HK1155734A1 - 用作丙型肝炎病毒抑制劑的大環吲哚衍生物 - Google Patents

用作丙型肝炎病毒抑制劑的大環吲哚衍生物

Info

Publication number
HK1155734A1
HK1155734A1 HK11109936.5A HK11109936A HK1155734A1 HK 1155734 A1 HK1155734 A1 HK 1155734A1 HK 11109936 A HK11109936 A HK 11109936A HK 1155734 A1 HK1155734 A1 HK 1155734A1
Authority
HK
Hong Kong
Prior art keywords
hepatitis
indole derivatives
derivatives useful
virus inhibitors
macrocyclic indole
Prior art date
Application number
HK11109936.5A
Other languages
English (en)
Inventor
Sandrine Marie Hlne Vendeville
Pierre Jean-Marie Bernard Raboisson
Tse-I Lin
Abdellah Tahri
Katie Ingrid Eduard Amssoms
Original Assignee
Janssen R & D Ireland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen R & D Ireland filed Critical Janssen R & D Ireland
Publication of HK1155734A1 publication Critical patent/HK1155734A1/zh

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D515/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D515/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen, oxygen, and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D515/18—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK11109936.5A 2008-07-08 2011-09-21 用作丙型肝炎病毒抑制劑的大環吲哚衍生物 HK1155734A1 (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP08159965 2008-07-08
EP08160254 2008-07-11
EP08161743 2008-08-04
PCT/EP2009/004942 WO2010003658A1 (en) 2008-07-08 2009-07-08 Macrocyclic indole derivatives useful as hepatitis c virus inhibitors

Publications (1)

Publication Number Publication Date
HK1155734A1 true HK1155734A1 (zh) 2012-05-25

Family

ID=40972916

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11109936.5A HK1155734A1 (zh) 2008-07-08 2011-09-21 用作丙型肝炎病毒抑制劑的大環吲哚衍生物

Country Status (32)

Country Link
US (2) US8921355B2 (zh)
EP (1) EP2310396B1 (zh)
JP (2) JP5426671B2 (zh)
KR (1) KR101640374B1 (zh)
CN (1) CN102089314B (zh)
AP (1) AP2743A (zh)
AR (1) AR072726A1 (zh)
AU (1) AU2009267389B8 (zh)
BR (1) BRPI0915887B8 (zh)
CA (1) CA2729307C (zh)
CL (1) CL2011000032A1 (zh)
CO (1) CO6351793A2 (zh)
CR (1) CR20110076A (zh)
DK (1) DK2310396T3 (zh)
EA (1) EA019008B1 (zh)
EC (1) ECSP11010750A (zh)
ES (1) ES2651038T3 (zh)
HK (1) HK1155734A1 (zh)
HN (1) HN2011000072A (zh)
HR (1) HRP20171892T1 (zh)
HU (1) HUE035244T2 (zh)
IL (1) IL210086A (zh)
LT (1) LT2310396T (zh)
MX (1) MX2011000276A (zh)
NI (1) NI201100010A (zh)
NO (1) NO2310396T3 (zh)
NZ (2) NZ603343A (zh)
SI (1) SI2310396T1 (zh)
SV (1) SV2011003796A (zh)
TW (1) TWI454476B (zh)
UY (1) UY31973A (zh)
WO (1) WO2010003658A1 (zh)

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BRPI0821836A2 (pt) 2007-12-24 2015-06-16 Tibotec Pharm Ltd Indóis macrocíclicos como inibidores do vírus da hepatite c
TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
UA108211C2 (uk) * 2009-11-04 2015-04-10 Янссен Рід Айрленд Бензімідазолімідазольні похідні
CN102844028B (zh) * 2010-04-13 2016-04-06 杨森制药公司 Hcv大环抑制剂、非核苷和核苷的组合
EP2585438B1 (en) * 2010-06-24 2014-08-20 Janssen R&D Ireland PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
EP2760821B1 (en) 2011-09-02 2017-10-11 Novartis AG Choline salt of an anti-inflammatory substituted cyclobutenedione compound
US8716275B2 (en) * 2011-10-20 2014-05-06 Bristol-Myers Squibb Company Compound for the treatment of hepatitis C
RU2015111491A (ru) 2012-08-31 2016-10-20 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора протеазы hcv, ненуклеозидного ингибитора hcv и ритонавира
WO2014152275A1 (en) * 2013-03-14 2014-09-25 Concert Pharmaceuticals, Inc. Deuterium modified derivatives of the ns5b polymerase inhibitor tmc647055
US10450263B2 (en) 2017-02-10 2019-10-22 Southern Research Institute Benzo annulenes as antiviral agents
KR101974388B1 (ko) 2017-06-23 2019-05-02 (주)에니켐텍 알킬 디에틸렌 트리아민 유도체 및 이의 제조방법
US11066357B2 (en) 2017-12-26 2021-07-20 Southern Research Institute Benzoannulene derivatives as antiviral agents
US12060148B2 (en) 2022-08-16 2024-08-13 Honeywell International Inc. Ground resonance detection and warning system and method

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NZ332405A (en) 1996-04-23 2000-06-23 Vertex Pharma oxazolyl, thiazolyl or phenyl urea derivatives as inhibitors of inosine monophosphate dehydrogenase enzyme
ES2201452T3 (es) 1997-03-14 2004-03-16 Vertex Pharmaceuticals Incorporated Inhibidores de la enzima impdh.
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JP4778665B2 (ja) 2000-08-30 2011-09-21 パナソニック株式会社 プラズマディスプレイ表示装置の製造方法
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US7153848B2 (en) * 2004-08-09 2006-12-26 Bristol-Myers Squibb Company Inhibitors of HCV replication
PE20070211A1 (es) 2005-07-29 2007-05-12 Medivir Ab Compuestos macrociclicos como inhibidores del virus de hepatitis c
JP2009507004A (ja) 2005-09-02 2009-02-19 テイボテク・フアーマシユーチカルズ・リミテツド Ｈｃｖ阻害剤としてのベンゾジアゼピン
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GB0522881D0 (en) 2005-11-10 2005-12-21 Angeletti P Ist Richerche Bio Therapeutic compounds
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TWI454476B (zh) * 2008-07-08 2014-10-01 Tibotec Pharm Ltd 用作ｃ型肝炎病毒抑制劑之巨環吲哚衍生物
TW201023858A (en) 2008-09-18 2010-07-01 Ortho Mcneil Janssen Pharm Synergistic combinations of a macrocyclic inhibitor of HCV and a nucleoside
HUE031738T2 (en) 2009-02-27 2017-07-28 Janssen Pharmaceuticals Inc Amorphous salts of the HCV macrocyclic inhibitor
CN102844028B (zh) 2010-04-13 2016-04-06 杨森制药公司 Hcv大环抑制剂、非核苷和核苷的组合
EP2585438B1 (en) 2010-06-24 2014-08-20 Janssen R&D Ireland PREPARATION OF 13-CYCLOHEXYL-3-METHOXY-6-[METHYL-(2-{2-[METHYL-(SULPHAMOYL)-AMINO]-ETHOXY}-ETHYL)-CARBAMOYL]-7H-INDOLO-[2,1-a]-[2]-BENZAZEPINE-10-CARBOXYLIC ACID
RU2015111491A (ru) 2012-08-31 2016-10-20 Янссен Фармасьютикалз, Инк. Комбинация макроциклического ингибитора протеазы hcv, ненуклеозидного ингибитора hcv и ритонавира

Also Published As

Publication number Publication date
HN2011000072A (es) 2013-09-01
TWI454476B (zh) 2014-10-01
CN102089314B (zh) 2014-07-23
US8921355B2 (en) 2014-12-30
HRP20171892T1 (hr) 2018-01-12
ECSP11010750A (es) 2011-08-31
IL210086A0 (en) 2011-02-28
EP2310396B1 (en) 2017-09-06
US9427440B2 (en) 2016-08-30
UY31973A (es) 2010-01-29
EP2310396A1 (en) 2011-04-20
CA2729307A1 (en) 2010-01-14
TW201014865A (en) 2010-04-16
US20110105473A1 (en) 2011-05-05
NZ590073A (en) 2012-11-30
DK2310396T3 (en) 2017-12-11
NO2310396T3 (zh) 2018-02-03
JP5426671B2 (ja) 2014-02-26
SI2310396T1 (en) 2018-01-31
AP2743A (en) 2013-09-30
BRPI0915887A2 (pt) 2015-11-03
CL2011000032A1 (es) 2011-07-15
LT2310396T (lt) 2017-12-27
JP2014028818A (ja) 2014-02-13
BRPI0915887B8 (pt) 2021-05-25
NZ603343A (en) 2013-08-30
KR101640374B1 (ko) 2016-07-18
EA201170153A1 (ru) 2011-08-30
EA019008B1 (ru) 2013-12-30
NI201100010A (es) 2011-09-07
AP2010005521A0 (en) 2010-12-31
SV2011003796A (es) 2011-04-08
ES2651038T3 (es) 2018-01-23
AR072726A1 (es) 2010-09-15
AU2009267389B2 (en) 2013-05-30
CO6351793A2 (es) 2011-12-20
IL210086A (en) 2014-05-28
US20140107101A1 (en) 2014-04-17
KR20110040889A (ko) 2011-04-20
AU2009267389B8 (en) 2013-07-04
BRPI0915887B1 (pt) 2020-02-18
WO2010003658A1 (en) 2010-01-14
CA2729307C (en) 2017-08-29
MX2011000276A (es) 2011-03-02
CR20110076A (es) 2011-11-10
HUE035244T2 (hu) 2018-05-02
JP5808370B2 (ja) 2015-11-10
JP2011527299A (ja) 2011-10-27
AU2009267389A8 (en) 2013-07-04
AU2009267389A1 (en) 2010-01-14
CN102089314A (zh) 2011-06-08

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