HK1130290A1 - Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo - Google Patents

Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

Info

Publication number
HK1130290A1
HK1130290A1 HK09109417.7A HK09109417A HK1130290A1 HK 1130290 A1 HK1130290 A1 HK 1130290A1 HK 09109417 A HK09109417 A HK 09109417A HK 1130290 A1 HK1130290 A1 HK 1130290A1
Authority
HK
Hong Kong
Prior art keywords
hematopoiesis
stimulant
vivo
producing recombinant
recombinant tat
Prior art date
Application number
HK09109417.7A
Other languages
English (en)
Inventor
Kou-Juey Wu
Chi-Hung Huang
Original Assignee
Taiwan Advance Bio Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiwan Advance Bio Pharm Inc filed Critical Taiwan Advance Bio Pharm Inc
Publication of HK1130290A1 publication Critical patent/HK1130290A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/14—Extraction; Separation; Purification
    • C07K1/34—Extraction; Separation; Purification by filtration, ultrafiltration or reverse osmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K19/00—Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/10—Fusion polypeptide containing a localisation/targetting motif containing a tag for extracellular membrane crossing, e.g. TAT or VP22
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/20—Fusion polypeptide containing a tag with affinity for a non-protein ligand
    • C07K2319/21—Fusion polypeptide containing a tag with affinity for a non-protein ligand containing a His-tag

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Immunology (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Analytical Chemistry (AREA)
  • Oncology (AREA)
  • Diabetes (AREA)
  • Water Supply & Treatment (AREA)
  • Epidemiology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Materials For Medical Uses (AREA)
HK09109417.7A 2008-03-04 2009-10-12 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo HK1130290A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US12/042,097 US8222206B2 (en) 2008-03-04 2008-03-04 Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H

Publications (1)

Publication Number Publication Date
HK1130290A1 true HK1130290A1 (en) 2009-12-24

Family

ID=40627112

Family Applications (2)

Application Number Title Priority Date Filing Date
HK12111667.5A HK1170933A1 (zh) 2008-03-04 2009-10-12 作為體內造血刺激劑之 重組蛋白質之製造方法
HK09109417.7A HK1130290A1 (en) 2008-03-04 2009-10-12 Method of producing recombinant tat-hoxb4h protein for use as a stimulant of hematopoiesis in vivo

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK12111667.5A HK1170933A1 (zh) 2008-03-04 2009-10-12 作為體內造血刺激劑之 重組蛋白質之製造方法

Country Status (15)

Country Link
US (4) US8222206B2 (fr)
EP (2) EP2100968B1 (fr)
JP (2) JP4755224B2 (fr)
KR (1) KR101160381B1 (fr)
CN (3) CN101524527B (fr)
BR (1) BRPI0803381A2 (fr)
CA (1) CA2658231C (fr)
ES (2) ES2464777T3 (fr)
HK (2) HK1170933A1 (fr)
HU (1) HUE027513T2 (fr)
MY (1) MY164521A (fr)
PL (2) PL2455099T3 (fr)
PT (1) PT2100968E (fr)
RU (1) RU2401863C2 (fr)
TW (1) TWI414598B (fr)

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* Cited by examiner, † Cited by third party
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US8222206B2 (en) * 2008-03-04 2012-07-17 Taiwan Advance Bio-Pharm Inc. Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H
US10354407B2 (en) 2013-03-15 2019-07-16 Spatial Cam Llc Camera for locating hidden objects
US10896327B1 (en) 2013-03-15 2021-01-19 Spatial Cam Llc Device with a camera for locating hidden object
KR101903339B1 (ko) * 2011-03-22 2018-10-01 플루리스템 리미티드 방사선 또는 화학적 손상을 치료하는 방법
RU2495125C2 (ru) * 2011-12-07 2013-10-10 Федеральное государственное бюджетное учреждение "Новосибирский научно-исследовательский институт патологии кровообращения имени академика Е.Н. Мешалкина" Министерства здравоохранения Российской Федерации (ФГБУ "ННИИПК им. акад. Е.Н. Мешалкина" Минздрава России) РЕКОМБИНАНТНАЯ ПЛАЗМИДА pOK-DsRed2, КОДИРУЮЩАЯ БЕЛКИ ОСТ4 И KLF4 ЧЕЛОВЕКА И ФЛУОРЕСЦЕНТНЫЙ БЕЛОК DsRed2, ПРЕДНАЗНАЧЕНАЯ ДЛЯ ПОЛУЧЕНИЯ ИНДУЦИРОВАННЫХ ПЛЮРИПОТЕНТНЫХ СТВОЛОВЫХ КЛЕТОК ЧЕЛОВЕКА
US9783783B2 (en) * 2013-01-30 2017-10-10 Cornell University Compositions and methods for the expansion of stem cells
SG11201508199QA (en) * 2013-04-05 2015-11-27 Claudia Zylberberg Matrix metalloproteinases and uses thereof
TWI548748B (zh) * 2015-04-16 2016-09-11 台灣尖端先進生技醫藥股份有限公司 造血幹／先驅細胞之體外放大培養方法及其立即可使用之組成物
WO2017143210A1 (fr) * 2016-02-19 2017-08-24 The General Hospital Corporation Méthodes de génération de cellules progénitrices hématopoïétiques compatibles avec mhc/hla personnalisées
CN112752547A (zh) 2018-09-24 2021-05-04 波士顿科学国际有限公司 具有改进的组织保持的侵略性特征的夹子
TW202026307A (zh) * 2019-01-11 2020-07-16 台灣尖端先進生技醫藥股份有限公司 Ｎ－端標記組胺酸之重組ｔａｔ－ｈｏｘ家族蛋白質及其製造方法
TWI756518B (zh) * 2019-02-27 2022-03-01 台灣尖端先進生技醫藥股份有限公司 突變型ｈｏｘｂ４重組蛋白質之製造方法與用途

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JP2838867B2 (ja) * 1986-01-22 1998-12-16 中外製薬株式会社 幹細胞増殖促進剤
JPH0276820A (ja) * 1988-06-15 1990-03-16 Ajinomoto Co Inc 骨髄移植療法支持剤
JPH06133780A (ja) * 1992-10-23 1994-05-17 Sumitomo Pharmaceut Co Ltd 新規なｔ−ＰＡ改変体
US5837507A (en) 1995-11-13 1998-11-17 The Regents Of The University Of California Hox-induced enhancement of in vivo and in vitro proliferative capacity and gene therapeutic methods
US6303337B1 (en) * 1999-08-25 2001-10-16 Amber Gen. Inc. N-terminal and C-terminal markers in nascent proteins
CA2337574C (fr) 2000-02-23 2013-01-22 Institut De Recherches Cliniques De Montreal/Ircm Amelioration de la croissance du facteur de cellules souches hematopoietiques et methode d'utilisation
US20040082003A1 (en) 2000-02-23 2004-04-29 Guy Sauvageau Stem cell expansion enhancing factor and method of use
US20040072298A1 (en) 2000-02-23 2004-04-15 Guy Sauvageau Stem cell expansion enhancing factor and method of use
DE10050935A1 (de) * 2000-10-11 2002-05-02 Tegenero Gmbh Verwendung CD28 spezifischer monoklonaler Antikörper zur Stimulation von Blutzellen, welche kein CD28 tragen
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EP1551970A2 (fr) * 2002-10-08 2005-07-13 Institut De Recherches Cliniques De Montreal Facteur d'expansion de cellule souche bloquant un gene limitant l'expansion induite par hox et procede associe
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US8222206B2 (en) * 2008-03-04 2012-07-17 Taiwan Advance Bio-Pharm Inc. Method of enhancing the mobilization of hematopoietic stem cells using TAT-HOXB4H

Also Published As

Publication number Publication date
CA2658231A1 (fr) 2009-09-04
TWI414598B (zh) 2013-11-11
US8222207B2 (en) 2012-07-17
PL2455099T3 (pl) 2016-07-29
JP2009207482A (ja) 2009-09-17
EP2100968B1 (fr) 2014-02-26
PL2100968T3 (pl) 2014-08-29
KR20090095473A (ko) 2009-09-09
US8124377B2 (en) 2012-02-28
US8222206B2 (en) 2012-07-17
ES2464777T3 (es) 2014-06-04
TW200938632A (en) 2009-09-16
US20110092412A1 (en) 2011-04-21
PT2100968E (pt) 2014-05-30
CN102805859A (zh) 2012-12-05
JP5738636B2 (ja) 2015-06-24
CN104650210A (zh) 2015-05-27
JP2011168597A (ja) 2011-09-01
HK1170933A1 (zh) 2013-03-15
EP2455099A1 (fr) 2012-05-23
ES2567780T3 (es) 2016-04-26
KR101160381B1 (ko) 2012-06-26
CN102805859B (zh) 2016-06-01
EP2100968A1 (fr) 2009-09-16
RU2401863C2 (ru) 2010-10-20
US20110092450A1 (en) 2011-04-21
CN101524527A (zh) 2009-09-09
JP4755224B2 (ja) 2011-08-24
HUE027513T2 (en) 2016-10-28
CN101524527B (zh) 2016-06-01
CA2658231C (fr) 2014-09-23
US8450458B2 (en) 2013-05-28
CN104650210B (zh) 2018-01-23
EP2455099B1 (fr) 2016-01-20
US20090227496A1 (en) 2009-09-10
BRPI0803381A2 (pt) 2011-08-23
US20120322979A1 (en) 2012-12-20
MY164521A (en) 2017-12-29
RU2008134247A (ru) 2010-02-27

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