HK1203211A1 - Cgrp antibodies cgrp - Google Patents

Cgrp antibodies cgrp

Info

Publication number
HK1203211A1
HK1203211A1 HK15103793.6A HK15103793A HK1203211A1 HK 1203211 A1 HK1203211 A1 HK 1203211A1 HK 15103793 A HK15103793 A HK 15103793A HK 1203211 A1 HK1203211 A1 HK 1203211A1
Authority
HK
Hong Kong
Prior art keywords
cgrp
antibodies
cgrp antibodies
antibodies cgrp
Prior art date
Application number
HK15103793.6A
Other languages
English (en)
Chinese (zh)
Inventor
Barrett Allan
Robert Jan Benschop
Mark Geoffrey Chambers
Ryan James Darling
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of HK1203211A1 publication Critical patent/HK1203211A1/xx

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/26Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K39/395Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00Drugs for skeletal disorders
    • A61P19/02Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/06Antimigraine agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57527Calcitonin gene related peptide
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/54Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57545Neuropeptide Y
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575Hormones
    • C07K14/57563Vasoactive intestinal peptide [VIP]; Related peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/90Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK15103793.6A 2010-06-10 2015-04-20 Cgrp antibodies cgrp HK1203211A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US35332310P 2010-06-10 2010-06-10

Publications (1)

Publication Number Publication Date
HK1203211A1 true HK1203211A1 (en) 2015-10-23

Family

ID=45096388

Family Applications (1)

Application Number Title Priority Date Filing Date
HK15103793.6A HK1203211A1 (en) 2010-06-10 2015-04-20 Cgrp antibodies cgrp

Country Status (34)

Country Link
US (3) US9073991B2 (ja)
EP (2) EP2579894B1 (ja)
JP (2) JP6021806B2 (ja)
KR (1) KR101489566B1 (ja)
CN (2) CN104292332B (ja)
AR (1) AR081434A1 (ja)
AU (1) AU2011265050B2 (ja)
BR (1) BR112012031501B1 (ja)
CA (1) CA2802102C (ja)
CY (2) CY1119789T1 (ja)
DK (1) DK2579894T3 (ja)
EA (1) EA022931B1 (ja)
ES (2) ES2656000T3 (ja)
HK (1) HK1203211A1 (ja)
HR (1) HRP20171992T1 (ja)
HU (2) HUE038135T2 (ja)
IL (2) IL222885B (ja)
JO (1) JO3330B1 (ja)
LT (2) LT2579894T (ja)
LU (1) LUC00112I2 (ja)
ME (1) ME02862B (ja)
MX (2) MX340999B (ja)
NL (1) NL300979I2 (ja)
NO (2) NO2579894T3 (ja)
NZ (1) NZ603607A (ja)
PL (1) PL2579894T3 (ja)
PT (1) PT2579894T (ja)
RS (1) RS56638B1 (ja)
SG (1) SG185648A1 (ja)
SI (1) SI2579894T1 (ja)
TW (1) TWI423818B (ja)
UA (1) UA109658C2 (ja)
WO (1) WO2011156324A1 (ja)
ZA (1) ZA201208996B (ja)

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EP3069731A1 (en) 2005-11-14 2016-09-21 Labrys Biologics Inc. Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
RU2522493C2 (ru) 2008-03-04 2014-07-20 Пфайзер Лимитед Способы лечения хронической боли
US8623366B2 (en) 2009-08-28 2014-01-07 Labrys Biologics, Inc. Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide
JO3330B1 (ar) * 2010-06-10 2019-03-13 Lilly Co Eli الأجسام المضادة cgrp
US9855332B2 (en) 2011-05-20 2018-01-02 Alderbio Holdings Llc Use of anti-CGRP antibodies and antibody fragments to treat diarrhea in subjects with diseases or treatments that result in elevated CGRP levels
SG194973A1 (en) 2011-05-20 2013-12-30 Alderbio Holdings Llc Use of anti-cgrp antibodies and antibody fragments to prevent or inhibit photophobia or light aversion in subjects in need thereof, especially migraine sufferers
HUE054437T2 (hu) 2011-05-20 2021-09-28 H Lundbeck As Anti-CGRP készítmények és alkalmazásuk
PT2888283T (pt) 2012-08-24 2018-11-16 Univ California Anticorpos e vacinas para serem utilizados no tratamento de cancros que expressam ror1 e inibição de metástases
US10556945B2 (en) 2014-03-21 2020-02-11 Teva Pharmaceuticals International Gmbh Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
CN106456759A (zh) 2014-03-21 2017-02-22 泰华制药国际有限公司 针对降钙素基因相关肽的拮抗剂抗体及其使用方法
CR20170164A (es) 2014-10-24 2017-08-29 Merck Sharp & Dohme Coagonistas de los receptores de glucagón y de glp-1
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗pd-1抗體類和使用彼等之方法
JOP20200116A1 (ar) 2015-04-24 2017-06-16 Amgen Inc طرق لعلاج أو الوقاية من الصداع النصفي
AR104847A1 (es) * 2015-06-17 2017-08-16 Lilly Co Eli Formulación de anticuerpo anti-cgrp
EA201890741A1 (ru) * 2015-10-30 2018-10-31 Эли Лилли Энд Компани Биспецифические антитела против cgrp/il-23 и их применения
CN105483091A (zh) * 2015-12-29 2016-04-13 天津三箭生物技术股份有限公司 小鼠抗人Calcitonin单克隆抗体及分泌该单克隆抗体的杂交瘤细胞株
MX2018009218A (es) * 2016-01-28 2018-11-09 Lilly Co Eli Anticuerpos de cgrp y sus usos.
CA3013443C (en) 2016-02-01 2021-06-15 Eli Lilly And Company Parathyroid hormone - anti-rankl antibody fusion compounds
CN109996544A (zh) 2016-06-27 2019-07-09 加利福尼亚大学董事会 癌症治疗组合
EP3515488A1 (en) 2016-09-23 2019-07-31 Teva Pharmaceuticals International GmbH Treating cluster headache
CN109952314A (zh) 2016-09-23 2019-06-28 泰瓦制药国际有限公司 治疗难治性偏头痛
AU2018226811A1 (en) 2017-03-02 2019-09-26 Beth Israel Deaconess Medical Center, Inc. Selecting headache patients responsive to antibodies directed against calcitonin gene related peptide
AR111845A1 (es) 2017-05-03 2019-08-28 Lilly Co Eli Anticuerpos biespecíficos anti-cgrp / anti-il-23 y usos de los mismos
JP2020525445A (ja) 2017-06-21 2020-08-27 セファロン・インコーポレイテッドCephalon,Incorporated カチオン交換クロマトグラフィーの洗浄緩衝液
TWI754772B (zh) * 2017-09-06 2022-02-11 美商美國禮來大藥廠 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法
EP3737699A1 (en) 2018-01-12 2020-11-18 Amgen Inc. Pac1 antibodies and uses thereof
WO2019231800A1 (en) 2018-05-31 2019-12-05 Eli Lilly And Company Anti-cgrp antibodies for treating menstrual-related migraines
US20210340230A1 (en) 2018-08-22 2021-11-04 Eli Lilly And Company Anti-CGRP Antibodies For Treatment-Resistant Patients
BR112020018192A2 (pt) 2019-01-08 2021-08-24 H. Lundbeck A/S Tratamento agudo e tratamento rápido de dor de cabeça com o uso de anticorpos anti-cgrp
EP3744400A1 (en) * 2019-05-28 2020-12-02 Etablissement Français du Sang Car-t cells targeting il-1rap and their use in acute myeloid leukemia (aml)
WO2020239014A1 (zh) * 2019-05-30 2020-12-03 山东博安生物技术有限公司 抗cgrp抗体及其应用
JP2022552323A (ja) 2019-10-15 2022-12-15 イーライ リリー アンド カンパニー 組換え操作された、リパーゼ/エステラーゼ欠損哺乳動物細胞株
EP4301362A1 (en) 2021-03-02 2024-01-10 CGRP Diagnostics GmbH Treatment and/or reduction of occurrence of migraine
WO2023161526A1 (en) 2022-02-28 2023-08-31 Tridem Bioscience Gmbh & Co Kg A CONJUGATE CONSISTING OF OR COMPRISING AT LEAST A ß-GLUCAN OR A MANNAN
WO2024032750A1 (zh) * 2022-08-11 2024-02-15 上海君实生物医药科技股份有限公司 抗cgrp抗体及用途

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GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
DE122009000019I1 (de) * 1991-04-25 2009-07-16 Chugai Seiyaku K K 5 1 Rekombinierte humane antikörper gegen den humanen interleukin-6 rezeptor
JP4124480B2 (ja) * 1991-06-14 2008-07-23 ジェネンテック・インコーポレーテッド 免疫グロブリン変異体
AU2003271174A1 (en) * 2003-10-10 2005-04-27 Chugai Seiyaku Kabushiki Kaisha Double specific antibodies substituting for functional protein
WO2006110214A2 (en) * 2005-04-08 2006-10-19 Medimmune, Inc. Antibodies against mammalian metapneumovirus
EP3069731A1 (en) * 2005-11-14 2016-09-21 Labrys Biologics Inc. Antagonist antibodies directed against calcitonin gene-related peptide and methods using same
WO2007076336A1 (en) 2005-12-22 2007-07-05 Eli Lilly And Company Treatment of migraine with anti-cgrp antibodies
RU2522493C2 (ru) * 2008-03-04 2014-07-20 Пфайзер Лимитед Способы лечения хронической боли
PL2265288T3 (pl) * 2008-03-04 2017-01-31 Labrys Biologics Inc Sposoby leczenia bólu zapalnego
JO3330B1 (ar) * 2010-06-10 2019-03-13 Lilly Co Eli الأجسام المضادة cgrp

Also Published As

Publication number Publication date
CA2802102A1 (en) 2011-12-15
NO2579894T3 (ja) 2018-04-21
NL300979I2 (nl) 2019-07-11
CA2802102C (en) 2016-07-26
MX363209B (es) 2019-03-14
JO3330B1 (ar) 2019-03-13
CN102946905A (zh) 2013-02-27
EA201270769A1 (ru) 2013-04-30
IL222885B (en) 2019-09-26
DK2579894T3 (en) 2018-01-15
BR112012031501B1 (pt) 2020-02-11
MX340999B (es) 2016-08-03
ME02862B (me) 2018-04-20
CN104292332B (zh) 2019-11-01
US20170073403A1 (en) 2017-03-16
BR112012031501A2 (pt) 2016-10-25
TW201210618A (en) 2012-03-16
KR101489566B1 (ko) 2015-02-03
LT2579894T (lt) 2018-02-26
MX2012014480A (es) 2013-02-07
CY2019017I1 (el) 2020-05-29
HUE038135T2 (hu) 2018-09-28
SG185648A1 (en) 2012-12-28
TWI423818B (zh) 2014-01-21
CN102946905B (zh) 2014-10-15
EP3318272A1 (en) 2018-05-09
UA109658C2 (xx) 2015-09-25
EP3318272B1 (en) 2022-08-10
ES2930321T3 (es) 2022-12-09
CY1119789T1 (el) 2018-06-27
SI2579894T1 (en) 2018-01-31
LTC2579894I2 (lt) 2020-03-25
US20110305711A1 (en) 2011-12-15
EA022931B1 (ru) 2016-03-31
JP2013532143A (ja) 2013-08-15
JP6466883B2 (ja) 2019-02-06
NL300979I1 (nl) 2019-04-17
ZA201208996B (en) 2014-05-28
CN104292332A (zh) 2015-01-21
IL242409B (en) 2020-07-30
US9505838B2 (en) 2016-11-29
IL222885A0 (en) 2012-12-31
JP2017014203A (ja) 2017-01-19
EP2579894B1 (en) 2017-11-22
RS56638B1 (sr) 2018-03-30
PT2579894T (pt) 2018-02-06
CY2019017I2 (el) 2020-05-29
US9073991B2 (en) 2015-07-07
NO2019017I1 (no) 2019-04-05
AR081434A1 (es) 2012-08-29
LTPA2019011I1 (lt) 2019-05-10
AU2011265050A1 (en) 2012-11-08
HRP20171992T1 (hr) 2018-02-09
US20150259415A1 (en) 2015-09-17
JP6021806B2 (ja) 2016-11-09
LUC00112I1 (ja) 2019-04-10
KR20130034024A (ko) 2013-04-04
WO2011156324A1 (en) 2011-12-15
EP2579894A1 (en) 2013-04-17
LUC00112I2 (ja) 2019-12-27
ES2656000T3 (es) 2018-02-22
PL2579894T3 (pl) 2018-04-30
AU2011265050B2 (en) 2013-06-27
EP2579894A4 (en) 2013-12-04
NZ603607A (en) 2014-09-26
HUS1900020I1 (hu) 2019-05-28

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