HK1176642A1 - 細胞編程和重編程 - Google Patents

細胞編程和重編程

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Publication number
HK1176642A1
HK1176642A1 HK13104163.8A HK13104163A HK1176642A1 HK 1176642 A1 HK1176642 A1 HK 1176642A1 HK 13104163 A HK13104163 A HK 13104163A HK 1176642 A1 HK1176642 A1 HK 1176642A1
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HK
Hong Kong
Prior art keywords
reprogramming
programming
cells
Prior art date
Application number
HK13104163.8A
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English (en)
Inventor
Jaenisch Rudolf
Woodbury Carey Bryce
Original Assignee
Whitehead Inst Biomedical Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Whitehead Inst Biomedical Res filed Critical Whitehead Inst Biomedical Res
Publication of HK1176642A1 publication Critical patent/HK1176642A1/zh

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    • AHUMAN NECESSITIES
    • A01AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
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    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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  • Health & Medical Sciences (AREA)
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  • Transplantation (AREA)
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  • Animal Husbandry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Plant Pathology (AREA)
  • Virology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK13104163.8A 2008-06-13 2013-04-05 細胞編程和重編程 HK1176642A1 (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US6152508P 2008-06-13 2008-06-13
US7706808P 2008-06-30 2008-06-30
PCT/US2009/047423 WO2009152529A2 (en) 2008-06-13 2009-06-15 Programming and reprogramming of cells

Publications (1)

Publication Number Publication Date
HK1176642A1 true HK1176642A1 (zh) 2013-08-02

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ID=41417431

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Application Number Title Priority Date Filing Date
HK13104163.8A HK1176642A1 (zh) 2008-06-13 2013-04-05 細胞編程和重編程
HK18104120.5A HK1244840A1 (zh) 2008-06-13 2018-03-26 細胞編程和重編程

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Application Number Title Priority Date Filing Date
HK18104120.5A HK1244840A1 (zh) 2008-06-13 2018-03-26 細胞編程和重編程

Country Status (11)

Country Link
US (3) US9497943B2 (zh)
EP (2) EP2300611B1 (zh)
JP (6) JP2011524174A (zh)
CN (2) CN102725409B (zh)
AU (1) AU2009257219B2 (zh)
BR (1) BRPI0915146A2 (zh)
CA (3) CA2727681C (zh)
ES (1) ES2644588T3 (zh)
HK (2) HK1176642A1 (zh)
SG (1) SG191673A1 (zh)
WO (1) WO2009152529A2 (zh)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
EP2626416A3 (en) 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
EP3078738B1 (en) * 2007-08-31 2020-05-20 Whitehead Institute for Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
US9497943B2 (en) * 2008-06-13 2016-11-22 Whitehead Institute For Biomedical Research Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides
JP5557288B2 (ja) * 2008-09-12 2014-07-23 株式会社chromocenter 細胞のリプログラミングに用いられる複数遺伝子の発現制御システム
WO2010050626A1 (en) * 2008-10-30 2010-05-06 Kyoto University Method for producing induced pluripotent stem cells
US20100150889A1 (en) * 2008-12-17 2010-06-17 The Uab Research Foundation Polycistronic Vector For Human Induced Pluripotent Stem Cell Production
WO2010124290A2 (en) * 2009-04-24 2010-10-28 Whitehead Institute For Biomedical Research Compositions and methods for deriving or culturing pluripotent cells
US8524498B2 (en) 2009-05-29 2013-09-03 The General Hospital Corporation Methods and compositions for homologous recombination in human cells
US20110003365A1 (en) * 2009-05-29 2011-01-06 Kyoto University Method of preparing induced pluripotent stem cells deprived of reprogramming gene
WO2011004854A1 (ja) * 2009-07-08 2011-01-13 株式会社ニコン 細胞ピッキング支援装置、表示装置、及び培養容器
CN102625837B (zh) * 2009-08-07 2015-01-14 国立大学法人京都大学 有效建立诱导的多能干细胞的方法
JPWO2011096482A1 (ja) * 2010-02-03 2013-06-13 国立大学法人 東京大学 多能性幹細胞を用いた免疫機能再建法
WO2012031288A1 (en) * 2010-09-03 2012-03-08 United States Of America As Represented By The Department Of Veterans Affairs Efficient generation of neurally-induced mesenchymal stem cells and applications thereof
US20130267029A1 (en) * 2010-10-01 2013-10-10 Fundacion Centro Nacional de Ivestigaciones Oncologicas, Carlos Manipulation of stem cell function by p53 isoforms
US20120276527A1 (en) * 2011-04-26 2012-11-01 Cohen Rick I Gene recombination screening methods
US10428309B2 (en) * 2011-12-01 2019-10-01 New York Stem Cell Foundation, Inc. Systems and methods for producing stem cells and differentiated cells
US20130157368A1 (en) * 2011-12-20 2013-06-20 Advanced Technologies And Regenerative Medicine, Llc Induced pluripotent stem cells prepared from human kidney-derived cells
EP2826855B1 (en) 2012-03-15 2018-08-29 iHeart Japan Corporation Myocardial sheet
WO2013140927A1 (ja) 2012-03-21 2013-09-26 国立大学法人京都大学 アルツハイマー病の治療薬および/または予防薬のスクリーニング方法
WO2013151186A1 (ja) 2012-04-06 2013-10-10 国立大学法人京都大学 エリスロポエチン産生細胞の誘導方法
CN103352052B (zh) * 2012-04-11 2014-11-26 埃提斯生物技术(上海)有限公司 一种多顺反子双标表达慢病毒载体构建及应用
US8799175B2 (en) * 2012-04-24 2014-08-05 Steven C. Sereboff Automated intellectual property licensing
CN107746852B (zh) * 2012-05-04 2021-10-08 辉瑞公司 前列腺相关抗原及基于疫苗的免疫治疗疗法
ES2729563T3 (es) * 2012-05-13 2019-11-04 Allele Biotechnology & Pharmaceuticals Inc Derivación sin alimentadores de células madre pluripotentes inducidas humanas con ARN mensajero sintético
US9862930B2 (en) * 2012-05-21 2018-01-09 The Regents Of The University Of California Generation of human iPS cells by a synthetic self-replicative RNA
WO2014066848A1 (en) 2012-10-25 2014-05-01 Whitehead Institute For Biomedical Research Super-enhancers and methods of use thereof
US10745668B2 (en) 2013-09-20 2020-08-18 Lonza Ltd Methods for nuclear reprogramming of cells
JP6536871B2 (ja) 2013-12-02 2019-07-03 国立大学法人京都大学 Fgfr3病の予防および治療剤ならびにそのスクリーニング方法
WO2017040815A1 (en) 2015-09-04 2017-03-09 Tocagen Inc. Recombinant vectors comprising 2a peptide
CA3011692A1 (en) * 2015-11-23 2017-06-01 The Regents Of The University Of Colorado, A Body Corporate Methods and compositions for reprogramming cells
JP7308143B2 (ja) 2016-08-19 2023-07-13 ホワイトヘッド・インスティテュート・フォー・バイオメディカル・リサーチ Dnaメチル化の編集方法
CN108148807B (zh) * 2016-12-03 2020-10-09 同济大学 生长因子诱导生成神经前体细胞的方法
ES2949801T3 (es) 2017-01-09 2023-10-03 Whitehead Inst Biomedical Res Métodos para alterar la expresión génica mediante la perturbación de multímeros de factores de transcripción que estructuran bucles reguladores
SG11202003790PA (en) * 2017-10-31 2020-05-28 Murdoch Childrens Res Inst Composition and method
WO2019204750A1 (en) * 2018-04-20 2019-10-24 Cellino Biotech, Inc. Directed cell fate specification and targeted maturation
JP2022501374A (ja) 2018-09-21 2022-01-06 プレジデント アンド フェローズ オブ ハーバード カレッジ 糖尿病を治療するための方法及び組成物、ならびに分泌タンパク質をコードするmRNAを濃縮する方法
CN115023233A (zh) 2019-12-12 2022-09-06 国立大学法人千叶大学 包含巨核细胞和血小板的冷冻干燥制剂
CN116981685A (zh) * 2020-12-03 2023-10-31 世纪治疗股份有限公司 基因工程化细胞及其用途
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
WO2023238074A1 (en) * 2022-06-08 2023-12-14 Mesoblast International Sarl Mesenchymal progenitor cells for enhancing partial reprogramming of target cells
CN115948524B (zh) * 2022-11-08 2024-05-24 吉林大学 Gcna在提高重编程效率、干细胞原始态多能性及促进原始生殖细胞转化中的应用

Family Cites Families (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1995003402A1 (en) 1993-07-22 1995-02-02 Merck & Co., Inc. EXPRESSION OF HUMAN INTERLEUKIN-1β IN A TRANSGENIC ANIMAL
US5843780A (en) 1995-01-20 1998-12-01 Wisconsin Alumni Research Foundation Primate embryonic stem cells
GB9517779D0 (en) 1995-08-31 1995-11-01 Roslin Inst Edinburgh Biological manipulation
GB9809178D0 (en) 1998-04-29 1998-07-01 Univ Edinburgh Nuclear reprogramming of somatic cells
CA2349415A1 (en) 1998-11-09 2000-05-18 Monash University Embryonic stem cells
US7015037B1 (en) 1999-08-05 2006-03-21 Regents Of The University Of Minnesota Multiponent adult stem cells and methods for isolation
US20020168660A1 (en) 2001-02-15 2002-11-14 Whitehead Institute For Biomedical Research Stem cell self-renewal and lineage commitment
WO2002097090A1 (en) 2001-05-31 2002-12-05 Sumitomo Pharmaceuticals Co., Ltd. Genes with es cell-specific expression
WO2003027277A1 (fr) 2001-09-21 2003-04-03 Japan Science And Technology Corporation Procede de criblage de facteur de reprogrammation, facteur de reprogrammation crible au moyen de ce procede, procede d'utilisation du facteur de reprogrammation, procede de differenciation de cellules fusionnees non differenciees et procede de construction de cellules, de tissus et d'organes
DE10162080A1 (de) 2001-12-10 2003-06-26 Albrecht Mueller Verfahren zur Herstellung von Stammzellen mit erhöhtem Entwicklungspotential
GB0202149D0 (en) 2002-01-30 2002-03-20 Univ Edinburgh Pluripotency determining factors and uses thereof
GB0211904D0 (en) 2002-05-23 2002-07-03 Medical Res Council Nuclear transfer
WO2004009758A2 (en) 2002-07-23 2004-01-29 Nanodiagnostics, Inc. Embryonic stem cell markers and uses thereof
US7560276B2 (en) 2003-06-27 2009-07-14 Ethicon, Incorporated Soft tissue repair and regeneration using postpartum-derived cells
US7682828B2 (en) 2003-11-26 2010-03-23 Whitehead Institute For Biomedical Research Methods for reprogramming somatic cells
WO2005080598A1 (ja) 2004-02-19 2005-09-01 Dainippon Sumitomo Pharma Co., Ltd. 体細胞核初期化物質のスクリーニング方法
WO2005090557A1 (ja) 2004-03-23 2005-09-29 Daiichi Asubio Pharma Co., Ltd. 多能性幹細胞の増殖方法
US20100138947A1 (en) 2005-04-29 2010-06-03 Ivan Vassiliev Method for Producing Stem Cells or Stel Cell-Like Cells from Mammalian Embryos
GB0515006D0 (en) 2005-07-22 2005-08-31 Univ Nottingham Reprogramming
US7601699B2 (en) 2005-08-01 2009-10-13 Nupotential, Inc. Production of reprogrammed cells with restored potential
US20090275032A1 (en) 2005-08-01 2009-11-05 Nupotential, Inc. Reprogramming a cell by inducing a pluripotent gene through use of an HDAC modulator
US20090227032A1 (en) 2005-12-13 2009-09-10 Kyoto University Nuclear reprogramming factor and induced pluripotent stem cells
US8278104B2 (en) 2005-12-13 2012-10-02 Kyoto University Induced pluripotent stem cells produced with Oct3/4, Klf4 and Sox2
AU2006325975B2 (en) 2005-12-13 2011-12-08 Kyoto University Nuclear reprogramming factor
GB0615327D0 (en) 2006-03-30 2006-09-13 Univ Edinburgh Culture medium containing kinase inhibitors and uses thereof
JP2009542626A (ja) 2006-06-27 2009-12-03 ジャワハーラル ネール センター フォー アドヴァンスド サイエンティフィック リサーチ メチルトランスフェラーゼ(hmtase)の部位特異的阻害剤及びその製剤方法
KR101516833B1 (ko) 2007-03-23 2015-05-07 위스콘신 얼럼나이 리서어치 화운데이션 체세포 재프로그래밍
EP2626416A3 (en) * 2007-04-07 2013-12-18 The Whitehead Institute for Biomedical Research Reprogramming of somatic cells
WO2009032456A2 (en) 2007-08-01 2009-03-12 Primegen Biotech Llc Non-viral delivery of transcription factors that reprogram human somatic cells into a stem cell-like state
EP3078738B1 (en) * 2007-08-31 2020-05-20 Whitehead Institute for Biomedical Research Wnt pathway stimulation in reprogramming somatic cells
US20110151447A1 (en) 2007-11-06 2011-06-23 Children's Medical Center Corporation Method to produce induced pluripotent stem (ips) cells from non-embryonic human cells
EP2268796A1 (en) * 2008-03-17 2011-01-05 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Vectors and methods for generating vector-free induced pluripotent stem (ips) cells using site-specific recombination
AU2009225665B9 (en) 2008-03-17 2015-01-15 The Scripps Research Institute Combined chemical and genetic approaches for generation of induced pluripotent stem cells
KR101661940B1 (ko) * 2008-05-02 2016-10-04 고쿠리츠 다이가쿠 호진 교토 다이가쿠 핵 초기화 방법
US20110136145A1 (en) * 2008-05-22 2011-06-09 The Johns Hopkins University Methods for promoting fusion and reprogramming of somatic cells
DK2297307T3 (en) * 2008-06-04 2016-07-25 Cellular Dynamics Int Inc PROCEDURES FOR THE MANUFACTURE OF IPS CELLS USING NON-VIRAL METHODS
US9497943B2 (en) 2008-06-13 2016-11-22 Whitehead Institute For Biomedical Research Nucleic acid constructs encoding reprogramming factors linked by self-cleaving peptides
WO2010033920A2 (en) 2008-09-19 2010-03-25 Whitehead Institute For Biomedical Research Compositions and methods for enhancing cell reprogramming
US20100150889A1 (en) * 2008-12-17 2010-06-17 The Uab Research Foundation Polycistronic Vector For Human Induced Pluripotent Stem Cell Production

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