HK1125924A1 - Thieno-pyridine derivatives as mek inhibitors mek - - Google Patents

Thieno-pyridine derivatives as mek inhibitors mek -

Info

Publication number
HK1125924A1
HK1125924A1 HK09103590.9A HK09103590A HK1125924A1 HK 1125924 A1 HK1125924 A1 HK 1125924A1 HK 09103590 A HK09103590 A HK 09103590A HK 1125924 A1 HK1125924 A1 HK 1125924A1
Authority
HK
Hong Kong
Prior art keywords
mek
thieno
pyridine derivatives
inhibitors
mek inhibitors
Prior art date
Application number
HK09103590.9A
Other languages
English (en)
Chinese (zh)
Inventor
Martin Clive Hutchings
Sarah Catherine Archibald
Daniel Christopher Brookings
Jeremy Martin Davis
James Andrew Johnson
Barry John Langham
Judi Charlotte Neuss
Original Assignee
Ucb Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ucb Pharma Sa filed Critical Ucb Pharma Sa
Publication of HK1125924A1 publication Critical patent/HK1125924A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Transplantation (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
HK09103590.9A 2006-01-31 2009-04-20 Thieno-pyridine derivatives as mek inhibitors mek - HK1125924A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0601962.4A GB0601962D0 (en) 2006-01-31 2006-01-31 Therapeutic agents
PCT/GB2007/000310 WO2007088345A1 (en) 2006-01-31 2007-01-30 Thieno-pyridine derivatives as mek inhibitors

Publications (1)

Publication Number Publication Date
HK1125924A1 true HK1125924A1 (en) 2009-08-21

Family

ID=36100789

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09103590.9A HK1125924A1 (en) 2006-01-31 2009-04-20 Thieno-pyridine derivatives as mek inhibitors mek -

Country Status (27)

Country Link
US (3) US8283359B2 (xx)
EP (1) EP1981892B1 (xx)
JP (1) JP5249787B2 (xx)
KR (1) KR101446919B1 (xx)
CN (1) CN101379067B (xx)
AU (1) AU2007211377B2 (xx)
BR (1) BRPI0708016B1 (xx)
CA (1) CA2640594C (xx)
CY (1) CY1115404T1 (xx)
DK (1) DK1981892T3 (xx)
EA (1) EA016128B1 (xx)
EC (1) ECSP088704A (xx)
ES (1) ES2471970T3 (xx)
GB (1) GB0601962D0 (xx)
HK (1) HK1125924A1 (xx)
HR (1) HRP20140503T1 (xx)
IL (1) IL192603A (xx)
MY (1) MY146387A (xx)
NO (1) NO341064B1 (xx)
NZ (1) NZ569638A (xx)
PL (1) PL1981892T3 (xx)
PT (1) PT1981892E (xx)
RS (1) RS53342B (xx)
SI (1) SI1981892T1 (xx)
UA (1) UA95939C2 (xx)
WO (1) WO2007088345A1 (xx)
ZA (1) ZA200807447B (xx)

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GB0601962D0 (en) 2006-01-31 2006-03-15 Ucb Sa Therapeutic agents
GB0616214D0 (en) * 2006-08-15 2006-09-27 Ucb Sa Therapeutic Agents
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EP2240494B1 (en) 2008-01-21 2016-03-30 UCB Biopharma SPRL Thieno-pyridine derivatives as mek inhibitors
GB0811304D0 (en) * 2008-06-19 2008-07-30 Ucb Pharma Sa Therapeutic agents
JP5503930B2 (ja) * 2009-09-18 2014-05-28 住友化学株式会社 ３−アミノ−１−ｔｅｒｔ−ブトキシカルボニルピペリジンの精製方法およびそのクエン酸塩
CA2806734A1 (en) 2010-07-26 2012-02-09 Biomatrica, Inc. Compositions for stabilizing dna, rna and proteins in saliva and other biological samples during shipping and storage at ambient temperatures
JP5933544B2 (ja) 2010-07-26 2016-06-08 バイオマトリカ， インコーポレーテッド 外界温度で出荷および貯蔵中の血中ｄｎａ、ｒｎａおよびタンパク質ならびに他の生体試料を安定化させるための組成物
EP2934572A4 (en) 2012-12-20 2016-11-23 Biomatrica Inc FORMULATIONS AND METHODS FOR STABILIZING PCR REAGENTS
US10011874B2 (en) 2013-02-25 2018-07-03 Novartis Ag Androgen receptor mutation
EA201690089A1 (ru) 2013-06-11 2017-04-28 Латвийский Институт Органического Синтеза ТИЕНО[2,3-b]ПИРИДИНЫ КАК МОДУЛЯТОРЫ СОСТОЯНИЯ МНОЖЕСТВЕННОЙ ЛЕКАРСТВЕННОЙ УСТОЙЧИВОСТИ
JP6604942B2 (ja) 2013-06-13 2019-11-13 バイオマトリカ，インク． 細胞安定化
CN106572650B (zh) 2014-06-10 2021-08-31 生物马特里卡公司 在环境温度下稳定凝血细胞
CN105384754B (zh) * 2014-09-02 2018-04-20 上海科州药物研发有限公司 作为蛋白激酶抑制剂的杂环类化合物及其制备方法和用途
WO2017033113A1 (en) 2015-08-21 2017-03-02 Acerta Pharma B.V. Therapeutic combinations of a mek inhibitor and a btk inhibitor
KR20230145258A (ko) 2015-12-08 2023-10-17 바이오매트리카 인코포레이티드 적혈구 침강 속도의 감소
MX2019013561A (es) 2017-05-19 2022-02-09 Nflection Therapeutics Inc Compuestos de pirrolopiridina-anilina para el tratamiento de trastornos dermicos.
CA3063535A1 (en) * 2017-05-19 2018-11-22 Nflection Therapeutics, Inc. Fused heteroaromatic-aniline compounds for treatment of dermal disorders
CN109836434B (zh) * 2017-11-27 2020-09-25 上海宇耀生物科技有限公司 噻吩并环类化合物及其合成方法和应用
WO2020106303A1 (en) * 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Aryl-aniline and heteroaryl-aniline compounds for treatment of skin cancers
CA3120371A1 (en) 2018-11-20 2020-05-28 Nflection Therapeutics, Inc. Cyanoaryl-aniline compounds for treatment of dermal disorders
CN114364798A (zh) 2019-03-21 2022-04-15 欧恩科斯欧公司 用于治疗癌症的Dbait分子与激酶抑制剂的组合
KR20220098759A (ko) 2019-11-08 2022-07-12 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) 키나제 억제제에 대해 내성을 획득한 암의 치료 방법
CN111138449B (zh) * 2020-01-15 2022-11-29 四川大学华西医院 双靶向erk1和erk5抑制剂的制备及其抗肿瘤应用
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
GB202205203D0 (en) 2022-04-08 2022-05-25 UCB Biopharma SRL Combination with inhibitor

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TW200808769A (en) 2006-04-18 2008-02-16 Astrazeneca Ab Therapeutic compounds
GB0616214D0 (en) 2006-08-15 2006-09-27 Ucb Sa Therapeutic Agents
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Also Published As

Publication number Publication date
PL1981892T3 (pl) 2014-08-29
US20090149437A1 (en) 2009-06-11
NO20083739L (no) 2008-08-29
WO2007088345A1 (en) 2007-08-09
CA2640594C (en) 2014-12-23
EP1981892B1 (en) 2014-03-12
EP1981892A1 (en) 2008-10-22
AU2007211377B2 (en) 2012-03-01
KR101446919B1 (ko) 2014-10-07
US8394822B2 (en) 2013-03-12
ZA200807447B (en) 2009-11-25
US8283359B2 (en) 2012-10-09
IL192603A (en) 2013-12-31
SI1981892T1 (sl) 2014-07-31
GB0601962D0 (en) 2006-03-15
US20130150573A1 (en) 2013-06-13
RS53342B (en) 2014-10-31
CN101379067A (zh) 2009-03-04
CY1115404T1 (el) 2017-01-04
BRPI0708016B1 (pt) 2021-07-06
US8604051B2 (en) 2013-12-10
JP5249787B2 (ja) 2013-07-31
IL192603A0 (en) 2009-02-11
US20120329774A1 (en) 2012-12-27
PT1981892E (pt) 2014-06-23
DK1981892T3 (da) 2014-06-23
CN101379067B (zh) 2011-03-23
EA200801684A1 (ru) 2009-04-28
MY146387A (en) 2012-08-15
ECSP088704A (es) 2008-09-29
JP2009525317A (ja) 2009-07-09
NZ569638A (en) 2010-08-27
ES2471970T3 (es) 2014-06-27
CA2640594A1 (en) 2007-08-09
EA016128B1 (ru) 2012-02-28
NO341064B1 (no) 2017-08-14
KR20080095870A (ko) 2008-10-29
UA95939C2 (xx) 2011-09-26
BRPI0708016A2 (pt) 2011-05-17
AU2007211377A1 (en) 2007-08-09
HRP20140503T1 (hr) 2014-07-04

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