPS55164685A (en) | 1979-06-08 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
JPS55164686A (en) | 1979-06-11 | 1980-12-22 | Takeda Chem Ind Ltd | Novel maytansinoid compound and its preparation |
US4309428A (en) | 1979-07-30 | 1982-01-05 | Takeda Chemical Industries, Ltd. | Maytansinoids |
JPS5645483A (en) | 1979-09-19 | 1981-04-25 | Takeda Chem Ind Ltd | C-15003phm and its preparation |
JPS5645485A (en) | 1979-09-21 | 1981-04-25 | Takeda Chem Ind Ltd | Production of c-15003pnd |
EP0028683A1 (en) | 1979-09-21 | 1981-05-20 | Takeda Chemical Industries, Ltd. | Antibiotic C-15003 PHO and production thereof |
WO1981001145A1 (en) | 1979-10-18 | 1981-04-30 | Univ Illinois | Hydrolytic enzyme-activatible pro-drugs |
WO1982001188A1 (en) | 1980-10-08 | 1982-04-15 | Takeda Chemical Industries Ltd | 4,5-deoxymaytansinoide compounds and process for preparing same |
US4450254A (en) | 1980-11-03 | 1984-05-22 | Standard Oil Company | Impact improvement of high nitrile resins |
US4315929A (en) | 1981-01-27 | 1982-02-16 | The United States Of America As Represented By The Secretary Of Agriculture | Method of controlling the European corn borer with trewiasine |
US4313946A (en) | 1981-01-27 | 1982-02-02 | The United States Of America As Represented By The Secretary Of Agriculture | Chemotherapeutically active maytansinoids from Trewia nudiflora |
JPS57192389A (en) | 1981-05-20 | 1982-11-26 | Takeda Chem Ind Ltd | Novel maytansinoid |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US5247069A (en) | 1986-06-13 | 1993-09-21 | Oncogen | Ligands and methods for augmenting B-cell proliferation |
US5182368A (en) * | 1986-06-13 | 1993-01-26 | Ledbetter Jeffrey A | Ligands and methods for augmenting B-cell proliferation |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
GB8705477D0 (en) | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US4975278A (en) | 1988-02-26 | 1990-12-04 | Bristol-Myers Company | Antibody-enzyme conjugates in combination with prodrugs for the delivery of cytotoxic agents to tumor cells |
CA2026147C (en) | 1989-10-25 | 2006-02-07 | Ravi J. Chari | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5208020A (en) | 1989-10-25 | 1993-05-04 | Immunogen Inc. | Cytotoxic agents comprising maytansinoids and their therapeutic use |
US5151510A (en) | 1990-04-20 | 1992-09-29 | Applied Biosystems, Inc. | Method of synethesizing sulfurized oligonucleotide analogs |
GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
US5264586A (en) | 1991-07-17 | 1993-11-23 | The Scripps Research Institute | Analogs of calicheamicin gamma1I, method of making and using the same |
ZA932522B (en) | 1992-04-10 | 1993-12-20 | Res Dev Foundation | Immunotoxins directed against c-erbB-2(HER/neu) related surface antigens |
US5397703A (en) | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US6765087B1 (en) | 1992-08-21 | 2004-07-20 | Vrije Universiteit Brussel | Immunoglobulins devoid of light chains |
JP3720353B2 (ja) | 1992-12-04 | 2005-11-24 | メディカル リサーチ カウンシル | 多価および多重特異性の結合タンパク質、それらの製造および使用 |
ES2162863T3 (es) | 1993-04-29 | 2002-01-16 | Unilever Nv | Produccion de anticuerpos o fragmentos (funcionalizados) de los mismos derivados de inmunoglobulinas de cadena pesada de camelidae. |
KR960704576A (ko) | 1993-10-01 | 1996-10-09 | 크리스토퍼 엘. 와이트 | CD40에 대한 항체(Antibodies to CD40) |
JPH09507074A (ja) * | 1993-12-23 | 1997-07-15 | イミュネックス・コーポレーション | Cd40を発現する腫瘍細胞を特徴とする疾患の予防又は治療方法 |
US5837458A (en) | 1994-02-17 | 1998-11-17 | Maxygen, Inc. | Methods and compositions for cellular and metabolic engineering |
US5773001A (en) | 1994-06-03 | 1998-06-30 | American Cyanamid Company | Conjugates of methyltrithio antitumor agents and intermediates for their synthesis |
GB9425060D0 (en) | 1994-12-13 | 1995-02-08 | Univ Birmingham | Carcinoma treatment |
US5675063A (en) | 1995-02-28 | 1997-10-07 | Loyola University Of Chicago | Immortalized rabbit hybridoma fusion partner |
JP3657271B2 (ja) | 1995-03-01 | 2005-06-08 | イミュネックス・コーポレーション | 病原性または日和見感染性生物に感染した哺乳動物の治療のための組成物 |
US5712374A (en) | 1995-06-07 | 1998-01-27 | American Cyanamid Company | Method for the preparation of substantiallly monomeric calicheamicin derivative/carrier conjugates |
US5714586A (en) | 1995-06-07 | 1998-02-03 | American Cyanamid Company | Methods for the preparation of monomeric calicheamicin derivative/carrier conjugates |
EP1033406A4 (en) * | 1997-10-27 | 2005-03-09 | Sumitomo Electric Industries | INDUCER FOR THE PRODUCTION OF ANTIGEN-SPECIFIC ANTIBODY, EXPRESSION VECTOR CONTAINING THE GENE REQUIRED THEREFOR, AND METHOD FOR INDUCING THE PRODUCTION OF THE ANTIGEN-SPECIFIC ANTIBODY |
US6051228A (en) | 1998-02-19 | 2000-04-18 | Bristol-Myers Squibb Co. | Antibodies against human CD40 |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
US6528624B1 (en) | 1998-04-02 | 2003-03-04 | Genentech, Inc. | Polypeptide variants |
KR100301796B1 (ko) * | 1998-10-01 | 2001-09-06 | 성재갑 | 면역억제능이 있는 항-씨디40 리간드 모노클로날 항체 |
US6680176B2 (en) | 1999-05-17 | 2004-01-20 | The United States Of America, As Represented By The Department Of Health And Human Services | Identification of candidate ligands which modulate antigen presenting cells |
US20030118588A1 (en) | 1999-05-22 | 2003-06-26 | Linda Diehl | Induction of anti-tumor CTL immunity through in vivo triggering of 4-1BB and/or CD40 |
US6946129B1 (en) | 1999-06-08 | 2005-09-20 | Seattle Genetics, Inc. | Recombinant anti-CD40 antibody and uses thereof |
EP1253942A4 (en) | 2000-02-01 | 2004-06-16 | Tanox Inc | CD40-BINDING AND APC-ACTIVATING MOLECULES |
WO2002011763A1 (en) | 2000-04-19 | 2002-02-14 | Tanox, Inc. | Cd40 antagonists for use in treating psoriasis and other inflammatory skin conditions |
US7063845B2 (en) | 2000-04-28 | 2006-06-20 | Gemini Science, Inc. | Human anti-CD40 antibodies |
CN1452636B (zh) | 2000-05-08 | 2011-06-15 | 塞尔德克斯医疗公司 | 抗树突细胞的人单克隆抗体 |
EP2009027B1 (en) | 2001-04-27 | 2014-05-21 | Kyowa Hakko Kirin Co., Ltd. | Anti-CD40 monoclonal antibody |
JP4025881B2 (ja) * | 2001-04-27 | 2007-12-26 | キリンファーマ株式会社 | 抗cd40モノクローナル抗体 |
AR039067A1 (es) | 2001-11-09 | 2005-02-09 | Pfizer Prod Inc | Anticuerpos para cd40 |
US7317091B2 (en) | 2002-03-01 | 2008-01-08 | Xencor, Inc. | Optimized Fc variants |
WO2003074679A2 (en) * | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
US8093357B2 (en) | 2002-03-01 | 2012-01-10 | Xencor, Inc. | Optimized Fc variants and methods for their generation |
US7657380B2 (en) | 2003-12-04 | 2010-02-02 | Xencor, Inc. | Methods of generating variant antibodies with increased host string content |
US20040132101A1 (en) | 2002-09-27 | 2004-07-08 | Xencor | Optimized Fc variants and methods for their generation |
US20080199471A1 (en) | 2002-03-01 | 2008-08-21 | Bernett Matthew J | Optimized cd40 antibodies and methods of using the same |
EP2368578A1 (en) | 2003-01-09 | 2011-09-28 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
US7960512B2 (en) | 2003-01-09 | 2011-06-14 | Macrogenics, Inc. | Identification and engineering of antibodies with variant Fc regions and methods of using same |
ES2349777T3 (es) * | 2003-01-22 | 2011-01-11 | Glycart Biotechnology Ag | Constructos de fusión y uso de los mismos para producir anticuerpos con mayor afinidad de unión al receptor de fc y función efectora. |
PL1682178T3 (pl) * | 2003-11-04 | 2010-12-31 | Novartis Vaccines & Diagnostics Inc | Sposoby terapii nowotworów wykazujących ekspresje antygenu CD40 |
US20050136055A1 (en) | 2003-12-22 | 2005-06-23 | Pfizer Inc | CD40 antibody formulation and methods |
NZ548325A (en) * | 2003-12-25 | 2009-07-31 | Kirin Pharma Kk | Mutants of anti-CD40 antibody |
DK1776384T3 (da) | 2004-08-04 | 2013-09-02 | Mentrik Biotech Llc | VARIANT-Fc-REGIONER |
US7462697B2 (en) | 2004-11-08 | 2008-12-09 | Epitomics, Inc. | Methods for antibody engineering |
US7632497B2 (en) | 2004-11-10 | 2009-12-15 | Macrogenics, Inc. | Engineering Fc Antibody regions to confer effector function |
AU2005325801A1 (en) | 2005-01-31 | 2006-08-03 | Ablynx N.V. | Method for generating variable domain sequences of heavy chain antibodies |
US20060257359A1 (en) | 2005-02-28 | 2006-11-16 | Cedric Francois | Modifying macrophage phenotype for treatment of disease |
CA2602663A1 (en) | 2005-03-31 | 2006-10-05 | Xencor, Inc. | Fc variants with optimized properties |
PT1889065E (pt) | 2005-05-18 | 2013-09-27 | Novartis Ag | Métodos para o diagnóstico e tratamento de doenças tendo uma componente autoimune e/ou inflamatória |
EP1894012A2 (en) | 2005-05-18 | 2008-03-05 | Novartis AG | Methods for diagnosis and treatment of proliferative disorders mediated by cd40 signaling |
CA2609269C (en) * | 2005-05-26 | 2014-08-05 | Seattle Genetics, Inc. | Humanized anti-cd40 antibodies and their methods of use |
US7429487B2 (en) | 2005-07-05 | 2008-09-30 | Epitomics, Inc. | Fusion partner for production of monoclonal rabbit antibodies |
ES2400660T3 (es) | 2005-11-01 | 2013-04-11 | Novartis Ag | Usos de anticuerpos anti-CD40 |
AU2006308860B2 (en) | 2005-11-01 | 2012-01-12 | Novartis Ag | Uses of anti-CD40 antibodies |
JP5525729B2 (ja) | 2005-11-28 | 2014-06-18 | ゲンマブ エー/エス | 組換え一価抗体およびその作製方法 |
US20090304687A1 (en) | 2005-12-09 | 2009-12-10 | Seattle Genetics , Inc. | Methods of using cd40 binding agents |
EP2125893A2 (en) * | 2007-01-23 | 2009-12-02 | Xencor, Inc. | Optimized cd40 antibodies and methods of using the same |
US8062864B2 (en) | 2007-05-21 | 2011-11-22 | Alderbio Holdings Llc | Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies |
US20090238825A1 (en) | 2007-05-21 | 2009-09-24 | Kovacevich Brian R | Novel rabbit antibody humanization methods and humanized rabbit antibodies |
EP2162469A4 (en) | 2007-05-21 | 2012-08-01 | Alderbio Holdings Llc | NEW METHODS OF HUMANIZING RABBIT ANTIBODIES AND HUMANIZED RABBIT ANTIBODIES |
DK2176298T3 (en) | 2007-05-30 | 2018-02-12 | Xencor Inc | Methods and compositions for inhibiting CD32B-expressing cells |
AU2009206506B2 (en) | 2008-01-23 | 2013-01-10 | Xencor, Inc. | Optimized CD40 antibodies and methods of using the same |
AU2009270771B2 (en) | 2008-07-16 | 2012-08-23 | Baylor Research Institute | HIV vaccine based on targeting maximized Gag and Nef to dendritic cells |
AU2009286247A1 (en) | 2008-08-29 | 2010-03-04 | Academisch Ziekenhuis Leiden H.O.D.N. Lumc | Delivery of a CD40 agonist to a tumor draining lymph node of a subject |
US8435514B2 (en) | 2008-12-05 | 2013-05-07 | Als Therapy Development Institute | Method for the treatment of neurodegenerative diseases |
US9562104B2 (en) | 2009-03-10 | 2017-02-07 | Baylor Research Institute | Anti-CD40 antibodies |
WO2010121231A1 (en) | 2009-04-18 | 2010-10-21 | Genentech, Inc. | Methods for assessing responsiveness of b-cell lymphoma to treatment with anti-cd40 antibodies |
PT2423228E (pt) | 2009-04-20 | 2016-02-26 | Kyowa Hakko Kirin Co Ltd | Anticorpo contendo igg2 em que foram introduzidas mutações de aminoácidos |
RU2012145183A (ru) * | 2010-03-29 | 2014-05-10 | Займворкс, Инк. | Антитела с повышенной или пониженной эффекторной функцией |
MY187990A (en) | 2010-03-31 | 2021-11-07 | Boehringer Ingelheim Int | Anti-cd40 antibodies |
EP2600878A4 (en) | 2010-08-04 | 2014-06-11 | Univ Duke | REGULATORY B-CELLS AND ITS USES |
AR083847A1 (es) | 2010-11-15 | 2013-03-27 | Novartis Ag | Variantes de fc (fragmento constante) silenciosas de los anticuerpos anti-cd40 |
CA3167037A1 (en) | 2010-12-20 | 2012-06-28 | The Rockefeller University | Modulating agonistic tnfr antibodies |
PT2699601T (pt) * | 2011-04-21 | 2018-04-05 | Domantis Ltd | Polipéptidos de anticorpo que antagonizam cd40 |
KR20190122889A (ko) | 2011-04-29 | 2019-10-30 | 아펙시젠, 인코포레이티드 | 항-cd40 항체 및 사용 방법 |
EP2914627B1 (en) | 2012-10-30 | 2021-04-07 | Apexigen, Inc. | Anti-cd40 antibodies and methods of use |
US9209965B2 (en) | 2014-01-14 | 2015-12-08 | Microsemi Semiconductor Ulc | Network interface with clock recovery module on line card |
-
2013
- 2013-10-30 EP EP13786884.0A patent/EP2914627B1/en active Active
- 2013-10-30 EP EP21166914.8A patent/EP3925977A1/en active Pending
- 2013-10-30 CA CA2888763A patent/CA2888763A1/en active Pending
- 2013-10-30 CN CN201811214790.8A patent/CN110066335B/zh active Active
- 2013-10-30 AU AU2013337903A patent/AU2013337903B2/en active Active
- 2013-10-30 WO PCT/US2013/067583 patent/WO2014070934A1/en active Application Filing
- 2013-10-30 NZ NZ707086A patent/NZ707086A/en unknown
- 2013-10-30 KR KR1020157013665A patent/KR102270618B1/ko active IP Right Grant
- 2013-10-30 JP JP2015539949A patent/JP6693745B2/ja active Active
- 2013-10-30 CN CN201380068690.8A patent/CN104918957B/zh active Active
- 2013-10-30 CN CN201811214473.6A patent/CN109265552A/zh active Pending
- 2013-10-30 DK DK13786884.0T patent/DK2914627T3/da active
- 2013-10-30 ES ES13786884T patent/ES2879552T3/es active Active
- 2013-10-30 US US14/067,770 patent/US9676861B2/en active Active
-
2016
- 2016-02-12 HK HK16101574.4A patent/HK1213581A1/zh unknown
-
2017
- 2017-05-12 US US15/594,367 patent/US9994640B2/en active Active
-
2018
- 2018-03-13 US US15/920,197 patent/US20180273630A1/en not_active Abandoned
- 2018-08-06 JP JP2018147573A patent/JP2018166522A/ja not_active Withdrawn
- 2018-11-02 AU AU2018256638A patent/AU2018256638B2/en active Active
-
2020
- 2020-08-21 JP JP2020139887A patent/JP2020195388A/ja not_active Withdrawn
-
2021
- 2021-04-15 US US17/231,483 patent/US20220049006A1/en not_active Abandoned
-
2022
- 2022-10-11 JP JP2022163062A patent/JP2022191360A/ja active Pending
-
2023
- 2023-03-13 US US18/182,827 patent/US20230406948A1/en active Pending
Also Published As
Publication number | Publication date |
---|---|
JP2018166522A (ja) | 2018-11-01 |
CN104918957B (zh) | 2018-11-16 |
KR102270618B1 (ko) | 2021-06-30 |
JP2020195388A (ja) | 2020-12-10 |
JP2022191360A (ja) | 2022-12-27 |
DK2914627T3 (da) | 2021-07-12 |
US20170246297A1 (en) | 2017-08-31 |
CN104918957A (zh) | 2015-09-16 |
AU2018256638B2 (en) | 2020-09-10 |
US20180273630A1 (en) | 2018-09-27 |
CA2888763A1 (en) | 2014-05-08 |
CN110066335B (zh) | 2024-04-05 |
AU2013337903A1 (en) | 2015-05-07 |
EP3925977A1 (en) | 2021-12-22 |
EP2914627A1 (en) | 2015-09-09 |
US20220049006A1 (en) | 2022-02-17 |
US9994640B2 (en) | 2018-06-12 |
AU2013337903B2 (en) | 2018-08-16 |
EP2914627B1 (en) | 2021-04-07 |
JP6693745B2 (ja) | 2020-05-13 |
NZ707086A (en) | 2019-07-26 |
ES2879552T3 (es) | 2021-11-22 |
CN110066335A (zh) | 2019-07-30 |
CN109265552A (zh) | 2019-01-25 |
AU2018256638A1 (en) | 2018-11-29 |
JP2015533853A (ja) | 2015-11-26 |
KR20150079787A (ko) | 2015-07-08 |
US9676861B2 (en) | 2017-06-13 |
US20140120103A1 (en) | 2014-05-01 |
WO2014070934A1 (en) | 2014-05-08 |
US20230406948A1 (en) | 2023-12-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1213581A1 (zh) | 抗- 抗體及其使用方法 | |
HK1255608A1 (zh) | 抗htra1抗體及使用方法 | |
HK1212256A1 (zh) | 抗- 抗體及相關使用方法 | |
ZA201308022B (en) | Anti-cd40 antibodies and methods of use | |
HK1205517A1 (zh) | 抗體及使用方法 | |
HK1231485A1 (zh) | 抗體及其使用方法 | |
GB201223276D0 (en) | Antibodies and methods of producing same | |
IL238227A0 (en) | Antibodies against c16orf54 and uses thereof | |
EP2748199A4 (en) | ANTI-OX40 ANTIBODIES AND METHOD FOR THEIR USE | |
FI3556774T3 (fi) | Anti-cd40-vasta-aineita ja niiden käyttötapoja | |
ZA201403760B (en) | Anti-cd98 antibodies and methods of use thereof | |
HK1201843A1 (zh) | 抗聚泛素抗體及使用方法 | |
ZA201404675B (en) | Anti-lrp5 antibodies and methods of use | |
EP2938632A4 (en) | ANTI-GRANULYSIN ANTIBODIES AND METHODS OF USE | |
HK1209432A1 (zh) | 抗鋸齒蛋白抗體及使用方法 |