HK1167142A1 - 用作激酶抑制劑的咪唑並吡嗪類化合物 - Google Patents

用作激酶抑制劑的咪唑並吡嗪類化合物

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Publication number
HK1167142A1
HK1167142A1 HK12107860.8A HK12107860A HK1167142A1 HK 1167142 A1 HK1167142 A1 HK 1167142A1 HK 12107860 A HK12107860 A HK 12107860A HK 1167142 A1 HK1167142 A1 HK 1167142A1
Authority
HK
Hong Kong
Prior art keywords
imidazopyrazines
inhibitors
protein kinases
kinases
protein
Prior art date
Application number
HK12107860.8A
Other languages
English (en)
Inventor
Fernandez Joaquin Pastor
Gonzalez Sonia Martinez
Santamarina Julen Oyarzabal
Original Assignee
Ct Nac De Investigaciones Oncologicas Cn
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ct Nac De Investigaciones Oncologicas Cn filed Critical Ct Nac De Investigaciones Oncologicas Cn
Publication of HK1167142A1 publication Critical patent/HK1167142A1/zh

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    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
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    • C07D243/06—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4
    • C07D243/10—Heterocyclic compounds containing seven-membered rings having two nitrogen atoms as the only ring hetero atoms having the nitrogen atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D243/14—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines
    • C07D243/16—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals
    • C07D243/18—1,4-Benzodiazepines; Hydrogenated 1,4-benzodiazepines substituted in position 5 by aryl radicals substituted in position 2 by nitrogen, oxygen or sulfur atoms
    • C07D243/20—Nitrogen atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
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    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
HK12107860.8A 2009-04-16 2012-08-10 用作激酶抑制劑的咪唑並吡嗪類化合物 HK1167142A1 (zh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP09380079 2009-04-16
PCT/GB2010/000773 WO2010119264A1 (en) 2009-04-16 2010-04-16 Imidazopyrazines for use as kinase inhibitors

Publications (1)

Publication Number Publication Date
HK1167142A1 true HK1167142A1 (zh) 2012-11-23

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Country Link
US (1) US8778935B2 (zh)
EP (1) EP2419429B1 (zh)
JP (1) JP5805623B2 (zh)
KR (2) KR101792837B1 (zh)
CN (1) CN102428087B (zh)
AU (1) AU2010238361B2 (zh)
BR (1) BRPI1014572B8 (zh)
CA (1) CA2756759C (zh)
DK (1) DK2419429T3 (zh)
EA (1) EA022629B1 (zh)
ES (1) ES2475091T3 (zh)
HK (1) HK1167142A1 (zh)
IL (1) IL215297A (zh)
MX (1) MX2011010915A (zh)
NZ (1) NZ596185A (zh)
SG (1) SG175195A1 (zh)
WO (1) WO2010119264A1 (zh)
ZA (1) ZA201107717B (zh)

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