PE20110830A1 - Derivados de tieno[3,2-c]piridina como inhibidores de quinasas - Google Patents

Derivados de tieno[3,2-c]piridina como inhibidores de quinasas

Info

Publication number
PE20110830A1
PE20110830A1 PE2011001146A PE2011001146A PE20110830A1 PE 20110830 A1 PE20110830 A1 PE 20110830A1 PE 2011001146 A PE2011001146 A PE 2011001146A PE 2011001146 A PE2011001146 A PE 2011001146A PE 20110830 A1 PE20110830 A1 PE 20110830A1
Authority
PE
Peru
Prior art keywords
phenyl
kinases
pyrazole
pyridin
urea
Prior art date
Application number
PE2011001146A
Other languages
English (en)
Inventor
Michael R Michaelides
Michael L Curtin
Robin R Frey
Original Assignee
Abbvie Bahamas Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbvie Bahamas Ltd filed Critical Abbvie Bahamas Ltd
Publication of PE20110830A1 publication Critical patent/PE20110830A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/36—Nitrogen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Enzymes And Modification Thereof (AREA)

Abstract

SE REFIERE A COMPUESTOS DERIVADOS DE TIENO[3,2-c]PIRIDINA DE FORMULA (I) DONDE R1 ES HIDROXIALQUILO; R2 ES ALCOXI, ALQUILO, HALO O HALOALCOXI; R3 ES H O ALQUILO. SON COMPUESTOS PREFERIDOS: N-(4-{4-AMINO-7-[1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]TIENO[3,2-c]PIRIDIN-3-IL}FENIL)-N'-(3-FLUOROFENIL)UREA; N-(4-{4-AMINO-7-[1-(2-HIDROXIETIL)-1H-PIRAZOL-4-IL]TIENO[3,2-c]PIRIDIN-3-IL}FENIL)-N'-[4-(DIFLUOROMETOXI)FENIL]UREA; N-[4-(4-AMINO-7-{1-[(2S)-2-HIDROXIPROPIL]-1H-PIRAZOL-4-IL}TIENO[3,2-c]PIRIDIN-3-IL)FENIL]-N'-(3-METILFENIL)UREA; ENTRE OTROS. TAMBIEN SE REFIERE A UNA COMPOSICION FARMACEUTICA. DICHOS COMPUESTOS SON INHIBIDORES DE PROTEINA QUINASAS COMO AURORA-QUINASAS, VEGFR Y PDGFR SIENDO UTILES EN EL TRATAMIENTO DE LEUCEMIA LINFOCITICA AGUDA, FIBROSARCOMA, GLIOMA, CANCER HEPATOCELULAR
PE2011001146A 2008-12-05 2009-12-04 Derivados de tieno[3,2-c]piridina como inhibidores de quinasas PE20110830A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US12028108P 2008-12-05 2008-12-05
US22376009P 2009-07-08 2009-07-08

Publications (1)

Publication Number Publication Date
PE20110830A1 true PE20110830A1 (es) 2011-12-14

Family

ID=41559043

Family Applications (1)

Application Number Title Priority Date Filing Date
PE2011001146A PE20110830A1 (es) 2008-12-05 2009-12-04 Derivados de tieno[3,2-c]piridina como inhibidores de quinasas

Country Status (26)

Country Link
US (2) US20100144783A1 (es)
EP (1) EP2373662B1 (es)
JP (1) JP5588458B2 (es)
KR (1) KR101639642B1 (es)
CN (1) CN102239171B (es)
AR (1) AR074481A1 (es)
AU (1) AU2009322270B2 (es)
BR (1) BRPI0921392A2 (es)
CA (1) CA2743592A1 (es)
CL (1) CL2011001312A1 (es)
CO (1) CO6382131A2 (es)
DO (1) DOP2011000153A (es)
EC (1) ECSP11011172A (es)
ES (1) ES2524966T3 (es)
HK (1) HK1159628A1 (es)
IL (1) IL212716A (es)
MX (1) MX2011005943A (es)
MY (1) MY179042A (es)
NZ (1) NZ592714A (es)
PA (1) PA8852401A1 (es)
PE (1) PE20110830A1 (es)
RU (2) RU2480472C2 (es)
TW (2) TWI441827B (es)
UA (1) UA103351C2 (es)
UY (1) UY32291A (es)
WO (1) WO2010065825A2 (es)

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TWI441827B (zh) * 2008-12-05 2014-06-21 Abbvie Bahamas Ltd 具改良ｃｙｐ安全性之激酶抑制劑
ES2559212T3 (es) * 2010-06-09 2016-02-11 Abbvie Bahamas Ltd. Formas cristalinas de inhibidores de cinasas
US8557995B2 (en) * 2010-06-09 2013-10-15 Abbvie Inc. Solid dispersions containing kinase inhibitors
TWI482770B (zh) * 2010-06-09 2015-05-01 Abbvie Bahamas Ltd 結晶型激酶抑制劑
TWI492949B (zh) * 2010-06-09 2015-07-21 Abbvie Bahamas Ltd 結晶型激酶抑制劑
US8911725B2 (en) 2010-06-23 2014-12-16 University Of Central Florida Research Foundation, Inc. Co-targeting of aurora A kinase and LIM kinase 1 for cancer therapy
US8436179B2 (en) 2011-07-20 2013-05-07 Abbvie Inc. Kinase inhibitor with improved solubility profile
TW201330850A (zh) 2011-12-14 2013-08-01 Abbvie Inc 包含激酶抑制劑之組合物
CA2882270A1 (en) * 2012-08-17 2014-02-20 Cancer Therapeutics Crc Pty Limited Vegfr3 inhibitors
US9238644B2 (en) * 2012-08-17 2016-01-19 Cancer Therapeutics Crc Pty Limited VEGFR3 inhibitors
CN103012428A (zh) * 2013-01-08 2013-04-03 中国药科大学 4-(五元杂环并嘧啶/吡啶取代)氨基-1H-3-吡唑甲酰胺类CDK/Aurora双重抑制剂及其用途
WO2015157360A1 (en) 2014-04-08 2015-10-15 Abbvie Inc. Processes to make protein kinase inhibitors
US20170197980A1 (en) * 2014-06-25 2017-07-13 Abbvie Inc. N-(4-phenyl)-n'-(3-fluorophenyl)urea docusate
CN113195000A (zh) 2018-12-21 2021-07-30 第一三共株式会社 抗体-药物缀合物和激酶抑制剂的组合
EP3983084A1 (en) * 2019-06-12 2022-04-20 Vanderbilt University Amino acid transport inhibitors and the uses thereof

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Also Published As

Publication number Publication date
TW201026706A (en) 2010-07-16
RU2011127451A (ru) 2013-01-10
UA103351C2 (uk) 2013-10-10
AR074481A1 (es) 2011-01-19
WO2010065825A2 (en) 2010-06-10
RU2012156958A (ru) 2014-06-27
HK1159628A1 (en) 2012-08-03
JP5588458B2 (ja) 2014-09-10
PA8852401A1 (es) 2010-07-27
AU2009322270A1 (en) 2011-07-14
KR20110091577A (ko) 2011-08-11
MX2011005943A (es) 2011-06-27
RU2480472C2 (ru) 2013-04-27
DOP2011000153A (es) 2011-06-30
TWI441827B (zh) 2014-06-21
AU2009322270B2 (en) 2014-12-18
ECSP11011172A (es) 2011-08-31
IL212716A0 (en) 2011-07-31
EP2373662A2 (en) 2011-10-12
US20100144783A1 (en) 2010-06-10
MY179042A (en) 2020-10-26
CO6382131A2 (es) 2012-02-15
WO2010065825A3 (en) 2010-08-26
UY32291A (es) 2010-07-30
JP2012511016A (ja) 2012-05-17
CA2743592A1 (en) 2010-06-10
TW201431862A (zh) 2014-08-16
US8722890B2 (en) 2014-05-13
NZ592714A (en) 2013-03-28
CN102239171B (zh) 2014-06-11
KR101639642B1 (ko) 2016-07-14
IL212716A (en) 2013-10-31
TWI500621B (zh) 2015-09-21
US20120309783A1 (en) 2012-12-06
EP2373662B1 (en) 2014-09-24
CL2011001312A1 (es) 2011-10-07
CN102239171A (zh) 2011-11-09
ES2524966T3 (es) 2014-12-16
BRPI0921392A2 (pt) 2016-04-26

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