HK1212991A1 - 轉化率優良的氧化反應 - Google Patents

轉化率優良的氧化反應

Info

Publication number
HK1212991A1
HK1212991A1 HK16101062.3A HK16101062A HK1212991A1 HK 1212991 A1 HK1212991 A1 HK 1212991A1 HK 16101062 A HK16101062 A HK 16101062A HK 1212991 A1 HK1212991 A1 HK 1212991A1
Authority
HK
Hong Kong
Prior art keywords
oxidation reaction
conversion rate
excellent conversion
oxidation
reaction
Prior art date
Application number
HK16101062.3A
Other languages
English (en)
Inventor
Yuji Kawakami
Tatsushi Murase
Daisuke Tanaka
Hideyuki Yoshiyama
Shinitsu Kuwabe
Original Assignee
Paion Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Uk Ltd filed Critical Paion Uk Ltd
Publication of HK1212991A1 publication Critical patent/HK1212991A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/70—Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
    • B01J2231/76—Dehydrogenation
    • B01J2231/763—Dehydrogenation of -CH-XH (X= O, NH/N, S) to -C=X or -CX triple bond species

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK16101062.3A 2013-03-04 2016-01-29 轉化率優良的氧化反應 HK1212991A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013041492 2013-03-04
PCT/JP2014/055329 WO2014136730A1 (ja) 2013-03-04 2014-03-03 転化率に優れた酸化反応

Publications (1)

Publication Number Publication Date
HK1212991A1 true HK1212991A1 (zh) 2016-06-24

Family

ID=51491247

Family Applications (1)

Application Number Title Priority Date Filing Date
HK16101062.3A HK1212991A1 (zh) 2013-03-04 2016-01-29 轉化率優良的氧化反應

Country Status (17)

Country Link
US (3) US9656987B2 (zh)
EP (1) EP2966069B1 (zh)
JP (2) JPWO2014136730A1 (zh)
KR (1) KR20150120453A (zh)
CN (1) CN105246881A (zh)
AR (1) AR094963A1 (zh)
AU (1) AU2014227095A1 (zh)
BR (1) BR112015021007A2 (zh)
CA (1) CA2902631A1 (zh)
EA (1) EA032065B1 (zh)
GE (1) GEP20186886B (zh)
HK (1) HK1212991A1 (zh)
IL (1) IL240890B (zh)
MX (1) MX2015011431A (zh)
TW (1) TW201443035A (zh)
UA (1) UA119138C2 (zh)
WO (1) WO2014136730A1 (zh)

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EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP3442539A1 (en) 2016-04-14 2019-02-20 Paion UK Limited Orally inhaled and nasal benzodiazepines
CN108264499B (zh) * 2017-01-04 2020-10-20 江苏恒瑞医药股份有限公司 一种苯并二氮杂*衍生物的制备方法
US11034697B2 (en) 2017-02-09 2021-06-15 Watson Laboratories Inc. Process for the preparation of Remimazolam and solid state forms of Remimazolam salts
ES2709298B2 (es) * 2017-10-13 2019-08-21 Moehs Iberica Sl Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento
CN112313745B (zh) * 2018-08-09 2022-07-05 三菱化学株式会社 全息记录介质用组合物和全息记录介质
US11806320B2 (en) * 2020-02-19 2023-11-07 Endo Ventures Limited Isoproterenol compositions and methods
CN112321594B (zh) * 2020-12-07 2022-05-20 扬子江药业集团有限公司 一种苯并二氮杂䓬类药物的制备方法
WO2023194945A1 (en) 2022-04-08 2023-10-12 Fresenius Kabi Oncology Ltd. An improved process for the preparation of remimazolam

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Also Published As

Publication number Publication date
AU2014227095A1 (en) 2015-10-08
CN105246881A (zh) 2016-01-13
GEP20186886B (en) 2018-08-10
JP2017122116A (ja) 2017-07-13
US9981941B2 (en) 2018-05-29
EP2966069A1 (en) 2016-01-13
US20170217925A1 (en) 2017-08-03
EP2966069A4 (en) 2016-11-30
EA032065B1 (ru) 2019-04-30
MX2015011431A (es) 2016-02-03
TW201443035A (zh) 2014-11-16
WO2014136730A1 (ja) 2014-09-12
US10414749B2 (en) 2019-09-17
US20160009680A1 (en) 2016-01-14
AR094963A1 (es) 2015-09-09
IL240890A0 (en) 2015-10-29
CA2902631A1 (en) 2014-09-12
JPWO2014136730A1 (ja) 2017-02-09
US20180141928A1 (en) 2018-05-24
IL240890B (en) 2018-04-30
US9656987B2 (en) 2017-05-23
BR112015021007A2 (pt) 2017-07-18
EA201591542A1 (ru) 2015-12-30
UA119138C2 (uk) 2019-05-10
KR20150120453A (ko) 2015-10-27
EP2966069B1 (en) 2020-01-08

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