BR112015021007A2 - reação de oxidação com excelente taxa de conversão - Google Patents

reação de oxidação com excelente taxa de conversão

Info

Publication number
BR112015021007A2
BR112015021007A2 BR112015021007A BR112015021007A BR112015021007A2 BR 112015021007 A2 BR112015021007 A2 BR 112015021007A2 BR 112015021007 A BR112015021007 A BR 112015021007A BR 112015021007 A BR112015021007 A BR 112015021007A BR 112015021007 A2 BR112015021007 A2 BR 112015021007A2
Authority
BR
Brazil
Prior art keywords
conversion rate
oxidation reaction
excellent conversion
pyridin
bromo
Prior art date
Application number
BR112015021007A
Other languages
English (en)
Inventor
Tanaka Daisuke
Yoshiyama Hideyuki
Kuwabe Shinitsu
Murase Tatsushi
Kawakami Yuji
Original Assignee
Paion Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Paion Uk Ltd filed Critical Paion Uk Ltd
Publication of BR112015021007A2 publication Critical patent/BR112015021007A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
    • A61K31/5513—1,4-Benzodiazepines, e.g. diazepam or clozapine
    • A61K31/5517—1,4-Benzodiazepines, e.g. diazepam or clozapine condensed with five-membered rings having nitrogen as a ring hetero atom, e.g. imidazobenzodiazepines, triazolam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J31/00—Catalysts comprising hydrides, coordination complexes or organic compounds
    • B01J31/02—Catalysts comprising hydrides, coordination complexes or organic compounds containing organic compounds or metal hydrides
    • B01J31/0234—Nitrogen-, phosphorus-, arsenic- or antimony-containing compounds
    • B01J31/0235—Nitrogen containing compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J2231/00—Catalytic reactions performed with catalysts classified in B01J31/00
    • B01J2231/70—Oxidation reactions, e.g. epoxidation, (di)hydroxylation, dehydrogenation and analogues
    • B01J2231/76—Dehydrogenation
    • B01J2231/763—Dehydrogenation of -CH-XH (X= O, NH/N, S) to -C=X or -CX triple bond species

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Materials Engineering (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • General Chemical & Material Sciences (AREA)
  • Anesthesiology (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Catalysts (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)

Abstract

resumo reação de oxidação com excelente taxa de conversão um processo para a preparação de 3 - [(s) -7-bromo-2- (2-oxo-propilamino) -5-piridin-2-il-3h-1,4, 3-benzodiazepin-il] propiônico a uma alta taxa de conversão, com boa reprodutibilidade por oxidação de 3 - [(s) -7-bromo-2- (2-hidroxi-propilamino) -5-piridin-2-il-3h-benzo [e] [1,4] diazepin-3-il] propiônico, na presença de um catalisador de oxidação é fornecido através da definição de o teor de íon de amônio, de 3 - [(s) -7-bromo-2- (2-hidroxi-propilamino) -5-piridin -2-il-3h-benzo [e] [1,4] diazepin-3-il] -propiônico.
BR112015021007A 2013-03-04 2014-03-03 reação de oxidação com excelente taxa de conversão BR112015021007A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2013041492 2013-03-04
PCT/JP2014/055329 WO2014136730A1 (ja) 2013-03-04 2014-03-03 転化率に優れた酸化反応

Publications (1)

Publication Number Publication Date
BR112015021007A2 true BR112015021007A2 (pt) 2017-07-18

Family

ID=51491247

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015021007A BR112015021007A2 (pt) 2013-03-04 2014-03-03 reação de oxidação com excelente taxa de conversão

Country Status (17)

Country Link
US (3) US9656987B2 (pt)
EP (1) EP2966069B1 (pt)
JP (2) JPWO2014136730A1 (pt)
KR (1) KR20150120453A (pt)
CN (1) CN105246881A (pt)
AR (1) AR094963A1 (pt)
AU (1) AU2014227095A1 (pt)
BR (1) BR112015021007A2 (pt)
CA (1) CA2902631A1 (pt)
EA (1) EA032065B1 (pt)
GE (1) GEP20186886B (pt)
HK (1) HK1212991A1 (pt)
IL (1) IL240890B (pt)
MX (1) MX2015011431A (pt)
TW (1) TW201443035A (pt)
UA (1) UA119138C2 (pt)
WO (1) WO2014136730A1 (pt)

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EP2450039A1 (en) 2010-11-08 2012-05-09 PAION UK Ltd. Dosing regimen for sedation with CNS 7056 (Remimazolam)
AR094963A1 (es) 2013-03-04 2015-09-09 Ono Pharmaceutical Co Reacción de oxidación excelente en el índice de conversión
EP3442539A1 (en) 2016-04-14 2019-02-20 Paion UK Limited Orally inhaled and nasal benzodiazepines
CN108264499B (zh) * 2017-01-04 2020-10-20 江苏恒瑞医药股份有限公司 一种苯并二氮杂*衍生物的制备方法
WO2018148361A1 (en) * 2017-02-09 2018-08-16 Watson Laboratories Inc. Process for the preparation of remimazolam and solid state forms of remimazolam salts
ES2709298B2 (es) * 2017-10-13 2019-08-21 Moehs Iberica Sl Procedimiento para preparar metil ester de acido 3-[(4s)-8-bromo-1-metil-6-(piridin-2-il)-4h-imidazo[1,2-a][1,4]benzodiazepin-4-il]-propionico, y compuestos utiles en ese procedimiento
JP7342870B2 (ja) * 2018-08-09 2023-09-12 三菱ケミカル株式会社 ホログラム記録媒体用組成物及びホログラム記録媒体
WO2021168133A1 (en) * 2020-02-19 2021-08-26 Nevakar Inc. Isoproterenol compositions and methods
CN112321594B (zh) * 2020-12-07 2022-05-20 扬子江药业集团有限公司 一种苯并二氮杂䓬类药物的制备方法
WO2023194945A1 (en) 2022-04-08 2023-10-12 Fresenius Kabi Oncology Ltd. An improved process for the preparation of remimazolam

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Also Published As

Publication number Publication date
US20160009680A1 (en) 2016-01-14
IL240890B (en) 2018-04-30
US20180141928A1 (en) 2018-05-24
CN105246881A (zh) 2016-01-13
US9981941B2 (en) 2018-05-29
AU2014227095A1 (en) 2015-10-08
CA2902631A1 (en) 2014-09-12
EA032065B1 (ru) 2019-04-30
TW201443035A (zh) 2014-11-16
US10414749B2 (en) 2019-09-17
WO2014136730A1 (ja) 2014-09-12
EP2966069A1 (en) 2016-01-13
US20170217925A1 (en) 2017-08-03
GEP20186886B (en) 2018-08-10
EP2966069B1 (en) 2020-01-08
JP2017122116A (ja) 2017-07-13
HK1212991A1 (zh) 2016-06-24
AR094963A1 (es) 2015-09-09
EP2966069A4 (en) 2016-11-30
KR20150120453A (ko) 2015-10-27
EA201591542A1 (ru) 2015-12-30
JPWO2014136730A1 (ja) 2017-02-09
IL240890A0 (en) 2015-10-29
US9656987B2 (en) 2017-05-23
MX2015011431A (es) 2016-02-03
UA119138C2 (uk) 2019-05-10

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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

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