HK1152898A1 - Beta turn peptidomimetic cyclic compounds for treating dry eye - Google Patents

Beta turn peptidomimetic cyclic compounds for treating dry eye

Info

Publication number
HK1152898A1
HK1152898A1 HK11107167.9A HK11107167A HK1152898A1 HK 1152898 A1 HK1152898 A1 HK 1152898A1 HK 11107167 A HK11107167 A HK 11107167A HK 1152898 A1 HK1152898 A1 HK 1152898A1
Authority
HK
Hong Kong
Prior art keywords
dry eye
cyclic compounds
treating dry
beta turn
peptidomimetic cyclic
Prior art date
Application number
HK11107167.9A
Other languages
English (en)
Chinese (zh)
Inventor
Garth Cumberlidge
Karen Meerovitch
Teresa Lama
Uri H Saragovi
Original Assignee
Mimetogen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mimetogen Pharmaceuticals Inc filed Critical Mimetogen Pharmaceuticals Inc
Publication of HK1152898A1 publication Critical patent/HK1152898A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/04—Artificial tears; Irrigation solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/12—Cyclic peptides with only normal peptide bonds in the ring
    • C07K5/123—Tripeptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Ophthalmology & Optometry (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
HK11107167.9A 2008-04-04 2011-07-11 Beta turn peptidomimetic cyclic compounds for treating dry eye HK1152898A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12303608P 2008-04-04 2008-04-04
US20887309P 2009-02-27 2009-02-27
PCT/US2009/002121 WO2009123761A1 (en) 2008-04-04 2009-04-03 Beta-turn peptidomimetic cyclic compounds for treating dry eye

Publications (1)

Publication Number Publication Date
HK1152898A1 true HK1152898A1 (en) 2012-03-16

Family

ID=40897413

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11107167.9A HK1152898A1 (en) 2008-04-04 2011-07-11 Beta turn peptidomimetic cyclic compounds for treating dry eye

Country Status (10)

Country Link
US (4) US8293713B2 (xx)
EP (1) EP2271337B1 (xx)
JP (2) JP5480242B2 (xx)
KR (1) KR101565185B1 (xx)
CN (1) CN102046166B (xx)
AU (1) AU2009232352B2 (xx)
CA (1) CA2720141C (xx)
ES (1) ES2521515T3 (xx)
HK (1) HK1152898A1 (xx)
WO (1) WO2009123761A1 (xx)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101565185B1 (ko) 2008-04-04 2015-11-02 미메토젠 파르마슈티칼스 인크. 건안증을 치료하기 위한 베타-턴 펩티도미메틱 환상 화합물
KR102061382B1 (ko) * 2012-06-22 2019-12-31 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 환상 화합물의 합성
KR20150004652A (ko) 2013-07-03 2015-01-13 삼성디스플레이 주식회사 표시 패널, 이를 포함하는 표시 장치 및 이를 이용하는 영상 표시 방법
JP6267003B2 (ja) * 2014-02-27 2018-01-24 参天製薬株式会社 ジクアホソルまたはその塩およびレバミピドまたはその塩を組み合わせたことを特徴とする涙液分泌促進剤
WO2016115050A1 (en) 2015-01-12 2016-07-21 Lagunita Llc Micro-droplet delivery device and methods
WO2016164830A1 (en) 2015-04-10 2016-10-13 Lagunita Llc Piezoelectric dispenser with replaceable ampoule
CN107849089B (zh) * 2015-07-09 2022-07-05 米梅奥亨制药公司 β-转角环状模拟肽盐的溶液相合成和结晶
KR101718733B1 (ko) 2015-08-21 2017-03-22 국제약품 주식회사 레바미피드의 가용화 방법 및 이에 의해 제조된 안구건조증 치료용 액제
WO2017152027A1 (en) 2016-03-04 2017-09-08 Rynerson James M Method of treating an eye disorder by inhibiting or disrupting bacterial biofilm formation
CA3039106A1 (en) 2017-01-20 2018-07-26 Kedalion Therapeutics, Inc. Piezoelectric fluid dispenser
JP7436363B2 (ja) 2017-12-08 2024-02-21 ノバルティス アーゲー 流体送達アライメントシステム
CN110092799B (zh) * 2018-01-29 2021-11-12 广州丹康医药生物有限公司 一种环状化合物、其制备方法和应用
US11679028B2 (en) 2019-03-06 2023-06-20 Novartis Ag Multi-dose ocular fluid delivery system
US11938057B2 (en) 2020-04-17 2024-03-26 Bausch + Lomb Ireland Limited Hydrodynamically actuated preservative free dispensing system
IL297215A (en) 2020-04-17 2022-12-01 Kedallon Therapeutics Inc A hydrodynamically activated preservative free distribution system
AU2022283808A1 (en) * 2021-06-02 2023-12-07 The Texas A&M University System Selective small molecule agonists and partial agonists of trk receptors
WO2023069549A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions
WO2023069255A1 (en) * 2021-10-20 2023-04-27 Stealth Biotherapeutics Inc. Methods and compositions comprising peptidomimitics for treating, preventing, inhibiting, ameliorating or delaying the onset of ophthalmic conditions

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8917217D0 (en) * 1989-07-27 1989-09-13 Smith & Nephew Ophthalmic compositions
US5545617A (en) * 1993-11-12 1996-08-13 The Schepens Eye Research Institute, Inc. Therapeutic regulation of abnormal conjunctival goblet cell mucous secretion
NZ505324A (en) * 1997-12-22 2002-11-26 Human Genome Sciences Inc Liquid and lyophilised KGF-2 polypeptide formulations used to accelerate soft tissue growth or regeneration
JP2001064198A (ja) * 1999-08-24 2001-03-13 Teika Seiyaku Kk 角膜疾患治療剤
US6881719B2 (en) * 2000-01-18 2005-04-19 Mcgill University β-turn peptidomimetic cyclic compounds
ATE423135T1 (de) 2005-06-13 2009-03-15 Primm Srl Heterodimere peptide mit ngf aktivität und deren verwendung zur behandlung von neurodegenerativen krankheiten
EP1921087A1 (en) 2006-11-10 2008-05-14 Primm S.R.L. Process for the preparation of cyclic peptides
CN101657212B (zh) * 2006-12-05 2014-03-19 皇家学习促进会/麦吉尔大学 Trk受体调节剂的使用方法
KR101565185B1 (ko) * 2008-04-04 2015-11-02 미메토젠 파르마슈티칼스 인크. 건안증을 치료하기 위한 베타-턴 펩티도미메틱 환상 화합물
KR20110130402A (ko) * 2009-02-27 2011-12-05 미메토젠 파르마슈티칼스 인크. 망막색소변성증의 치료를 위한 펩티도미메틱 고리화합물
KR102061382B1 (ko) * 2012-06-22 2019-12-31 미메토젠 파르마슈티칼스 인크. 베타-턴 펩티도미메틱 환상 화합물의 합성

Also Published As

Publication number Publication date
JP5480242B2 (ja) 2014-04-23
US9707267B2 (en) 2017-07-18
CN102046166A (zh) 2011-05-04
CN102046166B (zh) 2012-10-17
WO2009123761A1 (en) 2009-10-08
CA2720141C (en) 2014-01-28
KR101565185B1 (ko) 2015-11-02
ES2521515T3 (es) 2014-11-12
AU2009232352A1 (en) 2009-10-08
JP5870348B2 (ja) 2016-02-24
US9156882B2 (en) 2015-10-13
CA2720141A1 (en) 2009-10-08
KR20110010712A (ko) 2011-02-07
US20140274910A1 (en) 2014-09-18
US20160082072A1 (en) 2016-03-24
EP2271337B1 (en) 2014-09-03
US20120322747A1 (en) 2012-12-20
AU2009232352B2 (en) 2013-09-05
JP2011516477A (ja) 2011-05-26
US8293713B2 (en) 2012-10-23
EP2271337A1 (en) 2011-01-12
US8748391B2 (en) 2014-06-10
US20110105410A1 (en) 2011-05-05
JP2014080447A (ja) 2014-05-08

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