HK1212684A1 - 三環喹啉和喹喔啉衍生物 - Google Patents
三環喹啉和喹喔啉衍生物 Download PDFInfo
- Publication number
- HK1212684A1 HK1212684A1 HK16100520.1A HK16100520A HK1212684A1 HK 1212684 A1 HK1212684 A1 HK 1212684A1 HK 16100520 A HK16100520 A HK 16100520A HK 1212684 A1 HK1212684 A1 HK 1212684A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- quinoxaline derivatives
- ht2c receptor
- tricyclic quinoline
- disorders
- respond
- Prior art date
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/06—Peri-condensed systems
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
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- A—HUMAN NECESSITIES
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- A61P15/10—Drugs for genital or sexual disorders; Contraceptives for impotence
-
- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/16—Peri-condensed systems
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Dermatology (AREA)
- Reproductive Health (AREA)
- Obesity (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Ophthalmology & Optometry (AREA)
- Rheumatology (AREA)
- Child & Adolescent Psychology (AREA)
- Hospice & Palliative Care (AREA)
- Psychology (AREA)
- Anesthesiology (AREA)
- Emergency Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (9)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261701514P | 2012-09-14 | 2012-09-14 | |
| US201261701531P | 2012-09-14 | 2012-09-14 | |
| US61/701514 | 2012-09-14 | ||
| US61/701531 | 2012-09-14 | ||
| US201361793033P | 2013-03-15 | 2013-03-15 | |
| US61/793033 | 2013-03-15 | ||
| CN201310410951.1 | 2013-09-11 | ||
| CN201310410951.1A CN104418862A (zh) | 2013-09-11 | 2013-09-11 | 三环喹啉和喹喔啉衍生物 |
| PCT/EP2013/069036 WO2014041131A1 (en) | 2012-09-14 | 2013-09-13 | Tricyclic quinoline and quinoxaline derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1212684A1 true HK1212684A1 (zh) | 2016-06-17 |
Family
ID=50275085
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK16100520.1A HK1212684A1 (zh) | 2012-09-14 | 2013-09-13 | 三環喹啉和喹喔啉衍生物 |
Country Status (26)
Families Citing this family (41)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9428506B2 (en) | 2012-04-14 | 2016-08-30 | Intra-Cellular Therapies, Inc. | Substituted pyrido[3′,4′:4,5]pyrrolo[1,2,3-de]quinoxalines for the treatment of nervous system disorders |
| TWI568722B (zh) | 2012-06-15 | 2017-02-01 | 葛蘭馬克製藥公司 | 作爲ｍＰＧＥＳ－１抑制劑之三唑酮化合物 |
| EP2943485B1 (en) | 2013-01-14 | 2017-09-20 | Incyte Holdings Corporation | Bicyclic aromatic carboxamide compounds useful as pim kinase inhibitors |
| TWI662030B (zh) | 2013-01-15 | 2019-06-11 | 英塞特控股公司 | 適用作ｐｉｍ激酶抑制劑之噻唑甲醯胺及吡啶甲醯胺化合物 |
| WO2014145192A1 (en) | 2013-03-15 | 2014-09-18 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US9556197B2 (en) | 2013-08-23 | 2017-01-31 | Incyte Corporation | Furo- and thieno-pyridine carboxamide compounds useful as pim kinase inhibitors |
| WO2015066344A1 (en) | 2013-11-01 | 2015-05-07 | Arena Pharmaceuticals, Inc. | 5-ht2c receptor agonists and compositions and methods of use |
| KR102967223B1 (ko) | 2013-12-03 | 2026-05-19 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 신규한 방법 |
| US9540376B2 (en) | 2014-03-14 | 2017-01-10 | AbbVie Deutschland GmbH & Co. KG | Hexahydrodiazepinoquinolines carrying a substituted alkyl radical |
| US9573950B2 (en) | 2014-03-14 | 2017-02-21 | Abbvie Deutschland Gmbh & Co Kg | Substituted [1,4]diazepino[6,7,1-ij]quinolines as serotonin 5-HT2C receptor modulators |
| KR20220054908A (ko) | 2014-04-04 | 2022-05-03 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US9580418B2 (en) | 2014-07-14 | 2017-02-28 | Incyte Corporation | Bicyclic aromatic carboxamide compounds useful as Pim kinase inhibitors |
| WO2016010897A1 (en) | 2014-07-14 | 2016-01-21 | Incyte Corporation | Bicyclic heteroaromatic carboxamide compounds useful as pim kinase inhibitors |
| HUE047169T2 (hu) * | 2015-04-27 | 2020-04-28 | Arena Pharm Inc | 5-HT2C receptor agonisták és készítmények és felhasználási eljárások |
| WO2016196244A1 (en) | 2015-05-29 | 2016-12-08 | Incyte Corporation | Pyridineamine compounds useful as pim kinase inhibitors |
| JP6789578B2 (ja) * | 2015-07-31 | 2020-11-25 | アリーナ ファーマシューティカルズ， インコーポレイテッド | ５−ｈｔ２ｃ受容体アゴニストおよび組成物、ならびに使用方法 |
| AR105967A1 (es) | 2015-09-09 | 2017-11-29 | Incyte Corp | Sales de un inhibidor de pim quinasa |
| WO2017059251A1 (en) | 2015-10-02 | 2017-04-06 | Incyte Corporation | Heterocyclic compounds useful as pim kinase inhibitors |
| WO2017117514A1 (en) * | 2015-12-31 | 2017-07-06 | Tung Roger D | Deuterated iti-007 |
| RU2743513C2 (ru) | 2016-01-26 | 2021-02-19 | Интра-Селлулар Терапиз, Инк. | Органические соединения |
| IL281050B2 (en) | 2016-03-25 | 2023-04-01 | Intra Cellular Therapies Inc | A controlled or delayed release pharmaceutical preparation containing a deuterated compound |
| US20200392135A1 (en) * | 2016-03-25 | 2020-12-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| US10682354B2 (en) | 2016-03-28 | 2020-06-16 | Intra-Cellular Therapies, Inc. | Compositions and methods |
| JP7013454B2 (ja) | 2016-10-12 | 2022-02-15 | イントラ－セルラー・セラピーズ・インコーポレイテッド | アモルファス固体分散体 |
| EP3562484B1 (en) | 2016-12-29 | 2021-08-25 | Intra-Cellular Therapies, Inc. | Pyrido[3',4':4,5]pyrrolo[1,2,3-de]quinoxaline derivatives useful in the treatment of cns disorders |
| WO2018126140A1 (en) | 2016-12-29 | 2018-07-05 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP7224333B2 (ja) | 2017-07-26 | 2023-02-17 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| TW201924683A (zh) | 2017-12-08 | 2019-07-01 | 美商英塞特公司 | 用於治療骨髓增生性贅瘤的低劑量組合療法 |
| WO2019178484A1 (en) | 2018-03-16 | 2019-09-19 | Intra-Cellular Therapies, Inc. | Novel methods |
| SMT202600133T1 (it) * | 2018-03-23 | 2026-05-12 | Intra Cellular Therapies Inc | Composti organici |
| AU2019240226B2 (en) | 2018-03-23 | 2024-11-28 | Intra-Cellular Therapies, Inc. | Organic compounds |
| KR20210104785A (ko) | 2018-12-17 | 2021-08-25 | 인트라-셀룰라 써래피스, 인코퍼레이티드. | 유기 화합물 |
| US12331052B2 (en) | 2018-12-21 | 2025-06-17 | Intra-Cellular Therapies, Inc. | Organic compounds |
| JP7377871B2 (ja) | 2018-12-21 | 2023-11-10 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 有機化合物 |
| EP4134101A1 (en) | 2019-07-07 | 2023-02-15 | Intra-Cellular Therapies, Inc. | Deuterated lumateperone for the treatment of the bipolar ii disorder |
| JP2022549335A (ja) | 2019-09-25 | 2022-11-24 | イントラ－セルラー・セラピーズ・インコーポレイテッド | 新規方法 |
| WO2021119334A1 (en) | 2019-12-11 | 2021-06-17 | Intra-Cellular Therapies, Inc. | Organic compound |
| KR102600176B1 (ko) * | 2021-10-18 | 2023-11-10 | 주식회사 사피엔스바이오 | 신규한 화합물 및 이를 포함하는 약학적 조성물 |
| CA3235125A1 (en) * | 2021-10-18 | 2023-04-27 | Dong-Oh Yoon | Novel compound and pharmaceutical composition comprising same |
| US12414948B2 (en) | 2022-05-18 | 2025-09-16 | Intra-Cellular Therapies, Inc. | Methods |
| KR102715926B1 (ko) * | 2022-06-10 | 2024-10-15 | 주식회사 사피엔스바이오 | 신규한 화합물 및 이를 유효성분으로 포함하는 약학적 조성물 |
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| EP1998781A2 (en) * | 2006-03-24 | 2008-12-10 | Wyeth a Corporation of the State of Delaware | Treatment of pain |
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| MX2009008465A (es) | 2007-02-15 | 2009-08-20 | Hoffmann La Roche | Nuevas 2-aminooxazolinas como ligandos de taar1. |
| US7528131B2 (en) | 2007-04-19 | 2009-05-05 | Concert Pharmaceuticals Inc. | Substituted morpholinyl compounds |
| US7531685B2 (en) | 2007-06-01 | 2009-05-12 | Protia, Llc | Deuterium-enriched oxybutynin |
| US20090131485A1 (en) | 2007-09-10 | 2009-05-21 | Concert Pharmaceuticals, Inc. | Deuterated pirfenidone |
| US20090118238A1 (en) | 2007-09-17 | 2009-05-07 | Protia, Llc | Deuterium-enriched alendronate |
| US20090082471A1 (en) | 2007-09-26 | 2009-03-26 | Protia, Llc | Deuterium-enriched fingolimod |
| US20090088416A1 (en) | 2007-09-26 | 2009-04-02 | Protia, Llc | Deuterium-enriched lapaquistat |
| WO2009045476A1 (en) | 2007-10-02 | 2009-04-09 | Concert Pharmaceuticals, Inc. | Pyrimidinedione derivatives |
| US20090105338A1 (en) | 2007-10-18 | 2009-04-23 | Protia, Llc | Deuterium-enriched gabexate mesylate |
| EP2212298B1 (en) | 2007-10-18 | 2013-03-27 | Concert Pharmaceuticals Inc. | Deuterated etravirine |
| WO2009055006A1 (en) | 2007-10-26 | 2009-04-30 | Concert Pharmaceuticals, Inc. | Deuterated darunavir |
| EP2421870B1 (en) * | 2009-04-23 | 2016-03-09 | AbbVie Inc. | Modulators of 5-ht receptors and methods of use thereof |
| US20140080813A1 (en) * | 2012-09-14 | 2014-03-20 | AbbVie Deutschland GmbH & Co. KG | Tricyclic quinoline and quinoxaline derivatives |
-
2013
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- 2013-09-13 IN IN2070DEN2015 patent/IN2015DN02070A/en unknown
- 2013-09-13 CA CA2884548A patent/CA2884548A1/en not_active Abandoned
- 2013-09-13 UA UAA201503409A patent/UA116216C2/uk unknown
- 2013-09-13 CN CN201380059579.2A patent/CN104995191A/zh active Pending
- 2013-09-13 NZ NZ631187A patent/NZ631187A/en not_active IP Right Cessation
- 2013-09-13 PE PE2015000363A patent/PE20150777A1/es not_active Application Discontinuation
- 2013-09-13 AR ARP130103294A patent/AR092568A1/es unknown
- 2013-09-13 SG SG11201501894VA patent/SG11201501894VA/en unknown
- 2013-09-13 UY UY0001035029A patent/UY35029A/es not_active Application Discontinuation
- 2013-09-13 HK HK16100520.1A patent/HK1212684A1/zh unknown
- 2013-09-13 KR KR1020157009502A patent/KR20150056608A/ko not_active Withdrawn
- 2013-09-13 RU RU2015113558A patent/RU2015113558A/ru not_active Application Discontinuation
- 2013-09-13 WO PCT/EP2013/069036 patent/WO2014041131A1/en not_active Ceased
- 2013-09-13 AU AU2013314279A patent/AU2013314279B2/en not_active Ceased
- 2013-09-13 US US14/026,354 patent/US10118926B2/en active Active
- 2013-09-13 JP JP2015531577A patent/JP6290217B2/ja not_active Expired - Fee Related
- 2013-09-13 EP EP13762483.9A patent/EP2895485A1/en not_active Withdrawn
- 2013-09-13 MX MX2015003364A patent/MX2015003364A/es unknown
- 2013-09-14 TW TW102133403A patent/TW201414735A/zh unknown
-
2015
- 2015-03-12 IL IL237726A patent/IL237726A0/en unknown
- 2015-03-13 PH PH12015500551A patent/PH12015500551A1/en unknown
- 2015-03-13 DO DO2015000058A patent/DOP2015000058A/es unknown
- 2015-03-13 CL CL2015000628A patent/CL2015000628A1/es unknown
- 2015-04-01 EC ECIEPI201512766A patent/ECSP15012766A/es unknown
- 2015-04-10 CR CR20150186A patent/CR20150186A/es unknown
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2018
- 2018-01-24 AU AU2018200572A patent/AU2018200572A1/en not_active Abandoned
- 2018-11-02 US US16/179,050 patent/US20190071443A1/en not_active Abandoned
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2019
- 2019-10-14 US US16/601,075 patent/US20200283439A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| KR20150056608A (ko) | 2015-05-26 |
| TW201414735A (zh) | 2014-04-16 |
| US20200283439A1 (en) | 2020-09-10 |
| JP2015528478A (ja) | 2015-09-28 |
| PE20150777A1 (es) | 2015-06-20 |
| SG11201501894VA (en) | 2015-04-29 |
| US20190071443A1 (en) | 2019-03-07 |
| US10118926B2 (en) | 2018-11-06 |
| EP2895485A1 (en) | 2015-07-22 |
| NZ631187A (en) | 2017-03-31 |
| IN2015DN02070A (cg-RX-API-DMAC7.html) | 2015-08-14 |
| RU2015113558A (ru) | 2016-11-10 |
| AU2013314279A1 (en) | 2015-04-02 |
| MX2015003364A (es) | 2016-03-31 |
| AR092568A1 (es) | 2015-04-22 |
| CA2884548A1 (en) | 2014-03-20 |
| BR112015005743A2 (pt) | 2017-07-04 |
| CL2015000628A1 (es) | 2015-10-30 |
| JP6290217B2 (ja) | 2018-03-07 |
| AU2018200572A1 (en) | 2018-02-15 |
| CN104995191A (zh) | 2015-10-21 |
| UY35029A (es) | 2014-04-30 |
| WO2014041131A1 (en) | 2014-03-20 |
| CR20150186A (es) | 2015-08-28 |
| US20140080816A1 (en) | 2014-03-20 |
| DOP2015000058A (es) | 2015-04-15 |
| IL237726A0 (en) | 2015-05-31 |
| PH12015500551A1 (en) | 2015-05-04 |
| UA116216C2 (uk) | 2018-02-26 |
| ECSP15012766A (es) | 2017-06-30 |
| AU2013314279B2 (en) | 2017-11-02 |
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