HK1172329A1 - 製備苯並氮雜䓬化合物或其鹽的方法 - Google Patents

製備苯並氮雜䓬化合物或其鹽的方法

Info

Publication number
HK1172329A1
HK1172329A1 HK12113121.1A HK12113121A HK1172329A1 HK 1172329 A1 HK1172329 A1 HK 1172329A1 HK 12113121 A HK12113121 A HK 12113121A HK 1172329 A1 HK1172329 A1 HK 1172329A1
Authority
HK
Hong Kong
Prior art keywords
salts
preparing
compounds
benzazepine compounds
benzazepine
Prior art date
Application number
HK12113121.1A
Other languages
English (en)
Inventor
鳥澤保廣
阿部薰
六車寧成
藤田繁和
小川英則
宇積尚登
三宅將仁
Original Assignee
大塚制藥株式會社
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37398782&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1172329(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by 大塚制藥株式會社 filed Critical 大塚制藥株式會社
Publication of HK1172329A1 publication Critical patent/HK1172329A1/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
    • C07D223/16—Benzazepines; Hydrogenated benzazepines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/10—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH
    • A61P5/12—Drugs for disorders of the endocrine system of the posterior pituitary hormones, e.g. oxytocin, ADH for decreasing, blocking or antagonising the activity of the posterior pituitary hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
HK12113121.1A 2005-09-02 2012-12-19 製備苯並氮雜䓬化合物或其鹽的方法 HK1172329A1 (zh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP2005254744 2005-09-02

Publications (1)

Publication Number Publication Date
HK1172329A1 true HK1172329A1 (zh) 2013-04-19

Family

ID=37398782

Family Applications (5)

Application Number Title Priority Date Filing Date
HK09101266.6A HK1124318A1 (en) 2005-09-02 2009-02-11 Process for preparing benzazepine compounds or salts thereof
HK11103250.6A HK1148999A1 (en) 2005-09-02 2009-02-11 The process for preparing benzazepine compounds or salts thereof
HK10111584.7A HK1144932A1 (en) 2005-09-02 2010-12-13 Process for preparing derivatives of benzoic acid
HK11100027.4A HK1145835A1 (zh) 2005-09-02 2011-01-04 製備苯並氮雜卓化合物或其鹽的方法
HK12113121.1A HK1172329A1 (zh) 2005-09-02 2012-12-19 製備苯並氮雜䓬化合物或其鹽的方法

Family Applications Before (4)

Application Number Title Priority Date Filing Date
HK09101266.6A HK1124318A1 (en) 2005-09-02 2009-02-11 Process for preparing benzazepine compounds or salts thereof
HK11103250.6A HK1148999A1 (en) 2005-09-02 2009-02-11 The process for preparing benzazepine compounds or salts thereof
HK10111584.7A HK1144932A1 (en) 2005-09-02 2010-12-13 Process for preparing derivatives of benzoic acid
HK11100027.4A HK1145835A1 (zh) 2005-09-02 2011-01-04 製備苯並氮雜卓化合物或其鹽的方法

Country Status (16)

Country Link
US (2) US8273735B2 (zh)
EP (3) EP2251319B1 (zh)
JP (6) JP5046587B2 (zh)
KR (4) KR101019363B1 (zh)
CN (4) CN102219741B (zh)
AT (2) ATE544744T1 (zh)
CY (3) CY1111788T1 (zh)
DE (1) DE602006019882D1 (zh)
DK (3) DK1919874T3 (zh)
ES (3) ES2358217T3 (zh)
HK (5) HK1124318A1 (zh)
IL (5) IL189481A (zh)
PL (3) PL1919874T3 (zh)
PT (3) PT2251319E (zh)
SI (3) SI2261215T1 (zh)
WO (1) WO2007026971A2 (zh)

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CN102219741B (zh) * 2005-09-02 2013-05-15 大塚制药株式会社 制备苯并氮杂*化合物或其盐的方法
JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法
CN102020609A (zh) * 2009-09-17 2011-04-20 北京本草天源药物研究院 托伐普坦晶体或无定形物及其制备方法
CN101817783B (zh) * 2010-05-12 2012-02-22 天津泰普药品科技发展有限公司 一种托伐普坦中间体的制备方法
US9024015B2 (en) 2010-10-05 2015-05-05 Hetero Research Foundation Process for preparing tolvaptan intermediates
CN102093247B (zh) * 2010-12-15 2014-03-12 天津药物研究院 一种2-甲基-4-n-(2-甲基苯甲酰)苯甲酸的制备方法
CN102060769B (zh) * 2010-12-20 2013-09-18 天津药物研究院 一种托伐普坦的制备方法
CN102093293B (zh) * 2011-03-02 2012-06-13 宁波人健药业集团有限公司 一种制备7-氯-2,3,4,5-四氢-1h-1-苯并氮杂卓-5-酮的方法
CN102558051B (zh) * 2011-07-15 2016-08-10 天津泰普药品科技发展有限公司 一种托伐普坦晶体及其药物组合物
CN102382053B (zh) * 2011-08-31 2016-06-01 浙江华海药业股份有限公司 一种制备托伐普坦中间体的方法
CN102329268B (zh) * 2011-10-25 2014-03-12 天津药物研究院 7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103159641A (zh) * 2011-12-14 2013-06-19 天津泰普药品科技发展有限公司 托伐普坦中间体2-甲酸-5-(2-甲基苯甲酰氨基)甲苯的制备方法
CN102690211B (zh) * 2012-06-05 2015-12-09 郑州明泽医药科技有限公司 托伐普坦中间体的制备方法
CN103012266B (zh) * 2012-11-23 2014-07-23 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN103012265B (zh) * 2012-11-23 2014-10-15 天津药物研究院 一种7-氯-5-氧代-2,3,4,5-四氢-1h-1-苯并氮杂卓的制备方法
CN104418803A (zh) * 2013-08-21 2015-03-18 上海天慈生物谷生物工程有限公司 一种托伐普坦的制备方法
IN2013MU03296A (zh) 2013-10-21 2015-07-17 Rpg Life Sciences Ltd
CN103880747B (zh) * 2014-03-20 2015-08-26 成都百裕科技制药有限公司 无定形托伐普坦的制备方法
CN106883175A (zh) * 2015-12-16 2017-06-23 天津泰普制药有限公司 一种托伐普坦的制备方法
ITUB20160256A1 (it) * 2016-01-15 2017-07-15 Olon Spa Derivati idrossibenzazepinici esterificati e loro impiego nella sintesi di tolvaptan
CN107663171A (zh) * 2017-10-10 2018-02-06 常州市阳光药业有限公司 高纯度托伐普坦的制备方法
CN113004202B (zh) * 2019-12-20 2023-10-24 成都倍特药业股份有限公司 一种高纯度托伐普坦的制备方法
CN113717070A (zh) * 2020-05-25 2021-11-30 南京正大天晴制药有限公司 一种升压素v2受体拮抗剂的中间体的制备方法
EP4346795A1 (en) 2021-06-02 2024-04-10 Esperion Therapeutics, Inc. Compositions containing and therapies using bempedoic acid and tolvaptan

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JP2009035513A (ja) * 2007-08-02 2009-02-19 Ube Ind Ltd ４−ｎ−（メチルベンゾイル）アミノ−２−メチル安息香酸の製法

Also Published As

Publication number Publication date
IL217446A (en) 2016-08-31
KR101019363B1 (ko) 2011-03-07
SI2251319T1 (sl) 2012-05-31
JP5583172B2 (ja) 2014-09-03
EP1919874A2 (en) 2008-05-14
ES2379153T3 (es) 2012-04-23
DK2261215T3 (en) 2015-02-02
IL189481A0 (en) 2008-08-07
US20090306369A1 (en) 2009-12-10
CN102219741A (zh) 2011-10-19
IL217445A0 (en) 2012-02-29
EP2251319B1 (en) 2012-02-08
JP2012176979A (ja) 2012-09-13
CN101273017B (zh) 2011-09-14
IL217444A (en) 2013-05-30
IL189481A (en) 2013-08-29
CY1112496T1 (el) 2015-12-09
KR101119732B1 (ko) 2012-03-22
US8273735B2 (en) 2012-09-25
JP5893083B2 (ja) 2016-03-23
KR20100132087A (ko) 2010-12-16
EP2261215A1 (en) 2010-12-15
JP5046587B2 (ja) 2012-10-10
PT2251319E (pt) 2012-03-05
KR20080039459A (ko) 2008-05-07
EP2251319A3 (en) 2011-03-09
CN101273017A (zh) 2008-09-24
PL2251319T3 (pl) 2012-07-31
PT2261215E (pt) 2015-02-13
HK1148999A1 (en) 2011-09-23
JP5784164B2 (ja) 2015-09-24
SI2261215T1 (sl) 2015-02-27
SI1919874T1 (sl) 2011-04-29
IL217446A0 (en) 2012-02-29
CY1111788T1 (el) 2015-10-07
KR20110029184A (ko) 2011-03-22
DK1919874T3 (da) 2011-02-21
PT1919874E (pt) 2011-03-14
ATE544744T1 (de) 2012-02-15
CN102219741B (zh) 2013-05-15
ATE496895T1 (de) 2011-02-15
DK2251319T3 (da) 2012-03-05
IL217444A0 (en) 2012-02-29
CN102746229B (zh) 2015-04-08
CN102746229A (zh) 2012-10-24
CY1116082T1 (el) 2017-02-08
WO2007026971A3 (en) 2007-07-05
EP2251319A2 (en) 2010-11-17
US8501730B2 (en) 2013-08-06
IL217445A (en) 2013-11-28
US20120226034A1 (en) 2012-09-06
CN101967107B (zh) 2012-12-12
EP1919874B1 (en) 2011-01-26
KR20100133028A (ko) 2010-12-20
HK1144932A1 (en) 2011-03-18
JP2012197296A (ja) 2012-10-18
JP2014139203A (ja) 2014-07-31
KR101077329B1 (ko) 2011-10-26
EP2261215B1 (en) 2014-12-31
HK1145835A1 (zh) 2011-05-06
DE602006019882D1 (de) 2011-03-10
PL1919874T3 (pl) 2011-06-30
CN101967107A (zh) 2011-02-09
WO2007026971A2 (en) 2007-03-08
ES2358217T3 (es) 2011-05-06
HK1124318A1 (en) 2009-07-10
JP2012197295A (ja) 2012-10-18
PL2261215T3 (pl) 2015-06-30
IL222396A (en) 2014-05-28
ES2527794T3 (es) 2015-01-29
JP2007091738A (ja) 2007-04-12
JP2014205699A (ja) 2014-10-30

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