HK1145831A1 - Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)- acrylamide compounds n--3-(3--)- - Google Patents

Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)- acrylamide compounds n--3-(3--)-

Info

Publication number
HK1145831A1
HK1145831A1 HK11100011.2A HK11100011A HK1145831A1 HK 1145831 A1 HK1145831 A1 HK 1145831A1 HK 11100011 A HK11100011 A HK 11100011A HK 1145831 A1 HK1145831 A1 HK 1145831A1
Authority
HK
Hong Kong
Prior art keywords
phenylsulfamoyl
hydroxy
phenyl
synthesis
methods
Prior art date
Application number
HK11100011.2A
Other languages
English (en)
Chinese (zh)
Inventor
Helge A Reisch
Peter Leeming
Prasad S Raje
Original Assignee
Topotarget Uk Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Topotarget Uk Ltd filed Critical Topotarget Uk Ltd
Publication of HK1145831A1 publication Critical patent/HK1145831A1/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C303/00—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides
    • C07C303/36—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids
    • C07C303/40—Preparation of esters or amides of sulfuric acids; Preparation of sulfonic acids or of their esters, halides, anhydrides or amides of amides of sulfonic acids by reactions not involving the formation of sulfonamide groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
HK11100011.2A 2007-09-25 2011-01-03 Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)- acrylamide compounds n--3-(3--)- HK1145831A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US97488007P 2007-09-25 2007-09-25
PCT/GB2008/003226 WO2009040517A2 (en) 2007-09-25 2008-09-23 Methods of synthesis of certain hydroxamic acid compounds

Publications (1)

Publication Number Publication Date
HK1145831A1 true HK1145831A1 (en) 2011-05-06

Family

ID=40293778

Family Applications (1)

Application Number Title Priority Date Filing Date
HK11100011.2A HK1145831A1 (en) 2007-09-25 2011-01-03 Methods of synthesis of certain n-hydroxy-3-(3-phenylsulfamoyl-phenyl)- acrylamide compounds n--3-(3--)-

Country Status (8)

Country Link
US (1) US8642809B2 (xx)
EP (1) EP2203421B1 (xx)
JP (1) JP2010540426A (xx)
CN (1) CN101868446A (xx)
CA (1) CA2700173C (xx)
HK (1) HK1145831A1 (xx)
MX (1) MX2010003230A (xx)
WO (1) WO2009040517A2 (xx)

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US9701676B2 (en) 2012-08-24 2017-07-11 Board Of Regents Of The University Of Texas System Pro-neurogenic compounds
WO2015070237A1 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective chemicals and methods for identifying and using same
WO2015070234A2 (en) 2013-11-11 2015-05-14 Board Of Regents Of The University Of Texas System Neuroprotective compounds and use thereof
CN103724239A (zh) * 2013-12-31 2014-04-16 无锡万全医药技术有限公司 一种3-（3-苯基氨磺酰基-苯基）-丙烯酸酯的制备方法
CN103787924A (zh) * 2014-01-14 2014-05-14 北京万全德众医药生物技术有限公司 抗肿瘤药物Belinostat的一种新纯化方法
CN104478769B (zh) * 2014-12-22 2016-01-06 深圳万乐药业有限公司 一种适合工业化生产的贝利司他合成方法
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WO2018029699A1 (en) * 2016-08-11 2018-02-15 Msn Research & Development Center Solid state forms of (2e)-n-hydroxy-3-[3-(phenylsulfamoyl)phenyl]prop-2-enamide and process for preparation thereof
CN106565552A (zh) * 2016-10-31 2017-04-19 瑞阳制药有限公司 贝利司他结晶体及其制备方法
RU2748835C1 (ru) 2017-11-27 2021-05-31 Совет Научных И Прикладных Исследований Индол(сульфонил)-n-гидроксибензамидные производные в качестве селективных ингибиторов hdac
CN108033902B (zh) * 2017-12-26 2020-07-07 深圳万乐药业有限公司 一种高纯度贝利司他顺式异构体的制备方法
CN109265377B (zh) * 2018-10-25 2021-01-22 瑞阳制药股份有限公司 贝利司他的绿色合成方法
CN109336788A (zh) * 2018-10-31 2019-02-15 安徽省庆云医药股份有限公司 一种贝利司他的制备方法
CN111848591B (zh) * 2019-04-25 2022-03-18 成都先导药物开发股份有限公司 Hdac抑制剂及其制备方法和用途
CN115636774B (zh) * 2022-12-01 2023-12-22 南开大学 一种贝利司他的合成方法

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Also Published As

Publication number Publication date
US8642809B2 (en) 2014-02-04
JP2010540426A (ja) 2010-12-24
CA2700173A1 (en) 2009-04-02
US20100286279A1 (en) 2010-11-11
EP2203421A2 (en) 2010-07-07
WO2009040517A3 (en) 2009-06-25
CN101868446A (zh) 2010-10-20
WO2009040517A2 (en) 2009-04-02
CA2700173C (en) 2016-10-11
MX2010003230A (es) 2010-04-07
EP2203421B1 (en) 2014-05-07

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