HK1200844A1 - Improved assembly of bispecific antibodies - Google Patents

Improved assembly of bispecific antibodies

Info

Publication number
HK1200844A1
HK1200844A1 HK15101182.9A HK15101182A HK1200844A1 HK 1200844 A1 HK1200844 A1 HK 1200844A1 HK 15101182 A HK15101182 A HK 15101182A HK 1200844 A1 HK1200844 A1 HK 1200844A1
Authority
HK
Hong Kong
Prior art keywords
bispecific antibodies
improved assembly
assembly
improved
bispecific
Prior art date
Application number
HK15101182.9A
Other languages
English (en)
Chinese (zh)
Inventor
Glen Giese
Josefine Persson
Ambrose Williams
Amy Lim
Justin Scheer
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of HK1200844A1 publication Critical patent/HK1200844A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/36—Extraction; Separation; Purification by a combination of two or more processes of different types
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/46—Hybrid immunoglobulins
    • C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/70—Vectors or expression systems specially adapted for E. coli
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/522—CH1 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/524—CH2 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/526—CH3 domain
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/52—Constant or Fc region; Isotype
    • C07K2317/53—Hinge
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Analytical Chemistry (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
HK15101182.9A 2011-10-11 2015-02-04 Improved assembly of bispecific antibodies HK1200844A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201161545863P 2011-10-11 2011-10-11
US201161546503P 2011-10-12 2011-10-12
US201161560704P 2011-11-16 2011-11-16
US201261676837P 2012-07-27 2012-07-27
PCT/US2012/059810 WO2013055958A1 (en) 2011-10-11 2012-10-11 Improved assembly of bispecific antibodies

Publications (1)

Publication Number Publication Date
HK1200844A1 true HK1200844A1 (en) 2015-08-14

Family

ID=47073551

Family Applications (2)

Application Number Title Priority Date Filing Date
HK15101182.9A HK1200844A1 (en) 2011-10-11 2015-02-04 Improved assembly of bispecific antibodies
HK15103323.5A HK1202878A1 (en) 2011-10-11 2015-04-01 Improved assembly of bispecific antibodies

Family Applications After (1)

Application Number Title Priority Date Filing Date
HK15103323.5A HK1202878A1 (en) 2011-10-11 2015-04-01 Improved assembly of bispecific antibodies

Country Status (16)

Country Link
US (4) US9862778B2 (tr)
EP (2) EP3418306B1 (tr)
JP (1) JP6216321B2 (tr)
KR (3) KR102106002B1 (tr)
CN (2) CN107266577B (tr)
BR (1) BR112014008684B1 (tr)
CA (1) CA2850818A1 (tr)
ES (2) ES2682081T3 (tr)
HK (2) HK1200844A1 (tr)
HR (2) HRP20240230T1 (tr)
MX (1) MX359384B (tr)
PL (2) PL3418306T3 (tr)
RU (1) RU2654567C2 (tr)
SI (1) SI2766397T1 (tr)
TR (1) TR201809151T4 (tr)
WO (1) WO2013055958A1 (tr)

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Also Published As

Publication number Publication date
US20140336361A1 (en) 2014-11-13
US20240101714A1 (en) 2024-03-28
US20180162955A1 (en) 2018-06-14
MX359384B (es) 2018-09-25
KR20210021595A (ko) 2021-02-26
US20200317820A1 (en) 2020-10-08
PL3418306T3 (pl) 2024-04-15
EP2766397B1 (en) 2018-05-30
RU2014118743A (ru) 2015-11-20
EP3418306A1 (en) 2018-12-26
WO2013055958A1 (en) 2013-04-18
CA2850818A1 (en) 2013-04-18
KR102492792B1 (ko) 2023-01-30
ES2682081T3 (es) 2018-09-18
HRP20181189T1 (hr) 2018-10-05
RU2654567C2 (ru) 2018-05-21
ES2971444T3 (es) 2024-06-05
CN107266577A (zh) 2017-10-20
CN104093744A (zh) 2014-10-08
HK1202878A1 (en) 2015-10-09
EP3418306B1 (en) 2023-12-06
JP6216321B2 (ja) 2017-10-18
EP3418306C0 (en) 2023-12-06
KR20140082783A (ko) 2014-07-02
BR112014008684A2 (pt) 2019-10-15
SI2766397T1 (sl) 2018-09-28
PL2766397T3 (pl) 2018-10-31
US11725065B2 (en) 2023-08-15
MX2014004322A (es) 2014-07-28
US10626189B2 (en) 2020-04-21
KR20200046129A (ko) 2020-05-06
EP2766397A1 (en) 2014-08-20
BR112014008684B1 (pt) 2021-11-09
KR102219217B1 (ko) 2021-02-23
JP2014534198A (ja) 2014-12-18
US9862778B2 (en) 2018-01-09
HRP20240230T1 (hr) 2024-04-26
TR201809151T4 (tr) 2018-07-23
KR102106002B1 (ko) 2020-05-07
CN107266577B (zh) 2022-09-13

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