SI2880035T1 - Nove spojine pirolopirimidina kot inhibitorji protein kinaz - Google Patents

Nove spojine pirolopirimidina kot inhibitorji protein kinaz

Info

Publication number
SI2880035T1
SI2880035T1 SI201330554A SI201330554A SI2880035T1 SI 2880035 T1 SI2880035 T1 SI 2880035T1 SI 201330554 A SI201330554 A SI 201330554A SI 201330554 A SI201330554 A SI 201330554A SI 2880035 T1 SI2880035 T1 SI 2880035T1
Authority
SI
Slovenia
Prior art keywords
inhibitors
protein kinases
pyrrolopyrimidine compounds
novel pyrrolopyrimidine
novel
Prior art date
Application number
SI201330554A
Other languages
English (en)
Inventor
Xiao Xu
Xiaobo Wang
Long Mao
Li Zhao
Biao Xi
Original Assignee
Acea Biosciences Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acea Biosciences Inc. filed Critical Acea Biosciences Inc.
Priority claimed from EP13745491.4A external-priority patent/EP2880035B9/en
Publication of SI2880035T1 publication Critical patent/SI2880035T1/sl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
SI201330554A 2012-08-06 2013-07-11 Nove spojine pirolopirimidina kot inhibitorji protein kinaz SI2880035T1 (sl)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US201261680231P 2012-08-06 2012-08-06
US13/843,554 US9034885B2 (en) 2012-01-13 2013-03-15 EGFR modulators and uses thereof
US201361814147P 2013-04-19 2013-04-19
US13/917,514 US8685988B2 (en) 2012-08-06 2013-06-13 EGFR modulators and uses thereof
EP13745491.4A EP2880035B9 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases
PCT/US2013/050163 WO2014025486A1 (en) 2012-08-06 2013-07-11 Novel pyrrolopyrimidine compounds as inhibitors of protein kinases

Publications (1)

Publication Number Publication Date
SI2880035T1 true SI2880035T1 (sl) 2017-05-31

Family

ID=50026061

Family Applications (1)

Application Number Title Priority Date Filing Date
SI201330554A SI2880035T1 (sl) 2012-08-06 2013-07-11 Nove spojine pirolopirimidina kot inhibitorji protein kinaz

Country Status (4)

Country Link
US (5) US9034885B2 (sl)
PL (1) PL2880035T3 (sl)
RS (1) RS55746B1 (sl)
SI (1) SI2880035T1 (sl)

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WO2023187037A1 (en) 2022-03-31 2023-10-05 Astrazeneca Ab Epidermal growth factor receptor (egfr) tyrosine kinase inhibitors in combination with an akt inhibitor for the treatment of cancer
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Also Published As

Publication number Publication date
US20140038981A1 (en) 2014-02-06
US9763949B2 (en) 2017-09-19
US11007197B2 (en) 2021-05-18
US20180008607A1 (en) 2018-01-11
US20140038940A1 (en) 2014-02-06
US20150246047A1 (en) 2015-09-03
US20200129516A1 (en) 2020-04-30
US9034885B2 (en) 2015-05-19
PL2880035T3 (pl) 2017-07-31
US8685988B2 (en) 2014-04-01
US10449196B2 (en) 2019-10-22
RS55746B1 (sr) 2017-07-31

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