HK1131971A1 - Benzimidazole modulators of vr1 vr1 - Google Patents

Benzimidazole modulators of vr1 vr1

Info

Publication number
HK1131971A1
HK1131971A1 HK09109915.4A HK09109915A HK1131971A1 HK 1131971 A1 HK1131971 A1 HK 1131971A1 HK 09109915 A HK09109915 A HK 09109915A HK 1131971 A1 HK1131971 A1 HK 1131971A1
Authority
HK
Hong Kong
Prior art keywords
benzimidazole
modulators
benzimidazole modulators
compounds
directed
Prior art date
Application number
HK09109915.4A
Other languages
English (en)
Inventor
Raul R Calvo
Mark R Player
Scott L Dax
William H Parsons
Michael Brandt
Sharmila Patel
Jian Liu
Wing S Cheung
Michele C Jetter
Yu-Kai Lee
Mark A Youngman
Wenxi Pan
Kenneth M Wells
Derek A Beauchamp
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of HK1131971A1 publication Critical patent/HK1131971A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Pain & Pain Management (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
HK09109915.4A 2006-05-03 2009-10-27 Benzimidazole modulators of vr1 vr1 HK1131971A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79750406P 2006-05-03 2006-05-03
PCT/US2007/066748 WO2007130780A2 (en) 2006-05-03 2007-04-17 Benzimidazole modulators of vr1

Publications (1)

Publication Number Publication Date
HK1131971A1 true HK1131971A1 (en) 2010-02-12

Family

ID=38566108

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09109915.4A HK1131971A1 (en) 2006-05-03 2009-10-27 Benzimidazole modulators of vr1 vr1

Country Status (37)

Country Link
US (3) US7951829B2 (xx)
EP (1) EP2021330B1 (xx)
JP (1) JP5302884B2 (xx)
KR (1) KR101434883B1 (xx)
CN (1) CN101511797B (xx)
AR (1) AR060840A1 (xx)
AT (1) ATE482201T1 (xx)
AU (1) AU2007248341C1 (xx)
BR (1) BRPI0709803B8 (xx)
CA (1) CA2651128C (xx)
CO (1) CO6160329A2 (xx)
CR (1) CR10479A (xx)
CY (1) CY1111269T1 (xx)
DE (1) DE602007009378D1 (xx)
DK (1) DK2021330T3 (xx)
EA (1) EA019386B1 (xx)
EC (1) ECSP088854A (xx)
ES (1) ES2350959T3 (xx)
HK (1) HK1131971A1 (xx)
HR (1) HRP20100700T1 (xx)
IL (1) IL194916A (xx)
JO (1) JO3602B1 (xx)
MX (1) MX2008014108A (xx)
MY (1) MY154595A (xx)
NI (1) NI200800290A (xx)
NO (1) NO341965B1 (xx)
NZ (1) NZ572251A (xx)
PE (1) PE20080065A1 (xx)
PL (1) PL2021330T3 (xx)
PT (1) PT2021330E (xx)
RS (1) RS51473B (xx)
SI (1) SI2021330T1 (xx)
TW (1) TWI419882B (xx)
UA (1) UA94749C2 (xx)
UY (1) UY30322A1 (xx)
WO (1) WO2007130780A2 (xx)
ZA (1) ZA200810234B (xx)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2007333990A1 (en) 2006-12-15 2008-06-26 Janssen Pharmaceutica N.V. Benzimidazole TRPV1 inhibitors
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
US20090156598A1 (en) * 2007-12-17 2009-06-18 Lebsack Alec D Imidazolopyrimidine modulators of TRPV1
PE20091102A1 (es) 2007-12-17 2009-07-25 Janssen Pharmaceutica Nv Moduladores imidazolo-, oxazolo-, y tiazolopirimidina del trpv1
NZ587771A (en) * 2008-04-18 2011-05-27 Dae Woong Pharma Novel benzoxazine benzimidazole derivatives, pharmaceutical composition comprising same, and a use thereof
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en) * 2009-05-15 2012-07-10 Janssen Pharmaceutica, Nv Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) * 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) * 2009-08-31 2011-04-06 住友化学株式会社 双噁唑啉基烷烃化合物的精制方法
WO2012158672A2 (en) 2011-05-16 2012-11-22 Polymedix, Inc. Compounds for use in treatment of mucositis
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
WO2014143638A1 (en) 2013-03-14 2014-09-18 Novartis Ag 2-(1h-indol-4-ylmethyl)-3h-imidazo[4,5-b]pyridine-6-carbonitrile derivatives as complement factor b inhibitors useful for the treatment of ophthalmic diseases
US9895330B2 (en) 2013-07-11 2018-02-20 Bristol-Myers Squibb Company IDO inhibitors
US9676728B2 (en) 2013-10-30 2017-06-13 Novartis Ag 2-benzyl-benzimidazole complement factor B inhibitors and uses thereof
JP6705458B2 (ja) * 2015-09-08 2020-06-03 住友化学株式会社 トリアゾール化合物の製造方法
WO2018085171A1 (en) 2016-11-01 2018-05-11 Merck Sharp & Dohme Corp. Substituted bicyclic heteroaryl allosteric modulators of nicotinic acetylcholine receptors
EP3781161B1 (en) * 2018-05-03 2023-06-07 Jiangsu Hengrui Pharmaceuticals Co., Ltd. Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (rory) and pharmaceutical uses thereof
CN108997398B (zh) * 2018-07-23 2020-12-15 被忽略疾病药物研发组织 一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
CN114502535B (zh) * 2019-10-31 2024-04-12 江苏恒瑞医药股份有限公司 一种RORγ调节剂的酸加成盐
WO2021248008A1 (en) 2020-06-05 2021-12-09 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6299796B1 (en) 1997-12-18 2001-10-09 Fuji Photo Film Co., Ltd. Styryl compound, method for the preparation thereof and electroluminescent element employing the same
US6748803B1 (en) * 2000-02-22 2004-06-15 Simmonds Precison Products, Inc. Liquid measurement system and shared interface apparatus for use therein
MXPA05003948A (es) * 2002-10-17 2005-06-17 Amgen Inc Derivados de bencimidazol y su uso como ligandos de receptor vaniloide.
US7135493B2 (en) * 2003-01-13 2006-11-14 Astellas Pharma Inc. HDAC inhibitor
BRPI0412345A (pt) * 2003-07-28 2006-10-03 Janssen Pharmaceutica Nv derivados de benzimidazol, benzotiazol e benzoxazol e seu uso como moduladores de lta4h
WO2005042497A2 (en) * 2003-10-28 2005-05-12 Vertex Pharmaceuticals, Incorporated Benzimidazoles useful as modulators of ion channels
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
WO2008003665A1 (en) * 2006-07-04 2008-01-10 Janssen Pharmaceutica Nv Benzimidazole cannabinoid agonists bearing a substituted heterocyclic group
AU2007333990A1 (en) * 2006-12-15 2008-06-26 Janssen Pharmaceutica N.V. Benzimidazole TRPV1 inhibitors

Also Published As

Publication number Publication date
AU2007248341B2 (en) 2011-12-08
AR060840A1 (es) 2008-07-16
SI2021330T1 (sl) 2011-01-31
DE602007009378D1 (de) 2010-11-04
ATE482201T1 (de) 2010-10-15
ECSP088854A (es) 2008-11-27
CY1111269T1 (el) 2015-08-05
WO2007130780A3 (en) 2008-02-14
CN101511797A (zh) 2009-08-19
ES2350959T3 (es) 2011-01-28
CA2651128A1 (en) 2007-11-15
BRPI0709803B1 (pt) 2019-12-10
DK2021330T3 (da) 2010-12-06
KR20090008428A (ko) 2009-01-21
TW200808738A (en) 2008-02-16
BRPI0709803A2 (pt) 2011-07-26
JO3602B1 (ar) 2020-07-05
JP5302884B2 (ja) 2013-10-02
KR101434883B1 (ko) 2014-08-27
AU2007248341C1 (en) 2013-01-17
US20070259936A1 (en) 2007-11-08
IL194916A0 (en) 2009-08-03
CN101511797B (zh) 2013-01-02
BRPI0709803B8 (pt) 2021-05-25
ZA200810234B (en) 2010-02-24
EP2021330B1 (en) 2010-09-22
US20110190344A1 (en) 2011-08-04
PL2021330T3 (pl) 2011-03-31
EP2021330A2 (en) 2009-02-11
RS51473B (en) 2011-04-30
NO20085031L (no) 2009-01-06
PT2021330E (pt) 2010-12-03
US7951829B2 (en) 2011-05-31
CA2651128C (en) 2014-09-02
TWI419882B (zh) 2013-12-21
AU2007248341A1 (en) 2007-11-15
HRP20100700T1 (hr) 2011-02-28
UA94749C2 (xx) 2011-06-10
MY154595A (en) 2015-06-30
CO6160329A2 (es) 2010-05-20
IL194916A (en) 2013-01-31
WO2007130780A2 (en) 2007-11-15
EA019386B1 (ru) 2014-03-31
MX2008014108A (es) 2008-11-14
NZ572251A (en) 2010-08-27
JP2009535414A (ja) 2009-10-01
EA200870497A1 (ru) 2009-06-30
NO341965B1 (no) 2018-03-05
CR10479A (es) 2009-03-31
UY30322A1 (es) 2007-08-31
NI200800290A (es) 2012-01-30
PE20080065A1 (es) 2008-02-25
US20110190364A1 (en) 2011-08-04

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