ATE482201T1 - Vr1-benzimidazolmodulatoren - Google Patents

Vr1-benzimidazolmodulatoren

Info

Publication number
ATE482201T1
ATE482201T1 AT07760746T AT07760746T ATE482201T1 AT E482201 T1 ATE482201 T1 AT E482201T1 AT 07760746 T AT07760746 T AT 07760746T AT 07760746 T AT07760746 T AT 07760746T AT E482201 T1 ATE482201 T1 AT E482201T1
Authority
AT
Austria
Prior art keywords
benzimidazole
modulators
benzimidazole modulators
Prior art date
Application number
AT07760746T
Other languages
English (en)
Inventor
Raul CALVO
Mark Player
Scott Dax
William Parsons
Michael Brandt
Sharmila Patel
Jian Liu
Wing Cheung
Michele Jetter
Yu-Kai Lee
Mark Youngman
Wenxi Pan
Kenneth Wells
Derek Beauchamp
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of ATE482201T1 publication Critical patent/ATE482201T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/06—Benzimidazoles; Hydrogenated benzimidazoles with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached in position 2
    • C07D235/08—Radicals containing only hydrogen and carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4164—1,3-Diazoles
    • A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/10—Drugs for disorders of the urinary system of the bladder
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Rheumatology (AREA)
  • Pulmonology (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
AT07760746T 2006-05-03 2007-04-17 Vr1-benzimidazolmodulatoren ATE482201T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US79750406P 2006-05-03 2006-05-03
PCT/US2007/066748 WO2007130780A2 (en) 2006-05-03 2007-04-17 Benzimidazole modulators of vr1

Publications (1)

Publication Number Publication Date
ATE482201T1 true ATE482201T1 (de) 2010-10-15

Family

ID=38566108

Family Applications (1)

Application Number Title Priority Date Filing Date
AT07760746T ATE482201T1 (de) 2006-05-03 2007-04-17 Vr1-benzimidazolmodulatoren

Country Status (36)

Country Link
US (3) US7951829B2 (de)
EP (1) EP2021330B1 (de)
JP (1) JP5302884B2 (de)
KR (1) KR101434883B1 (de)
CN (1) CN101511797B (de)
AR (1) AR060840A1 (de)
AT (1) ATE482201T1 (de)
AU (1) AU2007248341C1 (de)
BR (1) BRPI0709803B8 (de)
CA (1) CA2651128C (de)
CO (1) CO6160329A2 (de)
CR (1) CR10479A (de)
CY (1) CY1111269T1 (de)
DE (1) DE602007009378D1 (de)
DK (1) DK2021330T3 (de)
EA (1) EA019386B1 (de)
EC (1) ECSP088854A (de)
ES (1) ES2350959T3 (de)
HR (1) HRP20100700T1 (de)
IL (1) IL194916A (de)
JO (1) JO3602B1 (de)
MX (1) MX2008014108A (de)
MY (1) MY154595A (de)
NI (1) NI200800290A (de)
NO (1) NO341965B1 (de)
NZ (1) NZ572251A (de)
PE (1) PE20080065A1 (de)
PL (1) PL2021330T3 (de)
PT (1) PT2021330E (de)
RS (1) RS51473B (de)
SI (1) SI2021330T1 (de)
TW (1) TWI419882B (de)
UA (1) UA94749C2 (de)
UY (1) UY30322A1 (de)
WO (1) WO2007130780A2 (de)
ZA (1) ZA200810234B (de)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101503286B1 (ko) * 2006-12-15 2015-03-17 얀센 파마슈티카 엔.브이. 벤즈이미다졸 ｔｒｐｖ1 저해제
US20090092574A1 (en) 2006-12-29 2009-04-09 Scott Richard W Ophthalmic And Otic Compositions Of Facially Amphiphilic Polymers And Oligomers And Uses Thereof
WO2009078999A1 (en) * 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolo-, oxazolo-, and thiazolopyrimidine modulators of trpv1
WO2009079000A1 (en) * 2007-12-17 2009-06-25 Janssen Pharmaceutica N.V. Imidazolopyrimidine modulators of trpv1
EP2264031B1 (de) * 2008-04-18 2015-04-15 Daewoong Pharmaceutical Co., Ltd. Neuartiges benzoxazin-benzimidazol-derivat, pharmazeutische zusammensetzung damit und verwendung davon
US8232409B2 (en) 2008-10-15 2012-07-31 Janssen Pharmaceutica N.V. Heterocyclic benzimidazoles as TRPM8 modulators
US8217060B2 (en) 2009-05-15 2012-07-10 Janssen Pharmaceutica, Nv Benzimidazole derivatives useful as TRP M8 receptor modulators
US8323805B2 (en) * 2009-06-04 2012-12-04 Nitto Denko Corporation Emissive aryl-heteroaryl acetylenes
CN102002010A (zh) * 2009-08-31 2011-04-06 住友化学株式会社 双噁唑啉基烷烃化合物的精制方法
RU2606128C2 (ru) 2011-05-16 2017-01-10 Селлсьютикс Корпорейшн Соединения для применения в лечении мукозита
US9056874B2 (en) 2012-05-04 2015-06-16 Novartis Ag Complement pathway modulators and uses thereof
CN105229003B (zh) 2013-03-14 2017-03-15 诺华股份有限公司 作为补体因子b抑制剂用于治疗眼科疾病的2‑(1h‑吲哚‑4‑基甲基)‑3h‑咪唑并[4,5‑b]吡啶‑6‑甲腈衍生物
CA2917964A1 (en) * 2013-07-11 2015-01-15 Bristol-Myers Squibb Company Ido inhibitors
CN105849090A (zh) 2013-10-30 2016-08-10 诺华股份有限公司 2-苄基-苯并咪唑补体因子b抑制剂及其用途
EP3348554B1 (de) * 2015-09-08 2020-05-06 Sumitomo Chemical Company, Limited Verfahren zur herstellung einer triazolverbindung
EP3534888B1 (de) * 2016-11-01 2022-04-06 Merck Sharp & Dohme Corp. Substituierte bicyclische heteroaryl-allosterische modulatoren von nikotinischen acetylcholin-rezeptoren
HUE062273T2 (hu) * 2018-05-03 2023-10-28 Jiangsu Hengrui Pharmaceuticals Co Ltd Benzimidazolszármazékok mint a retinsavreceptor rokon árvareceptor-gamma (RORy) modulátorai és gyógyszerészeti felhasználásaik
CN108997398B (zh) * 2018-07-23 2020-12-15 被忽略疾病药物研发组织 一种3,3-二甲基苯并[c][1,2]氧杂戊硼烷-1(3h)-醇的制备方法
CN112745268B (zh) * 2019-10-31 2022-09-16 江苏恒瑞医药股份有限公司 苯并咪唑衍生物的晶型及制备方法
AU2020377114A1 (en) * 2019-10-31 2022-06-16 Jiangsu Hengrui Medicine Co., Ltd. Acid addition salt of RORγ regulator
US11771694B2 (en) 2020-06-05 2023-10-03 Innovation Pharmaceuticals Inc. Arylamide compounds for treatment and prevention of viral infections

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5612360A (en) * 1992-06-03 1997-03-18 Eli Lilly And Company Angiotensin II antagonists
US6299796B1 (en) 1997-12-18 2001-10-09 Fuji Photo Film Co., Ltd. Styryl compound, method for the preparation thereof and electroluminescent element employing the same
US6748803B1 (en) * 2000-02-22 2004-06-15 Simmonds Precison Products, Inc. Liquid measurement system and shared interface apparatus for use therein
AU2003301436A1 (en) * 2002-10-17 2004-05-04 Amgen Inc. Benzimidazole derivatives and their use as vanilloid receptor ligands
TW200418806A (en) * 2003-01-13 2004-10-01 Fujisawa Pharmaceutical Co HDAC inhibitor
PT1660491E (pt) * 2003-07-28 2008-10-10 Janssen Pharmaceutica Nv Derivados de benzimidazole, benzotiazole e benzoxazole e a sua utilização como moduladores de lta4h
KR20060115396A (ko) * 2003-10-28 2006-11-08 버텍스 파마슈티칼스 인코포레이티드 이온 채널 조절인자로서 유용한 벤즈이미다졸
WO2006058338A2 (en) * 2004-11-29 2006-06-01 Janssen Pharmaceutica N.V. 4 - piperidinecarboxamide derivatives as modulators of vanilloid vr1 receptor
EA200970080A1 (ru) * 2006-07-04 2009-06-30 Янссен Фармацевтика Нв Бензимидазольные агонисты каннабиноидов, содержащие замещенную гетероциклическую группу
KR101503286B1 (ko) * 2006-12-15 2015-03-17 얀센 파마슈티카 엔.브이. 벤즈이미다졸 ｔｒｐｖ1 저해제

Also Published As

Publication number Publication date
JO3602B1 (ar) 2020-07-05
CA2651128A1 (en) 2007-11-15
UA94749C2 (en) 2011-06-10
KR20090008428A (ko) 2009-01-21
EA019386B1 (ru) 2014-03-31
US7951829B2 (en) 2011-05-31
EA200870497A1 (ru) 2009-06-30
TW200808738A (en) 2008-02-16
SI2021330T1 (sl) 2011-01-31
WO2007130780A3 (en) 2008-02-14
RS51473B (sr) 2011-04-30
KR101434883B1 (ko) 2014-08-27
AU2007248341B2 (en) 2011-12-08
IL194916A0 (en) 2009-08-03
HRP20100700T1 (hr) 2011-02-28
BRPI0709803B8 (pt) 2021-05-25
US20110190364A1 (en) 2011-08-04
MX2008014108A (es) 2008-11-14
CY1111269T1 (el) 2015-08-05
CR10479A (es) 2009-03-31
WO2007130780A2 (en) 2007-11-15
PE20080065A1 (es) 2008-02-25
NO20085031L (no) 2009-01-06
EP2021330A2 (de) 2009-02-11
NO341965B1 (no) 2018-03-05
PL2021330T3 (pl) 2011-03-31
TWI419882B (zh) 2013-12-21
CN101511797A (zh) 2009-08-19
AR060840A1 (es) 2008-07-16
IL194916A (en) 2013-01-31
PT2021330E (pt) 2010-12-03
EP2021330B1 (de) 2010-09-22
ECSP088854A (es) 2008-11-27
ZA200810234B (en) 2010-02-24
US20070259936A1 (en) 2007-11-08
AU2007248341C1 (en) 2013-01-17
JP2009535414A (ja) 2009-10-01
HK1131971A1 (en) 2010-02-12
BRPI0709803B1 (pt) 2019-12-10
BRPI0709803A2 (pt) 2011-07-26
CO6160329A2 (es) 2010-05-20
DK2021330T3 (da) 2010-12-06
ES2350959T3 (es) 2011-01-28
CN101511797B (zh) 2013-01-02
US20110190344A1 (en) 2011-08-04
NZ572251A (en) 2010-08-27
JP5302884B2 (ja) 2013-10-02
MY154595A (en) 2015-06-30
UY30322A1 (es) 2007-08-31
AU2007248341A1 (en) 2007-11-15
DE602007009378D1 (de) 2010-11-04
NI200800290A (es) 2012-01-30
CA2651128C (en) 2014-09-02

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