HK1183301A1 - Novel quinoline derivatives and their use thereof - Google Patents

Novel quinoline derivatives and their use thereof

Info

Publication number
HK1183301A1
HK1183301A1 HK13110673.8A HK13110673A HK1183301A1 HK 1183301 A1 HK1183301 A1 HK 1183301A1 HK 13110673 A HK13110673 A HK 13110673A HK 1183301 A1 HK1183301 A1 HK 1183301A1
Authority
HK
Hong Kong
Prior art keywords
quinoline derivatives
novel quinoline
novel
derivatives
quinoline
Prior art date
Application number
HK13110673.8A
Other languages
English (en)
Chinese (zh)
Inventor
宮平
趙燕芳
劉亞婧
翟鑫
Original Assignee
沈陽藥科大學
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 沈陽藥科大學 filed Critical 沈陽藥科大學
Publication of HK1183301A1 publication Critical patent/HK1183301A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/233—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/36—Sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C07D215/42—Nitrogen atoms attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
  • Quinoline Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK13110673.8A 2012-11-05 2013-09-16 Novel quinoline derivatives and their use thereof HK1183301A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201210436831.4A CN102977014B (zh) 2012-11-05 2012-11-05 新的喹啉类化合物及其用途

Publications (1)

Publication Number Publication Date
HK1183301A1 true HK1183301A1 (en) 2013-12-20

Family

ID=47851414

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13110673.8A HK1183301A1 (en) 2012-11-05 2013-09-16 Novel quinoline derivatives and their use thereof

Country Status (8)

Country Link
US (1) US9783499B2 (xx)
EP (1) EP2915806B1 (xx)
JP (1) JP6126233B2 (xx)
KR (1) KR101716068B1 (xx)
CN (1) CN102977014B (xx)
HK (1) HK1183301A1 (xx)
TW (1) TWI473792B (xx)
WO (1) WO2014067417A1 (xx)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102643268B (zh) * 2011-12-30 2014-05-21 沈阳药科大学 喹啉类及噌啉类化合物及其应用
CN102977014B (zh) * 2012-11-05 2015-01-07 沈阳药科大学 新的喹啉类化合物及其用途
CN104211682B (zh) * 2013-06-04 2017-06-06 沈阳药科大学 吡啶类化合物及其用途
CN103709145B (zh) * 2013-12-27 2016-09-28 沈阳药科大学 含六氢嘧啶酮的喹啉类化合物及其制备方法和应用
CN104086530A (zh) * 2014-07-07 2014-10-08 沈阳药科大学 4-取代喹啉类化合物及其应用
CN108329258B (zh) * 2018-04-09 2021-04-13 辽宁大学 含缩氨基脲结构的4-苯氧基吡啶类衍生物及其应用
WO2020158840A1 (ja) * 2019-01-30 2020-08-06 日産化学株式会社 抗がん剤
EP3942045A1 (en) 2019-03-21 2022-01-26 Onxeo A dbait molecule in combination with kinase inhibitor for the treatment of cancer
EP4054579A1 (en) 2019-11-08 2022-09-14 Institut National de la Santé et de la Recherche Médicale (INSERM) Methods for the treatment of cancers that have acquired resistance to kinase inhibitors
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
CN111393363B (zh) * 2020-04-27 2022-12-20 威海海洋生物医药产业技术研究院有限公司 4-苯氧基喹啉并n-磺酰脒类化合物及其制备方法和用途
CN113620873B (zh) * 2020-05-07 2023-12-08 沈阳药科大学 含锌结合基以及喹啉骨架的化合物的制备方法和用途
CN114524802B (zh) * 2022-03-07 2023-05-23 华润三九医药股份有限公司 一种喹啉化合物的合成方法
CN114560845B (zh) * 2022-03-07 2023-06-20 华润三九医药股份有限公司 喹啉化合物的晶型ɑ及其制备方法和应用

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
TWI281915B (en) * 1999-12-24 2007-06-01 Kirin Brewery Quinoline and quinazoline derivatives and drugs containing the same
EP1566379A4 (en) * 2002-10-29 2005-11-09 Kirin Brewery QUINOLINE AND QUINAZOLINE DERIVATIVES INHIBITING THE AUTOPHOSPHORYLATION OF FLT3 AND MEDICAL COMPOSITIONS CONTAINING SAME
ES2371383T3 (es) * 2003-09-26 2011-12-30 Exelixis, Inc. N-[3-fluoro-4-({6-(metiloxi)-7-[(3-morfolin-4-ilpropil)oxi]quinolin-4-il}oxi)fenil]-n'-(4-fluorofenil)ciclopropan-1,1-dicarboxamida para el tratamiento del cáncer.
US7919487B2 (en) * 2004-11-10 2011-04-05 Synta Pharmaceuticals Corporation Heteroaryl compounds
US20080004273A1 (en) * 2006-05-30 2008-01-03 Stephane Raeppel Inhibitors of protein tyrosine kinase activity
US8648071B2 (en) * 2008-06-27 2014-02-11 Synta Pharmaceuticals Corp. Hydrazonamide compounds that modulate Hsp90 activity
TW201035017A (en) 2008-09-26 2010-10-01 Smithkline Beecham Corp Preparation of a quinolinyloxydiphenylcyclopropanedicarboxamide
JP5781510B2 (ja) * 2009-08-12 2015-09-24 ノバルティス アーゲー ヘテロ環式ヒドラゾン化合物および癌および炎症の処置のためのそれらの使用
CN102746213B (zh) * 2012-05-18 2014-06-18 潍坊博创国际生物医药研究院 肉桂酰胺类组蛋白去乙酰化酶抑制剂及其制备方法和应用
CN102977014B (zh) * 2012-11-05 2015-01-07 沈阳药科大学 新的喹啉类化合物及其用途

Also Published As

Publication number Publication date
CN102977014B (zh) 2015-01-07
EP2915806A1 (en) 2015-09-09
WO2014067417A1 (zh) 2014-05-08
CN102977014A (zh) 2013-03-20
TW201418220A (zh) 2014-05-16
TWI473792B (zh) 2015-02-21
KR101716068B1 (ko) 2017-03-13
US9783499B2 (en) 2017-10-10
KR20150095652A (ko) 2015-08-21
JP6126233B2 (ja) 2017-05-10
JP2015535265A (ja) 2015-12-10
EP2915806A4 (en) 2016-05-18
US20150307453A1 (en) 2015-10-29
EP2915806B1 (en) 2018-04-25

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