HK1167655A1 - -末端激酶抑制劑 - Google Patents
-末端激酶抑制劑Info
- Publication number
- HK1167655A1 HK1167655A1 HK12108449.6A HK12108449A HK1167655A1 HK 1167655 A1 HK1167655 A1 HK 1167655A1 HK 12108449 A HK12108449 A HK 12108449A HK 1167655 A1 HK1167655 A1 HK 1167655A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- jun
- inhibitors
- terminal kinase
- terminal
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
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- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4196—1,2,4-Triazoles
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- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
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- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
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- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
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- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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US20712609P | 2009-02-06 | 2009-02-06 | |
US24439009P | 2009-09-21 | 2009-09-21 | |
PCT/US2010/023404 WO2010091310A1 (en) | 2009-02-06 | 2010-02-05 | Inhibitors of jun n-terminal kinase |
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US (10) | US8450363B2 (zh) |
EP (1) | EP2393806B1 (zh) |
JP (2) | JP2012517439A (zh) |
CN (1) | CN102365277B (zh) |
AU (1) | AU2010210426B2 (zh) |
BR (1) | BRPI1007923A2 (zh) |
CA (1) | CA2751141C (zh) |
HK (1) | HK1167655A1 (zh) |
IL (1) | IL214472A (zh) |
MX (1) | MX2011008276A (zh) |
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WO2009143865A1 (en) | 2008-05-30 | 2009-12-03 | Xigen S.A. | Use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
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UA103918C2 (en) * | 2009-03-02 | 2013-12-10 | Айерем Элелси | N-(hetero)aryl, 2-(hetero)aryl-substituted acetamides for use as wnt signaling modulators |
WO2011160653A1 (en) | 2010-06-21 | 2011-12-29 | Xigen S.A. | Novel jnk inhibitor molecules |
US9150618B2 (en) | 2010-10-14 | 2015-10-06 | Xigen Inflammation Ltd. | Use of cell-permeable peptide inhibitors of the JNK signal transduction pathway for the treatment of chronic or non-chronic inflammatory eye diseases |
WO2013091670A1 (en) | 2011-12-21 | 2013-06-27 | Xigen S.A. | Novel jnk inhibitor molecules for treatment of various diseases |
RU2015117950A (ru) | 2012-10-26 | 2016-12-20 | Ф. Хоффманн-Ля Рош Аг | 3,4-дизамещенный 1н-пиразол и 4,5-дизамещенный тиазол в качестве ингибиторов тирозинкиназы syk |
CA2903275A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2014206427A1 (en) | 2013-06-26 | 2014-12-31 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of various diseases |
WO2015197097A1 (en) | 2014-06-26 | 2015-12-30 | Xigen Inflammation Ltd. | New use for jnk inhibitor molecules for treatment of various diseases |
ES2949982T3 (es) * | 2014-06-26 | 2023-10-04 | Xigen Inflammation Ltd | Inhibidores peptídicos permeables en células de la ruta de transducción de señales de JNK para el tratamiento de la cistitis |
CN104177293A (zh) * | 2014-07-29 | 2014-12-03 | 苏州康润医药有限公司 | 5-氨基-7-三氟甲基喹啉及5-三氟甲基-7-氨基喹啉的合成方法 |
JP6903577B2 (ja) * | 2014-12-16 | 2021-07-14 | シグナル ファーマシューティカルズ,エルエルシー | 皮膚におけるc−Jun N末端キナーゼの阻害の測定方法 |
WO2016104434A1 (ja) * | 2014-12-24 | 2016-06-30 | 武田薬品工業株式会社 | 複素環化合物 |
EP3280716B1 (de) | 2015-04-08 | 2020-02-12 | Bayer CropScience AG | Imidazo[1,2-a]pyridin-2-yl-derivate als schädlingsbekämpfungsmittel und deren zwischenprodukte |
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EP3313428A1 (en) * | 2015-06-26 | 2018-05-02 | Xigen Inflammation Ltd. | New use of cell-permeable peptide inhibitors of the jnk signal transduction pathway for the treatment of mild cognitive impairment |
US10667517B2 (en) | 2015-08-07 | 2020-06-02 | Bayer Cropscience Aktiengesellschaft | 2-(Het)aryl-substituted fused heterocycle derivatives as pesticides |
WO2017072039A1 (de) | 2015-10-26 | 2017-05-04 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2017093180A1 (de) | 2015-12-01 | 2017-06-08 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2017144341A1 (de) | 2016-02-23 | 2017-08-31 | Bayer Cropscience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2017174414A1 (de) | 2016-04-05 | 2017-10-12 | Bayer Cropscience Aktiengesellschaft | Naphthalin-derivate als schädlingsbekämpfungsmittel |
EP3241830A1 (de) | 2016-05-04 | 2017-11-08 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
PE20190206A1 (es) | 2016-07-19 | 2019-02-07 | Bayer Cropscience Ag | Derivados de heterociclos biciclicos condensados como pesticidas |
WO2018029336A1 (en) | 2016-08-12 | 2018-02-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for determining whether a subject was administered with an activator of the ppar beta/delta pathway. |
US10660334B2 (en) | 2016-08-15 | 2020-05-26 | Bayer Cropscience Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
WO2018049353A1 (en) * | 2016-09-12 | 2018-03-15 | Imago Pharmaceuticals, Inc. | Treatment of fibrotic disorders with jun n-terminal kinase inhibitors |
KR102468453B1 (ko) | 2016-09-19 | 2022-11-17 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 농약으로서의 피라졸로[1,5-a]피리딘 유도체 |
WO2018138050A1 (de) | 2017-01-26 | 2018-08-02 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2018152223A1 (en) * | 2017-02-15 | 2018-08-23 | University Of Massachusetts | Methods of treating angiogenesis-related disorders using jnk3 inhibitors |
CN107502609A (zh) * | 2017-09-08 | 2017-12-22 | 中国科学院深圳先进技术研究院 | 一种靶向cJun信号通路的miRNA及其制备方法和应用 |
EP3305786A3 (de) | 2018-01-22 | 2018-07-25 | Bayer CropScience Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
WO2019162174A1 (de) | 2018-02-21 | 2019-08-29 | Bayer Aktiengesellschaft | Kondensierte bicyclische heterocyclen-derivate als schädlingsbekämpfungsmittel |
CA3100133A1 (en) * | 2018-03-28 | 2019-10-03 | Takeda Pharmaceutical Company Limited | Heterocyclic compound and use thereof |
CN108409649B (zh) * | 2018-04-12 | 2021-05-04 | 苏州康润医药有限公司 | 一种5-溴-7-三氟甲基喹啉的合成方法 |
EP3820868A1 (de) | 2018-04-20 | 2021-05-19 | Bayer Aktiengesellschaft | Heterocyclen-derivate als schädlingsbekämpfungsmittel |
JP2021527125A (ja) * | 2018-06-07 | 2021-10-11 | ディサーム・セラピューティクス・インコーポレイテッドDisarm Therapeutics, Inc. | Sarm1阻害剤 |
KR20210087033A (ko) * | 2018-10-01 | 2021-07-09 | 젠자임 코포레이션 | UDP 글리코실트랜스퍼라제 억제제로서의 티에노[3,2-b]피리딘 유도체 및 사용 방법 |
AU2020228119A1 (en) | 2019-02-26 | 2021-09-16 | Bayer Aktiengesellschaft | Condensed bicyclic heterocyclic derivatives as pest control agents |
WO2020173860A1 (en) | 2019-02-26 | 2020-09-03 | Bayer Aktiengesellschaft | Fused bicyclic heterocycle derivatives as pesticides |
JP2021050161A (ja) | 2019-09-25 | 2021-04-01 | 武田薬品工業株式会社 | 複素環化合物及びその用途 |
CN112778297B (zh) * | 2019-11-07 | 2022-05-20 | 西北农林科技大学 | 苯并噻唑类化合物及其制备方法和用途 |
CR20220325A (es) | 2019-12-20 | 2022-08-19 | Tenaya Therapeutics Inc | Fluoroalquil-oxadiazoles y sus usos |
CN113354575B (zh) * | 2021-06-07 | 2022-09-27 | 河南应用技术职业学院 | 一种特班布林的合成方法 |
WO2023214324A1 (en) * | 2022-05-04 | 2023-11-09 | Universita' Degli Studi Di Milano | Diagnostic method |
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GB0017676D0 (en) * | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
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JP2005022972A (ja) * | 2001-05-16 | 2005-01-27 | Teikoku Hormone Mfg Co Ltd | 4−(4−ピリダジニル)ピラゾール誘導体 |
SI1441734T1 (sl) * | 2001-10-26 | 2007-08-31 | Angeletti P Ist Richerche Bio | Dihidropirimidin karboksamidni inhibitorji HIV-integraze |
GB0201179D0 (en) * | 2002-01-18 | 2002-03-06 | Angeletti P Ist Richerche Bio | Therapeutic agents |
AU2003290507A1 (en) * | 2002-05-10 | 2004-04-08 | Cytokinetics, Inc. | Compounds, compositions and methods |
AU2003288956A1 (en) * | 2002-10-30 | 2004-06-07 | Vertex Pharmaceuticals Incorporated | Compositions useful as inhibitors of rock and other protein kinases |
CN1732164A (zh) * | 2002-10-30 | 2006-02-08 | 沃泰克斯药物股份有限公司 | 可用作rock及其他蛋白质激酶抑制剂的组合物 |
BRPI0620362A2 (pt) | 2005-12-22 | 2012-07-03 | Astrazeneca Ab | composto ou um sal farmaceuticamente aceitável do mesmo, uso do mesmo, métodos para produzir um efeito inibidor de csf-1r quinase em um animal de sangue quente, para produzir um efeito anti-cáncer em um animal de sangue quente e para tratar doença, e, composição farmacêutica |
WO2007129195A2 (en) * | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
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WO2008011337A1 (en) | 2006-07-19 | 2008-01-24 | Abbott Laboratories | Hcv inhibitors |
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JP2012517439A (ja) | 2012-08-02 |
CA2751141C (en) | 2018-01-09 |
AU2010210426A1 (en) | 2011-08-18 |
US20180319780A1 (en) | 2018-11-08 |
BRPI1007923A2 (pt) | 2020-08-25 |
IL214472A0 (en) | 2011-09-27 |
CN102365277A (zh) | 2012-02-29 |
SG173584A1 (en) | 2011-09-29 |
WO2010091310A1 (en) | 2010-08-12 |
US20220081427A1 (en) | 2022-03-17 |
AU2010210426B2 (en) | 2015-06-11 |
US20150259330A1 (en) | 2015-09-17 |
JP6121393B2 (ja) | 2017-04-26 |
JP2015091832A (ja) | 2015-05-14 |
CN102365277B (zh) | 2015-11-25 |
US8450363B2 (en) | 2013-05-28 |
US9073891B2 (en) | 2015-07-07 |
MX2011008276A (es) | 2011-12-14 |
EP2393806A1 (en) | 2011-12-14 |
US9796706B2 (en) | 2017-10-24 |
US20190194176A1 (en) | 2019-06-27 |
US20180037577A1 (en) | 2018-02-08 |
IL214472A (en) | 2017-12-31 |
US20130072494A1 (en) | 2013-03-21 |
US20200277285A1 (en) | 2020-09-03 |
SG10201407409WA (en) | 2015-01-29 |
CA2751141A1 (en) | 2010-08-12 |
US20170107209A1 (en) | 2017-04-20 |
US20100331335A1 (en) | 2010-12-30 |
US20200039972A1 (en) | 2020-02-06 |
EP2393806B1 (en) | 2017-10-25 |
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