HK1132515A1 - Receptor(sstr2)-selective somatostatin antagonists - Google Patents

Receptor(sstr2)-selective somatostatin antagonists

Info

Publication number
HK1132515A1
HK1132515A1 HK10100191.5A HK10100191A HK1132515A1 HK 1132515 A1 HK1132515 A1 HK 1132515A1 HK 10100191 A HK10100191 A HK 10100191A HK 1132515 A1 HK1132515 A1 HK 1132515A1
Authority
HK
Hong Kong
Prior art keywords
sstr2
receptor
somatostatin antagonists
selective somatostatin
selective
Prior art date
Application number
HK10100191.5A
Other languages
English (en)
Inventor
Jean E F Rivier
Judit Erchegyi
Jean Claude Reubi
Helmut R Maecke
Original Assignee
Salk Inst For Biological Studi
Univ Bern
Univ Hospital Basel
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Salk Inst For Biological Studi, Univ Bern, Univ Hospital Basel filed Critical Salk Inst For Biological Studi
Publication of HK1132515A1 publication Critical patent/HK1132515A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/655—Somatostatins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Endocrinology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
HK10100191.5A 2006-10-16 2010-01-08 Receptor(sstr2)-selective somatostatin antagonists HK1132515A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US82963706P 2006-10-16 2006-10-16
PCT/US2007/081430 WO2008048942A2 (fr) 2006-10-16 2007-10-15 Antagonistes de la somatostatine sélectifs du récepteur sstr2

Publications (1)

Publication Number Publication Date
HK1132515A1 true HK1132515A1 (en) 2010-02-26

Family

ID=39144622

Family Applications (1)

Application Number Title Priority Date Filing Date
HK10100191.5A HK1132515A1 (en) 2006-10-16 2010-01-08 Receptor(sstr2)-selective somatostatin antagonists

Country Status (14)

Country Link
US (2) US7960342B2 (fr)
EP (3) EP2383289B1 (fr)
JP (1) JP5295967B2 (fr)
CN (2) CN101631801B (fr)
AU (1) AU2007311137B2 (fr)
BR (1) BRPI0717135B8 (fr)
CA (1) CA2666642C (fr)
DK (1) DK2076535T3 (fr)
ES (2) ES2410207T3 (fr)
HK (1) HK1132515A1 (fr)
PL (3) PL2433963T3 (fr)
PT (1) PT2076535E (fr)
SI (1) SI2076535T1 (fr)
WO (1) WO2008048942A2 (fr)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8691761B2 (en) * 2006-10-16 2014-04-08 Jean E. F. Rivier Somatostatin receptor 2 antagonists
US7960342B2 (en) 2006-10-16 2011-06-14 The Salk Institute For Biological Studies Receptor(SSTR2)-selective somatostatin antagonists
EP2118123B1 (fr) 2007-01-31 2015-10-14 Dana-Farber Cancer Institute, Inc. Peptides p53 stabilises et utilisations de ceux-ci
WO2008121767A2 (fr) 2007-03-28 2008-10-09 President And Fellows Of Harvard College Polypeptides cousus
WO2012021876A2 (fr) 2010-08-13 2012-02-16 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques
AU2012326026B2 (en) 2011-10-18 2017-04-13 Aileron Therapeutics, Inc. Peptidomimetic macrocyles
KR102112373B1 (ko) 2012-02-15 2020-05-18 에일러론 테라퓨틱스 인코포레이티드 펩티드모방체 마크로사이클
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
SG11201503052RA (en) 2012-11-01 2015-05-28 Aileron Therapeutics Inc Disubstituted amino acids and methods of preparation and use thereof
US10738132B2 (en) 2013-01-14 2020-08-11 Xencor, Inc. Heterodimeric proteins
US11053316B2 (en) 2013-01-14 2021-07-06 Xencor, Inc. Optimized antibody variable regions
US10858417B2 (en) 2013-03-15 2020-12-08 Xencor, Inc. Heterodimeric proteins
BR112016022385A2 (pt) 2014-03-28 2018-06-19 Xencor, Inc anticorpos específicos que se ligam a cd38 e cd3
CN104045690B (zh) * 2014-06-25 2016-06-08 舟山医院 生长抑素受体激动剂多肽及其应用
CN104086630B (zh) * 2014-06-25 2016-06-29 天津欧德莱生物医药科技有限公司 一种生长抑素受体激动剂多肽及其应用
CN104045689B (zh) * 2014-06-25 2016-08-24 新乡医学院 一种关于生长抑素受体激动剂多肽及其应用
WO2016049359A1 (fr) 2014-09-24 2016-03-31 Aileron Therapeutics, Inc. Macrocycles peptidomimétiques et leurs utilisations
CN104491890A (zh) * 2014-11-21 2015-04-08 北京肿瘤医院 放射性核素标记的新型生长抑素类似物分子探针及其应用
CN110894240B (zh) 2014-11-26 2022-04-15 森科股份有限公司 结合cd3和肿瘤抗原的异二聚体抗体
US10259887B2 (en) 2014-11-26 2019-04-16 Xencor, Inc. Heterodimeric antibodies that bind CD3 and tumor antigens
AU2016235424A1 (en) 2015-03-20 2017-10-05 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and uses thereof
JP7058219B2 (ja) 2015-12-07 2022-04-21 ゼンコア インコーポレイテッド Ｃｄ３及びｐｓｍａに結合するヘテロ二量体抗体
CN109104863A (zh) * 2016-02-09 2018-12-28 克德瑞德风险投资公司 生长抑素受体拮抗剂化合物及其使用方法
CA3026151A1 (fr) 2016-06-14 2017-12-21 Xencor, Inc. Anticorps inhibiteurs de points de controle bispecifiques
EP3475304B1 (fr) 2016-06-28 2022-03-23 Xencor, Inc. Anticorps hétérodimériques qui se lient au récepteur 2 de la somatostatine
US10849955B2 (en) 2016-09-28 2020-12-01 City Of Hope Methods of treating pancreatic cancer using GPCR antagonists
TW202015744A (zh) 2018-06-21 2020-05-01 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
TW202017600A (zh) * 2018-06-21 2020-05-16 法商艾普森藥品公司 用於放射性醫藥之含有體抑素類似物之組成物
WO2021231976A1 (fr) 2020-05-14 2021-11-18 Xencor, Inc. Anticorps hétérodimères qui se lient à l'antigène membranaire spécifique de la prostate (psma) et cd3
JP2023538891A (ja) 2020-08-19 2023-09-12 ゼンコア インコーポレイテッド 抗ｃｄ２８組成物
AU2022232375A1 (en) 2021-03-09 2023-09-21 Xencor, Inc. Heterodimeric antibodies that bind cd3 and cldn6
KR20230154311A (ko) 2021-03-10 2023-11-07 젠코어 인코포레이티드 Cd3 및 gpc3에 결합하는 이종이량체 항체
CN115583989B (zh) * 2022-12-09 2023-02-28 烟台蓝纳成生物技术有限公司 一种靶向sstr2的化合物及其制备方法和应用

Family Cites Families (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3773919A (en) * 1969-10-23 1973-11-20 Du Pont Polylactide-drug mixtures
US3904594A (en) 1973-07-02 1975-09-09 Salk Inst For Biological Studi Somatostatin and acylated des-(ala' 1', gly' 2') derivatives thereof
US4372884A (en) 1975-08-06 1983-02-08 The Salk Institute For Biological Studies Pharmaceutically active peptides
US4428942A (en) * 1982-05-17 1984-01-31 The Salk Institute For Biological Studies Analogs of somatostatin
US4725577A (en) * 1985-04-25 1988-02-16 Administrators Of The Tulane Educational Fund Biologically active lysine containing octapeptides
US5776894A (en) * 1988-12-05 1998-07-07 Novartis Ag Chelated somatostatin peptides and complexes thereof, pharmaceutical compositions containing them and their use in treating tumors
US7238340B1 (en) * 1991-11-27 2007-07-03 Cis Bio International Monoamine, diamide, thiol-containing metal chelating agents
US5590656A (en) * 1992-09-15 1997-01-07 The Ohio State University Research Foundation Application of peptide/cell receptor kinetics utilizing radiolabeled somatostatin congeners in the in situ, in vivo detection and differentiation of neoplastic tissue
US5879657A (en) 1993-03-30 1999-03-09 The Dupont Merck Pharmaceutical Company Radiolabeled platelet GPIIb/IIIa receptor antagonists as imaging agents for the diagnosis of thromboembolic disorders
JPH11514329A (ja) 1994-02-18 1999-12-07 マリンクロット・メディカル・インコーポレイテッド 標識化ペプチド化合物
US5663292A (en) 1994-12-12 1997-09-02 The Salk Institute For Biological Studies Cyclic CRF analogs
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
US5708135A (en) 1995-09-29 1998-01-13 Biomeasure Incorporated Cyclic peptide analogs of somatostatin
US5750499A (en) 1995-10-18 1998-05-12 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
US5846934A (en) 1996-02-20 1998-12-08 American Cyanamid Company Pure somatostatin antagonist and methods of use thereof
US6262229B1 (en) * 1996-12-04 2001-07-17 Biomeasure Incorporated Somatostatin antagonists
CA2274144C (fr) 1996-12-04 2004-03-30 Societe De Conseils De Recherches Et D'applications Scientifiques S.A. (A.S.) Antagonistes de la somatostatine
US5925618A (en) * 1997-03-06 1999-07-20 American Cyanamid Company Peptides useful as somatostatin antagonists
CA2246791A1 (fr) 1998-09-01 2000-03-01 Alison Buchan Traitement de l'endothelium avec des analogues de la somatostatine
US6579967B1 (en) 1999-12-14 2003-06-17 The Salk Institute For Biological Studies Receptor-selective somatostatin analogs
KR100795427B1 (ko) * 2000-10-20 2008-01-17 더 어드미니스트레이터즈 오브 더 튜래인 어듀케이셔널 훤드 유로텐신-ⅱ 작용제 및 길항제
DE60226419D1 (de) * 2001-03-08 2008-06-19 Univ Tulane Somatostatin-antagonisten
US7019109B2 (en) 2001-03-16 2006-03-28 The Salk Institute For Bilogical Studies SSTR1-selective analogs
EP1283216A1 (fr) 2001-08-10 2003-02-12 Mallinckrodt Inc. Analogues de la somatostatine réagissants avec tous les différents types de récepteurs de la somatostatine
MXPA04002621A (es) * 2001-09-21 2004-07-08 Univ Tulane Conjugados de analogos de somatostatina o bombesina para diagnostico o terapeuticos y usos de los mismos.
WO2004009614A2 (fr) * 2002-07-24 2004-01-29 The Salk Institute For Biological Studies Analogues de la somastatine selectifs du recepteur (sstr4)
EP1603598B1 (fr) 2003-03-19 2008-10-08 Universitätsspital Basel Conjuges radiomarques bases sur la substance p et leur utilisation
US7960342B2 (en) 2006-10-16 2011-06-14 The Salk Institute For Biological Studies Receptor(SSTR2)-selective somatostatin antagonists

Also Published As

Publication number Publication date
CN103288919A (zh) 2013-09-11
CN103288919B (zh) 2014-11-12
CN101631801A (zh) 2010-01-20
CA2666642A1 (fr) 2008-04-24
US8501687B2 (en) 2013-08-06
WO2008048942A3 (fr) 2008-09-18
EP2383289B1 (fr) 2014-10-08
DK2076535T3 (da) 2013-06-10
JP5295967B2 (ja) 2013-09-18
PT2076535E (pt) 2013-06-12
EP2433963A1 (fr) 2012-03-28
PL2383289T3 (pl) 2015-03-31
PL2076535T3 (pl) 2013-08-30
CA2666642C (fr) 2015-11-17
US7960342B2 (en) 2011-06-14
AU2007311137B2 (en) 2013-06-20
US20110269683A1 (en) 2011-11-03
EP2076535B1 (fr) 2013-03-06
SI2076535T1 (sl) 2013-07-31
US20080260638A1 (en) 2008-10-23
BRPI0717135B1 (pt) 2020-09-15
EP2076535A2 (fr) 2009-07-08
EP2383289A1 (fr) 2011-11-02
ES2526292T3 (es) 2015-01-09
PL2433963T3 (pl) 2014-11-28
WO2008048942A2 (fr) 2008-04-24
ES2410207T3 (es) 2013-07-01
AU2007311137A1 (en) 2008-04-24
CN101631801B (zh) 2013-06-05
BRPI0717135A2 (pt) 2013-10-15
EP2433963B1 (fr) 2014-06-04
BRPI0717135B8 (pt) 2021-05-25
JP2010506943A (ja) 2010-03-04

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