HK1152898A1 - Beta turn peptidomimetic cyclic compounds for treating dry eye - Google Patents

Beta turn peptidomimetic cyclic compounds for treating dry eye

Info

Publication number
HK1152898A1
HK1152898A1 HK11107167.9A HK11107167A HK1152898A1 HK 1152898 A1 HK1152898 A1 HK 1152898A1 HK 11107167 A HK11107167 A HK 11107167A HK 1152898 A1 HK1152898 A1 HK 1152898A1
Authority
HK
Hong Kong
Prior art keywords
dry eye
cyclic compounds
treating dry
beta turn
peptidomimetic cyclic
Prior art date
Application number
HK11107167.9A
Other languages
English (en)
Chinese (zh)
Inventor
Garth Cumberlidge
Karen Meerovitch
Teresa Lama
Uri H Saragovi
Original Assignee
Mimetogen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimetogen Pharmaceuticals Inc filed Critical Mimetogen Pharmaceuticals Inc
Publication of HK1152898A1 publication Critical patent/HK1152898A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK11107167.9A 2008-04-04 2011-07-11 Beta turn peptidomimetic cyclic compounds for treating dry eye HK1152898A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12303608P 2008-04-04 2008-04-04
US20887309P 2009-02-27 2009-02-27
PCT/US2009/002121 WO2009123761A1 (fr) 2008-04-04 2009-04-03 Composés cycliques peptidomimétiques à spire bêta utilisés pour traiter l'œil sec

Publications (1)

Publication Number Publication Date
HK1152898A1 true HK1152898A1 (en) 2012-03-16

Family

ID=40897413

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11107167.9A HK1152898A1 (en) 2008-04-04 2011-07-11 Beta turn peptidomimetic cyclic compounds for treating dry eye

Country Status (10)

Country Link
US (4) US8293713B2 (fr)
EP (1) EP2271337B1 (fr)
JP (2) JP5480242B2 (fr)
KR (1) KR101565185B1 (fr)
CN (1) CN102046166B (fr)
AU (1) AU2009232352B2 (fr)
CA (1) CA2720141C (fr)
ES (1) ES2521515T3 (fr)
HK (1) HK1152898A1 (fr)
WO (1) WO2009123761A1 (fr)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102046166B (zh) 2008-04-04 2012-10-17 米梅托根药物公司 用于治疗干眼症的β-转角模拟肽环状化合物
CN104619717B (zh) * 2012-06-22 2019-04-02 米梅奥亨制药公司 β-转角模拟肽环状化合物的合成
KR20150004652A (ko) 2013-07-03 2015-01-13 삼성디스플레이 주식회사 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법
JP6267003B2 (ja) * 2014-02-27 2018-01-24 参天製薬株式会社 ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤
CN113230021A (zh) 2015-01-12 2021-08-10 科达莱昂治疗公司 微滴递送设备和方法
EP3253433A4 (fr) 2015-04-10 2018-08-22 Kedalion Therapeutics, Inc. Distributeur piézoélectrique avec ampoule remplaçable
CA2991661A1 (fr) 2015-07-09 2017-01-12 Mimetogen Pharmaceuticals, Inc. Synthese en phase de solution et cristallisation de sels cycliques peptidomimetiques a coude beta
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
JP2019507193A (ja) 2016-03-04 2019-03-14 ジェームズ・エム・ライナーソン 細菌のバイオフィルム形成を阻止又は妨害することによって眼障害を治療する方法
CA3039106A1 (fr) 2017-01-20 2018-07-26 Kedalion Therapeutics, Inc. Distributeur de fluide piezoelectrique
WO2019113483A1 (fr) 2017-12-08 2019-06-13 Kedalion Therapeutics, Inc. Système d'alignement pour administration de fluide
CN110092799B (zh) * 2018-01-29 2021-11-12 广州丹康医药生物有限公司 一种环状化合物、其制备方法和应用
US12097145B2 (en) 2019-03-06 2024-09-24 Bausch + Lomb Ireland Limited Vented multi-dose ocular fluid delivery system
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US11925577B2 (en) 2020-04-17 2024-03-12 Bausch + Lomb Ireland Limted Hydrodynamically actuated preservative free dispensing system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
WO2021212038A1 (fr) 2020-04-17 2021-10-21 Kedalion Therapeutics, Inc. Système de distribution sans conservateur à actionnement hydrodynamique comprenant un réservoir de liquide pliable
JP2024520670A (ja) * 2021-06-02 2024-05-24 ザ テキサス エーアンドエム ユニヴァーシティ システム Ｔｒｋ受容体の選択的小分子アゴニスト及び部分アゴニスト
KR20240108412A (ko) * 2021-10-20 2024-07-09 스텔스 바이오테라퓨틱스 인코포레이티드 안과 병태를 치료하거나, 예방하거나, 억제하거나, 경감하거나 발병을 지연시키기 위한 방법 및 펩타이드 모방체를 포함하는 조성물
WO2023069255A1 (fr) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Procédés et compositions comprenant des peptidomimétiques pour le traitement, la prévention, l'inhibition, l'amélioration ou le retardement de l'apparition d'affections ophtalmiques

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5545617A (en) 1993-11-12 1996-08-13 The Schepens Eye Research Institute, Inc. Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
KR20010033484A (ko) * 1997-12-22 2001-04-25 휴먼 게놈 사이언시즈, 인크. 각질세포 성장 인자-2 제제
JP2001064198A (ja) 1999-08-24 2001-03-13 Teika Seiyaku Kk 角膜疾患治療剤
ATE340571T1 (de) 2000-01-18 2006-10-15 Univ Mcgill Pharmazeutische zubereitungen enthaltend beta- turn peptidomimetische zyklische substanzen
ATE423135T1 (de) 2005-06-13 2009-03-15 Primm Srl Heterodimere peptide mit ngf aktivität und deren verwendung zur behandlung von neurodegenerativen krankheiten
EP1921087A1 (fr) 2006-11-10 2008-05-14 Primm S.R.L. Procede de preparation des peptides cycliques
CA2671613C (fr) 2006-12-05 2018-07-03 The Royal Institution For The Advancement Of Learning/Mcgill University Procedes d'utilisation de modulateurs de recepteur trk
CN102046166B (zh) 2008-04-04 2012-10-17 米梅托根药物公司 用于治疗干眼症的β-转角模拟肽环状化合物
AU2010217889B2 (en) * 2009-02-27 2014-12-18 Mimetogen Pharmaceuticals Inc. Peptidomimetic cyclic compounds for treating retinitis pigmentosa
CN104619717B (zh) * 2012-06-22 2019-04-02 米梅奥亨制药公司 β-转角模拟肽环状化合物的合成

Also Published As

Publication number Publication date
CN102046166B (zh) 2012-10-17
EP2271337B1 (fr) 2014-09-03
EP2271337A1 (fr) 2011-01-12
CA2720141C (fr) 2014-01-28
ES2521515T3 (es) 2014-11-12
CN102046166A (zh) 2011-05-04
AU2009232352B2 (en) 2013-09-05
US20120322747A1 (en) 2012-12-20
JP2014080447A (ja) 2014-05-08
JP5870348B2 (ja) 2016-02-24
US9707267B2 (en) 2017-07-18
KR20110010712A (ko) 2011-02-07
KR101565185B1 (ko) 2015-11-02
US20160082072A1 (en) 2016-03-24
US9156882B2 (en) 2015-10-13
CA2720141A1 (fr) 2009-10-08
US8748391B2 (en) 2014-06-10
US8293713B2 (en) 2012-10-23
JP5480242B2 (ja) 2014-04-23
AU2009232352A1 (en) 2009-10-08
JP2011516477A (ja) 2011-05-26
WO2009123761A1 (fr) 2009-10-08
US20140274910A1 (en) 2014-09-18
US20110105410A1 (en) 2011-05-05

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