HK1176288A1 - Histidyl trna synthetases for reducing inflammation trna - Google Patents
Histidyl trna synthetases for reducing inflammation trnaInfo
- Publication number
- HK1176288A1 HK1176288A1 HK13103208.7A HK13103208A HK1176288A1 HK 1176288 A1 HK1176288 A1 HK 1176288A1 HK 13103208 A HK13103208 A HK 13103208A HK 1176288 A1 HK1176288 A1 HK 1176288A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- trna
- histidyl
- reducing inflammation
- synthetases
- trna synthetases
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/53—Ligases (6)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39541—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against normal tissues, cells
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P39/06—Free radical scavengers or antioxidants
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/38—Drugs for disorders of the endocrine system of the suprarenal hormones
- A61P5/44—Glucocorticosteroids; Drugs increasing or potentiating the activity of glucocorticosteroids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y601/00—Ligases forming carbon-oxygen bonds (6.1)
- C12Y601/01—Ligases forming aminoacyl-tRNA and related compounds (6.1.1)
- C12Y601/01021—Histidine-tRNA ligase (6.1.1.21)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US28592309P | 2009-12-11 | 2009-12-11 | |
US28591309P | 2009-12-11 | 2009-12-11 | |
US28591909P | 2009-12-11 | 2009-12-11 | |
PCT/US2010/059963 WO2011072265A1 (fr) | 2009-12-11 | 2010-12-10 | AMINOACYL-ARNt SYNTHÉTASES DESTINÉES À MODULER UNE INFLAMMATION |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1176288A1 true HK1176288A1 (en) | 2013-07-26 |
Family
ID=43617978
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK13103208.7A HK1176288A1 (en) | 2009-12-11 | 2013-03-14 | Histidyl trna synthetases for reducing inflammation trna |
Country Status (10)
Country | Link |
---|---|
US (4) | US9127268B2 (fr) |
EP (2) | EP2509625B1 (fr) |
JP (4) | JP5819314B2 (fr) |
CN (2) | CN102821784B (fr) |
AU (3) | AU2010327926B2 (fr) |
CA (1) | CA2783731C (fr) |
DK (1) | DK2509625T3 (fr) |
ES (1) | ES2535951T3 (fr) |
HK (1) | HK1176288A1 (fr) |
WO (1) | WO2011072265A1 (fr) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2727622A1 (fr) | 2008-06-11 | 2009-12-17 | Atyr Pharma, Inc. | Activite thrombopoietique de polypeptides de tyrosyl-arnt synthetase |
JP5756751B2 (ja) | 2008-06-26 | 2015-07-29 | エータイアー ファーマ, インコーポレイテッド | 非正準的な生物学的活性を有するグリシル−tRNA合成酵素を含む組成物および方法 |
US20120004185A1 (en) | 2009-02-27 | 2012-01-05 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
AU2010236913B2 (en) * | 2009-03-31 | 2016-03-24 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities |
EP2509625B1 (fr) | 2009-12-11 | 2015-01-28 | Atyr Pharma, Inc. | HISTIDYL-ARNt SYNTHÉTASES DESTINÉES À RÉDUIRE L'INFLAMMATION |
WO2011097031A2 (fr) | 2010-02-04 | 2011-08-11 | The Scripps Research Institute | Formes monomères d'aminoacyl-arnt synthétases humaines ayant des activités biologiques non canoniques |
AU2011248625B2 (en) | 2010-04-26 | 2017-01-05 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of cysteinyl-tRNA synthetase |
JP6294074B2 (ja) * | 2010-04-27 | 2018-03-14 | エータイアー ファーマ, インコーポレイテッド | イソロイシルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
JP6240500B2 (ja) | 2010-04-27 | 2017-11-29 | エータイアー ファーマ, インコーポレイテッド | スレオニルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CA2797271C (fr) | 2010-04-28 | 2021-05-25 | Atyr Pharma, Inc. | Compositions therapeutiques, diagnostiques et d'anticorps a base de fragments de proteines d'aminoacyl-arnt synthetases |
CA2797393C (fr) | 2010-04-29 | 2020-03-10 | Atyr Pharma, Inc. | Decouverte innovatrice de compositions therapeutiques, diagnostiques, et d'anticorps associees aux fragments proteiques des valyle arnt synthesases |
CN103097523B (zh) | 2010-04-29 | 2016-09-28 | Atyr医药公司 | 与天冬酰胺酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
ES2668207T3 (es) | 2010-05-03 | 2018-05-17 | Atyr Pharma, Inc. | Descubrimiento innovador de composiciones terapéuticas, de diagnóstico y de anticuerpos relacionadas con fragmentos de proteínas de metionil-ARNt sintetasas |
JP6039546B2 (ja) | 2010-05-03 | 2016-12-07 | エータイアー ファーマ, インコーポレイテッド | セリルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CN103096925A (zh) | 2010-05-03 | 2013-05-08 | Atyr医药公司 | 与精氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
AU2011248227B2 (en) | 2010-05-03 | 2016-12-01 | Pangu Biopharma Limited | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-alpha-tRNA synthetases |
CN103096909A (zh) | 2010-05-04 | 2013-05-08 | Atyr医药公司 | 与谷氨酰-脯氨酰-tRNA合成酶的蛋白片段相关的治疗、诊断和抗体组合物的创新发现 |
CN102985103A (zh) | 2010-05-04 | 2013-03-20 | Atyr医药公司 | 与p38多-tRNA合成酶复合物相关的治疗、诊断和抗体组合物的创新发现 |
US8945541B2 (en) | 2010-05-14 | 2015-02-03 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of phenylalanyl-beta-tRNA synthetases |
CA2799480C (fr) | 2010-05-17 | 2020-12-15 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, de diagnostic, et d'anticorps associees a des fragments proteiques de leucyl-arnt synthetases |
EP2575856B1 (fr) * | 2010-05-27 | 2017-08-16 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à fragments protéiques de glutaminyl-arnt synthétases |
EP2575857B1 (fr) | 2010-06-01 | 2018-01-24 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, diagnostiques, et d'anticorps associés à des fragments de protéine de lysyl-tarn synthétases |
US8999321B2 (en) | 2010-07-12 | 2015-04-07 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of glycyl-tRNA synthetases |
WO2012021247A2 (fr) | 2010-07-12 | 2012-02-16 | Atyr Pharma, Inc. | DÉCOUVERTE INNOVANTE DE COMPOSITIONS THÉRAPEUTIQUES, DE DIAGNOSTIC ET D'ANTICORPS SE RAPPORTANT À DES FRAGMENTS PROTÉIQUES DE GLYCYL-ARNt SYNTHÉTASES |
JP6177129B2 (ja) * | 2010-07-12 | 2017-08-09 | エータイアー ファーマ, インコーポレイテッド | ヒスチジルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
CA2804278C (fr) | 2010-07-12 | 2021-07-13 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, diagnostiques et d'anticorps relatives a des fragments proteiques d'aspartyl-arnt synthetases |
CA2808539C (fr) | 2010-08-25 | 2021-05-25 | Atyr Pharma, Inc. | Decouverte innovante de compositions therapeutiques, diagnostiques et d'anticorps associees a des fragments proteiniques des tyrosyl-arnt synthetases |
US9399770B2 (en) | 2010-10-06 | 2016-07-26 | Atyr Pharma, Inc. | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of tryptophanyl-tRNA synthetases |
US20160144003A1 (en) * | 2011-05-19 | 2016-05-26 | The Scripps Research Institute | Compositions and methods for treating charcot-marie-tooth diseases and related neuronal diseases |
US9714419B2 (en) | 2011-08-09 | 2017-07-25 | Atyr Pharma, Inc. | PEGylated tyrosyl-tRNA synthetase polypeptides |
WO2013086216A1 (fr) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Aspartyl-arnt synthétases améliorées |
WO2013086228A1 (fr) | 2011-12-06 | 2013-06-13 | Atyr Pharma, Inc. | Polypeptides aspartyl-arnt synthétase pégylés |
AU2012368189B2 (en) | 2011-12-29 | 2017-08-31 | Atyr Pharma, Inc. | Aspartyl-tRNA synthetase-Fc conjugates |
US8835387B2 (en) * | 2012-02-16 | 2014-09-16 | Atyr Pharma, Inc. | Histidyl-tRNA synthetases for treating autoimmune and inflammatory diseases |
GB201300049D0 (en) * | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
ES2708565T3 (es) * | 2013-03-15 | 2019-04-10 | Atyr Pharma Inc | Conjugados de Fc-histidil-ARNt sintetasa |
US9906088B2 (en) * | 2013-04-15 | 2018-02-27 | Mitsubishi Electric Corporation | Rotor-holding structure of rotating electrical machine for hybrid vehicle |
CN103409378B (zh) * | 2013-04-25 | 2016-04-20 | 复旦大学 | 一种酪氨酰tRNA合成酶突变体的制备方法及应用 |
CN105431739A (zh) * | 2013-05-15 | 2016-03-23 | 医药生命融合研究团 | 使用其中进行了调控使赖氨酰-tRNA合成酶被表达或不被表达的细胞或球状聚集的细胞的培养筛选癌症转移抑制剂的方法 |
WO2015102341A1 (fr) * | 2013-12-30 | 2015-07-09 | 재단법인 의약바이오컨버젼스연구단 | Anticorps monoclonal anti-krs et son utilisation |
KR101787468B1 (ko) | 2014-05-28 | 2017-11-15 | 재단법인 의약바이오컨버젼스연구단 | 신규한 라이실 티알엔에이 합성효소 단편 및 이를 포함하는 마이크로베지클 |
WO2016137280A1 (fr) * | 2015-02-26 | 2016-09-01 | 재단법인 의약바이오컨버젼스연구단 | Composition pour le traitement ou la prévention de maladies infectieuses inflammatoires ou composition pour l'amélioration de l'immunité comprenant de la tryptophanyl-arnt synthétase en tant que principe actif |
KR20170027258A (ko) * | 2015-09-01 | 2017-03-09 | 제이더블유바이오사이언스 주식회사 | 트립토파닐 티알엔에이 합성효소를 이용한 패혈증의 진단용 조성물과 진단 마커 검출 방법 |
KR101917677B1 (ko) * | 2016-06-01 | 2018-11-12 | 연세대학교 산학협력단 | 폐암의 예후 예측용 바이오 마커로서 메티오닐-티알엔에이 합성효소(mrs)의 유용성 |
EP3512550A4 (fr) * | 2016-09-13 | 2020-05-06 | EV71 (HK) Limited | Compositions et procédés pour le traitement d'infections |
US10767164B2 (en) | 2017-03-30 | 2020-09-08 | The Research Foundation For The State University Of New York | Microenvironments for self-assembly of islet organoids from stem cells differentiation |
WO2018195338A1 (fr) * | 2017-04-20 | 2018-10-25 | Atyr Pharma, Inc. | Compositions et procédés pour le traitement d'inflammation pulmonaire |
CN110998327A (zh) | 2017-05-12 | 2020-04-10 | 温口特 | 胆管细胞中使用甲硫氨酰-tRNA合成酶诊断胆管癌的方法 |
WO2019050273A1 (fr) * | 2017-09-05 | 2019-03-14 | (주)온코태그디아그노스틱 | Méthode de diagnostic du cancer du pancréas à l'aide de méthionyl-arnt synthétase et marqueur spécifique aux cellules acineuses |
KR101886415B1 (ko) * | 2017-09-15 | 2018-08-08 | 충남대학교산학협력단 | 트립토파닐-tRNA 합성효소 유전자를 포함하는 재조합 벡터 및 이의 용도 |
CA3084461A1 (fr) * | 2017-09-15 | 2019-03-21 | Medicinal Bioconvergence Research Center | Composition pharmaceutique comprenant un anticorps se liant de maniere specifique a l'extremite n-terminale de la lysyl-arnt synthetase en tant que principe actif pour la prevention ou le traitement d'une maladie liee a la migration des cellules immunitaires |
EP3826666A4 (fr) * | 2018-07-26 | 2022-05-11 | Atyr Pharma, Inc. | Compositions et méthodes de traitement de maladies associées à la nrp2 |
Family Cites Families (128)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4489710A (en) | 1981-06-23 | 1984-12-25 | Xoma Corporation | Composition and method for transplantation therapy |
US4671958A (en) | 1982-03-09 | 1987-06-09 | Cytogen Corporation | Antibody conjugates for the delivery of compounds to target sites |
US5155214A (en) | 1984-03-05 | 1992-10-13 | The Salk Institute For Biological Studies | Basic fibroblast growth factor |
US4625014A (en) | 1984-07-10 | 1986-11-25 | Dana-Farber Cancer Institute, Inc. | Cell-delivery agent |
US4542225A (en) | 1984-08-29 | 1985-09-17 | Dana-Farber Cancer Institute, Inc. | Acid-cleavable compound |
US4638045A (en) | 1985-02-19 | 1987-01-20 | Massachusetts Institute Of Technology | Non-peptide polyamino acid bioerodible polymers |
US4751180A (en) | 1985-03-28 | 1988-06-14 | Chiron Corporation | Expression using fused genes providing for protein product |
US4935233A (en) | 1985-12-02 | 1990-06-19 | G. D. Searle And Company | Covalently linked polypeptide cell modulators |
US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
US4873192A (en) | 1987-02-17 | 1989-10-10 | The United States Of America As Represented By The Department Of Health And Human Services | Process for site specific mutagenesis without phenotypic selection |
US5091513A (en) | 1987-05-21 | 1992-02-25 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5132405A (en) | 1987-05-21 | 1992-07-21 | Creative Biomolecules, Inc. | Biosynthetic antibody binding sites |
US5725871A (en) | 1989-08-18 | 1998-03-10 | Danbiosyst Uk Limited | Drug delivery compositions comprising lysophosphoglycerolipid |
US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5556645A (en) | 1990-01-12 | 1996-09-17 | Bockman; Richard | Methods of enhancing wound healing and tissue repair |
US5466468A (en) | 1990-04-03 | 1995-11-14 | Ciba-Geigy Corporation | Parenterally administrable liposome formulation comprising synthetic lipids |
US5399363A (en) | 1991-01-25 | 1995-03-21 | Eastman Kodak Company | Surface modified anticancer nanoparticles |
US5981606A (en) | 1991-03-01 | 1999-11-09 | Warner-Lambert Company | Therapeutic TGF-beta-wound healing compositions and methods for preparing and using same |
DE69233482T2 (de) | 1991-05-17 | 2006-01-12 | Merck & Co., Inc. | Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen |
US5756353A (en) | 1991-12-17 | 1998-05-26 | The Regents Of The University Of California | Expression of cloned genes in the lung by aerosol-and liposome-based delivery |
WO1993023011A1 (fr) | 1992-05-18 | 1993-11-25 | Minnesota Mining And Manufacturing Company | Dispositif d'apport de medicament a travers des muqueuses |
US5484703A (en) | 1993-04-22 | 1996-01-16 | United States Of America | Assay using recombinant histidyl-tRNA synthetase |
US5543158A (en) | 1993-07-23 | 1996-08-06 | Massachusetts Institute Of Technology | Biodegradable injectable nanoparticles |
US5641867A (en) | 1993-09-29 | 1997-06-24 | The Trustees Of Columbia University In The City Of New York | Antibody which specifically binds to endothelial-monocyte activating polypeptide II |
IE80468B1 (en) | 1995-04-04 | 1998-07-29 | Elan Corp Plc | Controlled release biodegradable nanoparticles containing insulin |
US6013483A (en) | 1995-06-07 | 2000-01-11 | Human Genome Sciences, Inc. | DNA encoding endothelial monocyte activating polypeptide III |
JPH11503618A (ja) * | 1996-01-19 | 1999-03-30 | スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー | スタフィロコッカス・アウレウスのロイシル−tRNAシンセターゼ |
EP0785269A1 (fr) * | 1996-01-19 | 1997-07-23 | Smithkline Beecham Plc | Histidyl-tRNA synthétase de Staphylococcus Aureus |
GB9601067D0 (en) | 1996-01-19 | 1996-03-20 | Smithkline Beecham Plc | Novel compounds |
GB9607993D0 (en) | 1996-04-18 | 1996-06-19 | Smithkline Beecham Plc | Novel compounds |
US5795758A (en) * | 1997-04-18 | 1998-08-18 | Smithkline Beecham Corporation | DNA encoding histidyl tRNA synthetase variant from Streptococcus pneumoniae |
US5882892A (en) * | 1997-07-23 | 1999-03-16 | Smithkline Beecham Corporation | Asps |
US5858720A (en) | 1997-07-23 | 1999-01-12 | Smithkline Beecham Corporation | Hiss |
US6391311B1 (en) | 1998-03-17 | 2002-05-21 | Genentech, Inc. | Polypeptides having homology to vascular endothelial cell growth factor and bone morphogenetic protein 1 |
WO1999045130A1 (fr) | 1998-03-04 | 1999-09-10 | Onyx Pharmaceuticals, Inc. | Systeme et procede d'expression de baculovirus pour l'expression a haut rendement de materiel genetique |
US6428960B1 (en) | 1998-03-04 | 2002-08-06 | Onyx Pharmaceuticals, Inc. | Selection method for producing recombinant baculovirus |
US6800286B1 (en) | 1998-08-19 | 2004-10-05 | The Regents Of The University Of Colorado | Chimeric fibroblast growth factor proteins, nucleic acid molecules, and uses thereof |
MXPA01002875A (es) | 1998-11-13 | 2002-04-08 | Los Angeles Childrens Hospital | Metodos para facilitar el crecimiento vascular. |
US6548060B1 (en) * | 1999-11-18 | 2003-04-15 | Sunghoon Kim | Anti-apoptotic use of human glutaminyl-tRNA synthetase with two consecutive pro-apoptotic mediators |
US20030158400A1 (en) | 2000-02-03 | 2003-08-21 | Tang Y. Tom | Novel nucleic acids and polypeptides |
US20020128187A1 (en) | 2000-02-03 | 2002-09-12 | Tang Y. Tom | Novel nucleic acids and polypeptides |
US20070042392A1 (en) | 2000-02-03 | 2007-02-22 | Nuvelo, Inc. | Novel nucleic acids and polypeptides |
US20030165921A1 (en) | 2000-02-03 | 2003-09-04 | Tang Y. Tom | Novel nucleic acids and polypeptides |
WO2001057190A2 (fr) | 2000-02-03 | 2001-08-09 | Hyseq, Inc. | Acides nucleiques et polypeptides |
CN1314486A (zh) * | 2000-03-17 | 2001-09-26 | 上海博德基因开发有限公司 | 一种新的多肽——人组氨酰-tRNA合成酶85和编码这种多肽的多核苷酸 |
US7144984B2 (en) | 2000-03-31 | 2006-12-05 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
CA2404484C (fr) | 2000-03-31 | 2017-04-18 | The Scripps Research Institute | Polypeptides humains d'aminoacyl-arnt synthetase utiles pour reguler l'angiogenese |
US6436703B1 (en) | 2000-03-31 | 2002-08-20 | Hyseq, Inc. | Nucleic acids and polypeptides |
US7273844B2 (en) | 2000-03-31 | 2007-09-25 | The Scripps Research Institute | Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis |
CN1322818A (zh) | 2000-05-09 | 2001-11-21 | 上海博德基因开发有限公司 | 一种新的多肽——人II类氨酰基-tRNA合成酶10和编码这种多肽的多核苷酸 |
US20040181830A1 (en) | 2001-05-07 | 2004-09-16 | Kovalic David K. | Nucleic acid molecules and other molecules associated with plants and uses thereof for plant improvement |
AU2001256780A1 (en) | 2000-05-18 | 2001-11-26 | Nihon University, School Juridical Person | Method for examining ischemic conditions |
WO2001090330A2 (fr) | 2000-05-25 | 2001-11-29 | Incyte Genomics, Inc. | Aminoacyl-arnt synthetases |
CN1341725A (zh) | 2000-09-07 | 2002-03-27 | 上海博德基因开发有限公司 | 一种新的多肽——人苏氨酰-tRNA合成酶48.73和编码这种多肽的多核苷酸 |
CN1341727A (zh) | 2000-09-07 | 2002-03-27 | 上海博德基因开发有限公司 | 一种新的多肽——甲硫氨酰tRNA合成酶35.09和编码这种多肽的多核苷酸 |
US20070037165A1 (en) | 2000-09-08 | 2007-02-15 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
US6812339B1 (en) | 2000-09-08 | 2004-11-02 | Applera Corporation | Polymorphisms in known genes associated with human disease, methods of detection and uses thereof |
CN1352242A (zh) | 2000-11-02 | 2002-06-05 | 上海博德基因开发有限公司 | 一种新的多肽——人谷氨酰tRNA合成酶12.65和编码这种多肽的多核苷酸 |
CN1352252A (zh) | 2000-11-06 | 2002-06-05 | 上海博德基因开发有限公司 | 一种新的多肽——人II类氨酰基-tRNA合成酶11.77和编码这种多肽的多核苷酸 |
JP2004537270A (ja) | 2000-12-15 | 2004-12-16 | インサイト・ゲノミックス・インコーポレイテッド | アミノアシルtRNA合成酵素 |
AU2002255478A1 (en) | 2001-01-10 | 2002-09-12 | Pe Corporation (Ny) | Kits, such as nucleic acid arrays, comprising a majority of human exons or transcripts, for detecting expression and other uses thereof |
JP2004524021A (ja) | 2001-01-12 | 2004-08-12 | エクセリクシス・インコーポレイテッド | HisRSをターゲッティングすることによるSREBP経路の調節 |
AU2002306558B2 (en) | 2001-02-23 | 2007-06-28 | The Scripps Research Institute | Tryptophanyl-tRNA synthetase derived polypeptides useful for the regulation of angiogenesis |
US6903189B2 (en) | 2001-03-21 | 2005-06-07 | The Scripps Research Institute | Human aminoacyl-tRNA synthetase polypeptides useful for the regulation of angiogenesis |
US20030215827A1 (en) * | 2001-05-22 | 2003-11-20 | Henry Yue | Aminoacyl trna synthetases |
KR100405919B1 (ko) | 2001-06-05 | 2003-11-14 | 주식회사 이매진 | p43의 N-말단 펩타이드를 유효성분으로 하는 면역증강용 약학조성물 |
US20040018505A1 (en) * | 2001-06-29 | 2004-01-29 | Lee Ernestine A. | Aminoacyl trna synthetases |
AU2002332430A1 (en) | 2001-07-26 | 2003-02-17 | Novartis Ag | Methods of treating neuropilin-mediated diseases |
US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
US20040048290A1 (en) * | 2001-12-13 | 2004-03-11 | Lee Ernestine A | Aminoacyl trna synthetases |
US20040101879A1 (en) | 2002-01-11 | 2004-05-27 | Cynthia Seidel-Dugan | Srebp pathway modulation through targeting hisrs |
WO2003080648A2 (fr) | 2002-03-20 | 2003-10-02 | University Of Florida Research Foundation, Inc. | Compositions a base de vecteur viral adeno-associe de recombinaison (raav) et procedes correspondants pour le traitement de la neovascularisation choroidienne |
WO2003094848A2 (fr) | 2002-05-10 | 2003-11-20 | Incyte Corporation | Proteines associees a des acides nucleiques |
WO2003094862A2 (fr) | 2002-05-13 | 2003-11-20 | Rigel Pharmaceuticals, Inc. | Arnt synthase utilisee comme modulateur de l'angiogenese |
KR100515016B1 (ko) | 2002-07-22 | 2005-09-15 | 재단법인서울대학교산학협력재단 | p43을 유효성분으로 하는 창상 치료용 약학적 조성물 |
AU2003289716A1 (en) | 2002-09-12 | 2004-04-30 | Incyte Corporation | Molecules for diagnostics and therapeutics |
WO2004060262A2 (fr) | 2003-01-07 | 2004-07-22 | Lorantis Limited | Traitement medical |
US20050181375A1 (en) | 2003-01-10 | 2005-08-18 | Natasha Aziz | Novel methods of diagnosis of metastatic cancer, compositions and methods of screening for modulators of metastatic cancer |
CN1519315A (zh) * | 2003-01-21 | 2004-08-11 | 上海博德基因开发有限公司 | 一种多肽——人组氨酰-trna合成酶13.09和编码这种多肽的多核苷酸 |
WO2004064863A1 (fr) | 2003-01-23 | 2004-08-05 | Lorantis Limited | Traitement de maladies autoimmunes au moyen d'un activateur de la voie de signalisation notch |
KR100575251B1 (ko) | 2003-03-03 | 2006-05-02 | 재단법인서울대학교산학협력재단 | p38/JTV-1을 유효성분으로 하는 암 치료용 약학적조성물 및 암 치료용 약학적 조성물의 스크리닝 방법 |
US20070054278A1 (en) | 2003-11-18 | 2007-03-08 | Applera Corporation | Polymorphisms in nucleic acid molecules encoding human enzyme proteins, methods of detection and uses thereof |
EP1713914A2 (fr) | 2004-01-28 | 2006-10-25 | Celldex Therapeutics Limited | TRAITEMENT MEDICAL UTILISANT UN AGENT ARNi POUR CIBLAGE UN ELEMENT HUMAIN DE LA VOIE DE SIGNILISATION NOTCH |
WO2005087953A2 (fr) | 2004-03-05 | 2005-09-22 | Applera Corporation | Polymorphismes genetiques associes a des maladies coronariennes, procedes de detection et utilisations |
WO2005113812A2 (fr) | 2004-04-23 | 2005-12-01 | Invitrogen Corporation | Collections de reactifs biologiques adaptes et procedes d'identification de reactifs adaptes |
KR100599454B1 (ko) | 2004-04-27 | 2006-07-12 | 재단법인서울대학교산학협력재단 | 종양 억제자로 작용하는 aim3의 신규 용도 |
US7528106B2 (en) | 2004-06-04 | 2009-05-05 | The Scripps Research Institute | Compositions and methods for treatment of neovascular diseases |
US8282921B2 (en) | 2004-08-02 | 2012-10-09 | Paul Glidden | tRNA synthetase fragments |
US20060078553A1 (en) | 2004-10-07 | 2006-04-13 | Paul Glidden | Diverse multi-unit complexes including a tRNA synthetase fragment |
US20060024288A1 (en) | 2004-08-02 | 2006-02-02 | Pfizer Inc. | tRNA synthetase fragments |
US20060079673A1 (en) | 2004-08-02 | 2006-04-13 | Paul Glidden | Polynucleotides encoding tRNA synthetase fragments and uses thereof |
CA2586201A1 (fr) | 2004-11-03 | 2006-05-11 | Almac Diagnostics Limited | Technologie de micro-reseaux de transcriptome et procedes d'utilisation de celle-ci |
EP1657232A1 (fr) | 2004-11-05 | 2006-05-17 | Cellzome Ag | utilisation d'acides 2-arylacetiques alphasubstitues pour prevenir la maladie d'alzheimer |
US7459529B2 (en) | 2004-11-24 | 2008-12-02 | Seoul National University Industry Foundation | AIMP2-DX2 and its uses |
US8003780B2 (en) | 2004-11-24 | 2011-08-23 | Neomics Co., Ltd. | AIMP2-DX2 gene and SiRNA targeting AIMP2-DX2 |
MX2007009368A (es) | 2005-02-01 | 2008-01-14 | Imagene Co Ltd | Metodo para estimular la sintesis de colagena y/o expresion de factor de crecimiento de queratinocitos. |
US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
KR100689274B1 (ko) | 2005-03-30 | 2007-03-08 | 김현기 | 인간 원암 유전자, 이에 의해 코드되는 단백질 |
US7842467B1 (en) | 2005-05-12 | 2010-11-30 | Celera Corporation | Breast disease targets and uses thereof |
US20070072175A1 (en) | 2005-05-13 | 2007-03-29 | Biogen Idec Ma Inc. | Nucleotide array containing polynucleotide probes complementary to, or fragments of, cynomolgus monkey genes and the use thereof |
US7514229B2 (en) | 2005-09-29 | 2009-04-07 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for diagnosing and evaluating treatment of blood disorders |
AU2006320361B2 (en) | 2005-12-02 | 2012-10-25 | The Scripps Research Institute | Angiogenic tyrosyl tRNA synthetase compositions and methods |
US8014957B2 (en) | 2005-12-15 | 2011-09-06 | Fred Hutchinson Cancer Research Center | Genes associated with progression and response in chronic myeloid leukemia and uses thereof |
CN101370821B (zh) | 2006-01-23 | 2012-07-18 | 伊玛吉恩有限公司 | 新型肽及其用途 |
US9181543B2 (en) | 2006-05-26 | 2015-11-10 | Obodies Limited | OB fold domains |
WO2008007818A1 (fr) | 2006-07-13 | 2008-01-17 | Seoul National University Industry Foundation | Nouvelle utilisation de aimp1 destinée à réguler la glycémie |
US20100120627A1 (en) | 2006-08-02 | 2010-05-13 | Abdelmajid Belouchi | Genemap of the human genes associated with psoriasis |
WO2008021290A2 (fr) | 2006-08-09 | 2008-02-21 | Homestead Clinical Corporation | Protéines spécifiques d'organes et procédés d'utilisation |
WO2008094012A1 (fr) | 2007-02-01 | 2008-08-07 | Imagene Co., Ltd. | Nouveau polypeptide ayant une activité antitumorale |
CN101688230A (zh) | 2007-04-27 | 2010-03-31 | 伊玛吉恩有限公司 | 免疫调节剂的筛选方法 |
WO2009114623A2 (fr) * | 2008-03-11 | 2009-09-17 | University Of North Carolina At Chapel Hill | Compositions angiostatiques comportant des polypeptides de tyrosyle-arn de transfert synthétase tronqués et procédés d'utilisation de ceux-ci |
CA2727622A1 (fr) | 2008-06-11 | 2009-12-17 | Atyr Pharma, Inc. | Activite thrombopoietique de polypeptides de tyrosyl-arnt synthetase |
JP5756751B2 (ja) | 2008-06-26 | 2015-07-29 | エータイアー ファーマ, インコーポレイテッド | 非正準的な生物学的活性を有するグリシル−tRNA合成酵素を含む組成物および方法 |
CA2734892A1 (fr) | 2008-08-18 | 2010-02-25 | Seoul National University Industry Foundation | Procede pour la lutte contre la metastase cancereuse ou la migration de cellules cancereuses par modulation du taux cellulaire de lysyl-arnt synthetase |
KR101067817B1 (ko) | 2008-10-10 | 2011-09-27 | 서울대학교산학협력단 | Aimp1 폴리펩티드에 대한 항체를 포함하는 관절염 진단용 조성물 |
KR101102485B1 (ko) | 2008-10-10 | 2012-01-05 | 서울대학교산학협력단 | Grs단백질 또는 이의 단편의 신규한 용도 |
KR101067815B1 (ko) | 2009-02-05 | 2011-09-27 | 서울대학교산학협력단 | 제1형 당뇨병의 신규한 진단 마커 |
US20120058133A1 (en) | 2009-02-19 | 2012-03-08 | President And Fellows Of Harvard College | Inhibition of trna synthetases and therapeutic applications thereof |
US20120004185A1 (en) | 2009-02-27 | 2012-01-05 | Atyr Pharma, Inc. | Polypeptide structural motifs associated with cell signaling activity |
DK3255146T3 (da) | 2009-03-16 | 2019-08-19 | Pangu Biopharma Ltd | Præparater og fremgangsmåder omfattende histidyl-tRNA-synthetasesplejsningsvarianter med ikke-kanoniske biologiske aktiviteter |
AU2010236913B2 (en) | 2009-03-31 | 2016-03-24 | Atyr Pharma, Inc. | Compositions and methods comprising aspartyl-tRNA synthetases having non-canonical biological activities |
JP5590540B2 (ja) * | 2009-05-13 | 2014-09-17 | 国立大学法人東北大学 | ポジトロン標識タンパク質の合成方法 |
US8828395B2 (en) | 2009-12-11 | 2014-09-09 | Atyr Pharma, Inc. | Antibodies that bind tyrosyl-tRNA synthetases |
WO2011072266A2 (fr) | 2009-12-11 | 2011-06-16 | Atyr Pharma, Inc. | Aminoacyl-arnt synthétases destinées à moduler l'hématopoïèse |
EP2509625B1 (fr) | 2009-12-11 | 2015-01-28 | Atyr Pharma, Inc. | HISTIDYL-ARNt SYNTHÉTASES DESTINÉES À RÉDUIRE L'INFLAMMATION |
WO2011097031A2 (fr) | 2010-02-04 | 2011-08-11 | The Scripps Research Institute | Formes monomères d'aminoacyl-arnt synthétases humaines ayant des activités biologiques non canoniques |
EP2575856B1 (fr) * | 2010-05-27 | 2017-08-16 | aTyr Pharma, Inc. | Découverte innovante de compositions thérapeutiques, de diagnostic et d'anticorps liées à fragments protéiques de glutaminyl-arnt synthétases |
JP6177129B2 (ja) | 2010-07-12 | 2017-08-09 | エータイアー ファーマ, インコーポレイテッド | ヒスチジルtRNA合成酵素のタンパク質フラグメントに関連した治療用、診断用および抗体組成物の革新的発見 |
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US20150140072A1 (en) | 2015-05-21 |
CN106474462A (zh) | 2017-03-08 |
US20130273045A1 (en) | 2013-10-17 |
CA2783731A1 (fr) | 2011-06-16 |
JP5819314B2 (ja) | 2015-11-24 |
CA2783731C (fr) | 2018-03-27 |
EP2939689A1 (fr) | 2015-11-04 |
AU2010327926A1 (en) | 2012-06-21 |
EP2939689B1 (fr) | 2017-09-13 |
US9127268B2 (en) | 2015-09-08 |
AU2014210626B2 (en) | 2017-02-16 |
JP2017070313A (ja) | 2017-04-13 |
JP2015145425A (ja) | 2015-08-13 |
US9943577B2 (en) | 2018-04-17 |
EP2509625B1 (fr) | 2015-01-28 |
WO2011072265A1 (fr) | 2011-06-16 |
AU2010327926B2 (en) | 2014-05-08 |
US20130108630A1 (en) | 2013-05-02 |
DK2509625T3 (en) | 2015-04-27 |
ES2535951T3 (es) | 2015-05-19 |
CN102821784B (zh) | 2016-09-21 |
CN102821784A (zh) | 2012-12-12 |
US20170202933A1 (en) | 2017-07-20 |
AU2014210626A1 (en) | 2014-08-28 |
US9540628B2 (en) | 2017-01-10 |
EP2509625A1 (fr) | 2012-10-17 |
JP2017071651A (ja) | 2017-04-13 |
AU2017203261A1 (en) | 2017-06-08 |
US9328340B2 (en) | 2016-05-03 |
JP6248218B2 (ja) | 2017-12-13 |
JP2013513390A (ja) | 2013-04-22 |
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