HK1159628A1 - Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c] - Google Patents
Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c]Info
- Publication number
- HK1159628A1 HK1159628A1 HK12100183.3A HK12100183A HK1159628A1 HK 1159628 A1 HK1159628 A1 HK 1159628A1 HK 12100183 A HK12100183 A HK 12100183A HK 1159628 A1 HK1159628 A1 HK 1159628A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- thieno
- cancer
- treatment
- kinase inhibitors
- pyridine derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D333/30—Hetero atoms other than halogen
- C07D333/36—Nitrogen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12028108P | 2008-12-05 | 2008-12-05 | |
| US22376009P | 2009-07-08 | 2009-07-08 | |
| PCT/US2009/066725 WO2010065825A2 (en) | 2008-12-05 | 2009-12-04 | Kinase inhibitors with improved cyp safety profile |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| HK1159628A1 true HK1159628A1 (en) | 2012-08-03 |
Family
ID=41559043
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| HK12100183.3A HK1159628A1 (en) | 2008-12-05 | 2012-01-06 | Thieno[3,2-c]pyridine derivatives as kinase inhibitors for use in the treatment of cancer [32- c] |
Country Status (26)
| Country | Link |
|---|---|
| US (2) | US20100144783A1 (xx) |
| EP (1) | EP2373662B1 (xx) |
| JP (1) | JP5588458B2 (xx) |
| KR (1) | KR101639642B1 (xx) |
| CN (1) | CN102239171B (xx) |
| AR (1) | AR074481A1 (xx) |
| AU (1) | AU2009322270B2 (xx) |
| BR (1) | BRPI0921392A2 (xx) |
| CA (1) | CA2743592A1 (xx) |
| CL (1) | CL2011001312A1 (xx) |
| CO (1) | CO6382131A2 (xx) |
| DO (1) | DOP2011000153A (xx) |
| EC (1) | ECSP11011172A (xx) |
| ES (1) | ES2524966T3 (xx) |
| HK (1) | HK1159628A1 (xx) |
| IL (1) | IL212716A (xx) |
| MX (1) | MX2011005943A (xx) |
| MY (1) | MY179042A (xx) |
| NZ (1) | NZ592714A (xx) |
| PA (1) | PA8852401A1 (xx) |
| PE (1) | PE20110830A1 (xx) |
| RU (2) | RU2480472C2 (xx) |
| TW (2) | TWI500621B (xx) |
| UA (1) | UA103351C2 (xx) |
| UY (1) | UY32291A (xx) |
| WO (1) | WO2010065825A2 (xx) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| MX2011005943A (es) * | 2008-12-05 | 2011-06-27 | Abbott Lab | Derivados de tieno[3,2-c]piridina como inhibidores de cinasa para utilizarse en el tratamiento de cancer. |
| TWI482770B (zh) | 2010-06-09 | 2015-05-01 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| EP2580221B1 (en) * | 2010-06-09 | 2015-10-21 | AbbVie Bahamas Ltd. | Crystalline forms of kinase inhibitors |
| MX2012014387A (es) * | 2010-06-09 | 2013-05-01 | Abbvie Inc | Dispersiones solidas que contienen inhibidores de cinasa. |
| TWI492949B (zh) | 2010-06-09 | 2015-07-21 | Abbvie Bahamas Ltd | 結晶型激酶抑制劑 |
| US8911725B2 (en) | 2010-06-23 | 2014-12-16 | University Of Central Florida Research Foundation, Inc. | Co-targeting of aurora A kinase and LIM kinase 1 for cancer therapy |
| US8436179B2 (en) | 2011-07-20 | 2013-05-07 | Abbvie Inc. | Kinase inhibitor with improved solubility profile |
| EP2790726A1 (en) * | 2011-12-14 | 2014-10-22 | AbbVie Inc. | Compositions containing kinase inhibitors |
| US20150225377A1 (en) * | 2012-08-17 | 2015-08-13 | Cancer Therapeutics Crc Pty Limited | Vegfr3 inhibitors |
| US20160009686A1 (en) * | 2012-08-17 | 2016-01-14 | Cancer Therapeutics Crc Pty Limited | Vegfr3 inhibitors |
| CN103012428A (zh) * | 2013-01-08 | 2013-04-03 | 中国药科大学 | 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途 |
| WO2015157360A1 (en) | 2014-04-08 | 2015-10-15 | Abbvie Inc. | Processes to make protein kinase inhibitors |
| WO2015200635A1 (en) | 2014-06-25 | 2015-12-30 | Abbvie Inc. | N-(4-{4-AMINO-7-[1-(2-HYDROXYETHYL)-1H-PYRAZOL-4-yl]THIENO[3,2-c]PYRIDIN-3-YL}PHENYL)-N'-(3-FLUOROPHENYL)UREA DOCUSATE |
| TW202038957A (zh) | 2018-12-21 | 2020-11-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與激酶抑制劑之組合 |
| WO2020252353A1 (en) * | 2019-06-12 | 2020-12-17 | Vanderbilt University | Amino acid transport inhibitors and the uses thereof |
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|---|---|---|---|---|
| GB1188529A (en) | 1966-06-09 | 1970-04-15 | Wellcome Found | Pyramidine Derivatives |
| US4357535A (en) | 1980-04-30 | 1982-11-02 | North American Philips Corporation | Apparatus for inspecting hand-held articles and persons carrying same |
| GB8307154D0 (en) | 1983-03-15 | 1983-04-20 | Mk Electric Ltd | Terminals |
| US4767766A (en) | 1987-01-30 | 1988-08-30 | Merck & Co., Inc. | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors |
| EP0300688A1 (en) | 1987-07-21 | 1989-01-25 | FISONS plc | Pyrrole derivatives, process for their preparation and pharmaceutical compositions containing them |
| JPH0436810Y2 (xx) | 1987-12-29 | 1992-08-31 | ||
| US4843949A (en) | 1988-08-29 | 1989-07-04 | Pneumo Abex Corporation | Fluid control valve with variable pressure gain |
| GB8912498D0 (en) | 1989-05-31 | 1989-07-19 | De Beers Ind Diamond | Diamond growth |
| EP0438261A3 (en) | 1990-01-16 | 1992-02-26 | Takeda Chemical Industries, Ltd. | Condensed heterocyclic glutamic acid derivatives, their production and use |
| DE4129603A1 (de) | 1991-09-06 | 1993-03-11 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE69431173T2 (de) | 1993-06-16 | 2003-05-08 | Du Pont | Mit Wasser reinigbare Dickfilmpastenzusammensetzung |
| IL112759A0 (en) | 1994-02-25 | 1995-05-26 | Khepri Pharmaceuticals Inc | Novel cysteine protease inhibitors |
| DE29511756U1 (de) | 1995-07-20 | 1995-09-28 | Ferco International Usine de Ferrures de Bâtiment S.A.R.L., Sarrebourg | Flügelseitiges Ecklagerbeschlagteil für Drehkippfenster |
| AR004010A1 (es) | 1995-10-11 | 1998-09-30 | Glaxo Group Ltd | Compuestos heterociclicos |
| DE19620508A1 (de) | 1996-05-22 | 1997-11-27 | Hoechst Ag | Schwefelenthaltende heterocyclische Bradykinin-Antagonisten, Verfahren zu ihrer Herstellung und ihre Verwendung |
| CN1118462C (zh) | 1997-04-22 | 2003-08-20 | 神经研究公司 | 取代的苯基衍生物、其制备方法以及用途 |
| NZ503685A (en) | 1997-10-20 | 2002-05-31 | F | Fused pyrrole compounds as kinase inhibitors |
| AU2381600A (en) * | 1998-12-23 | 2000-07-31 | Du Pont Pharmaceuticals Company | Thrombin or factor xa inhibitors |
| TR200201506T2 (tr) | 1999-09-17 | 2002-10-21 | Abbott Gmbh & Co. Kg | Terapötik maddeler olarak kinaz inhibitörleri |
| US6608053B2 (en) | 2000-04-27 | 2003-08-19 | Yamanouchi Pharmaceutical Co., Ltd. | Fused heteroaryl derivatives |
| US20020004511A1 (en) | 2000-06-28 | 2002-01-10 | Luzzio Michael Joseph | Thiophene derivatives useful as anticancer agents |
| ES2342357T3 (es) | 2000-12-15 | 2010-07-06 | British Telecommunications Public Limited Company | Transmision y recepcion de material de audio y/o video. |
| CA2438586A1 (en) | 2001-03-14 | 2002-09-19 | Eli Lilly And Company | Retinoid x receptor modulators |
| GB0115109D0 (en) | 2001-06-21 | 2001-08-15 | Aventis Pharma Ltd | Chemical compounds |
| JP2005508904A (ja) | 2001-09-11 | 2005-04-07 | スミスクライン ビーチャム コーポレーション | 血管新生阻害剤としてのフロ−及びチエノピリミジン誘導体 |
| JP2006503796A (ja) | 2001-12-21 | 2006-02-02 | バイエル・フアーマシユーチカルズ・コーポレーシヨン | ピリダジンまたはピリジン誘導体を含んでなる抗−脈管形成組み合わせ療法 |
| JP4564952B2 (ja) | 2003-01-17 | 2010-10-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 糖尿病の治療および予防のためのジペプチジルペプチダーゼ阻害薬としての３−アミノ−４−フェニルブタン酸誘導体 |
| DE10303311A1 (de) | 2003-01-28 | 2004-07-29 | Basf Ag | Addukte auf Basis cyclischer Verbindungen und ihre Verwendung als Gerbstoffe und Konservierungsmittel |
| US7592352B2 (en) * | 2003-05-06 | 2009-09-22 | Smithkline Beecham Corporation | Substituted thieno and furo-pyridines |
| US20050026944A1 (en) * | 2003-07-24 | 2005-02-03 | Patrick Betschmann | Thienopyridine and furopyridine kinase inhibitors |
| US7202363B2 (en) * | 2003-07-24 | 2007-04-10 | Abbott Laboratories | Thienopyridine and furopyridine kinase inhibitors |
| US7419978B2 (en) | 2003-10-22 | 2008-09-02 | Bristol-Myers Squibb Company | Phenyl-aniline substituted bicyclic compounds useful as kinase inhibitors |
| GB0420719D0 (en) | 2004-09-17 | 2004-10-20 | Addex Pharmaceuticals Sa | Novel allosteric modulators |
| KR20070108856A (ko) | 2004-11-11 | 2007-11-13 | 아칠리온 파르마세우티칼스 인코포레이티드 | Ｈｉｖ－1 캡시드 형성의 억제제: 치환된 아릴 아미노메틸티아졸 우레아 및 그것의 유사체 |
| AU2006313456B2 (en) | 2005-05-20 | 2011-06-23 | Methylgene Inc. | Inhibitors of VEGF receptor and HGF receptor signaling |
| US7566721B2 (en) | 2005-08-08 | 2009-07-28 | Osi Pharmaceuticals, Inc. | Substituted thienol[2,3-d]pyrimidines as kinase inhibitors |
| JP2009504759A (ja) | 2005-08-16 | 2009-02-05 | メモリ ファーマセチカル コーポレーション | ホスホジエステラーゼ１０阻害剤 |
| JP2009514899A (ja) | 2005-11-04 | 2009-04-09 | スミスクライン ビーチャム コーポレーション | チエノピリジンＢ−Ｒａｆキナーゼ阻害剤 |
| JP5237108B2 (ja) * | 2005-12-08 | 2013-07-17 | アボット・ラボラトリーズ | タンパク質キナーゼ阻害薬としての９員ヘテロ二環式化合物 |
| CA2658764A1 (en) | 2006-07-20 | 2008-01-24 | Mehmet Kahraman | Benzothiophene inhibitors of rho kinase |
| MX2011005943A (es) * | 2008-12-05 | 2011-06-27 | Abbott Lab | Derivados de tieno[3,2-c]piridina como inhibidores de cinasa para utilizarse en el tratamiento de cancer. |
-
2009
- 2009-12-04 MX MX2011005943A patent/MX2011005943A/es active IP Right Grant
- 2009-12-04 BR BRPI0921392A patent/BRPI0921392A2/pt not_active IP Right Cessation
- 2009-12-04 EP EP09768290.0A patent/EP2373662B1/en active Active
- 2009-12-04 MY MYPI2011002382A patent/MY179042A/en unknown
- 2009-12-04 UA UAA201108416A patent/UA103351C2/uk unknown
- 2009-12-04 AU AU2009322270A patent/AU2009322270B2/en not_active Ceased
- 2009-12-04 NZ NZ592714A patent/NZ592714A/xx not_active IP Right Cessation
- 2009-12-04 PA PA20098852401A patent/PA8852401A1/es unknown
- 2009-12-04 KR KR1020117015162A patent/KR101639642B1/ko active IP Right Grant
- 2009-12-04 TW TW103115668A patent/TWI500621B/zh not_active IP Right Cessation
- 2009-12-04 JP JP2011539724A patent/JP5588458B2/ja not_active Expired - Fee Related
- 2009-12-04 WO PCT/US2009/066725 patent/WO2010065825A2/en active Application Filing
- 2009-12-04 UY UY0001032291A patent/UY32291A/es not_active Application Discontinuation
- 2009-12-04 PE PE2011001146A patent/PE20110830A1/es not_active Application Discontinuation
- 2009-12-04 CA CA2743592A patent/CA2743592A1/en not_active Abandoned
- 2009-12-04 CN CN200980148902.7A patent/CN102239171B/zh not_active Expired - Fee Related
- 2009-12-04 ES ES09768290.0T patent/ES2524966T3/es active Active
- 2009-12-04 TW TW098141587A patent/TWI441827B/zh not_active IP Right Cessation
- 2009-12-04 RU RU2011127451/04A patent/RU2480472C2/ru not_active IP Right Cessation
- 2009-12-04 AR ARP090104710A patent/AR074481A1/es unknown
- 2009-12-07 US US12/632,183 patent/US20100144783A1/en not_active Abandoned
-
2011
- 2011-05-05 IL IL212716A patent/IL212716A/en not_active IP Right Cessation
- 2011-05-24 DO DO2011000153A patent/DOP2011000153A/es unknown
- 2011-06-02 CL CL2011001312A patent/CL2011001312A1/es unknown
- 2011-06-16 CO CO11075260A patent/CO6382131A2/es active IP Right Grant
- 2011-07-01 EC EC2011011172A patent/ECSP11011172A/es unknown
-
2012
- 2012-01-06 HK HK12100183.3A patent/HK1159628A1/xx unknown
- 2012-08-14 US US13/585,333 patent/US8722890B2/en active Active
- 2012-12-25 RU RU2012156958/04A patent/RU2012156958A/ru not_active Application Discontinuation
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