HK1206368A1 - Targeting complement factor h for treatment of diseases by the sue of cr2-fh molecules - Google Patents
Targeting complement factor h for treatment of diseases by the sue of cr2-fh molecules Download PDFInfo
- Publication number
- HK1206368A1 HK1206368A1 HK15106966.0A HK15106966A HK1206368A1 HK 1206368 A1 HK1206368 A1 HK 1206368A1 HK 15106966 A HK15106966 A HK 15106966A HK 1206368 A1 HK1206368 A1 HK 1206368A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- disease
- molecule
- loss
- eye
- degeneration
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/04—Antipruritics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/70596—Molecules with a "CD"-designation not provided for elsewhere
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Zoology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Cell Biology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pulmonology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Ophthalmology & Optometry (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US81574806P | 2006-06-21 | 2006-06-21 | |
| US815748P | 2006-06-21 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1206368A1 true HK1206368A1 (en) | 2016-01-08 |
Family
ID=38695591
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK15106966.0A HK1206368A1 (en) | 2006-06-21 | 2015-07-21 | Targeting complement factor h for treatment of diseases by the sue of cr2-fh molecules |
Country Status (14)
| Country | Link |
|---|---|
| US (3) | US7759304B2 (enExample) |
| EP (2) | EP2826788B1 (enExample) |
| JP (1) | JP5250548B2 (enExample) |
| CN (1) | CN101563363B (enExample) |
| AU (1) | AU2007261315B2 (enExample) |
| BR (1) | BRPI0712987A2 (enExample) |
| CA (1) | CA2656063C (enExample) |
| DK (1) | DK2044111T3 (enExample) |
| ES (1) | ES2523640T3 (enExample) |
| HK (1) | HK1206368A1 (enExample) |
| PL (1) | PL2044111T3 (enExample) |
| PT (1) | PT2044111E (enExample) |
| SI (1) | SI2044111T1 (enExample) |
| WO (1) | WO2007149567A2 (enExample) |
Families Citing this family (52)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6820011B2 (en) * | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| EP2292259A3 (en) * | 2002-11-15 | 2011-03-23 | MUSC Foundation For Research Development | Complement receptor 2 targeted complement modulators |
| DK1713503T3 (da) | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
| ES2548700T3 (es) * | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
| AU2007261315B2 (en) | 2006-06-21 | 2012-10-25 | Musc Foundation For Research Development | Targeting complement factor H for treatment of diseases |
| WO2008048675A2 (en) * | 2006-10-20 | 2008-04-24 | Celldex Therapeutics, Inc. | Treatment for age-related macular degeneration and other diseases of the eye |
| AU2008251943B2 (en) | 2007-03-14 | 2013-09-05 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| EP2208737B1 (en) * | 2007-05-03 | 2017-07-05 | Lysomab GmbH | Complement factor H-derived short consensus repeat-antibody constructs |
| US20090324585A1 (en) * | 2008-06-12 | 2009-12-31 | The Trustees of the Leland Standford Junior University | Complement inhibitory agents as therapeutics in posttraumatic and degenerative arthritis |
| GB0904427D0 (en) * | 2009-03-13 | 2009-04-29 | Lachmann Peter | Treatment of diseases related to hyperactivity of the complement system |
| AU2010266127B2 (en) * | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| GB0922659D0 (en) * | 2009-12-24 | 2010-02-10 | Univ Edinburgh | Factor H |
| CA2791841C (en) | 2010-03-05 | 2023-01-03 | Rigshospitalet | Chimeric inhibitor molecules of complement activation |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| EP2585110A4 (en) * | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| CN110078831A (zh) * | 2011-12-01 | 2019-08-02 | 圆祥生命科技股份有限公司 | 补体和vegf途径的蛋白质抑制剂及其使用方法 |
| FR2988298A1 (fr) * | 2012-03-23 | 2013-09-27 | Lfb Biotechnologies | Facteur h pour son utilisation comme molecule antioxydante |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| AU2013302441B2 (en) | 2012-08-17 | 2018-05-10 | The Regents Of The University Of Colorado, A Body Corporate | Compositions and methods for detecting complement activation |
| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| PL2968457T3 (pl) * | 2013-03-14 | 2018-12-31 | Baxalta Incorporated | Czynnik h do transplantacji |
| JP6484215B2 (ja) * | 2013-03-14 | 2019-03-13 | バクスアルタ インコーポレイテッド | 関節リウマチの治療のためのh因子 |
| AU2013202965B2 (en) | 2013-03-15 | 2016-07-21 | Takeda Pharmaceutical Company Limited | Improved method for producing factor h from a plasma precipitation fraction |
| CN104293901A (zh) * | 2013-07-19 | 2015-01-21 | 金弗康生物科技(上海)有限公司 | 一种用于系统性红斑狼疮的早期诊断的检测试剂盒 |
| AU2014306002B2 (en) | 2013-08-07 | 2017-05-25 | Alexion Pharmaceuticals, Inc. | Atypical hemolytic uremic syndrome (aHUS) biomarker proteins |
| EP3033093A1 (en) * | 2013-08-16 | 2016-06-22 | Alexion Pharmaceuticals, Inc. | Treatment of graft rejection by administering a complement inhibitor to an organ prior to transplant |
| CN104231085B (zh) * | 2013-09-05 | 2017-03-15 | 复旦大学附属肿瘤医院 | 靶向特异性补体系统抑制剂、其制备方法及应用 |
| US20150093331A1 (en) * | 2013-10-01 | 2015-04-02 | OncoLock Co., Ltd. | Biomarkers for breast cancer |
| FR3015484A1 (fr) * | 2013-12-20 | 2015-06-26 | Lab Francais Du Fractionnement | Proteines recombinantes possedant une activite de facteur h |
| US10155983B2 (en) | 2014-03-31 | 2018-12-18 | Machaon Diagnostics, Inc. | Method of diagnosis of complement-mediated thrombotic microangiopathies |
| FR3038517B1 (fr) | 2015-07-06 | 2020-02-28 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Utilisation de fragments fc modifies en immunotherapie |
| US11848037B2 (en) * | 2015-07-29 | 2023-12-19 | National University Of Singapore | Method of protecting a magnetic layer of a magnetic recording medium |
| RU2727411C2 (ru) | 2015-09-24 | 2020-07-21 | Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания | Композиция и способ для лечения заболевания, опосредованного комплементом |
| GB201519086D0 (en) * | 2015-10-28 | 2015-12-09 | Syncona Partners Llp | Gene Therapy |
| FR3046355A1 (fr) * | 2015-12-30 | 2017-07-07 | Lab Francais Du Fractionnement | Fragments du facteur h pour son utilisation comme agent anti-angiogenique |
| WO2017114401A1 (zh) * | 2015-12-31 | 2017-07-06 | 江苏匡亚生物医药科技有限公司 | 具有补体调节活性的重组补体因子h-免疫球蛋白融合蛋白及其制备方法与应用 |
| GB201709222D0 (en) * | 2017-06-09 | 2017-07-26 | Univ Manchester | C3b Inactivating Polypeptide |
| GB201800620D0 (en) | 2018-01-15 | 2018-02-28 | Univ Manchester | C3b Binding Polypeptide |
| US20190247560A1 (en) | 2018-02-13 | 2019-08-15 | Gambro Lundia Ab | Extracorporeal devices and methods of treating complement factor related diseases |
| US20190345516A1 (en) * | 2018-03-12 | 2019-11-14 | Musc Foundation For Research Development | Methods for treating eye disease |
| WO2019215330A1 (en) * | 2018-05-10 | 2019-11-14 | The University Of Manchester | Methods for assessing macular degeneration |
| WO2020041644A1 (en) * | 2018-08-22 | 2020-02-27 | Alexion Pharmaceuticals, Inc. | Fusion proteins and methods of treating complement dysregulation using the same |
| US20240254177A1 (en) * | 2018-08-22 | 2024-08-01 | Alexion Pharmaceuticals, Inc. | COMPLEMENT FACTOR H AND Fc BINDING DOMAIN FUSION PROTEINS |
| KR102668789B1 (ko) * | 2018-11-23 | 2024-05-24 | (주)메디코스바이오텍 | 창상치료용 약학조성물 |
| GB201821089D0 (en) * | 2018-12-21 | 2019-02-06 | Gyroscope Therapeutics Ltd | Codon-optimised complement factor I |
| CN110330561B (zh) * | 2019-05-27 | 2020-10-27 | 北京康普美特创新医药科技有限责任公司 | 人源靶向补体抑制物蛋白双突变体mCR2-mDAF及应用 |
| WO2021067526A1 (en) | 2019-10-02 | 2021-04-08 | Alexion Pharmaceuticals, Inc. | Complement inhibitors for treating drug-induced complement-mediated response |
| IL299048A (en) | 2020-06-14 | 2023-02-01 | Vertex Pharma | Variants of complement factor - 1 fusion structures and preparations containing them and their uses |
| BR112023024627A2 (pt) * | 2021-05-25 | 2024-02-20 | Alexion Pharma Inc | Proteínas renais de fusão ativas e métodos de tratamento usando as mesmas |
| JP2024520497A (ja) | 2021-05-28 | 2024-05-24 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | Cm-tmaバイオマーカーを検出するための方法 |
| CN120303303A (zh) * | 2023-05-19 | 2025-07-11 | 合肥星眸生物科技有限公司 | 用于治疗补体旁路相关疾病的aav载体 |
Family Cites Families (117)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5981481A (en) | 1974-12-06 | 1999-11-09 | The Johns Hopkins University | Human C3b/C4b receptor (CR1) |
| US5212071A (en) | 1988-04-01 | 1993-05-18 | The Johns Hopkins University | Nucleic acids encoding a human C3b/C4b receptor (CR1) |
| US4454151A (en) | 1982-03-22 | 1984-06-12 | Syntex (U.S.A.) Inc. | Use of pyrrolo pyrroles in treatment of ophthalmic diseases |
| US4943529A (en) | 1982-05-19 | 1990-07-24 | Gist-Brocades Nv | Kluyveromyces as a host strain |
| AU3145184A (en) | 1983-08-16 | 1985-02-21 | Zymogenetics Inc. | High expression of foreign genes in schizosaccharomyces pombe |
| US4879231A (en) | 1984-10-30 | 1989-11-07 | Phillips Petroleum Company | Transformation of yeasts of the genus pichia |
| US4797368A (en) | 1985-03-15 | 1989-01-10 | The United States Of America As Represented By The Department Of Health And Human Services | Adeno-associated virus as eukaryotic expression vector |
| US5139941A (en) | 1985-10-31 | 1992-08-18 | University Of Florida Research Foundation, Inc. | AAV transduction vectors |
| JPH0742235B2 (ja) | 1985-11-08 | 1995-05-10 | 三共株式会社 | 自己免疫性疾病の予防・治療剤 |
| GB8610600D0 (en) | 1986-04-30 | 1986-06-04 | Novo Industri As | Transformation of trichoderma |
| US5260203A (en) | 1986-09-02 | 1993-11-09 | Enzon, Inc. | Single polypeptide chain binding molecules |
| US5733254A (en) | 1987-10-15 | 1998-03-31 | Cypress Bioscience, Inc. | Method for treating patients suffering from immune thrombocytopenic purpura |
| US5256642A (en) | 1988-04-01 | 1993-10-26 | The Johns Hopkins University | Compositions of soluble complement receptor 1 (CR1) and a thrombolytic agent, and the methods of use thereof |
| DE3830271A1 (de) | 1988-09-06 | 1990-03-15 | Goetze Otto | Mittel mit immunsuppressiver wirkung |
| ATE189526T1 (de) | 1988-10-28 | 2000-02-15 | Genentech Inc | Verfahren zum nachweis von aktiven domänen und aminosäureresten in polypeptiden und hormonvarianten |
| US5328470A (en) | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DE394538T1 (de) | 1989-04-28 | 1991-04-11 | Rhein Biotech Ges. Fuer Biotechnologische Prozesse Und Produkte Mbh, 4000 Duesseldorf | Hefezellen der schwanniomyces-gattung. |
| EP0402226A1 (en) | 1989-06-06 | 1990-12-12 | Institut National De La Recherche Agronomique | Transformation vectors for yeast yarrowia |
| FR2648133B1 (fr) | 1989-06-08 | 1992-02-21 | Sanofi Sa | Lauramides n-substitues, leur preparation et compositions les contenant |
| FR2649120B1 (fr) | 1989-06-30 | 1994-01-28 | Cayla | Nouvelle souche et ses mutants de champignons filamenteux, procede de production de proteines recombinantes a l'aide de ladite souche et souches et proteines obtenues selon ce procede |
| US5331090A (en) | 1989-09-08 | 1994-07-19 | California Institute Of Biological Research | CR2 ligand compositions and methods for modulating immune cell functions |
| US5310729A (en) | 1990-04-20 | 1994-05-10 | California Institute Of Biological Research | Interferon-related polypeptides as CR2 ligands and their use for modulating immune cell functions |
| US6458360B1 (en) | 1990-04-25 | 2002-10-01 | The Johns Hopkins University | Soluble complement regulatory molecules |
| KR0185215B1 (ko) | 1990-11-30 | 1999-05-01 | 요시다 쇼오지 | 서방성 안구삽입용 약제 |
| EP0512733A2 (en) | 1991-05-03 | 1992-11-11 | Washington University | Modified complement system regulator |
| US5178635A (en) | 1992-05-04 | 1993-01-12 | Allergan, Inc. | Method for determining amount of medication in an implantable device |
| DE4222534A1 (de) | 1992-07-09 | 1994-01-13 | Behringwerke Ag | Verwendung von Komplement-Inhibitoren zur Herstellung eines Arzneimittels zur Prophylaxe und Therapie von entzündlichen Darm- und Hauterkrankungen sowie Purpura |
| US5679546A (en) | 1993-09-24 | 1997-10-21 | Cytomed, Inc. | Chimeric proteins which block complement activation |
| US6074642A (en) | 1994-05-02 | 2000-06-13 | Alexion Pharmaceuticals, Inc. | Use of antibodies specific to human complement component C5 for the treatment of glomerulonephritis |
| US5679345A (en) | 1994-06-02 | 1997-10-21 | The Johns Hopkins University | Method for preventing complement-dependent rejection of organ or tissue transplants |
| NZ295352A (en) | 1994-10-25 | 1999-09-29 | Glaxo Group Ltd | Use of binding agents like antibodies for inhibiting cd23 in treating prophylaxis of autoimmune diseases |
| US5922320A (en) | 1996-06-14 | 1999-07-13 | Georgetown University | Recombinant proCVF |
| US5843778A (en) | 1996-06-14 | 1998-12-01 | The Johns Hopkins University School Of Medicine | Use of chimeric vaccinia virus complement control proteins to inhibit complement |
| CA2263838A1 (en) | 1996-08-21 | 1998-02-26 | Sugen, Inc. | Crystal structures of a protein tyrosine kinase |
| US6214966B1 (en) | 1996-09-26 | 2001-04-10 | Shearwater Corporation | Soluble, degradable poly(ethylene glycol) derivatives for controllable release of bound molecules into solution |
| GB9624731D0 (en) | 1996-11-28 | 1997-01-15 | Univ Leicester | Complement inhibitor |
| WO1999002567A2 (en) | 1997-07-08 | 1999-01-21 | Board Of Regents, The University Of Texas System | Compositions and methods for producing homoconjugates of antibodies which induce growth arrest or apoptosis of tumor cells |
| US8088386B2 (en) | 1998-03-20 | 2012-01-03 | Genentech, Inc. | Treatment of complement-associated disorders |
| WO1999037149A1 (en) | 1998-01-27 | 1999-07-29 | Brigham & Women's Hospital | Methods of treating cytotoxic damage |
| DE69939813D1 (de) | 1998-02-20 | 2008-12-11 | Tanox Inc | Inhibitoren der komplement-aktivierung |
| US7112327B2 (en) | 1998-02-20 | 2006-09-26 | Tanox, Inc. | Inhibition of complement activation |
| WO1999044625A1 (en) | 1998-03-03 | 1999-09-10 | John Hopkins University | Smallpox inhibitor of complement enzymes (spice) protein and methods of inhibiting complement activation |
| JP5138844B2 (ja) | 1998-06-12 | 2013-02-06 | ザ・ヘンリー・エム・ジャクソン・ファンデイション・フォー・ジ・アドヴァンスメント・オヴ・ミリタリー・メディシン、インコーポレイテッド | 抗原およびEBVGp350/220の受容体の同時刺激によるB細胞活性化および免疫グロブリン分泌の増強 |
| US6572856B1 (en) | 1998-09-10 | 2003-06-03 | The University Of Virginia Patent Foundation | Methods for the prevention and treatment of cancer using anti-C3b(i) antibodies |
| EP1001021B1 (en) | 1998-09-25 | 2003-08-27 | Wolfgang Prodinger | Monoclonal antibody to human CD21, and its uses |
| US6224866B1 (en) | 1998-10-07 | 2001-05-01 | Biocrystal Ltd. | Immunotherapy of B cell involvement in progression of solid, nonlymphoid tumors |
| ATE352559T1 (de) | 1998-12-08 | 2007-02-15 | Biovation Ltd | Verfahren zur verminderung der immunogenität von proteinen |
| WO2000040749A2 (en) | 1999-01-06 | 2000-07-13 | Genenews Inc. | Method for the detection of gene transcripts in blood and uses thereof |
| US6943153B1 (en) | 1999-03-15 | 2005-09-13 | The Regents Of The University Of California | Use of recombinant gene delivery vectors for treating or preventing diseases of the eye |
| KR20020027311A (ko) | 1999-05-07 | 2002-04-13 | 제넨테크, 인크. | B 세포 표면 마커에 결합하는 길항물질을 이용한자가면역 질환의 치료 |
| US7282562B2 (en) | 1999-08-31 | 2007-10-16 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
| US6331313B1 (en) | 1999-10-22 | 2001-12-18 | Oculex Pharmaceticals, Inc. | Controlled-release biocompatible ocular drug delivery implant devices and methods |
| GB0008582D0 (en) | 2000-04-08 | 2000-05-31 | Adprotech Plc | DNA immunization vectors |
| EP2026073B1 (en) | 2000-04-29 | 2016-03-30 | University Of Iowa Research Foundation | Diagnostics and therapeutics for macular degeneration-related disorders |
| US7439330B2 (en) | 2000-05-08 | 2008-10-21 | President And Fellows Of Harvard College | Anti-glycated CD59 antibodies and uses thereof |
| CN1592645A (zh) | 2000-09-18 | 2005-03-09 | 拜奥根Idec公司 | 使用b细胞耗尽/免疫调节抗体组合治疗自身免疫病的联合疗法 |
| US7122181B2 (en) | 2000-12-19 | 2006-10-17 | Research Development Foundation | Lentiviral vector-mediated gene transfer and uses thereof |
| WO2002068579A2 (en) | 2001-01-10 | 2002-09-06 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
| US7645739B2 (en) | 2001-02-21 | 2010-01-12 | Alavita Pharmaceuticals, Inc. | Modified annexin compositions and methods of using same |
| EP1839670A3 (en) | 2001-02-21 | 2009-11-11 | Alavita Pharmaceuticals, Inc. | Modified Annexin Proteins and their use against thrombosis |
| US7635676B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaccuticals, Inc. | Modified annexin proteins and methods for their use in organ transplantation |
| US7635680B2 (en) | 2001-02-21 | 2009-12-22 | Alavita Pharmaceuticals, Inc. | Attenuation of reperfusion injury |
| US6820011B2 (en) | 2001-04-11 | 2004-11-16 | The Regents Of The University Of Colorado | Three-dimensional structure of complement receptor type 2 and uses thereof |
| CN1511041A (zh) | 2001-05-17 | 2004-07-07 | ������ҩ������˾ | 利用抑制cd21的药剂治疗抗体介导的病变的方法 |
| US20030181531A1 (en) | 2003-02-11 | 2003-09-25 | David Sherris | Compositions and methods of administering tubulin binding agents for the treatment of ocular diseases |
| WO2003018774A2 (en) | 2001-08-29 | 2003-03-06 | University Of Virginia Patent Foundation | Therapeutic uses of complement receptor 2 |
| US20030129164A1 (en) | 2001-12-03 | 2003-07-10 | Flannery John G. | Expression of glial-derived neurotrophic factor for treatment of diseases of the eye |
| EP1336618A1 (en) | 2002-02-15 | 2003-08-20 | HANS-KNÖLL-INSTITUT FÜR NATURSTOFF-FORSCHUNG e.V. | Porcine complement regulator factor H and its use |
| US20030180292A1 (en) | 2002-03-14 | 2003-09-25 | Idec Pharmaceuticals | Treatment of B cell malignancies using anti-CD40L antibodies in combination with anti-CD20 antibodies and/or chemotherapeutics and radiotherapy |
| WO2003077796A2 (en) | 2002-03-15 | 2003-09-25 | University Of Southern California | Ophthalmic solutions for delivery of expression vectors |
| US20040058313A1 (en) | 2002-04-24 | 2004-03-25 | Abreu Marcio Marc | Compositions, targets, methods and devices for the therapy of ocular and periocular disorders |
| EP2292259A3 (en) | 2002-11-15 | 2011-03-23 | MUSC Foundation For Research Development | Complement receptor 2 targeted complement modulators |
| US7534427B2 (en) | 2002-12-31 | 2009-05-19 | Immunomedics, Inc. | Immunotherapy of B cell malignancies and autoimmune diseases using unconjugated antibodies and conjugated antibodies and antibody combinations and fusion proteins |
| CN1791422A (zh) | 2003-03-28 | 2006-06-21 | 应用研究系统Ars股份公司 | 凝聚素在治疗和/或预防周围神经疾病中的用途 |
| US20070123466A1 (en) | 2003-05-13 | 2007-05-31 | New York Society For The Ruptured And Crippled Maintaining The Hospital For Special Surgery | Method of treating recurrent miscarriages |
| JP4029772B2 (ja) | 2003-05-16 | 2008-01-09 | 株式会社日立製作所 | 磁気ヘッドおよびそれを用いた磁気記録再生装置 |
| EP1488798A1 (en) | 2003-06-18 | 2004-12-22 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | HIP/PAP polypeptide composition for use in liver regeneration and for the prevention of liver failure |
| JP4818917B2 (ja) | 2003-08-08 | 2011-11-16 | イミューノメディクス、インコーポレイテッド | 腫瘍および罹患細胞のアポトーシスを誘発するための二重特異性抗体 |
| EP1682179A4 (en) | 2003-11-05 | 2008-09-03 | Palingen Inc | IMPROVED B-CELL CYTOTOXICITY OF CDIM BINDING ANTIBODY |
| US8454963B2 (en) | 2003-11-13 | 2013-06-04 | Musc Foundation For Research Development | Tissue targeted complement modulators |
| CA2554729A1 (en) | 2004-01-27 | 2005-08-11 | University Of Southern California | Polymer-bound antibody cancer therapeutic agent |
| DK1713503T3 (da) | 2004-02-10 | 2013-11-04 | Univ Colorado Regents | Hæmning af faktor b, den alternative komplemenpathway og dertil relaterede fremgangsmåde |
| EP1713503B1 (en) | 2004-02-10 | 2013-07-31 | The Regents of the University of Colorado, a Body Corporate | Inhibition of factor b, the alternative complement pathway and methods related thereto |
| US7919094B2 (en) | 2004-06-10 | 2011-04-05 | Omeros Corporation | Methods for treating conditions associated with MASP-2 dependent complement activation |
| EP1797118A2 (en) | 2004-09-03 | 2007-06-20 | Creabilis Therapeutics S.P.A. | Protease resistant human and non-human hmgb1 box-a mutants and their therapeutic/diagnostic use |
| US7563443B2 (en) | 2004-09-17 | 2009-07-21 | Domantis Limited | Monovalent anti-CD40L antibody polypeptides and compositions thereof |
| US7423128B2 (en) | 2004-11-03 | 2008-09-09 | Amgen Fremont Inc. | Anti-properdin antibodies, and methods for making and using same |
| WO2006062716A2 (en) | 2004-11-18 | 2006-06-15 | Yale University | Methods and compositions for treating ocular disorders |
| WO2006083533A2 (en) | 2005-01-14 | 2006-08-10 | The Regents Of The University Of California | Compositions and methods for inhibiting drusen formation and for diagnosing or treating drusen-related disorders |
| EP2357257B1 (en) | 2005-02-14 | 2019-07-31 | University of Iowa Research Foundation | Methods and reagents for treatment and diagnosis of age-related macular degeneration |
| ES2548700T3 (es) | 2005-05-26 | 2015-10-20 | The Regents Of The University Of Colorado, A Body Corporate | Inhibición de la vía alternativa del complemento para el tratamiento de lesión cerebral traumática, lesión de médula espinal y afecciones relacionadas |
| US20090087907A1 (en) | 2005-07-29 | 2009-04-02 | Alice Pebay | Compositions and Methods for Growth of Pluripotent Cells |
| CN101262855A (zh) | 2005-09-08 | 2008-09-10 | 帝斯曼知识产权资产管理有限公司 | 治疗或预防年龄相关性黄斑变性的方法 |
| AU2006292132A1 (en) | 2005-09-19 | 2007-03-29 | Palingen, Inc. | Treatment of B cell diseases using anti-germline antibody binding agents |
| ES2551202T5 (es) | 2005-11-04 | 2018-11-30 | Genentech, Inc. | Uso de inhibidores de la vía del complemento para tratar enfermedades oculares |
| US20110014270A1 (en) | 2006-03-27 | 2011-01-20 | The Regents Of The University Of Colorado | Prevention and treatment of ischemia-reperfusion injury and related conditions |
| GEP20125628B (en) | 2006-04-21 | 2012-09-10 | Novartis Ag | Pharmaceutical compositions containing antagonist anti-cd40 antibody |
| EP1854810A1 (en) | 2006-05-09 | 2007-11-14 | PanGenetics B.V. | Deimmunized antagonistic anti-human CD40 monoclonal antibody from the ch5D12 antibody |
| AU2007261315B2 (en) | 2006-06-21 | 2012-10-25 | Musc Foundation For Research Development | Targeting complement factor H for treatment of diseases |
| US7705475B2 (en) | 2006-08-03 | 2010-04-27 | Stats Chippac Ltd. | Integrated circuit package system |
| CN106084054A (zh) | 2006-11-02 | 2016-11-09 | 健泰科生物技术公司 | 人源化的抗‑d因子抗体 |
| AU2008251943B2 (en) * | 2007-03-14 | 2013-09-05 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
| AU2008262048B2 (en) | 2007-06-07 | 2013-09-26 | Genentech, Inc. | C3b antibodies and methods for the prevention and treatment of complement- associated disorders |
| AU2008293487A1 (en) | 2007-08-27 | 2009-03-05 | Novelmed Therapeutics, Inc. | Method of inhibiting complement activation with factor Bb specific antibodies |
| PE20091388A1 (es) | 2007-11-02 | 2009-09-24 | Novartis Ag | Moleculas y metodos para modular el componente de complemento |
| ES2538114T3 (es) | 2008-03-03 | 2015-06-17 | Novelmed Therapeutics, Inc. | Anticuerpos anti-properdina |
| WO2010015608A1 (en) | 2008-08-05 | 2010-02-11 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c5 |
| EP2358392B1 (en) | 2008-11-12 | 2019-01-09 | MedImmune, LLC | Antibody formulation |
| US8840868B2 (en) | 2009-02-04 | 2014-09-23 | The Regents Of The University Of Colorado, A Body Corporate | Non-invasive detection of complement-mediated inflammation using CR2-targeted nanoparticles |
| US20100291106A1 (en) | 2009-05-06 | 2010-11-18 | Novartis Ag | Compositions and methods for antibodies targeting complement protein c3b |
| US9291622B2 (en) | 2009-05-21 | 2016-03-22 | Apellis Pharmaceuticals, Inc. | Complement assays and uses thereof |
| AU2010266127B2 (en) * | 2009-07-02 | 2015-11-05 | Musc Foundation For Research Development | Methods of stimulating liver regeneration |
| EA201290286A1 (ru) | 2009-11-05 | 2013-01-30 | Алексион Кембридж Корпорейшн | Лечение пароксизмальной ночной гемоглобинурии, гемолитических анемий и патологических состояний с вовлечением внутрисосудистого и внесосудистого гемолиза |
| SG185483A1 (en) | 2010-05-14 | 2012-12-28 | Univ Colorado Regents | Improved complement receptor 2 (cr2) targeting groups |
| EP2585110A4 (en) | 2010-06-22 | 2014-01-22 | Univ Colorado Regents | ANTIBODIES AGAINST THE C3D FRAGMENT OF THE COMPLEMENT COMPONENT 3 |
| CN103248395A (zh) | 2012-02-09 | 2013-08-14 | 中兴通讯股份有限公司 | 一种窄带干扰抑制方法及装置 |
| US9803005B2 (en) | 2012-05-24 | 2017-10-31 | Alexion Pharmaceuticals, Inc. | Humaneered anti-factor B antibody |
-
2007
- 2007-06-21 AU AU2007261315A patent/AU2007261315B2/en not_active Ceased
- 2007-06-21 EP EP14170690.3A patent/EP2826788B1/en active Active
- 2007-06-21 SI SI200731549T patent/SI2044111T1/sl unknown
- 2007-06-21 PT PT78452505T patent/PT2044111E/pt unknown
- 2007-06-21 CA CA2656063A patent/CA2656063C/en not_active Expired - Fee Related
- 2007-06-21 EP EP07845250.5A patent/EP2044111B1/en active Active
- 2007-06-21 DK DK07845250.5T patent/DK2044111T3/en active
- 2007-06-21 ES ES07845250.5T patent/ES2523640T3/es active Active
- 2007-06-21 BR BRPI0712987-4A patent/BRPI0712987A2/pt not_active IP Right Cessation
- 2007-06-21 WO PCT/US2007/014602 patent/WO2007149567A2/en not_active Ceased
- 2007-06-21 JP JP2009516588A patent/JP5250548B2/ja active Active
- 2007-06-21 PL PL07845250T patent/PL2044111T3/pl unknown
- 2007-06-21 CN CN2007800294588A patent/CN101563363B/zh not_active Expired - Fee Related
- 2007-06-21 US US11/821,370 patent/US7759304B2/en active Active
-
2010
- 2010-05-18 US US12/782,526 patent/US8569225B2/en active Active
-
2013
- 2013-10-01 US US14/043,317 patent/US9212212B2/en active Active
-
2015
- 2015-07-21 HK HK15106966.0A patent/HK1206368A1/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007261315A1 (en) | 2007-12-27 |
| JP5250548B2 (ja) | 2013-07-31 |
| BRPI0712987A2 (pt) | 2012-04-10 |
| DK2044111T3 (en) | 2014-11-17 |
| WO2007149567A2 (en) | 2007-12-27 |
| CA2656063C (en) | 2016-10-18 |
| AU2007261315B2 (en) | 2012-10-25 |
| US20110015127A1 (en) | 2011-01-20 |
| ES2523640T3 (es) | 2014-11-28 |
| CA2656063A1 (en) | 2007-12-27 |
| WO2007149567A3 (en) | 2008-05-02 |
| US7759304B2 (en) | 2010-07-20 |
| US9212212B2 (en) | 2015-12-15 |
| US20140073572A1 (en) | 2014-03-13 |
| HK1129689A1 (en) | 2009-12-04 |
| CN101563363B (zh) | 2013-01-02 |
| EP2826788B1 (en) | 2017-12-13 |
| US20080221011A1 (en) | 2008-09-11 |
| JP2009540831A (ja) | 2009-11-26 |
| US8569225B2 (en) | 2013-10-29 |
| CN101563363A (zh) | 2009-10-21 |
| EP2044111A2 (en) | 2009-04-08 |
| SI2044111T1 (sl) | 2015-02-27 |
| EP2044111B1 (en) | 2014-08-13 |
| PL2044111T3 (pl) | 2015-02-27 |
| PT2044111E (pt) | 2014-11-12 |
| EP2826788A1 (en) | 2015-01-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP2826788B1 (en) | Targeting complement factor h for treatment of diseases by the use of cr2-fh molecules | |
| EP2496259B1 (en) | Treatment of paroxysmal nocturnal hemoglobinuria | |
| JP6563815B2 (ja) | 天然抗体に由来する構築物を標的化すること及びその使用 | |
| US11642394B2 (en) | Methods and compositions using GDF15 polypeptides for increasing red blood cells | |
| JP2012531400A (ja) | 少なくとも2つのα3ドメインを含むHLA−Gの多量体ポリペプチド及び医薬としてのその使用 | |
| JP2021006581A (ja) | 天然抗体に基づくMAp44ポリペプチドおよび構築物ならびにそれらの使用 | |
| US20250144190A1 (en) | Compositions and methods for treating central nervous system injury | |
| JP2022547111A (ja) | 治療用融合タンパク質 | |
| US20250222127A1 (en) | Compositions and methods for treating and preventing transplant-associated injury | |
| HK1129689B (en) | Targeting complement factor h for treatment of diseases | |
| CN102574905A (zh) | HLA-Gα1多聚体及其药学用途 | |
| AU2016375187C1 (en) | Soluble glycoprotein V for treating thrombotic diseases | |
| WO2018075450A1 (en) | Compositions and methods for treating central nervous system injury |