HK1151068A1 - Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life viii von willebrand - Google Patents
Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life viii von willebrandInfo
- Publication number
- HK1151068A1 HK1151068A1 HK11105187.9A HK11105187A HK1151068A1 HK 1151068 A1 HK1151068 A1 HK 1151068A1 HK 11105187 A HK11105187 A HK 11105187A HK 1151068 A1 HK1151068 A1 HK 1151068A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- von willebrand
- viii
- factor
- complexes
- prolonged
- Prior art date
Links
- 108010047303 von Willebrand Factor Proteins 0.000 title 2
- 229960000301 factor viii Drugs 0.000 title 1
- 238000001727 in vivo Methods 0.000 title 1
- 230000002035 prolonged effect Effects 0.000 title 1
- 102100036537 von Willebrand factor Human genes 0.000 title 1
- 229960001134 von willebrand factor Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/76—Albumins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Hematology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Gastroenterology & Hepatology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Wood Science & Technology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP08011429 | 2008-06-24 | ||
PCT/EP2009/004549 WO2009156137A1 (en) | 2008-06-24 | 2009-06-24 | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1151068A1 true HK1151068A1 (en) | 2012-01-20 |
Family
ID=40042814
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK11105187.9A HK1151068A1 (en) | 2008-06-24 | 2011-05-24 | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life viii von willebrand |
Country Status (13)
Country | Link |
---|---|
US (2) | US8575104B2 (ko) |
EP (2) | EP2291523B1 (ko) |
JP (1) | JP5832285B2 (ko) |
KR (2) | KR101648734B1 (ko) |
CN (2) | CN102076855A (ko) |
AU (1) | AU2009262476C1 (ko) |
CA (1) | CA2728012C (ko) |
DK (2) | DK2865760T3 (ko) |
ES (2) | ES2654336T3 (ko) |
HK (1) | HK1151068A1 (ko) |
PL (1) | PL2291523T3 (ko) |
RU (1) | RU2528855C2 (ko) |
WO (1) | WO2009156137A1 (ko) |
Families Citing this family (46)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6263355A (ja) * | 1985-09-13 | 1987-03-20 | Hitachi Ltd | バツテリバツクアツプramのチエツク方法 |
ES2654336T3 (es) | 2008-06-24 | 2018-02-13 | Csl Behring Gmbh | Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada |
US8716448B2 (en) | 2009-02-03 | 2014-05-06 | Amunix Operating Inc. | Coagulation factor VII compositions and methods of making and using same |
US8759293B2 (en) * | 2009-11-13 | 2014-06-24 | Grifols Therapeutics Inc. | von Willebrand factor (vWF)-containing preparations, and methods, kits, and uses related thereto |
JP5914363B2 (ja) * | 2010-02-16 | 2016-05-11 | ノヴォ ノルディスク アー/エス | 低減されたvwf結合を有する因子viii分子 |
CN102812039B (zh) * | 2010-02-16 | 2016-01-20 | 诺沃—诺迪斯克有限公司 | 缀合蛋白质 |
CN105153313A (zh) * | 2010-02-16 | 2015-12-16 | 诺沃—诺迪斯克有限公司 | 因子viii融合蛋白 |
US8772462B2 (en) | 2010-05-26 | 2014-07-08 | Baxter International Inc. | Removal of serine proteases by treatment with finely divided silicon dioxide |
AU2010202125B1 (en) | 2010-05-26 | 2010-09-02 | Takeda Pharmaceutical Company Limited | A method to produce an immunoglobulin preparation with improved yield |
EP3858375B1 (en) * | 2011-06-10 | 2024-03-20 | Takeda Pharmaceutical Company Limited | Treatment of coagulation disease by administration of recombinant vwf |
NZ626945A (en) * | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
CN104254603A (zh) * | 2012-02-14 | 2014-12-31 | 博尔托拉制药公司 | 用于制备xa因子抑制剂的重组解毒剂的方法 |
CN111548418A (zh) | 2012-02-15 | 2020-08-18 | 比奥贝拉蒂治疗公司 | 因子viii组合物及其制备和使用方法 |
US9458223B2 (en) | 2012-02-15 | 2016-10-04 | Csl Behring Gmbh | Von willebrand factor variants having improved factor VIII binding affinity |
KR20190094480A (ko) | 2012-02-15 | 2019-08-13 | 바이오버라티브 테라퓨틱스 인크. | 재조합 인자 viii 단백질 |
US20150080309A1 (en) | 2012-04-24 | 2015-03-19 | Nova Nordisk A/S | Compounds Suitable for Treatment of Haemophilia |
PT2882450T (pt) * | 2012-07-11 | 2020-02-19 | Bioverativ Therapeutics Inc | Complexo de fator viii com xten e a proteína fator de von willebrand, e utilizações do mesmo |
EP2796145B1 (en) * | 2013-04-22 | 2017-11-01 | CSL Ltd. | A covalent complex of von willebrand factor and faktor viii linked by a disulphide bridge |
WO2014210546A1 (en) | 2013-06-27 | 2014-12-31 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
US20160229903A1 (en) * | 2013-06-28 | 2016-08-11 | Biogen Ma Inc. | Thrombin cleavable linker |
IL297611A (en) * | 2013-06-28 | 2022-12-01 | Bioverativ Therapeutics Inc | Binding of thrombin that degrades with castane and uses thereof |
TW202003554A (zh) | 2013-08-14 | 2020-01-16 | 美商百歐維拉提夫治療公司 | 因子viii-xten融合物及其用途 |
WO2015066769A1 (en) | 2013-11-08 | 2015-05-14 | Csl Ltd. | New method to concentrate von willebrand factor or complexes thereof |
SI3091997T1 (sl) * | 2014-01-10 | 2022-10-28 | Bioverativ Therapeutics Inc. | Himerni proteini faktorja VIII in njihova uporaba |
AU2015274238B2 (en) | 2014-06-13 | 2020-11-05 | Csl Limited | Improved production of recombinant von Willebrand factor in a bioreactor |
DE102014011653A1 (de) * | 2014-06-20 | 2015-12-24 | Ulrich Loos | Nachweis von Autoantikörpern gegen den TSH-Rezeptor |
KR20170026580A (ko) | 2014-07-02 | 2017-03-08 | 씨에스엘 리미티드 | 변형된 폰 빌레브란트 인자 |
US10626164B2 (en) | 2014-07-25 | 2020-04-21 | Csl Limited | Purification of VWF |
SG11201706659WA (en) | 2015-03-06 | 2017-09-28 | Csl Behring Recombinant Facility Ag | Modified von willebrand factor having improved half-life |
RU2017145002A (ru) | 2015-05-22 | 2019-06-24 | Цсл Беринг Ленгнау Аг | Способы получения модифицированного фактора фон виллебранда |
AU2016266627A1 (en) | 2015-05-22 | 2018-01-18 | CSL Behring Lengnau AG | Truncated von Willebrand Factor polypeptides for treating hemophilia |
JP6909203B2 (ja) | 2015-08-03 | 2021-07-28 | バイオベラティブ セラピューティクス インコーポレイテッド | 第ix因子融合タンパク質及びそれらの製造方法及び使用方法 |
WO2017112895A1 (en) * | 2015-12-23 | 2017-06-29 | Haplomics, Inc. | F8 gene repair |
RU2018128582A (ru) * | 2016-01-07 | 2020-02-11 | Цсл Беринг Ленгнау Аг | Мутированный укороченный фактор фон виллебранда |
ES2881701T3 (es) * | 2016-01-07 | 2021-11-30 | CSL Behring Lengnau AG | Factor de von Willebrand mutado |
US20190169268A1 (en) * | 2016-05-20 | 2019-06-06 | Octapharma Ag | Glycosylated vwf fusion proteins with improved pharmacokinetics |
JP6877469B2 (ja) * | 2016-06-24 | 2021-05-26 | モガム・インスティテュート・フォー・バイオメディカル・リサーチMogam Institute For Biomedical Research | Fviiiおよびvwf因子を含むキメラタンパク質、ならびにそれらの使用 |
TW201828974A (zh) | 2016-11-11 | 2018-08-16 | 瑞士商Csl貝林重組技能公司 | 用於血管外施予以治療或預防凝血疾病之截短型類血友病因子(von Willebrand factor)多肽類 |
KR20190085021A (ko) | 2016-11-11 | 2019-07-17 | 체에스엘 베링 렝나우 아게 | 혈우병을 치료하기 위한 절단된 폰 빌레브란트 인자 폴리펩타이드 |
KR20200018690A (ko) | 2017-06-22 | 2020-02-19 | 체에스엘 베링 렝나우 아게 | 절단된 vwf에 의한 fviii 면역원성의 조절 |
AU2018298232A1 (en) * | 2017-07-07 | 2020-01-30 | Takeda Pharmaceutical Company Limited | Treatment of patients with severe von willebrand disease undergoing elective surgery by administration of recombinant VWF |
CA3069295A1 (en) | 2017-07-07 | 2019-01-10 | Baxalta Incorporated | Treatment of gastrointestinal bleeding in patients with severe von willebrand disease by administration of recombinant vwf |
KR20200038309A (ko) | 2017-08-23 | 2020-04-10 | 체에스엘 베링 게엠베하 | 폰 빌레브란트 인자의 바이러스 여과 방법 |
WO2019222682A1 (en) | 2018-05-18 | 2019-11-21 | Bioverativ Therapeutics Inc. | Methods of treating hemophilia a |
BR112021012318A2 (pt) * | 2018-12-23 | 2022-01-18 | Csl Behring Llc | Células t doadoras com interruptor de eliminação |
CN111592591B (zh) * | 2020-06-17 | 2021-12-14 | 博雅生物制药集团股份有限公司 | 一种人血管性血友病因子/人凝血因子ⅷ复合物的制备方法及产物和应用 |
Family Cites Families (44)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4970300A (en) * | 1985-02-01 | 1990-11-13 | New York University | Modified factor VIII |
FR2673632A1 (fr) * | 1991-03-08 | 1992-09-11 | Lille Transfusion Sanguine | Procede de preparation de concentre de facteur von willebrand humain de tres haute purete, approprie a un usage therapeutique. |
FR2686899B1 (fr) * | 1992-01-31 | 1995-09-01 | Rhone Poulenc Rorer Sa | Nouveaux polypeptides biologiquement actifs, leur preparation et compositions pharmaceutiques les contenant. |
US5364771A (en) * | 1992-04-07 | 1994-11-15 | Emory University | Hybrid human/porcine factor VIII |
AU6029594A (en) | 1993-01-15 | 1994-08-15 | Enzon, Inc. | Factor viii - polymeric conjugates |
DE4435485C1 (de) * | 1994-10-04 | 1996-03-21 | Immuno Ag | Verfahren zur Gewinnung von hochreinem von Willebrand-Faktor |
CA2205572A1 (en) | 1994-12-12 | 1996-06-20 | Beth Israel Hospital Association | Chimeric cytokines and uses thereof |
WO1997003193A1 (en) | 1995-07-11 | 1997-01-30 | Chiron Corporation | Novel factor viii:c polypeptide analogs with altered metal-binding properties |
SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
GB9526733D0 (en) | 1995-12-30 | 1996-02-28 | Delta Biotechnology Ltd | Fusion proteins |
AT403764B (de) * | 1996-03-15 | 1998-05-25 | Immuno Ag | Stabiler faktor viii/vwf-komplex |
US20040092442A1 (en) | 1996-04-24 | 2004-05-13 | University Of Michigan | Inactivation resistant factor VIII |
DE69740154D1 (de) | 1996-04-24 | 2011-05-05 | Univ Michigan | Gegen Inaktivierung resistenter Faktor VIII |
US6103077A (en) * | 1998-01-02 | 2000-08-15 | De Nora S.P.A. | Structures and methods of manufacture for gas diffusion electrodes and electrode components |
CA2329768C (en) | 1998-04-27 | 2008-06-10 | Opperbas Holding B.V. | Pharmaceutical composition comprising factor viii and neutral liposomes |
US6660843B1 (en) * | 1998-10-23 | 2003-12-09 | Amgen Inc. | Modified peptides as therapeutic agents |
CA2405709A1 (en) * | 2000-04-12 | 2001-10-25 | Human Genome Sciences, Inc. | Albumin fusion proteins |
EP1148063A1 (de) | 2000-04-18 | 2001-10-24 | Octapharma AG | Haemostatisch aktives vWF enthaltendes Präparat und Verfahren zu seiner Herstellung |
WO2002060951A2 (en) | 2001-01-12 | 2002-08-08 | The American National Red Cross | Methods and compositions for reducing heparan sulfate proteoglycan-mediated clearance of factor viii |
DE60234193D1 (de) | 2001-06-14 | 2009-12-10 | Scripps Research Inst | Stabilisierte faktor viii mit gentechnisch konstruierten disulfidbindungen |
AU2003210806A1 (en) | 2002-03-05 | 2003-09-22 | Eli Lilly And Company | Heterologous g-csf fusion proteins |
CA2484155C (en) | 2002-04-29 | 2015-10-13 | Baxter International Inc. | Antagonists of factor viii interaction with low-density lipoprotein receptor-related protein |
KR20180098702A (ko) | 2002-12-09 | 2018-09-04 | 아브락시스 바이오사이언스, 엘엘씨 | 약리학적 물질의 조성물 및 그 전달방법 |
EP1444986A1 (en) * | 2003-02-07 | 2004-08-11 | Aventis Behring GmbH | Pharmaceutical preparation for the improved treatment of blood-clotting disorders |
HUE058897T2 (hu) | 2003-02-26 | 2022-09-28 | Nektar Therapeutics | Polimer VIII-as faktor egység konjugátumok |
TWI353991B (en) | 2003-05-06 | 2011-12-11 | Syntonix Pharmaceuticals Inc | Immunoglobulin chimeric monomer-dimer hybrids |
DK2298347T3 (en) * | 2003-05-06 | 2016-01-11 | Biogen Hemophilia Inc | COAGULATION FACTOR CHEMICAL PROTEINS FOR TREATING A HEMOSTATIC DISORDER |
SI1641823T1 (sl) | 2003-06-12 | 2011-12-30 | Lilly Co Eli | Fuzijski proteini analogni glp-1 |
EP1502921A1 (en) * | 2003-07-29 | 2005-02-02 | ZLB Behring GmbH | Recombinant mutated human factor VIII (FVIII) with improved stability |
US7550263B2 (en) * | 2003-09-05 | 2009-06-23 | Gtc Biotherapeutics, Inc. | Method for the production of fusion proteins in transgenic mammal milk |
ES2387028T3 (es) | 2003-12-31 | 2012-09-12 | Merck Patent Gmbh | Proteína de fusión de Fc-eritropoyetina con farmacocinética mejorada |
US7670595B2 (en) | 2004-06-28 | 2010-03-02 | Merck Patent Gmbh | Fc-interferon-beta fusion proteins |
EP1824988B1 (en) | 2004-11-12 | 2017-04-19 | Bayer HealthCare LLC | Site-directed modification of fviii |
CN101163506B (zh) * | 2004-12-27 | 2012-09-26 | 巴克斯特国际公司 | 聚合物-von Willebrand因子偶联物 |
WO2006108590A1 (en) | 2005-04-14 | 2006-10-19 | Csl Behring Gmbh | Modified coagulation factor viii with enhanced stability and its derivates |
EP1958648A4 (en) | 2005-10-28 | 2009-12-30 | Dnavec Corp | THERAPEUTIC PROCESS FOR BLOOD CLEANING DISORDER |
EP1816201A1 (en) | 2006-02-06 | 2007-08-08 | CSL Behring GmbH | Modified coagulation factor VIIa with extended half-life |
BRPI0708832A2 (pt) | 2006-03-31 | 2011-06-14 | Baxter Int | construÇço proteinÁcea |
JP5800458B2 (ja) | 2006-06-14 | 2015-10-28 | ツェー・エス・エル・ベーリング・ゲー・エム・ベー・ハー | 血液凝固因子を有するタンパク質分解によって切断可能な融合タンパク質 |
EP1867660A1 (en) * | 2006-06-14 | 2007-12-19 | CSL Behring GmbH | Proteolytically cleavable fusion protein comprising a blood coagulation factor |
ES2654336T3 (es) | 2008-06-24 | 2018-02-13 | Csl Behring Gmbh | Factor VIII, factor de von Willebrand o sus complejos con semivida in vivo prolongada |
US9402754B2 (en) * | 2010-05-18 | 2016-08-02 | Abbott Cardiovascular Systems, Inc. | Expandable endoprostheses, systems, and methods for treating a bifurcated lumen |
NZ626945A (en) | 2012-01-12 | 2016-10-28 | Biogen Ma Inc | Chimeric factor viii polypeptides and uses thereof |
US20150080309A1 (en) | 2012-04-24 | 2015-03-19 | Nova Nordisk A/S | Compounds Suitable for Treatment of Haemophilia |
-
2009
- 2009-06-24 ES ES14192277.3T patent/ES2654336T3/es active Active
- 2009-06-24 CN CN200980123818XA patent/CN102076855A/zh active Pending
- 2009-06-24 WO PCT/EP2009/004549 patent/WO2009156137A1/en active Application Filing
- 2009-06-24 RU RU2011102366/10A patent/RU2528855C2/ru active
- 2009-06-24 CA CA2728012A patent/CA2728012C/en not_active Expired - Fee Related
- 2009-06-24 JP JP2011515200A patent/JP5832285B2/ja not_active Expired - Fee Related
- 2009-06-24 ES ES09768986.3T patent/ES2531464T3/es active Active
- 2009-06-24 CN CN201310596839.1A patent/CN103739712B/zh not_active Expired - Fee Related
- 2009-06-24 US US13/000,938 patent/US8575104B2/en active Active
- 2009-06-24 DK DK14192277.3T patent/DK2865760T3/en active
- 2009-06-24 EP EP09768986.3A patent/EP2291523B1/en active Active
- 2009-06-24 PL PL09768986T patent/PL2291523T3/pl unknown
- 2009-06-24 KR KR1020147018123A patent/KR101648734B1/ko active IP Right Grant
- 2009-06-24 DK DK09768986T patent/DK2291523T3/en active
- 2009-06-24 AU AU2009262476A patent/AU2009262476C1/en not_active Ceased
- 2009-06-24 KR KR1020117001530A patent/KR101507718B1/ko active IP Right Grant
- 2009-06-24 EP EP14192277.3A patent/EP2865760B1/en active Active
-
2011
- 2011-05-24 HK HK11105187.9A patent/HK1151068A1/xx unknown
-
2013
- 2013-09-17 US US14/028,869 patent/US9290561B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN103739712B (zh) | 2016-10-05 |
CN103739712A (zh) | 2014-04-23 |
EP2865760A1 (en) | 2015-04-29 |
RU2011102366A (ru) | 2012-07-27 |
ES2654336T3 (es) | 2018-02-13 |
JP2011525363A (ja) | 2011-09-22 |
EP2291523A1 (en) | 2011-03-09 |
CN102076855A (zh) | 2011-05-25 |
ES2531464T3 (es) | 2015-03-16 |
AU2009262476C1 (en) | 2016-06-02 |
CA2728012C (en) | 2017-10-31 |
US9290561B2 (en) | 2016-03-22 |
US20140072561A1 (en) | 2014-03-13 |
KR20110044978A (ko) | 2011-05-03 |
DK2291523T3 (en) | 2015-03-23 |
AU2009262476A1 (en) | 2009-12-30 |
US20110183907A1 (en) | 2011-07-28 |
EP2291523B1 (en) | 2014-12-17 |
AU2009262476B2 (en) | 2014-06-26 |
JP5832285B2 (ja) | 2015-12-16 |
PL2291523T3 (pl) | 2015-05-29 |
WO2009156137A1 (en) | 2009-12-30 |
KR101507718B1 (ko) | 2015-04-10 |
CA2728012A1 (en) | 2009-12-30 |
EP2865760B1 (en) | 2017-10-11 |
KR20140090703A (ko) | 2014-07-17 |
RU2528855C2 (ru) | 2014-09-20 |
KR101648734B1 (ko) | 2016-08-18 |
DK2865760T3 (en) | 2018-01-15 |
US8575104B2 (en) | 2013-11-05 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
HK1151068A1 (en) | Factor viii, von willebrand factor or complexes thereof with prolonged in vivo half-life viii von willebrand | |
AP3856A (en) | Improvements in feedwells. | |
ZA201104540B (en) | Usirna complexes | |
PL2257493T3 (pl) | Ramię załadowcze z bezpośrednią regulacją, w szczególności regulacją proporcjonalną | |
EP2147006A4 (en) | ORGANOMETALLIC COMPLEX, COMPOSITION AND LIGHT-EMITTING ELEMENT COMPRISING THE ORGANOMETALLIC COMPLEX | |
IL216014A0 (en) | Antibodies immunorective with heregulin-her3 complexes, compositions comprising the same and uses thereof | |
EP2344417A4 (en) | NANOCRYSTALS HAVING FUNCTIONAL LIGANDS | |
EP2332328A4 (en) | PROVIDING ADDITIONAL INFORMATION | |
GB0810203D0 (en) | Cannaboids in combination with non-cannabinoid chemotherapeutic agents | |
EP2257198A4 (en) | CONTAINER FOR COSMETICS OF PUMPING TYPE | |
EP2173358A4 (en) | DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION | |
EP2269558A4 (en) | PLASTIC CARTRIDGE | |
AP2011005690A0 (en) | Combination therapy with peptide epoxyketones. | |
EP1839508A4 (en) | CLOTHES WITH LINING OF THE GLOVE TYPE | |
ZA201101923B (en) | Dual character polymer useful in fabric care products | |
HK1149186A1 (en) | Plastic ampule | |
PL2203439T3 (pl) | 1',3'-dipodstawione-4-fenylo-3,4,5,6-tetrahydro-2H, 1'H-[1, 4']bipirydynylo-2'-ketony | |
TWI370040B (en) | Simultanes doppelseitenschleifen von halbleiterscheiben | |
HK1151986A1 (en) | Factor ix conjugates with extended half-lives ix | |
IL211674A0 (en) | 3-amino-indazole or 3-amino-4,5,6,7- tetrahydro-indazole derivatives | |
SI2356123T1 (sl) | Piro-5,6-dihidro-4h-2,3,5,10b-tetraaza-benzo(e)azuleni | |
EP2305771A4 (en) | PHOSPHORESCENCE-EMITTING COMPOSITION, AND LIGHT-EMITTING ELEMENT USING THE SAME | |
EP1896492A4 (en) | PLATINUM COMPLEXES WITH MONONITRYLIC LIGANDS | |
PL2358468T3 (pl) | Ulepszenia dotyczące katalizatorów | |
GB0705076D0 (en) | The Pump |