HK1156026A1 - Pyrazolopyridine kinase inhibitors - Google Patents
Pyrazolopyridine kinase inhibitorsInfo
- Publication number
- HK1156026A1 HK1156026A1 HK11110226A HK11110226A HK1156026A1 HK 1156026 A1 HK1156026 A1 HK 1156026A1 HK 11110226 A HK11110226 A HK 11110226A HK 11110226 A HK11110226 A HK 11110226A HK 1156026 A1 HK1156026 A1 HK 1156026A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kinase inhibitors
- pyrazolopyridine
- pyrazolopyridine kinase
- inhibitors
- kinase
- Prior art date
Links
- AMFYRKOUWBAGHV-UHFFFAOYSA-N 1h-pyrazolo[4,3-b]pyridine Chemical compound C1=CN=C2C=NNC2=C1 AMFYRKOUWBAGHV-UHFFFAOYSA-N 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 title 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 title 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K39/00—Feeding or drinking appliances for poultry or other birds
- A01K39/01—Feeding devices, e.g. chainfeeders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Diabetes (AREA)
- Physical Education & Sports Medicine (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Pulmonology (AREA)
- Environmental Sciences (AREA)
- Hematology (AREA)
- Virology (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Animal Husbandry (AREA)
- Birds (AREA)
- Biodiversity & Conservation Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Tropical Medicine & Parasitology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- AIDS & HIV (AREA)
- Transplantation (AREA)
- Cardiology (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US8292908P | 2008-07-23 | 2008-07-23 | |
US14010108P | 2008-12-23 | 2008-12-23 | |
US16317609P | 2009-03-25 | 2009-03-25 | |
PCT/US2009/051413 WO2010011756A1 (en) | 2008-07-23 | 2009-07-22 | Pyrazolopyridine kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1156026A1 true HK1156026A1 (en) | 2012-06-01 |
Family
ID=41327642
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11110226A HK1156026A1 (en) | 2008-07-23 | 2011-09-28 | Pyrazolopyridine kinase inhibitors |
Country Status (13)
Country | Link |
---|---|
US (2) | US9137973B2 (xx) |
EP (1) | EP2318407B1 (xx) |
JP (2) | JP2011529062A (xx) |
KR (1) | KR20110039563A (xx) |
CN (1) | CN102131807B (xx) |
AU (1) | AU2009274011B2 (xx) |
CA (1) | CA2731451A1 (xx) |
ES (1) | ES2402087T3 (xx) |
HK (1) | HK1156026A1 (xx) |
IL (1) | IL210821A0 (xx) |
MX (1) | MX2011000839A (xx) |
NZ (1) | NZ590784A (xx) |
WO (1) | WO2010011756A1 (xx) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8569337B2 (en) | 2008-07-23 | 2013-10-29 | Vertex Pharmaceuticals Incorporated | Tri-cyclic pyrazolopyridine kinase inhibitors |
JP2011530527A (ja) * | 2008-08-06 | 2011-12-22 | バーテックス ファーマシューティカルズ インコーポレイテッド | アミノピリジンキナーゼ阻害剤 |
KR101702609B1 (ko) | 2009-06-17 | 2017-02-03 | 버텍스 파마슈티칼스 인코포레이티드 | 인플루엔자 바이러스 복제의 억제제 |
JP5769733B2 (ja) * | 2010-01-27 | 2015-08-26 | バーテックス ファーマシューティカルズ インコーポレイテッドVertex Pharmaceuticals Incorporated | ピラゾロピリジンキナーゼ阻害剤 |
WO2011094283A1 (en) * | 2010-01-27 | 2011-08-04 | Vertex Pharmaceuticals Incorporated | Pyrazolopyridine kinase inhibitors |
RU2013132717A (ru) | 2010-12-16 | 2015-01-27 | Вертекс Фармасьютикалз Инкорпорейтед | Ингибиторы репликации вирусов гриппа |
WO2012083122A1 (en) | 2010-12-16 | 2012-06-21 | Vertex Pharmaceutical Incorporated | Inhibitors of influenza viruses replication |
AU2011343642A1 (en) | 2010-12-16 | 2013-05-02 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
UA118010C2 (uk) | 2011-08-01 | 2018-11-12 | Вертекс Фармасьютікалз Інкорпорейтед | Інгібітори реплікації вірусів грипу |
NZ700928A (en) | 2012-04-24 | 2017-06-30 | Vertex Pharma | Dna-pk inhibitors |
US9013997B2 (en) | 2012-06-01 | 2015-04-21 | Broadcom Corporation | System for performing distributed data cut-through |
WO2013184985A1 (en) | 2012-06-08 | 2013-12-12 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
MX2015004615A (es) * | 2012-10-16 | 2015-07-17 | Hoffmann La Roche | Inhibidores de serina/treonina cinasa. |
KR102216284B1 (ko) | 2013-03-12 | 2021-02-18 | 버텍스 파마슈티칼스 인코포레이티드 | Dna-pk 억제제 |
HUE041877T2 (hu) | 2013-10-17 | 2019-06-28 | Vertex Pharma | (S)-N-Metil-8-(1-((2'-metil-[4,5'-bipirimidin]-6-il)amino)propán-2-il)kinolin-4-karboxamid kokristályai és deuterált származékai DNS-PK inhibitorokként |
RU2019104421A (ru) | 2013-11-13 | 2019-04-17 | Вертекс Фармасьютикалз Инкорпорейтед | Способы получения ингибиторов репликации вирусов гриппа |
NZ719729A (en) | 2013-11-13 | 2022-04-29 | Vertex Pharma | Inhibitors of influenza viruses replication |
WO2016183120A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Inhibitors of influenza viruses replication |
WO2016183116A1 (en) | 2015-05-13 | 2016-11-17 | Vertex Pharmaceuticals Incorporated | Methods of preparing inhibitors of influenza viruses replication |
CN105254628B (zh) * | 2015-11-13 | 2017-06-23 | 南京华威医药科技开发有限公司 | 吡唑并吡啶类抗肿瘤化合物及其制备方法和应用 |
CN105503863A (zh) * | 2015-12-11 | 2016-04-20 | 南京华威医药科技开发有限公司 | 新型抗肿瘤化合物 |
CN105503865A (zh) * | 2015-12-24 | 2016-04-20 | 南京华威医药科技开发有限公司 | 新型吡唑并吡啶类抗肿瘤化合物 |
US9825597B2 (en) | 2015-12-30 | 2017-11-21 | Skyworks Solutions, Inc. | Impedance transformation circuit for amplifier |
WO2017184654A1 (en) | 2016-04-19 | 2017-10-26 | Skyworks Solutions, Inc. | Selective shielding of radio frequency modules |
RU2758669C2 (ru) | 2016-09-27 | 2021-11-01 | Вертекс Фармасьютикалз Инкорпорейтед | Способ лечения рака с применением сочетания днк-поражающих агентов и ингибиторов днк-пк |
TW202329611A (zh) * | 2016-12-29 | 2023-07-16 | 美商天工方案公司 | 前端系統及相關裝置、積體電路、模組及方法 |
US10515924B2 (en) | 2017-03-10 | 2019-12-24 | Skyworks Solutions, Inc. | Radio frequency modules |
CN113423707A (zh) * | 2018-11-16 | 2021-09-21 | 加利福尼亚技术学院 | Erk抑制剂及其用途 |
Family Cites Families (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3853898A (en) | 1971-07-20 | 1974-12-10 | Sandoz Ag | 3-(2-substituted amino) pyridyl-phenyl ketone imines |
US4988705A (en) | 1985-06-13 | 1991-01-29 | Schering Corporation | Polycyclic quinoline, naphthyridine and pyrazinopyridine derivatives |
FR2601015B1 (fr) | 1986-07-04 | 1988-08-05 | Rhone Poulenc Sante | Nouveaux derives du 1h,3h-pyrrolo (1,2-c) thiazole, leur preparation et les compositions pharmaceutiques qui les contiennent |
DE3827253A1 (de) | 1987-08-20 | 1989-03-02 | Sandoz Ag | Ester und amide von cyclischen carbonsaeuren und cyclischen alkoholen und aminen sowie verfahren zu deren herstellung und sie enthaltende therapeutische zusammensetzungen |
CA1339423C (en) | 1988-09-14 | 1997-09-02 | Yuji Ono | Pyridine compounds and pharmaceutical use thereof |
US5100768A (en) | 1989-05-09 | 1992-03-31 | Kabushiki Kaisha Toshiba | Photosensitive composition |
JPH03206450A (ja) | 1990-01-09 | 1991-09-09 | Fuji Photo Film Co Ltd | 新規な色素形成カプラー及びそれを用いたハロゲン化銀カラー写真感光材料及びその処理方法 |
US5308854A (en) | 1990-06-18 | 1994-05-03 | Merck & Co., Inc. | Inhibitors of HIV reverse transcriptase |
JPH05331163A (ja) | 1991-03-26 | 1993-12-14 | Kumiai Chem Ind Co Ltd | ピリジン誘導体及び除草剤 |
UA44220C2 (uk) | 1991-11-07 | 2002-02-15 | Агрево Юк Лімітед | Сульфонаміди,що мають гербіцидну активність,спосіб їх одержання, гербіцидна композиція та спосіб боротьби з бур'янами |
US5476750A (en) | 1992-12-29 | 1995-12-19 | Hoechst Celanese Corporation | Metal ion reduction in the raw materials and using a Lewis base to control molecular weight of novolak resin to be used in positive photoresists |
JPH08507297A (ja) | 1993-05-28 | 1996-08-06 | ファイザー・インク. | 2−フェニル−3−アミノピペリジンを調製および分割する方法 |
CA2133355A1 (en) | 1993-10-04 | 1995-04-05 | Itaru Nitta | Method for producing polypeptide |
WO1995032963A1 (fr) | 1994-06-01 | 1995-12-07 | Yoshitomi Pharmaceutical Industries, Ltd. | Compose de thienylazole et compose de thienotriazolodiazepine |
MX9701600A (es) | 1994-08-29 | 1997-05-31 | Yamanouchi Pharma Co Ltd | Derivados de naftiridina novedosos y composicion medicinal de los mismos. |
US5646330A (en) | 1995-02-17 | 1997-07-08 | Ciba-Geigy Corporation | Production of enantiomerically enriched ortho-substituted α,α-diaromatic methanols |
US6194581B1 (en) | 1995-04-07 | 2001-02-27 | Merck & Co., Inc. | Substituted pyridines useful as modulators of acetylcholine receptors |
NZ322197A (en) | 1995-11-21 | 1999-02-25 | Yamanouchi Pharma Co Ltd | Pyrido[2,3-d] pyrimidine derivatives and pharmaceutical compositions thereof |
AU6748398A (en) | 1997-04-18 | 1998-11-13 | Kissei Pharmaceutical Co. Ltd. | Preventives or remedies for diseases affecting excessive proliferation of retinal pigment epithelial cells |
WO1998057957A1 (fr) | 1997-06-18 | 1998-12-23 | Nissan Chemical Industries, Ltd. | Composes pyridiniques et herbicides associes |
US6452008B2 (en) | 1998-02-25 | 2002-09-17 | Sumitomo Pharmaceuticals Company, Limited | Pyridone derivatives and process for preparing the same |
US6225329B1 (en) | 1998-03-12 | 2001-05-01 | Novo Nordisk A/S | Modulators of protein tyrosine phosphatases (PTPases) |
GB9908410D0 (en) | 1999-04-13 | 1999-06-09 | Pfizer Ltd | Pyridines |
US6844367B1 (en) | 1999-09-17 | 2005-01-18 | Millennium Pharmaceuticals, Inc. | Benzamides and related inhibitors of factor Xa |
WO2001083492A1 (en) | 2000-05-02 | 2001-11-08 | Newbiotics, Inc. | Improved beta-lactam antibiotics |
AR029289A1 (es) | 2000-07-05 | 2003-06-18 | Ishihara Sangyo Kaisha | Derivado de benzoilpiridina o su sal, fungicida que lo contiene como un ingrediente activo, su proceso de produccion e intermediario para producirlo |
DE10035908A1 (de) | 2000-07-21 | 2002-03-07 | Asta Medica Ag | Neue Heteroaryl-Derivate und deren Verwendung als Arzneimittel |
EP1326835A1 (en) | 2000-10-05 | 2003-07-16 | Fujisawa Pharmaceutical Co., Ltd. | Benzamide compounds as apo b secretion inhibitors |
ES2200617B1 (es) | 2001-01-19 | 2005-05-01 | Almirall Prodesfarma, S.A. | Derivados de urea como antagonistas de integrinas alfa 4. |
GB2373245A (en) | 2001-03-12 | 2002-09-18 | Bayer Ag | Pyridinyl pyrazoles and their use for the treatment of COPD |
JO3429B1 (ar) | 2001-08-13 | 2019-10-20 | Janssen Pharmaceutica Nv | مشتقات برميدينات مثبطة فيروس الايدز |
CA2463822A1 (en) | 2001-11-01 | 2003-05-08 | Janssen Pharmaceutica N.V. | Heteroaryl amines as glycogen synthase kinase 3beta inhibitors (gsk3 inhibitors) |
US20030187026A1 (en) | 2001-12-13 | 2003-10-02 | Qun Li | Kinase inhibitors |
EP2399903A1 (en) | 2002-05-24 | 2011-12-28 | Millennium Pharmaceuticals, Inc. | Ccr9 inhibitors and methods of use thereof |
AU2003259749A1 (en) * | 2002-08-12 | 2004-02-25 | Sugen, Inc. | 3-pyrrolyl-pyridopyrazoles and 3-pyrrolyl-indazoles as novel kinase inhibitors |
US7279576B2 (en) | 2002-12-31 | 2007-10-09 | Deciphera Pharmaceuticals, Llc | Anti-cancer medicaments |
US7202257B2 (en) | 2003-12-24 | 2007-04-10 | Deciphera Pharmaceuticals, Llc | Anti-inflammatory medicaments |
AP2005003365A0 (en) | 2003-02-07 | 2005-09-30 | Janssen Pharmaceutica Nv | Hiv inhibiting 1, 2, 4-triazines. |
DE602004013427T2 (de) | 2003-02-28 | 2009-06-04 | Schering Corp. | Biaryltetrahydroisochinolin-piperidine als selektive mch-rezeptor-antagonisten zur behandlung von adipositas und verwandten erkrankungen |
WO2004096130A2 (en) * | 2003-04-24 | 2004-11-11 | Merck & Co., Inc. | Inhibitors of akt activity |
US20050203067A1 (en) | 2003-05-12 | 2005-09-15 | Hresko Michelle C. | Pesticidal compositions and methods |
WO2005000813A1 (en) | 2003-05-30 | 2005-01-06 | Imclone Systems Incorporated | Heteroarylamino-phenylketone derivatives and their use as kinase inhibitors |
EP1660087A2 (en) | 2003-07-22 | 2006-05-31 | Janssen Pharmaceutica N.V. | Quinolinone derivatives as inhibitors of c-fms kinase |
DE602004031641D1 (de) | 2003-09-25 | 2011-04-14 | Janssen Pharmaceutica Nv | Die replikation von hiv hemmende purinderivate |
JP4948173B2 (ja) | 2003-10-10 | 2012-06-06 | ニツポネツクス・インコーポレーテツド | 過剰増殖性疾患治療用ピリミジン誘導体 |
EP1894917B1 (en) | 2003-12-22 | 2010-01-20 | Basilea Pharmaceutica AG | Aryloxy- and arylthioxyacetophenone-type compounds for the treatment of cancer |
ES2398712T3 (es) * | 2004-03-30 | 2013-03-21 | Vertex Pharmaceuticals Incorporated | Azaindoles útiles como inhibidores de JAK y otras proteínas quinasas |
AR049333A1 (es) * | 2004-04-02 | 2006-07-19 | Vertex Pharma | Azaindoles inhibidores de proteinquinasas rock y otras proteinas quinasas. composiciones farmaceuticas. |
US20070275954A1 (en) | 2004-05-19 | 2007-11-29 | Astrazeneca Ab | Novel Fused Heterocycles and Uses Thereof |
US7709645B2 (en) | 2004-07-27 | 2010-05-04 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
US7626021B2 (en) * | 2004-07-27 | 2009-12-01 | Sgx Pharmaceuticals, Inc. | Fused ring heterocycle kinase modulators |
BRPI0513916A (pt) | 2004-07-27 | 2008-05-20 | Sgx Pharmaceuticals Inc | moduladores de pirrol-piridina cinase |
US7361764B2 (en) | 2004-07-27 | 2008-04-22 | Sgx Pharmaceuticals, Inc. | Pyrrolo-pyridine kinase modulators |
US20090227799A1 (en) | 2004-08-09 | 2009-09-10 | Kazutaka Nakamoto | Novel Antimalarial Agent Containing Heterocyclic Compound |
WO2006058074A1 (en) * | 2004-11-22 | 2006-06-01 | Vertex Pharmaceuticals Incorporated | Pyrrolopyrazines and pyrazolopyrazines useful as inhibitors of protein kinases |
DE602006014502D1 (de) | 2005-01-14 | 2010-07-08 | Janssen Pharmaceutica Nv | Pyrazolopyrimidine als zellzyklus-kinasehemmer |
US7622583B2 (en) | 2005-01-14 | 2009-11-24 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2 |
BRPI0609719B8 (pt) | 2005-03-23 | 2021-05-25 | Hoffmann La Roche | derivados de acetilenil-pirazol-pirimidina como antagonistas de mgbur2 |
EP1871369A4 (en) | 2005-04-04 | 2009-11-11 | Eisai R&D Man Co Ltd | DIHYDROPYRIDINE COMPOUNDS AND COMPOSITIONS FOR HEADACHES |
KR20080004584A (ko) | 2005-04-08 | 2008-01-09 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 불수의 운동 치료제 |
ES2345629T3 (es) * | 2005-05-16 | 2010-09-28 | Irm Llc | Derivados de pirrolopiridina como inhibidores de proteina quinasas. |
US7547782B2 (en) | 2005-09-30 | 2009-06-16 | Bristol-Myers Squibb Company | Met kinase inhibitors |
TWI424999B (zh) * | 2006-01-17 | 2014-02-01 | Vertex Pharma | 適合作為傑納斯激酶(janus kinase)抑制劑之氮雜吲哚 |
US8519135B2 (en) | 2006-07-14 | 2013-08-27 | Chemocentryx, Inc. | Heteroaryl sulfonamides and CCR2/CCR9 |
WO2008094992A2 (en) | 2007-01-31 | 2008-08-07 | Vertex Pharmaceuticals Incorporated | 2-aminopyridine derivatives useful as kinase inhibitors |
-
2009
- 2009-07-22 ES ES09790729T patent/ES2402087T3/es active Active
- 2009-07-22 CA CA 2731451 patent/CA2731451A1/en not_active Abandoned
- 2009-07-22 NZ NZ59078409A patent/NZ590784A/xx not_active IP Right Cessation
- 2009-07-22 CN CN2009801327338A patent/CN102131807B/zh not_active Expired - Fee Related
- 2009-07-22 AU AU2009274011A patent/AU2009274011B2/en not_active Ceased
- 2009-07-22 KR KR20117004090A patent/KR20110039563A/ko not_active Application Discontinuation
- 2009-07-22 WO PCT/US2009/051413 patent/WO2010011756A1/en active Application Filing
- 2009-07-22 EP EP20090790729 patent/EP2318407B1/en active Active
- 2009-07-22 JP JP2011520166A patent/JP2011529062A/ja not_active Withdrawn
- 2009-07-22 MX MX2011000839A patent/MX2011000839A/es active IP Right Grant
-
2011
- 2011-01-23 IL IL210821A patent/IL210821A0/en unknown
- 2011-09-28 HK HK11110226A patent/HK1156026A1/xx not_active IP Right Cessation
- 2011-12-01 US US13/308,609 patent/US9137973B2/en active Active
-
2013
- 2013-09-18 US US14/030,153 patent/US9029546B2/en active Active
-
2014
- 2014-08-14 JP JP2014165108A patent/JP2014237702A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
CN102131807B (zh) | 2013-11-20 |
ES2402087T3 (es) | 2013-04-26 |
WO2010011756A1 (en) | 2010-01-28 |
IL210821A0 (en) | 2011-04-28 |
CA2731451A1 (en) | 2010-01-28 |
CN102131807A (zh) | 2011-07-20 |
JP2014237702A (ja) | 2014-12-18 |
MX2011000839A (es) | 2011-04-05 |
EP2318407B1 (en) | 2013-01-02 |
US9029546B2 (en) | 2015-05-12 |
EP2318407A1 (en) | 2011-05-11 |
JP2011529062A (ja) | 2011-12-01 |
NZ590784A (en) | 2012-12-21 |
US20140148434A1 (en) | 2014-05-29 |
AU2009274011B2 (en) | 2014-12-18 |
AU2009274011A1 (en) | 2010-01-28 |
KR20110039563A (ko) | 2011-04-19 |
US20120184524A1 (en) | 2012-07-19 |
US9137973B2 (en) | 2015-09-22 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HUS1900014I1 (hu) | Proteinkináz inhibitorok | |
HK1219950A1 (zh) | 作爲激酶抑制劑的吡咯並吡啶 | |
HK1156026A1 (en) | Pyrazolopyridine kinase inhibitors | |
ZA201004942B (en) | Ptrrolopyrazine kinase inhibitors | |
HK1179477A1 (en) | Kinase inhibitors | |
ZA201203842B (en) | Kinase inhibitors | |
HRP20130787T1 (xx) | Imidazopiridazinkarbonitrili korisni kao inhibitori kinaza | |
HRP20130698T1 (xx) | Novi fenilpirazinoni kao inhibitori kinaze | |
IL211549A0 (en) | Aminotriazolopyridines and their use as kinase inhibitors | |
EP2346508A4 (en) | HETEROCYCLIC INHIBITORS OF KINASES | |
EP2558099A4 (en) | Kinase Inhibitors | |
IL210073A0 (en) | Protein kinase inhibitors | |
EP2396004A4 (en) | SELECTIVE KINASE HEMMER | |
IL210069A0 (en) | Protein kinase inhibitors | |
IL212842A0 (en) | Azaindole derivatives as kinase inhibitors | |
EP2515657A4 (en) | TYROSINE KINASE INHIBITORS | |
EP2231152A4 (en) | THIENOPYRANONES AS KINASE INHIBITORS | |
EP2480076A4 (en) | IMIDAZOTHIAZOLIC INHIBITORS OF KINASES | |
ZA201102837B (en) | Phosphodiestarase inhibitors | |
GB0914726D0 (en) | Kinase inhibitors | |
GB201019387D0 (en) | Inhibitors | |
GB0803891D0 (en) | Glyoxalase inhibitors | |
GB0807642D0 (en) | IKK- serine-threonine protein kinase inhibitors |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20180722 |