HK1197238A1 - 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis (cetp) 5- -6-[34-b] - Google Patents
5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis (cetp) 5- -6-[34-b]Info
- Publication number
- HK1197238A1 HK1197238A1 HK14110754A HK14110754A HK1197238A1 HK 1197238 A1 HK1197238 A1 HK 1197238A1 HK 14110754 A HK14110754 A HK 14110754A HK 14110754 A HK14110754 A HK 14110754A HK 1197238 A1 HK1197238 A1 HK 1197238A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- cetp
- benzylaminomethyl
- aminopyrazolo
- atherosclerosis
- treatment
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IN3337CH2011 | 2011-09-27 | ||
US201161558262P | 2011-11-10 | 2011-11-10 | |
PCT/IB2012/002435 WO2013046045A1 (en) | 2011-09-27 | 2012-09-27 | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1197238A1 true HK1197238A1 (en) | 2015-01-09 |
Family
ID=47994351
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK14110754A HK1197238A1 (en) | 2011-09-27 | 2014-10-27 | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis (cetp) 5- -6-[34-b] |
Country Status (11)
Country | Link |
---|---|
US (1) | US9000007B2 (es) |
EP (1) | EP2760864B1 (es) |
JP (1) | JP6140168B2 (es) |
KR (1) | KR101803866B1 (es) |
CN (1) | CN103958511A (es) |
AU (1) | AU2012313971B2 (es) |
CA (1) | CA2850022C (es) |
HK (1) | HK1197238A1 (es) |
IN (1) | IN2014CN02290A (es) |
MX (1) | MX352074B (es) |
WO (1) | WO2013046045A1 (es) |
Families Citing this family (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPWO2014017569A1 (ja) * | 2012-07-26 | 2016-07-11 | 興和株式会社 | 血中ldlを低下させるための医薬 |
JP2015054838A (ja) * | 2013-09-12 | 2015-03-23 | 興和株式会社 | 血中ldlコレステロールを低下させる医薬 |
EP3081566B1 (en) * | 2013-12-13 | 2018-03-07 | Daiichi Sankyo Company, Limited | 5-hydroxy-4-(trifluoromethyl)pyrazolopyridine derivative |
CN109956940A (zh) * | 2019-05-14 | 2019-07-02 | 上海贤鼎生物科技有限公司 | 一种帕博昔布中间体氰基化反应制备杂芳基氰化物的方法 |
Family Cites Families (105)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2965643A (en) | 1960-12-20 | Derivatives of pyrazolo | ||
US2858309A (en) | 1956-05-07 | 1958-10-28 | Ciba Pharm Prod Inc | New aminobenzene sulfonamide |
US3546295A (en) | 1968-08-01 | 1970-12-08 | Exxon Research Engineering Co | N-cycloalkyl anilines |
IT8124760A0 (it) | 1980-10-29 | 1981-10-29 | Nippon Kayaku Kk | Derivati di 5,6,7,8-tetraidro-1,6-naftiridina e procedimento per la loro preparazione. |
JPH01104052A (ja) | 1987-06-12 | 1989-04-21 | Yoshitomi Pharmaceut Ind Ltd | ピリジン誘導体 |
ES2058288T3 (es) | 1987-07-08 | 1994-11-01 | American Home Prod | Composiciones de ibuprofen secadas por atomizacion. |
US5474989A (en) | 1988-11-11 | 1995-12-12 | Kurita Water Industries, Ltd. | Drug composition |
US5260331A (en) | 1989-01-02 | 1993-11-09 | John Wyeth & Brother Limited | Composition for treating depression with (S- or O-heteroaryl)alkyl amines |
US5422355A (en) | 1989-06-02 | 1995-06-06 | John Wyeth & Brother, Limited | Composition for treating depression with (N-heteroaryl)alkylamines |
AU641394B2 (en) | 1989-06-02 | 1993-09-23 | John Wyeth & Brother Limited | Amines |
ES2111065T5 (es) | 1991-04-16 | 2005-06-16 | Nippon Shinyaku Company, Limited | Procedimiento para producir una dispersion solida. |
WO1993000332A1 (en) | 1991-06-25 | 1993-01-07 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
US5348953A (en) | 1991-06-25 | 1994-09-20 | Merck & Co., Inc. | Substituted azetidinones as anti-inflammatory and antidegenerative agents |
TW225469B (es) | 1991-11-12 | 1994-06-21 | Nissan Kagakl Kogyo | |
FR2686339B1 (fr) | 1992-01-22 | 1994-03-11 | Adir Cie | Nouveaux amides et sulfonamides naphtaleniques, leurs procedes de preparation et les compositions pharmaceutiques qui les contiennent. |
DE69315920T2 (de) | 1992-09-04 | 1998-06-10 | Takeda Chemical Industries Ltd | Kondensierte heterozyklische Verbindungen, deren Herstellung und Verwendung |
EP0585500A1 (en) | 1992-09-04 | 1994-03-09 | Merrell Dow Pharmaceuticals Inc. | Diaryl piperazineacetamides as antimuscarinic agents |
MY131441A (en) | 1992-12-29 | 2007-08-30 | American Cyanamid Co | Amidrazones and their use as insecticidal and acaricidal agents |
PL180081B1 (pl) | 1993-08-12 | 2000-12-29 | Astra Ab | Nowe pochodne amidyny i sposób ich wytwarzania PL PL PL PL PL PL PL |
US5491152A (en) | 1994-03-23 | 1996-02-13 | The Du Pont Merck Pharmaceutical Company | Derivatives of cyclic ethers and sulfides for the treatment of atherosclerosis |
JPH07285962A (ja) | 1994-04-20 | 1995-10-31 | Nissan Chem Ind Ltd | ピリジンカルボン酸アミド誘導体 |
IT1270615B (it) | 1994-07-14 | 1997-05-07 | Smithkline Beecham Farma | Uso di derivati di chinolina |
JPH0892224A (ja) | 1994-09-16 | 1996-04-09 | Kumiai Chem Ind Co Ltd | 3,5−置換フェニルトリアゾール誘導体および殺虫、殺ダニ剤 |
JPH0892225A (ja) | 1994-09-29 | 1996-04-09 | Nissan Chem Ind Ltd | トリアゾールグリコール酸アミド誘導体 |
WO1996016650A1 (fr) | 1994-11-29 | 1996-06-06 | Hisamitsu Pharmaceutical Co., Inc. | Antibacterien et bactericide comprenant un derive de 2-aminothiazole et sels de ce derive |
GB9511220D0 (en) | 1995-06-02 | 1995-07-26 | Glaxo Group Ltd | Solid dispersions |
US6730679B1 (en) | 1996-03-22 | 2004-05-04 | Smithkline Beecham Corporation | Pharmaceutical formulations |
DE19615262A1 (de) | 1996-04-18 | 1997-10-23 | Bayer Ag | Heteroverknüpfte Phenylglycinolamide |
DE69726729T2 (de) | 1996-05-20 | 2004-12-02 | Janssen Pharmaceutica N.V. | Fungizide mittel mit verbesserter bioverfügbarkeit |
AR008789A1 (es) | 1996-07-31 | 2000-02-23 | Bayer Corp | Piridinas y bifenilos substituidos |
DE19636150A1 (de) | 1996-09-06 | 1998-03-12 | Asta Medica Ag | N-substituierte Indol-3-glyoxylamide mit antiasthmatischer, antiallergischer und immunsuppressiver/immunmodulierender Wirkung |
TW523506B (en) | 1996-12-18 | 2003-03-11 | Ono Pharmaceutical Co | Sulfonamide or carbamide derivatives and drugs containing the same as active ingredients |
AU7688398A (en) | 1997-06-16 | 1999-01-04 | American Home Products Corporation | Elevation of hdl cholesterol by 2-{(aminothioxomethyl)-hydrazono}-2-arylethyl carbamates |
US6008362A (en) | 1997-06-16 | 1999-12-28 | Commons; Thomas Joseph | Elevation of HDL cholesterol by 2-(-4-chlorol-1-aryl-butylidene)-hydrazinecarbothioamides |
US5977170A (en) | 1997-06-16 | 1999-11-02 | American Home Products Corporation | Elevation of HDL cholesterol by 4-[(aminothioxomethyl)hydrazono]-4-arylbutyl carbamates |
WO1998057927A1 (en) | 1997-06-16 | 1998-12-23 | American Home Products Corporation | Elevation of hdl cholesterol by 4-[(aminothioxomethyl)hydrazono]-4-arylbutyl carbamates |
AU7589598A (en) | 1997-06-16 | 1999-01-04 | American Home Products Corporation | Elevation of hdl cholesterol by 2-(4-chloro -1-aryl-butylidene) -hydrazinecarbothioamides |
EP1745774A3 (en) | 1997-08-11 | 2007-04-11 | Pfizer Products Inc. | Solid pharmaceutical dispersions with enhanced bioavailability |
UA67754C2 (uk) | 1997-10-10 | 2004-07-15 | Пфайзер, Інк. | Агоністи простагландину, фармацевтична композиція на їх основі (варіанти), спосіб нарощення та збереження кісткової маси у хребетних та спосіб лікування (варіанти) |
JPH11209366A (ja) | 1998-01-23 | 1999-08-03 | Nissan Chem Ind Ltd | クロマン誘導体及び心不全治療薬 |
DE19814838C2 (de) | 1998-04-02 | 2001-01-18 | Asta Medica Ag | Indolyl-3-glyoxylsäure-Derivate mit Antitumorwirkung |
US6121271A (en) | 1998-05-12 | 2000-09-19 | American Home Products Corporation | Naphtho[2,3-B]heteroar-4-yl derivatives |
GT199900147A (es) | 1998-09-17 | 1999-09-06 | 1, 2, 3, 4- tetrahidroquinolinas 2-sustituidas 4-amino sustituidas. | |
US6350786B1 (en) | 1998-09-22 | 2002-02-26 | Hoffmann-La Roche Inc. | Stable complexes of poorly soluble compounds in ionic polymers |
DE19845202A1 (de) | 1998-10-01 | 2000-04-06 | Wella Ag | Haarwuchsmittel |
KR100602725B1 (ko) | 1998-12-11 | 2006-07-20 | 파마솔루션스, 인코포레이티드 | 물에서 불충분하게 용해되는 약제를 위한 자가-유화용조성물 |
EP1970052A2 (en) | 1999-02-09 | 2008-09-17 | Pfizer Products Inc. | Basic drug compositions with enhanced bioavailability |
WO2000050398A2 (en) | 1999-02-24 | 2000-08-31 | F. Hoffmann-La Roche Ag | Phenyl- and pyridinyl derivatives as neurokinin 1 antagonists |
ES2284506T3 (es) | 1999-06-23 | 2007-11-16 | Syngenta Participations Ag | Metodo de producir tiametoxam. |
DE19930075A1 (de) | 1999-06-30 | 2001-01-04 | Bayer Ag | Neue Amino- und Amidosulfonamide als antivirale Mittel |
US6479552B2 (en) | 1999-09-23 | 2002-11-12 | G.D. Searle & Co. | Use of substituted N, N-disubstituted diamino compounds for inhibiting cholesteryl ester transfer protein activity |
TWI269654B (en) | 1999-09-28 | 2007-01-01 | Baxter Healthcare Sa | N-substituted indole-3-glyoxylamide compounds having anti-tumor action |
IL139941A0 (en) | 1999-12-02 | 2002-02-10 | Pfizer Prod Inc | Use of prostaglandin agonists to treat erectile dysfunction or impotence |
DE60020732T2 (de) | 1999-12-20 | 2006-05-11 | Kerkhof, Nicholas J., Rio Vista | Verfahren zur herstellung von nanometer partikeln durch fliessbett- sprühtrocknung |
DE19962300A1 (de) | 1999-12-23 | 2001-06-28 | Asta Medica Ag | Substituierte N-Benzyl-Indol-3-yl-glyoxylsäure-Derivate mit Antitumorwirkung |
US6306911B1 (en) | 2000-02-07 | 2001-10-23 | Ortho-Mcneil Pharmaceutical, Inc. | Substituted amino acids as neutral sphingomyelinase inhibitors |
WO2001060369A1 (en) | 2000-02-18 | 2001-08-23 | Merck & Co., Inc. | Inhibitors of prenyl-protein transferase |
AU2001238424A1 (en) | 2000-02-18 | 2001-08-27 | Merck And Co., Inc. | Inhibitors of prenyl-protein transferase |
DE10023484A1 (de) | 2000-05-09 | 2001-11-22 | Schering Ag | Anthranylamide und deren Verwendung als Arzneimittel |
EP1302201A4 (en) | 2000-07-17 | 2007-09-05 | Astellas Pharma Inc | PHARMACEUTICAL COMPOSITION WITH IMPROVED ABSORBABILITY |
US7115279B2 (en) | 2000-08-03 | 2006-10-03 | Curatolo William J | Pharmaceutical compositions of cholesteryl ester transfer protein inhibitors |
US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
WO2002022584A1 (en) | 2000-09-11 | 2002-03-21 | Merck & Co., Inc. | Thrombin inhibitors |
WO2002042273A2 (en) | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
US6869617B2 (en) | 2000-12-22 | 2005-03-22 | Baxter International Inc. | Microprecipitation method for preparing submicron suspensions |
ES2292830T3 (es) | 2001-02-21 | 2008-03-16 | Astrazeneca Ab | Compuestos heteropoliciclicos y su uso como antagonistas del receptor metabotropico de glutamato. |
DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
US7034013B2 (en) | 2001-03-20 | 2006-04-25 | Cydex, Inc. | Formulations containing propofol and a sulfoalkyl ether cyclodextrin |
WO2002090349A1 (de) | 2001-05-08 | 2002-11-14 | Schering Aktiengesellschaft | N-oxidanthranylamid-derivate und deren verwendung als arzneimittel |
CZ20033341A3 (cs) | 2001-06-21 | 2004-10-13 | Pfizeráproductsáinc | Samoemulgující se kompozice inhibitorů přenosového proteinu cholesterylesteru |
KR100759635B1 (ko) | 2001-06-22 | 2007-09-17 | 화이자 프로덕츠 인코포레이티드 | 비정질 약물의 흡착체의 약학 조성물 |
WO2003000226A2 (en) | 2001-06-22 | 2003-01-03 | Pfizer Products Inc. | Pharmaceutical compositions containing polymer and drug assemblies |
EP1269994A3 (en) | 2001-06-22 | 2003-02-12 | Pfizer Products Inc. | Pharmaceutical compositions comprising drug and concentration-enhancing polymers |
ATE361758T1 (de) | 2001-06-22 | 2007-06-15 | Pfizer Prod Inc | Pharmazeutische zusammensetzungen enthaltend eine feste dispersion eines im wasser schwerlöslichen arzneimittels und ein löslichkeitsteigerndes polymer |
WO2003030909A1 (en) | 2001-09-25 | 2003-04-17 | Bayer Pharmaceuticals Corporation | 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer |
US6713499B2 (en) | 2001-12-12 | 2004-03-30 | Hoffman-La Roche Inc. | 7-Amino-benzothiazole derivatives |
DE60322665D1 (de) | 2002-02-01 | 2008-09-18 | Pfizer Prod Inc | Pharmazeutische darreichungsform mit gesteuerter freigabe eines cholesterylester-transferproteininhibitors |
AR038375A1 (es) | 2002-02-01 | 2005-01-12 | Pfizer Prod Inc | Composiciones farmaceuticas de inhibidores de la proteina de transferencia de esteres de colesterilo |
GB0208280D0 (en) | 2002-04-10 | 2002-05-22 | Glaxo Group Ltd | Novel compounds |
US20040053842A1 (en) | 2002-07-02 | 2004-03-18 | Pfizer Inc. | Methods of treatment with CETP inhibitors and antihypertensive agents |
US7071210B2 (en) | 2002-07-02 | 2006-07-04 | Pfizer Inc. | CETP inhibitors in combination with antihypertensive agents and uses thereof |
PT1533292E (pt) | 2002-08-30 | 2007-05-31 | Japan Tobacco Inc | Compostos de dibenzilamina e sua utilização farmacêutica. |
MXPA05005813A (es) | 2002-12-20 | 2005-12-12 | Pfizer Prod Inc | Formas de dosificacion que comprenden un inhibidor de la cetp y un inhibidor de la hmg-coa reductasa. |
GB0303683D0 (en) | 2003-02-18 | 2003-03-19 | Prolysis Ltd | Antimicrobial agents |
EP1603879A2 (en) | 2003-02-28 | 2005-12-14 | Bayer Pharmaceuticals Corporation | Substituted pyridine derivatives useful in the treatment of cancer and other disorders |
AU2004216898A1 (en) | 2003-03-04 | 2004-09-16 | Pfizer Products Inc. | Use of EP2 selective receptor agonists in medical treatment |
WO2005000811A1 (en) | 2003-06-11 | 2005-01-06 | Eli Lilly And Company | 3-aminopyrrolidines as inhibitors of monoamine uptake |
MXPA06001506A (es) | 2003-08-04 | 2006-05-15 | Pfizer Prod Inc | Formas de dosificacion de inhibidores de la proteina de transferencia de colesteril ester e inhibidores de la hmg-coa reductasa. |
CA2536461A1 (en) | 2003-08-27 | 2005-03-10 | Janssen Pharmaceutica, N.V. | Aryl piperidine amides |
KR20070087197A (ko) | 2003-09-26 | 2007-08-27 | 니뽄 다바코 산교 가부시키가이샤 | 잔여 리포프로테인 생산 저해 방법 |
DE602005014955D1 (de) | 2004-03-26 | 2009-07-30 | Lilly Co Eli | Verbindungen und verfahren zur behandlung von dyslipidämie |
UA90269C2 (ru) | 2004-04-02 | 2010-04-26 | Мицубиси Танабе Фарма Корпорейшн | Тетрагидрохинолиновые производные и способ их получения |
MY139887A (en) | 2004-04-02 | 2009-11-30 | Mitsubishi Tanabe Pharma Corp | Tetrahydronaphthyridine derivatives and a process for preparing the same. |
CA2562082C (en) | 2004-04-13 | 2013-06-25 | Merck & Co., Inc. | Cetp inhibitors for the treatment and prevention of atherosclerosis |
WO2006056854A1 (en) | 2004-11-23 | 2006-06-01 | Pfizer Products Inc. | Dibenzyl amine compounds and derivatives |
US8604055B2 (en) * | 2004-12-31 | 2013-12-10 | Dr. Reddy's Laboratories Ltd. | Substituted benzylamino quinolines as cholesterol ester-transfer protein inhibitors |
CN103102303B (zh) * | 2004-12-31 | 2015-10-28 | 雷迪博士实验室有限公司 | 作为cetp抑制剂的苄胺衍生物 |
EP1893178A1 (en) | 2005-05-31 | 2008-03-05 | Pfizer Products Incorporated | PHARMACEUTICAL COMPOSITIONS OF CHOLESTERYL ESTER TRANSFER PROTEIN INHIBITORS AND HMG-CoA REDUCTASE INHIBITORS |
CA2642130C (en) * | 2005-12-28 | 2013-04-02 | Reddy Us Therapeutics, Inc. | Selective benzylamine derivatives and their utility as cholesterol ester-transfer protein inhibitors |
PE20071025A1 (es) * | 2006-01-31 | 2007-10-17 | Mitsubishi Tanabe Pharma Corp | Compuesto amina trisustituido |
CA2641451C (en) | 2006-02-09 | 2012-10-02 | Merck & Co., Inc. | Polymer formulations of cetp inhibitors |
WO2007128568A1 (en) | 2006-05-10 | 2007-11-15 | Novartis Ag | Bicyclic derivatives as cetp inhibitors |
US7790737B2 (en) * | 2007-03-13 | 2010-09-07 | Kowa Company, Ltd. | Substituted pyrimidine compounds and their utility as CETP inhibitors |
JP4834699B2 (ja) * | 2007-07-30 | 2011-12-14 | 田辺三菱製薬株式会社 | 医薬組成物 |
CN101418397A (zh) * | 2008-12-02 | 2009-04-29 | 西北有色金属研究院 | 一种TiB2强化的MgAlB14超硬材料的制备方法 |
-
2012
- 2012-09-27 JP JP2014532500A patent/JP6140168B2/ja not_active Expired - Fee Related
- 2012-09-27 CN CN201280057987.XA patent/CN103958511A/zh active Pending
- 2012-09-27 IN IN2290CHN2014 patent/IN2014CN02290A/en unknown
- 2012-09-27 AU AU2012313971A patent/AU2012313971B2/en not_active Ceased
- 2012-09-27 KR KR1020147009133A patent/KR101803866B1/ko active IP Right Grant
- 2012-09-27 WO PCT/IB2012/002435 patent/WO2013046045A1/en active Application Filing
- 2012-09-27 US US14/347,519 patent/US9000007B2/en not_active Expired - Fee Related
- 2012-09-27 EP EP12816102.3A patent/EP2760864B1/en not_active Not-in-force
- 2012-09-27 MX MX2014003660A patent/MX352074B/es active IP Right Grant
- 2012-09-27 CA CA2850022A patent/CA2850022C/en not_active Expired - Fee Related
-
2014
- 2014-10-27 HK HK14110754A patent/HK1197238A1/xx unknown
Also Published As
Publication number | Publication date |
---|---|
CN103958511A (zh) | 2014-07-30 |
CA2850022C (en) | 2018-05-01 |
KR20140082689A (ko) | 2014-07-02 |
IN2014CN02290A (es) | 2015-06-19 |
AU2012313971A1 (en) | 2014-05-01 |
MX352074B (es) | 2017-11-08 |
CA2850022A1 (en) | 2013-04-04 |
MX2014003660A (es) | 2014-10-17 |
US9000007B2 (en) | 2015-04-07 |
EP2760864A1 (en) | 2014-08-06 |
AU2012313971A8 (en) | 2014-06-19 |
US20140288072A1 (en) | 2014-09-25 |
EP2760864B1 (en) | 2018-01-24 |
JP2014527997A (ja) | 2014-10-23 |
KR101803866B1 (ko) | 2017-12-04 |
NZ622698A (en) | 2016-09-30 |
JP6140168B2 (ja) | 2017-05-31 |
WO2013046045A1 (en) | 2013-04-04 |
AU2012313971B2 (en) | 2016-09-29 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HRP20181696T1 (hr) | Postupak za pripremu dipeptidnih derivata lizin-glutaminske kiseline | |
ZA201405503B (en) | Novel nicotinamide derivative or salt thereof | |
HK1189223A1 (zh) | 用作β分泌酶 抑制劑的 -二氫-吡咯並 吡嗪- -基胺衍生物 | |
IL227648A0 (en) | Process for preparing 4-amino-5-fluoro-3-halo-6-(converted) picolinates | |
IL230635A (en) | An outgrowth of 4,3,2,1-tetrahydroquinoline used to treat diabetes | |
PL2697207T3 (pl) | Pochodne 3-(2-arylocykloalkenylometylo)oksazolidyn-2-onu jako inhibitory białka transportującego estry cholesterolu (cetp) | |
HK1199245A1 (en) | Process for the preparation of 4-amino-3-chloro-5-fluoro-6- (substituted) picolinates 4--3--5--6-()-2- | |
EP2635587A4 (en) | NOVEL 6-ARYLAMINOPYRIDONECARBOXAMIDES AS MEK INHIBITORS | |
HK1188684A1 (zh) | -氨基- -氟- -鹵代- 取代的 吡啶- -甲酸酯的製備方法 | |
HK1187493A1 (en) | Process for the preparation of 4-amino-3-chloro-5-fluoro-6- (substituted)picolinates 4--3--5--6-()-2- | |
ZA201403736B (en) | Process for the preparation of sterol derivatives | |
HK1197238A1 (en) | 5 - benzylaminomethyl - 6 - aminopyrazolo [3, 4 -b] pyridine derivatives as cholesteryl ester -transfer protein (cetp) inhibitors useful for the treatment of atherosclerosis (cetp) 5- -6-[34-b] | |
EP2922543A4 (en) | SUBSTITUTED PYRIDONE DERIVATIVES AS PDE10 INHIBITORS | |
EP2663646A4 (en) | METHOD FOR PRODUCING NICOTIC ACID | |
EP2744788A4 (en) | Benzopiperazine derivatives as CETP inhibitors | |
AP2014007697A0 (en) | Quinoline derivatives as PDE1OA enzyme inhibitors | |
ZA201503472B (en) | Pyridone derivatives as acid secretion inhibitors and process for preparation thereof | |
EP3054945A4 (en) | 3,3'-disubstituted indolines as inhibitors of cholesterol ester transfer protein | |
PL393723A1 (pl) | Sposób oczyszczania 3-podstawionych pochodnych ß- diketonów | |
HK1170240A1 (en) | Process for the preparation of 2-substituted-5-(1-alkylthio) alkylpyridines | |
PL396622A1 (pl) | Pochodne diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych, sposób wytwarzania pochodnych diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych oraz zastosowanie pochodnych diestrów 4-metylotiofenylowych kwasów 1-amino-2-metylo-propanofosfonowych |