HK1177781A1 - 使用 -甲基吡啶硼烷作為還原劑還原胺化和分析糖類 - Google Patents

使用 -甲基吡啶硼烷作為還原劑還原胺化和分析糖類

Info

Publication number
HK1177781A1
HK1177781A1 HK13104764.1A HK13104764A HK1177781A1 HK 1177781 A1 HK1177781 A1 HK 1177781A1 HK 13104764 A HK13104764 A HK 13104764A HK 1177781 A1 HK1177781 A1 HK 1177781A1
Authority
HK
Hong Kong
Prior art keywords
carbohydrates
analysis
reducing agent
reductive amination
picoline borane
Prior art date
Application number
HK13104764.1A
Other languages
English (en)
Inventor
．拉哈克
．沃洛爾
Original Assignee
萊頓大學醫學中心名義下的萊頓大學醫院
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 萊頓大學醫學中心名義下的萊頓大學醫院 filed Critical 萊頓大學醫學中心名義下的萊頓大學醫院
Publication of HK1177781A1 publication Critical patent/HK1177781A1/zh

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/66—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood sugars, e.g. galactose
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
    • G01N27/416—Systems
    • G01N27/447—Systems using electrophoresis
    • G01N27/44704—Details; Accessories
    • G01N27/44717—Arrangements for investigating the separated zones, e.g. localising zones
    • G01N27/44721—Arrangements for investigating the separated zones, e.g. localising zones by optical means
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/62—Detectors specially adapted therefor
    • G01N30/74—Optical detectors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/96—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation using ion-exchange
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10T—TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION
    • Y10T436/00—Chemistry: analytical and immunological testing
    • Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
    • Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
    • Y10T436/143333—Saccharide [e.g., DNA, etc.]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Immunology (AREA)
  • Biotechnology (AREA)
  • Analytical Chemistry (AREA)
  • Cell Biology (AREA)
  • Diabetes (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Saccharide Compounds (AREA)
  • Other Investigation Or Analysis Of Materials By Electrical Means (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK13104764.1A 2009-09-29 2013-04-18 使用 -甲基吡啶硼烷作為還原劑還原胺化和分析糖類 HK1177781A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09252309A EP2306199A1 (en) 2009-09-29 2009-09-29 Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent
PCT/EP2010/005880 WO2011038873A1 (en) 2009-09-29 2010-09-27 Reductive amination and analysis of carbohydrates using 2-picoline borane as reducing agent

Publications (1)

Publication Number Publication Date
HK1177781A1 true HK1177781A1 (zh) 2013-08-30

Family

ID=41697858

Family Applications (1)

Application Number Title Priority Date Filing Date
HK13104764.1A HK1177781A1 (zh) 2009-09-29 2013-04-18 使用 -甲基吡啶硼烷作為還原劑還原胺化和分析糖類

Country Status (6)

Country Link
US (1) US20120244625A1 (zh)
EP (2) EP2306199A1 (zh)
JP (1) JP2013506115A (zh)
CN (1) CN102770765B (zh)
HK (1) HK1177781A1 (zh)
WO (1) WO2011038873A1 (zh)

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EP3309549B1 (en) * 2011-09-28 2021-11-10 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced ms signals
US11352325B2 (en) 2011-09-28 2022-06-07 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
US10436790B2 (en) 2011-09-28 2019-10-08 Waters Technologies Corporation Rapid fluorescence tagging of glycans and other biomolecules with enhanced MS signals
JP2013076629A (ja) * 2011-09-30 2013-04-25 Sumitomo Bakelite Co Ltd α２，６−シアロ糖鎖とα２，３−シアロ糖鎖とを識別する方法
CN105431733B (zh) * 2013-07-11 2019-01-22 台湾神隆股份有限公司 用于检测硫酸化寡糖的分析方法
WO2016069764A1 (en) 2014-10-30 2016-05-06 Waters Technologies Corporation Methods for the rapid preparation of labeled glycosylamines and for the analysis of glycosylated biomolecules producing the same
CN111796039B (zh) * 2014-11-13 2023-03-17 沃特世科技公司 快速标记的n-聚糖的液相色谱校准方法
CN104597187A (zh) * 2014-12-30 2015-05-06 佛山安普泽生物医药有限公司 快速全面检测药用单克隆抗体n糖基化位点上寡糖的方法
WO2017034024A1 (ja) * 2015-08-27 2017-03-02 株式会社カネカ リガンドの固定化方法
CN115261425A (zh) * 2015-10-09 2022-11-01 住友电木株式会社 糖蛋白的糖链的制备方法、试剂盒及装置
WO2017222954A1 (en) 2016-06-21 2017-12-28 Waters Technologies Corporation Fluorescence tagging of glycans and other biomolecules through reductive amination for enhanced ms signals
EP3472621A4 (en) 2016-06-21 2020-03-04 Waters Technologies Corporation ELECTRONIZED IONIZATION METHODS OF HIGHLY BASIC AMPHIPATHIC FRAGMENT MODIFIED GLYCANES
CN106083618A (zh) * 2016-06-23 2016-11-09 艾美科健（中国）生物医药有限公司 一种四苄基伏格列波糖盐酸盐的制备工艺
EP3479103B1 (en) 2016-07-01 2022-04-20 Waters Technologies Corporation Methods for the rapid preparation of labeled glycosylamines from complex matrices using molecular weight cut off filtration and on-filter deglycosylation
JP6885958B2 (ja) * 2016-08-26 2021-06-16 昭和電工株式会社 Ｈｉｌｉｃカラム用充填剤、それが充填されたｈｉｌｉｃカラム、及びそれを用いたオリゴ糖の分析方法
CN117101743A (zh) * 2017-03-23 2023-11-24 安捷伦科技有限公司 改进还原或标记碳水化合物的方法、装置和试剂盒
JP7315564B2 (ja) * 2018-02-02 2023-07-26 アジレント・テクノロジーズ・インク グリカン分析のためのブロックされた２－ａａを使用するための方法およびキット
CN109232711A (zh) * 2018-10-25 2019-01-18 厦门大学 一种合成爱德万甜的方法
CN109970874A (zh) * 2019-03-20 2019-07-05 武汉理工大学 提高纤维素纳米晶再分散性、悬浮液稳定性的末端修饰方法
CN110161147A (zh) * 2019-06-19 2019-08-23 北京三元食品股份有限公司 乳中游离低聚糖的高通量定量测定方法
TW202208844A (zh) * 2020-05-15 2022-03-01 中央研究院 供碳水化合物分析之流動化學系統及方法

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Publication number Priority date Publication date Assignee Title
JPS6410177A (en) * 1987-07-02 1989-01-13 Takara Shuzo Co Fluorescent labeling method for saccharides
JPH06298789A (ja) * 1993-04-16 1994-10-25 Takara Shuzo Co Ltd アミノ化糖誘導体の製造方法
JP2004256511A (ja) * 2003-02-27 2004-09-16 Yasuo Kikukawa ピコリンボランを用いる還元反応
WO2004085480A2 (en) * 2003-03-20 2004-10-07 Indiana University Research And Technology Corporation Process and composition for assaying carbohydrates
TWI385169B (zh) * 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
WO2008057083A1 (en) * 2006-11-09 2008-05-15 Wyeth Methods of analyzing glycomolecules
EP1964846A1 (en) * 2007-02-27 2008-09-03 Bracco Imaging, S.P.A. Process for the preparation of contrast agents
WO2008128216A1 (en) * 2007-04-16 2008-10-23 Momenta Pharmaceuticals, Inc. Methods for labeling glycans
EP2135090A1 (en) * 2007-04-16 2009-12-23 Momenta Pharmaceuticals, Inc. Proteolytic release of glycans
US20110213137A1 (en) * 2007-04-16 2011-09-01 Momenta Pharmaceuticals, Inc. Isotopically-labeled glycans
US8828732B2 (en) * 2008-04-30 2014-09-09 Sumitomo Bakelite Co., Ltd. Method of labeling sugar chain
WO2010090591A1 (en) * 2009-02-05 2010-08-12 Swetree Technologies Ab Aminated hemicellulose molecule and method for production thereof

Also Published As

Publication number Publication date
CN102770765A (zh) 2012-11-07
US20120244625A1 (en) 2012-09-27
WO2011038873A1 (en) 2011-04-07
EP2483691A1 (en) 2012-08-08
CN102770765B (zh) 2016-02-10
EP2306199A1 (en) 2011-04-06
JP2013506115A (ja) 2013-02-21

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20230926