HK1150746A1 - Mtor inhibitors in the treatment of endocrine tumors mtor - Google Patents

Mtor inhibitors in the treatment of endocrine tumors mtor

Info

Publication number
HK1150746A1
HK1150746A1 HK11104451.1A HK11104451A HK1150746A1 HK 1150746 A1 HK1150746 A1 HK 1150746A1 HK 11104451 A HK11104451 A HK 11104451A HK 1150746 A1 HK1150746 A1 HK 1150746A1
Authority
HK
Hong Kong
Prior art keywords
mtor
treatment
endocrine tumors
inhibitors
mtor inhibitors
Prior art date
Application number
HK11104451.1A
Other languages
English (en)
Chinese (zh)
Inventor
Peter Wayne Marks
David Lebwohl
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37671355&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1150746(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GB0523658A external-priority patent/GB0523658D0/en
Priority claimed from GB0601082A external-priority patent/GB0601082D0/en
Priority claimed from GB0602747A external-priority patent/GB0602747D0/en
Priority claimed from GB0607942A external-priority patent/GB0607942D0/en
Priority claimed from GB0609272A external-priority patent/GB0609272D0/en
Priority claimed from GB0609912A external-priority patent/GB0609912D0/en
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1150746A1 publication Critical patent/HK1150746A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22Hormones
    • A61K38/31Somatostatins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/04Antineoplastic agents specific for metastasis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
HK11104451.1A 2005-11-21 2008-09-23 Mtor inhibitors in the treatment of endocrine tumors mtor HK1150746A1 (en)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
GB0523658A GB0523658D0 (en) 2005-11-21 2005-11-21 Organic compounds
GB0601082A GB0601082D0 (en) 2006-01-19 2006-01-19 Organic Compounds
GB0602747A GB0602747D0 (en) 2006-02-10 2006-02-10 Organic compounds
GB0607942A GB0607942D0 (en) 2006-04-21 2006-04-21 Organic compounds
GB0609272A GB0609272D0 (en) 2006-05-10 2006-05-10 Organic compounds
GB0609912A GB0609912D0 (en) 2006-05-18 2006-05-18 Organic compounds
EP06120660 2006-09-14

Publications (1)

Publication Number Publication Date
HK1150746A1 true HK1150746A1 (en) 2012-01-13

Family

ID=37671355

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11104451.1A HK1150746A1 (en) 2005-11-21 2008-09-23 Mtor inhibitors in the treatment of endocrine tumors mtor

Country Status (22)

Country Link
US (3) US9006224B2 (ru)
EP (3) EP2022498A3 (ru)
JP (3) JP2009516671A (ru)
KR (2) KR20140012218A (ru)
CN (1) CN103446138A (ru)
AU (2) AU2006314444C1 (ru)
BR (1) BRPI0618808A2 (ru)
CA (2) CA2629245C (ru)
CY (1) CY1115299T1 (ru)
DK (1) DK2275103T3 (ru)
ES (1) ES2481671T3 (ru)
HK (1) HK1150746A1 (ru)
HR (1) HRP20140708T1 (ru)
IL (3) IL191475A (ru)
MA (1) MA29966B1 (ru)
NO (4) NO346575B1 (ru)
NZ (1) NZ568182A (ru)
PL (1) PL2275103T3 (ru)
PT (1) PT2275103E (ru)
RU (1) RU2487711C2 (ru)
SI (1) SI2275103T1 (ru)
WO (1) WO2007057457A2 (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2705016T3 (es) 2001-02-19 2019-03-21 Novartis Int Pharmaceutical Ag Derivado de rapamicina para el tratamiento de cáncer de pulmón
EP2591775A1 (en) 2006-04-05 2013-05-15 Novartis AG Combinations comprising mtor inhibitors for treating cancer
MX2008012728A (es) * 2006-04-05 2008-10-14 Novartis Ag Combinaciones de agentes terapeuticos para el tratamiento de cancer.
AU2013205002B2 (en) * 2008-03-21 2016-09-15 The University Of Chicago Treatment with opioid antagonists and mTOR inhibitors
EP2278966B1 (en) 2008-03-21 2019-10-09 The University of Chicago Treatment with opioid antagonists and mtor inhibitors
MX2011002836A (es) 2008-09-17 2011-04-28 Chiasma Inc Composiciones farmaceúticas y métodos de administración relacionados.
WO2010151517A2 (en) 2009-06-25 2010-12-29 The Regents Of The University Of Michigan Antigen-specific long-term memory t-cells
KR102283091B1 (ko) 2010-03-10 2021-07-30 인사이트 홀딩스 코포레이션 Jak1 저해제로서의 피페리딘­4­일 아제티딘 유도체
TWI629983B (zh) 2011-10-19 2018-07-21 標誌製藥公司 以tor激酶抑制劑治療癌症
AU2014223501A1 (en) * 2013-02-28 2015-09-17 Signal Pharmaceuticals, Llc Treatment of cancer with TOR kinase inhibitors
WO2014144405A1 (en) * 2013-03-15 2014-09-18 The Board Of Regents Of The University Of Texas System Use of mtor inhibitors for prevention of neuroendocrine tumor development and growth
CN107474051B (zh) 2013-05-29 2020-10-30 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
AU2014373683B2 (en) 2013-12-31 2020-05-07 Rapamycin Holdings, Llc Oral rapamycin nanoparticle preparations and use
MA41462A (fr) 2015-02-03 2021-05-12 Chiasma Inc Méthode de traitement de maladies
WO2017000085A1 (zh) * 2015-06-30 2017-01-05 上海交通大学 Sunlidac在制备抗肺癌产品中的应用
AU2017210227A1 (en) * 2016-01-21 2018-09-06 Amryt Endo, Inc. Oral octreotide for the treatment of disease
EP3618867A4 (en) 2017-05-02 2021-01-20 Cornell University METHODS AND REAGENTS FOR AGAINST TUMOR WITH HIGHER EFFICIENCY AND LOWER TOXICITY
SG11201912403SA (en) 2017-06-22 2020-01-30 Celgene Corp Treatment of hepatocellular carcinoma characterized by hepatitis b virus infection
WO2019157363A2 (en) * 2018-02-09 2019-08-15 Mount Tam Therapeutics, Inc. Rapamycin analog for prevention and/or treatment of cancer
IL312291A (en) 2018-05-01 2024-06-01 Revolution Medicines Inc C-26-linked rapamycin analogs as MTOR inhibitors
US20220184084A1 (en) * 2019-03-18 2022-06-16 The Regents Of The University Of California Compositions and methods for treating cushing's disease
US11141457B1 (en) 2020-12-28 2021-10-12 Amryt Endo, Inc. Oral octreotide therapy and contraceptive methods
JP2024520888A (ja) * 2021-06-07 2024-05-24 ナノファーマスーティカルス エルエルシー 神経内分泌腫瘍の治療における二重標的化のための組成物および方法
US11723888B2 (en) 2021-12-09 2023-08-15 Nanopharmaceuticals Llc Polymer conjugated thyrointegrin antagonists

Family Cites Families (70)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE28864T1 (de) 1982-07-23 1987-08-15 Ici Plc Amide-derivate.
GB8327256D0 (en) 1983-10-12 1983-11-16 Ici Plc Steroid derivatives
IL86632A0 (en) 1987-06-15 1988-11-30 Ciba Geigy Ag Derivatives substituted at methyl-amino nitrogen
US5538739A (en) * 1989-07-07 1996-07-23 Sandoz Ltd. Sustained release formulations of water soluble peptides
US5010099A (en) 1989-08-11 1991-04-23 Harbor Branch Oceanographic Institution, Inc. Discodermolide compounds, compositions containing same and method of preparation and use
GB9013448D0 (en) 1990-06-15 1990-08-08 Sandoz Ltd Pharmaceutical resorption-improved somatostatin compositions,their preparation and use
PT98990A (pt) 1990-09-19 1992-08-31 American Home Prod Processo para a preparacao de esteres de acidos carboxilicos de rapamicina
NZ243082A (en) 1991-06-28 1995-02-24 Ici Plc 4-anilino-quinazoline derivatives; pharmaceutical compositions, preparatory processes, and use thereof
AU661533B2 (en) 1992-01-20 1995-07-27 Astrazeneca Ab Quinazoline derivatives
TW225528B (ru) 1992-04-03 1994-06-21 Ciba Geigy Ag
ZA935112B (en) 1992-07-17 1994-02-08 Smithkline Beecham Corp Rapamycin derivatives
US5234140A (en) 1992-07-28 1993-08-10 S. C. Johnson & Son, Inc. Re-useable aerosol container
HU221343B1 (en) 1992-10-28 2002-09-28 Genentech Inc Use of anti-vegf antibodies for the treatment of cancer
GB9314893D0 (en) 1993-07-19 1993-09-01 Zeneca Ltd Quinazoline derivatives
IL115742A (en) 1994-10-26 2000-06-01 Novartis Ag Pharmaceutical compositions comprising a difficultly soluble active agent a hydrophilic phase a lipophilic phase and a surfactant
WO1996030347A1 (en) 1995-03-30 1996-10-03 Pfizer Inc. Quinazoline derivatives
GB9508538D0 (en) 1995-04-27 1995-06-14 Zeneca Ltd Quinazoline derivatives
US5747498A (en) 1996-05-28 1998-05-05 Pfizer Inc. Alkynyl and azido-substituted 4-anilinoquinazolines
US5880141A (en) 1995-06-07 1999-03-09 Sugen, Inc. Benzylidene-Z-indoline compounds for the treatment of disease
DK0836605T3 (da) 1995-07-06 2002-05-13 Novartis Ag Pyrrolopyrimidiner og fremgangsmåder til deres fremstilling
IT1277391B1 (it) 1995-07-28 1997-11-10 Romano Deghenghi Peptidi ciclici analoghi della somatostatina ad attivita' inibitrice dell'ormone della crescita
US5760041A (en) 1996-02-05 1998-06-02 American Cyanamid Company 4-aminoquinazoline EGFR Inhibitors
GB9603095D0 (en) 1996-02-14 1996-04-10 Zeneca Ltd Quinazoline derivatives
EP0892789B2 (en) 1996-04-12 2009-11-18 Warner-Lambert Company LLC Irreversible inhibitors of tyrosine kinases
US6362164B1 (en) * 1996-06-11 2002-03-26 Novartis Ag Combination of a somatostatin analogue and a rapamycin
DE69734513T2 (de) 1996-06-24 2006-07-27 Pfizer Inc. Phenylamino-substituierte tricyclische derivate zur behandlung hyperproliferativer krankheiten
US5932613A (en) 1996-07-03 1999-08-03 Millennium Pharmaceuticals, Inc. Anticancer agents
AU735648B2 (en) 1996-07-12 2001-07-12 Ariad Pharmaceuticals, Inc. Materials and method for treating or preventing pathogenic fungal infection
JP2001500851A (ja) 1996-08-30 2001-01-23 ノバルティス アクチエンゲゼルシャフト エポシロンの製造法および製造過程中に得られる中間生産物
DE19638745C2 (de) 1996-09-11 2001-05-10 Schering Ag Monoklonale Antikörper gegen die extrazelluläre Domäne des menschlichen VEGF - Rezeptorproteins (KDR)
WO1998010767A2 (en) 1996-09-13 1998-03-19 Sugen, Inc. Use of quinazoline derivatives for the manufacture of a medicament in the treatment of hyperproliferative skin disorders
EP0837063A1 (en) 1996-10-17 1998-04-22 Pfizer Inc. 4-Aminoquinazoline derivatives
AU753546B2 (en) 1996-11-18 2002-10-24 Helmholtz-Zentrum Fuer Infektionsforschung Gmbh Epothilone C, D, E and F, production process, and their use as cytostatic as well as phytosanitary agents
US6441186B1 (en) 1996-12-13 2002-08-27 The Scripps Research Institute Epothilone analogs
CO4950519A1 (es) 1997-02-13 2000-09-01 Novartis Ag Ftalazinas, preparaciones farmaceuticas que las comprenden y proceso para su preparacion
CO4940418A1 (es) 1997-07-18 2000-07-24 Novartis Ag Modificacion de cristal de un derivado de n-fenil-2- pirimidinamina, procesos para su fabricacion y su uso
GB9721069D0 (en) 1997-10-03 1997-12-03 Pharmacia & Upjohn Spa Polymeric derivatives of camptothecin
US6194181B1 (en) 1998-02-19 2001-02-27 Novartis Ag Fermentative preparation process for and crystal forms of cytostatics
DE69927790T2 (de) 1998-02-25 2006-07-20 Sloan-Kettering Institute For Cancer Research Synthese von epothilonen, ihren zwischenprodukten und analogen verbindungen
DE69942097D1 (de) 1998-08-11 2010-04-15 Novartis Ag Isochinoline derivate mit angiogenesis-hemmender wirkung
UA71587C2 (ru) 1998-11-10 2004-12-15 Шерінг Акцієнгезелльшафт Translated By PlajАМИДЫ АНТРАНИЛОВОЙ КИСЛОТЫ И ИХ ПРИМЕНЕНИЕ В КАЧЕСТВЕ ЛЕЧЕБНЫХ СРЕДСТВ
GB9824579D0 (en) 1998-11-10 1999-01-06 Novartis Ag Organic compounds
JP4662635B2 (ja) 1998-11-20 2011-03-30 コーサン バイオサイエンシーズ, インコーポレイテッド エポチロンおよびエポチロン誘導体を生成するための組換え方法および材料
WO2000037502A2 (en) 1998-12-22 2000-06-29 Genentech, Inc. Vascular endothelial cell growth factor antagonists and uses thereof
EP1165085B1 (en) 1999-03-30 2006-06-14 Novartis AG Phthalazine derivatives for treating inflammatory diseases
EP1212331B1 (en) 1999-08-24 2004-04-21 Ariad Gene Therapeutics, Inc. 28-epirapalogs
RU2264405C2 (ru) 1999-12-06 2005-11-20 Новартис Аг 40-o-(2-гидрокси)этилрапамицин в кристаллической несольватированной форме, фармацевтическая композиция, содержащая такой макролид в качестве действующего вещества, и способ его получения
PE20020354A1 (es) 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
DE60140201D1 (en) 2000-11-07 2009-11-26 Novartis Ag Indolylmaleimidderivative als proteinkinase-c-inhibitoren
TWI286074B (en) * 2000-11-15 2007-09-01 Wyeth Corp Pharmaceutical composition containing CCI-779 as an antineoplastic agent
ES2705016T3 (es) 2001-02-19 2019-03-21 Novartis Int Pharmaceutical Ag Derivado de rapamicina para el tratamiento de cáncer de pulmón
TWI296196B (en) 2001-04-06 2008-05-01 Wyeth Corp Antineoplastic combinations
BR0208627A (pt) * 2001-04-06 2004-03-09 Wyeth Corp Combinações antineoplásicas tal como rapamicina junto com gencitabina ou fluorouracila
TWI233359B (en) 2001-04-06 2005-06-01 Wyeth Corp Pharmaceutical composition for treating neoplasm
UA78706C2 (en) 2001-06-01 2007-04-25 Wyeth Corp Combination of rapamycin derivative and antitumor alkylating agent and method for treating soft tissue sarcoma and colonic cancer
PL367267A1 (en) * 2001-06-01 2005-02-21 Wyeth Antineoplastic combinations
GB0119249D0 (en) 2001-08-07 2001-10-03 Novartis Ag Organic compounds
UA77200C2 (en) * 2001-08-07 2006-11-15 Wyeth Corp Antineoplastic combination of cci-779 and bkb-569
CA2472341C (en) 2002-02-01 2011-06-21 Ariad Gene Therapeutics, Inc. Phosphorus-containing compounds & uses thereof
PE20040079A1 (es) 2002-04-03 2004-04-19 Novartis Ag Derivados de indolilmaleimida
US20060094674A1 (en) * 2002-07-05 2006-05-04 Neel Benjamin G Combination of mtor inhibitor and a tyrosine kinase inhibitor for the treatment of neoplasms
HUP0500844A2 (en) 2002-12-09 2007-08-28 Univ Texas Methods for selectively inhibiting janus tyrosine kinase 3(jak3)
UA83484C2 (ru) * 2003-03-05 2008-07-25 Уайт Способ лечения рака молочной железы комбинацией производного рапамицина и ингибитора ароматазы - летрозола, фармацевтическая композиция
US7160867B2 (en) 2003-05-16 2007-01-09 Isotechnika, Inc. Rapamycin carbohydrate derivatives
EP1709449A1 (en) 2003-12-22 2006-10-11 Novartis AG Biomarkers for sensitivity of proliferative diseases to mtor inhibitors
GB2424882B (en) 2004-01-12 2008-08-06 Cytopia Res Pty Ltd Selective kinase inhibitors
AU2005215910B2 (en) * 2004-02-23 2008-05-01 Novartis Ag P53 wild-type as biomarker for the treatment with mTOR inhibitors in combination with a cytotoxic agent
EP1720574A4 (en) * 2004-02-23 2009-09-09 Sugen Inc METHOD OF TREATING ABNORMAL CELL GROWTH USING C-MET AND M-TOR INHIBITORS
US8975248B2 (en) 2004-12-15 2015-03-10 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Combinations of therapeutic agents for treating cancer
WO2006071966A2 (en) 2004-12-29 2006-07-06 The Brigham And Women's Hospital, Inc. Rapamycin compounds in the treatment of neurofibromatosis type 1

Also Published As

Publication number Publication date
CY1115299T1 (el) 2017-01-04
NO20220050A1 (no) 2008-08-12
CA2629245C (en) 2016-07-12
AU2006314444A1 (en) 2007-05-24
RU2487711C2 (ru) 2013-07-20
US20170128425A1 (en) 2017-05-11
CA2933875A1 (en) 2007-05-24
EP2275103A3 (en) 2011-10-12
NZ568182A (en) 2010-08-27
JP5963836B2 (ja) 2016-08-03
JP2009516671A (ja) 2009-04-23
WO2007057457A2 (en) 2007-05-24
CA2933875C (en) 2018-06-26
NO20161045A1 (no) 2008-08-12
AU2006314444B2 (en) 2010-08-26
AU2010202866A1 (en) 2010-07-29
EP2022498A3 (en) 2012-08-15
NO20082683L (no) 2008-08-12
IL253698A0 (en) 2017-09-28
MA29966B1 (fr) 2008-11-03
PL2275103T3 (pl) 2014-09-30
JP2013144706A (ja) 2013-07-25
RU2008124827A (ru) 2009-12-27
EP2022498A2 (en) 2009-02-11
KR20080071600A (ko) 2008-08-04
CN103446138A (zh) 2013-12-18
DK2275103T3 (da) 2014-07-07
ES2481671T3 (es) 2014-07-31
EP2275103B1 (en) 2014-04-23
CA2629245A1 (en) 2007-05-24
BRPI0618808A2 (pt) 2011-09-13
SI2275103T1 (sl) 2014-07-31
JP2015061868A (ja) 2015-04-02
WO2007057457A3 (en) 2008-01-10
EP1954269A2 (en) 2008-08-13
IL191475A (en) 2017-08-31
NO344288B1 (no) 2019-10-28
US20080255029A1 (en) 2008-10-16
EP2275103A2 (en) 2011-01-19
NO341023B1 (no) 2017-08-07
KR20140012218A (ko) 2014-01-29
JP5833048B2 (ja) 2015-12-16
US9006224B2 (en) 2015-04-14
HRP20140708T1 (hr) 2014-09-26
AU2006314444C1 (en) 2018-01-04
NO20170956A1 (no) 2008-08-12
NO346575B1 (no) 2022-10-17
US20150148294A1 (en) 2015-05-28
IL250697A0 (en) 2017-04-30
PT2275103E (pt) 2014-07-24

Similar Documents

Publication Publication Date Title
PL2275103T3 (pl) Inhibitory mTOR w leczeniu nowotworów neuroendokrynnych
IL188430A0 (en) Treatment of tumors
PL2100618T3 (pl) Przeciwciało anty-PDGFR alfa do zastosowania w leczeniu przerzutowego raka kości
IL186447A0 (en) Methods for the treatment of substance abuse and dependence
PL2101731T3 (pl) Endoksyfen do zastosowania w leczeniu nowotworu
GB0506759D0 (en) Combination treatment methods
IL176919A0 (en) Methods and compositions for treating cancer
EP1845970A4 (en) INHIBITORS OF TUMOR NECROSIS FACTOR
HK1215683A1 (zh) 抗葉酸藥在癌症治療中的聯合應用
PT1611890E (pt) Métodos para avaliação e tratamento do cancro
IL185258A (en) Oligodeoxyribonucleotides for use in the treatment of angiogenesis-dependent tumors in human
EP1830847A4 (en) CANCER TREATMENT
HK1164767A1 (en) Compounds and methods for the treatment of cancer
EP1855662A4 (en) METHODS AND COMPOSITIONS FOR TREATING CANCER
AU2006251169A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
AU2006251167A8 (en) Tetrahydropyridothiophenes for use in the treatment of cancer
IL202307A0 (en) Multikinase inhibitors for use in the treatment of cancer
GB0517387D0 (en) Combinations for the treatment of cancer
ZA200709443B (en) Methods for the treatment of substance abuse and dependence
EP1904088A4 (en) COMPOSITIONS AND METHODS FOR TREATING CANCER
IL226363A0 (en) Compounds and methods for treating cancer
ZA200804027B (en) Neuroendocrine tumor treatment using m TOR inhibitors
GB0516610D0 (en) Compounds for use in therapy
GB0517386D0 (en) Combinations for the treatment of cancer
GB0522671D0 (en) Spisulosine compounds for use in cancer therapy