HK1133635A1 - Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3- benzazepine and intermediates thereof (r)-8--1--2345--1h-3- - Google Patents
Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3- benzazepine and intermediates thereof (r)-8--1--2345--1h-3-Info
- Publication number
- HK1133635A1 HK1133635A1 HK10100875.8A HK10100875A HK1133635A1 HK 1133635 A1 HK1133635 A1 HK 1133635A1 HK 10100875 A HK10100875 A HK 10100875A HK 1133635 A1 HK1133635 A1 HK 1133635A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- benzazepine
- tetrahydro
- intermediates
- chloro
- methyl
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
- C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
- C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
- C07C231/02—Preparation of carboxylic acid amides from carboxylic acids or from esters, anhydrides, or halides thereof by reaction with ammonia or amines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/16—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
- C07C233/17—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom
- C07C233/22—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom having the carbon atom of the carboxamide group bound to an acyclic carbon atom of a carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/14—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom condensed with carbocyclic rings or ring systems
- C07D223/16—Benzazepines; Hydrogenated benzazepines
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87303606P | 2006-12-05 | 2006-12-05 | |
PCT/US2007/024900 WO2008070111A2 (en) | 2006-12-05 | 2007-12-04 | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1133635A1 true HK1133635A1 (en) | 2010-04-01 |
Family
ID=39322362
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK10100875.8A HK1133635A1 (en) | 2006-12-05 | 2010-01-27 | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3- benzazepine and intermediates thereof (r)-8--1--2345--1h-3- |
Country Status (9)
Country | Link |
---|---|
US (1) | US8299241B2 (ja) |
EP (1) | EP2099743B1 (ja) |
JP (1) | JP5404414B2 (ja) |
CN (1) | CN101547892B (ja) |
CA (1) | CA2670285A1 (ja) |
ES (1) | ES2522587T3 (ja) |
HK (1) | HK1133635A1 (ja) |
SG (1) | SG177128A1 (ja) |
WO (1) | WO2008070111A2 (ja) |
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KR20130087622A (ko) | 2004-12-23 | 2013-08-06 | 아레나 파마슈티칼스, 인크. | 5ht2c 수용체 조정물질 조성물 및 그의 사용 방법 |
CN101466684B (zh) | 2006-04-03 | 2012-06-20 | 艾尼纳制药公司 | 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备工艺和其相关中间体 |
WO2008070111A2 (en) | 2006-12-05 | 2008-06-12 | Arena Pharmaceuticals, Inc. | Processes for preparing (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine and intermediates thereof |
WO2009111004A1 (en) | 2008-03-04 | 2009-09-11 | Arena Pharmaceuticals, Inc. | Processes for the preparation of intermediates related to the 5-ht2c agonist (r)-8-chloro-1-methyl-2,3,4,5-tetrahydro-1h-3-benzazepine |
US8952197B2 (en) | 2009-06-18 | 2015-02-10 | Arena Pharmaceuticals, Inc. | Processes for the preparation of 5-HT2C receptor agonists |
KR20130112848A (ko) | 2010-06-02 | 2013-10-14 | 아레나 파마슈티칼스, 인크. | 5-ht2c 수용체 아고니스트의 제조 방법 |
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CN103333111A (zh) * | 2013-06-14 | 2013-10-02 | 苏州汇和药业有限公司 | 氯卡色林盐酸盐的制备方法 |
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CN103601645B (zh) * | 2013-11-07 | 2016-05-25 | 上海适济生物科技有限公司 | 1-(苯乙基氨基)丙烷-2-醇类化合物或其盐的制备方法 |
US9714225B2 (en) * | 2013-11-13 | 2017-07-25 | Cadila Healthcare Limited | Processes for the preparation of lorcaserin |
CN103755636B (zh) * | 2014-01-20 | 2016-08-31 | 中国计量学院 | 氯卡色林消旋体衍生物的合成方法 |
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CN104130188B (zh) * | 2014-08-05 | 2016-08-31 | 南京工业大学 | 8-氯-1-甲基-2,3,4,5-四氢-1h-3-苯并氮杂卓的制备方法 |
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KR101726819B1 (ko) * | 2014-10-27 | 2017-04-13 | 동아에스티 주식회사 | Gpr119 작용 활성을 갖는 화합물, 이의 제조방법 및 이를 유효성분으로 함유하는 약제학적 조성물 |
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-
2007
- 2007-12-04 WO PCT/US2007/024900 patent/WO2008070111A2/en active Application Filing
- 2007-12-04 US US12/517,625 patent/US8299241B2/en not_active Expired - Fee Related
- 2007-12-04 ES ES07867623.6T patent/ES2522587T3/es active Active
- 2007-12-04 EP EP07867623.6A patent/EP2099743B1/en active Active
- 2007-12-04 JP JP2009540272A patent/JP5404414B2/ja not_active Expired - Fee Related
- 2007-12-04 CA CA002670285A patent/CA2670285A1/en not_active Abandoned
- 2007-12-04 SG SG2011087202A patent/SG177128A1/en unknown
- 2007-12-04 CN CN200780045133.9A patent/CN101547892B/zh not_active Expired - Fee Related
-
2010
- 2010-01-27 HK HK10100875.8A patent/HK1133635A1/xx not_active IP Right Cessation
Also Published As
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WO2008070111A2 (en) | 2008-06-12 |
JP5404414B2 (ja) | 2014-01-29 |
CA2670285A1 (en) | 2008-06-12 |
SG177128A1 (en) | 2012-01-30 |
JP2010511711A (ja) | 2010-04-15 |
WO2008070111A3 (en) | 2008-08-07 |
ES2522587T3 (es) | 2014-11-17 |
CN101547892A (zh) | 2009-09-30 |
CN101547892B (zh) | 2014-08-20 |
EP2099743A2 (en) | 2009-09-16 |
US8299241B2 (en) | 2012-10-30 |
US20100305316A1 (en) | 2010-12-02 |
EP2099743B1 (en) | 2014-08-27 |
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