HK1121174A1 - Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use - Google Patents

Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Info

Publication number
HK1121174A1
HK1121174A1 HK09101212.1A HK09101212A HK1121174A1 HK 1121174 A1 HK1121174 A1 HK 1121174A1 HK 09101212 A HK09101212 A HK 09101212A HK 1121174 A1 HK1121174 A1 HK 1121174A1
Authority
HK
Hong Kong
Prior art keywords
ptk7
monoclonal antibodies
tyrosine kinase
human monoclonal
protein tyrosine
Prior art date
Application number
HK09101212.1A
Other languages
English (en)
Inventor
Li-Sheng Lu
Jonathan Alexander Terrett
Chin Pan
Original Assignee
Medarex Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38123515&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1121174(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Medarex Llc filed Critical Medarex Llc
Publication of HK1121174A1 publication Critical patent/HK1121174A1/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18Growth factors; Growth regulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/20Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/50Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565Complementarity determining region [CDR]
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/70Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/77Internalization into the cell

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Cell Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Zoology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
HK09101212.1A 2005-12-08 2009-02-10 Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use HK1121174A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US74837305P 2005-12-08 2005-12-08
PCT/US2006/046837 WO2007067730A2 (en) 2005-12-08 2006-12-08 Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use

Publications (1)

Publication Number Publication Date
HK1121174A1 true HK1121174A1 (en) 2009-04-17

Family

ID=38123515

Family Applications (1)

Application Number Title Priority Date Filing Date
HK09101212.1A HK1121174A1 (en) 2005-12-08 2009-02-10 Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use

Country Status (22)

Country Link
US (3) US8222375B2 (zh)
EP (1) EP1957539B1 (zh)
JP (1) JP5401639B2 (zh)
KR (1) KR101373464B1 (zh)
CN (1) CN101360761B (zh)
AU (1) AU2006321841C1 (zh)
BR (1) BRPI0619582A2 (zh)
CA (1) CA2632552C (zh)
DK (1) DK1957539T3 (zh)
EA (1) EA017812B1 (zh)
ES (1) ES2406063T3 (zh)
HK (1) HK1121174A1 (zh)
IL (1) IL191788A (zh)
ME (1) ME02002B (zh)
NO (1) NO20082559L (zh)
NZ (2) NZ594466A (zh)
PL (1) PL1957539T3 (zh)
PT (1) PT1957539E (zh)
RS (1) RS52804B (zh)
SG (1) SG177194A1 (zh)
SI (1) SI1957539T1 (zh)
WO (1) WO2007067730A2 (zh)

Families Citing this family (60)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007067730A2 (en) 2005-12-08 2007-06-14 Medarex, Inc. Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use
NZ568015A (en) * 2005-12-08 2012-03-30 Medarex Inc Human monoclonal antibodies to O8E
EP2185188B1 (en) 2007-08-22 2014-08-06 Medarex, L.L.C. Site-specific attachment of drugs or other agents to engineered antibodies with c-terminal extensions
WO2009042209A2 (en) * 2007-09-25 2009-04-02 The Board Of Trustees Of The Leland Stanford Junior University Identification of thymically derived cd4 t cells by protein tyrosine kinase 7 expression
EP2570137A3 (en) * 2007-11-07 2013-08-21 Celldex Therapeutics, Inc. Antibodies that bind human dendritic and epithelial cell 205 (DEC-205)
CL2008003527A1 (es) * 2007-11-30 2009-10-09 Medarex Inc Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7
KR101123130B1 (ko) * 2008-03-17 2012-03-30 연세대학교 산학협력단 Ptk7 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제
WO2009116764A2 (ko) * 2008-03-17 2009-09-24 연세대학교 산학협력단 Ptk7 단백질의 기능 저해를 통한 세포의 이동, 침윤 또는 혈관신생 억제제
AU2010270163B2 (en) 2009-07-10 2016-05-05 Innate Pharma, S.A. TLR3 binding agents
US8394922B2 (en) * 2009-08-03 2013-03-12 Medarex, Inc. Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof
EP2380909A1 (en) * 2010-04-26 2011-10-26 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. PTK-7 protein involved in breast cancer
WO2011146313A1 (en) 2010-05-19 2011-11-24 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
SA112330278B1 (ar) * 2011-02-18 2015-10-09 ستيم سينتركس، انك. مواد ضابطة جديدة وطرق للاستخدام
US8852599B2 (en) 2011-05-26 2014-10-07 Bristol-Myers Squibb Company Immunoconjugates, compositions for making them, and methods of making and use
EP2763988B1 (en) 2011-10-03 2017-09-20 The University of North Carolina At Chapel Hill Pyrrolopyrimidine compounds for the treatment of cancer
AR089972A1 (es) 2012-02-13 2014-10-01 Bristol Myers Squibb Co Compuestos de enediino, conjugados de estos y sus usos y metodos
MX2014013632A (es) 2012-05-22 2015-02-05 Univ North Carolina Compuestos de pirimidina para el tratamiento de cancer.
AU2013269652B2 (en) 2012-05-31 2017-07-06 Innate Pharma TLR3 binding agents
US9562047B2 (en) 2012-10-17 2017-02-07 The University Of North Carolina At Chapel Hill Pyrazolopyrimidine compounds for the treatment of cancer
WO2014085225A1 (en) 2012-11-27 2014-06-05 The University Of North Carolina At Chapel Hill Pyrimidine compounds for the treatment of cancer
SG11201506243XA (en) 2013-02-14 2015-09-29 Bristol Myers Squibb Co Tubulysin compounds, methods of making and use
CN105899515B (zh) 2013-08-14 2020-01-14 威廉马歇莱思大学 uncialamycin的衍生物、合成方法及其作为抗肿瘤剂的用途
EP3129377A4 (en) * 2014-04-11 2017-12-20 The University of North Carolina at Chapel Hill Mertk-specific pyrimidine compounds
PL3137114T3 (pl) 2014-04-30 2021-06-28 Pfizer Inc. Koniugaty przeciwciało anty-ptk7-lek
US10077287B2 (en) 2014-11-10 2018-09-18 Bristol-Myers Squibb Company Tubulysin analogs and methods of making and use
DK3221346T3 (da) 2014-11-21 2020-10-12 Bristol Myers Squibb Co Antistoffer omfattende modificerede konstante områder af tungkæden
WO2016115201A1 (en) 2015-01-14 2016-07-21 Bristol-Myers Squibb Company Heteroarylene-bridged benzodiazepine dimers, conjugates thereof, and methods of making and using
HRP20230060T1 (hr) * 2015-05-29 2023-03-17 Bristol-Myers Squibb Company Antitijela protiv ox40 i njihova primjena
US20180362619A1 (en) 2015-12-21 2018-12-20 Bristol-Myers Squibb Company Variant antibodies for site-specific conjugation
KR20180104036A (ko) 2016-01-22 2018-09-19 머크 샤프 앤드 돔 코포레이션 항-응고 인자 xi 항체
US10709708B2 (en) 2016-03-17 2020-07-14 The University Of North Carolina At Chapel Hill Method of treating cancer with a combination of MER tyrosine kinase inhibitor and an epidermal growth factor receptor (EGFR) inhibitor
CN109069665A (zh) 2016-05-10 2018-12-21 百时美施贵宝公司 具有增强的稳定性的微管溶素类似物的抗体-药物缀合物
TWI802193B (zh) 2016-06-14 2023-05-11 美商默沙東有限責任公司 抗凝血因子xi抗體
CN109641911B (zh) 2016-08-19 2023-02-21 百时美施贵宝公司 seco-环丙吡咯并吲哚化合物和其抗体-药物缀合物以及制备和使用方法
US10398783B2 (en) 2016-10-20 2019-09-03 Bristol-Myers Squibb Company Antiproliferative compounds and conjugates made therefrom
CN116333129A (zh) 2017-05-25 2023-06-27 百时美施贵宝公司 包含经修饰的重链恒定区的抗体
US10457681B2 (en) 2017-08-16 2019-10-29 Bristol_Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a tricyclic moiety, conjugates thereof, and methods and uses therefor
US10508115B2 (en) 2017-08-16 2019-12-17 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having heteroatom-linked aromatic moieties, conjugates thereof, and methods and uses therefor
US10494370B2 (en) 2017-08-16 2019-12-03 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a pyridine or pyrazine moiety, conjugates thereof, and methods and uses therefor
US10472361B2 (en) 2017-08-16 2019-11-12 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a benzotriazole moiety, conjugates thereof, and methods and uses therefor
US10487084B2 (en) 2017-08-16 2019-11-26 Bristol-Myers Squibb Company Toll-like receptor 7 (TLR7) agonists having a heterobiaryl moiety, conjugates thereof, and methods and uses therefor
US11485741B2 (en) 2018-04-24 2022-11-01 Bristol-Myers Squibb Company Macrocyclic toll-like receptor 7 (TLR7) agonists
IL278938B1 (en) 2018-05-29 2024-05-01 Bristol Myers Squibb Co Modified atom groups that sacrifice themselves for use in prodrugs and conjugates and methods of use and preparation
US11554120B2 (en) 2018-08-03 2023-01-17 Bristol-Myers Squibb Company 1H-pyrazolo[4,3-d]pyrimidine compounds as toll-like receptor 7 (TLR7) agonists and methods and uses therefor
BR112021008083A2 (pt) * 2018-11-07 2021-08-10 Crispr Therapeutics Ag terapia contra o câncer com célula imunológica anti-ptk7
CN113348177A (zh) 2018-11-28 2021-09-03 百时美施贵宝公司 包含经修饰的重链恒定区的抗体
PT3886914T (pt) 2018-11-30 2023-05-05 Bristol Myers Squibb Co Anticorpo compreendendo uma extensão c-terminal de cadeia leve contendo glutamina, conjugados do mesmo, e métodos e utilizações
KR20210102334A (ko) 2018-12-12 2021-08-19 브리스톨-마이어스 스큅 컴퍼니 트랜스글루타미나제 접합을 위해 변형된 항체, 그의 접합체, 및 방법 및 용도
KR102236127B1 (ko) * 2019-08-08 2021-04-07 주식회사 하울바이오 티로시나아제를 억제하는 항-티로시나아제 항체 및 이의 용도
WO2021055306A1 (en) 2019-09-16 2021-03-25 Bristol-Myers Squibb Company Dual capture method for analysis of antibody-drug conjugates
TW202208412A (zh) * 2020-05-06 2022-03-01 瑞士商Crispr治療公司 對酪胺酸蛋白激酶樣7(ptk7)特異的經掩蔽的嵌合抗原受體和表現其的免疫細胞
WO2022015113A1 (ko) * 2020-07-16 2022-01-20 연세대학교 산학협력단 Ptk7에 특이적으로 결합하는 항체 및 이의 용도
CN115894696A (zh) * 2021-08-18 2023-04-04 和迈生物科技有限公司 抗ptk7单域抗体及其应用
CN114213541B (zh) * 2021-12-20 2022-12-30 南京诺唯赞生物科技股份有限公司 一种全能核酸酶的单克隆抗体及其制备方法
WO2023180484A1 (en) 2022-03-23 2023-09-28 Synaffix B.V. Antibody-conjugates for targeting of tumours expressing ptk7
WO2023225639A1 (en) * 2022-05-19 2023-11-23 Mythic Therapeutics, Inc. Ptk7-binding proteins with ph-dependent binding and uses thereof
GB202209196D0 (en) * 2022-06-22 2022-08-10 Almac Discovery Ltd Bi-specific antigen binding molecules
WO2024037621A1 (en) * 2022-08-19 2024-02-22 Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. Ptk7-binding protein and use thereof
WO2024054030A1 (ko) * 2022-09-06 2024-03-14 연세대학교 산학협력단 항-ptk7 항체 및 이의 용도
WO2024080325A1 (ja) * 2022-10-14 2024-04-18 Jsr株式会社 抗体及びその使用

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4708930A (en) * 1984-11-09 1987-11-24 Coulter Corporation Monoclonal antibody to a human carcinoma tumor associated antigen
WO1996037610A2 (en) * 1995-05-25 1996-11-28 MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. Cck-4, a receptor tyrosine kinase, and methods for diagnosis and treatment of cck-4 signal transduction disorders
JPH11513391A (ja) 1995-10-03 1999-11-16 ザ スクリップス リサーチ インスティテュート Cc−1065 及びズオカーマイシンのcbi 類縁体
WO1998045708A1 (en) 1997-04-08 1998-10-15 Sugen, Inc. Study and treatment of diseases related to specific cellular functions of receptor protein tyrosine kinases
AU754083B2 (en) 1997-05-22 2002-11-07 Scripps Research Institute, The Analogs of duocarmycin and CC-1065
DE60037896D1 (de) 1999-07-29 2008-03-13 Medarex Inc Menschliche antikörper gegen her2/neu
MXPA03006617A (es) 2001-01-24 2004-12-02 Protein Design Labs Inc Metodos de diagnostico de cancer de pecho, composiciones y metodos de rastreo de moduladores de cancer de pecho.
AU2002309583A1 (en) 2001-04-18 2002-11-05 Protein Desing Labs, Inc. Methods of diagnosis of lung cancer, compositions and methods of screening for modulators of lung cancer
MXPA03011094A (es) 2001-05-31 2004-12-06 Medarex Inc Citotoxinas, profarmacos, ligadores, y estabilizadores utiles para ello.
GB0114033D0 (en) 2001-06-09 2001-08-01 Innovata Biomed Ltd Process
EP1404356B1 (en) 2001-06-11 2011-04-06 Medarex, Inc. Method for designing cd10-activated prodrug compounds
CN100497389C (zh) 2001-06-13 2009-06-10 根马布股份公司 表皮生长因子受体(egfr)的人单克隆抗体
US20040076955A1 (en) 2001-07-03 2004-04-22 Eos Biotechnology, Inc. Methods of diagnosis of bladder cancer, compositions and methods of screening for modulators of bladder cancer
WO2003022806A2 (en) 2001-09-07 2003-03-20 The Scripps Research Institute Cbi analogues of cc-1065 and the duocarmycins
JP2003088388A (ja) 2001-09-14 2003-03-25 Herikkusu Kenkyusho:Kk 新規な全長cDNA
AU2002330039A1 (en) 2001-09-17 2003-04-01 Eos Biotechnology, Inc. Methods of diagnosis of cancer compositions and methods of screening for modulators of cancer
EP1487501B1 (en) 2001-10-09 2012-12-05 The Johns Hopkins University A phosphatase associated with metastasis
WO2003042661A2 (en) 2001-11-13 2003-05-22 Protein Design Labs, Inc. Methods of diagnosis of cancer, compositions and methods of screening for modulators of cancer
JP2005517674A (ja) 2002-01-03 2005-06-16 フラームス・インテルウニフェルシタイル・インステイチュート・フォール・ビオテヒノロヒー・ヴェーゼットウェー 腫瘍の処置に有用な新規免疫コンジュゲート
DE60312639T2 (de) * 2002-01-18 2007-11-29 Pierre Fabre Médicament Antikörper gegen igf-ir und ihre verwendungen
US20040197792A1 (en) 2002-07-15 2004-10-07 Sugen, Inc. Novel Kinases
GB0219776D0 (en) 2002-08-24 2002-10-02 Oxford Glycosciences Uk Ltd A protein involved in carcinoma
ATE488588T1 (de) 2003-03-10 2010-12-15 Japan Science & Tech Agency Verfahren zur kennzeichnung mesenchymaler stammzellen unter verwendung verschiedener marker
EP2481814A3 (en) 2003-06-09 2012-10-10 The Regents of the University of Michigan Compositions and methods for treating and diagnosing cancer
WO2005063987A1 (en) 2003-12-19 2005-07-14 Aveo Pharmaceuticals, Inc. Gp153: methods and compositions for treating cancer
CA2564092A1 (en) 2004-04-29 2005-12-15 Genzyme Corporation Methods and compositions for the treatment of polycystic diseases
AU2005244980B2 (en) 2004-05-19 2011-09-15 E. R. Squibb & Sons, L.L.C. Chemical linkers and conjugates thereof
RU2402548C2 (ru) 2004-05-19 2010-10-27 Медарекс, Инк. Химические линкеры и их конъюгаты
BRPI0512496A (pt) 2004-06-23 2008-03-04 Genzyme Corp processos e composições para o tratamento de doenças policìsticas
WO2006110593A2 (en) 2005-04-07 2006-10-19 Macrogenics, Inc. Biological targets for the diagnosis, treatment and prevention of cancer
JP5290756B2 (ja) 2005-09-26 2013-09-18 メダレックス インコーポレイテッド 抗体−薬剤コンジュゲート及びその使用
WO2007067730A2 (en) 2005-12-08 2007-06-14 Medarex, Inc. Human monoclonal antibodies to protein tyrosine kinase 7 ( ptk7 ) and their use
CL2008003527A1 (es) 2007-11-30 2009-10-09 Medarex Inc Conjugado de anticuerpo o porcion de union de antigeno del mismo, que se une a la proteina tirosina quinasa 7 (ptk-7/cck4); composicion que lo comprende; acido nulceico cidificante del anticuerpo; vector y celula huesped; uso del conjugado para tratar o prevenir una enfermedad de celulas tumorales que expresan ptk7
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos

Also Published As

Publication number Publication date
AU2006321841C1 (en) 2013-01-24
KR101373464B1 (ko) 2014-03-14
KR20080082660A (ko) 2008-09-11
US9505845B2 (en) 2016-11-29
AU2006321841A1 (en) 2007-06-14
DK1957539T3 (da) 2013-05-06
CA2632552A1 (en) 2007-06-14
NZ569236A (en) 2012-06-29
WO2007067730A3 (en) 2007-11-01
IL191788A0 (en) 2009-02-11
NZ594466A (en) 2012-08-31
EA017812B1 (ru) 2013-03-29
CA2632552C (en) 2015-02-03
ES2406063T3 (es) 2013-06-05
ME02002B (me) 2013-10-31
EP1957539A2 (en) 2008-08-20
AU2006321841B2 (en) 2012-08-30
EP1957539B1 (en) 2013-04-17
PT1957539E (pt) 2013-06-25
BRPI0619582A2 (pt) 2012-12-11
PL1957539T3 (pl) 2013-08-30
CN101360761B (zh) 2012-09-12
US8222375B2 (en) 2012-07-17
JP5401639B2 (ja) 2014-01-29
CN101360761A (zh) 2009-02-04
SI1957539T1 (sl) 2013-05-31
JP2009518039A (ja) 2009-05-07
EA200801509A1 (ru) 2008-12-30
US20100034826A1 (en) 2010-02-11
NO20082559L (no) 2008-07-07
IL191788A (en) 2014-06-30
WO2007067730A2 (en) 2007-06-14
RS52804B (en) 2013-10-31
US20120207764A1 (en) 2012-08-16
US9102738B2 (en) 2015-08-11
SG177194A1 (en) 2012-01-30
US20120219557A1 (en) 2012-08-30

Similar Documents

Publication Publication Date Title
HK1121174A1 (en) Human monoclonal antibodies to protein tyrosine kinase 7 (ptk7) and their use
IL228034A0 (en) Formulations with a high concentration of antibodies and proteins
TWI367102B (en) Therapeutic human anti-il-1r1 monoclonal antibody
IL239320B (en) Antibodies that bind human protein tyrosine phosphate in the cell and their uses
IL231169A0 (en) Human monoclonal antibodies to fucosil - 1gm and methods of using antibodies against fucosil - 1gm
PL398596A1 (pl) Preparat zawierający ludzkie przeciwciała do leczenia zaburzeń związanych z TNF-α
SI2940044T1 (sl) Anti-TNF-alfa protitelesa za uporabo pri terapiji
IS7668A (is) Manngerð mótefni gegn 4-1BB í mönnum
AU2003223285A8 (en) Human monoclonal antibodies to influenza m2 protein and methods of making and using same
EP1969008A4 (en) ANTIBODIES TO INTERLEUKIN-22 BINDING PROTEIN AND ITS APPLICATIONS IN THE TREATMENT OF METABOLISM DISORDERS
EP1819733A4 (en) MONOCLONAL ANTIBODY TO GENE H3 INDUCED BY HUMAN TGF-BETA AND APPLICATION THEREOF
GB0119497D0 (en) Expression of modified antibodies in avian cells
ZA200807978B (en) Antibodies that bind human protein tyrosine phosphatase beta (HPTPBETA) and uses thereof
EP1736775A4 (en) NEW LIGAND OF G PROTEIN-COUPLED RECEPTOR PROTEIN AND USE THEREOF
AU2003211292A1 (en) Monoclonal antibody against human hepatoma and use thereof
SI1610820T1 (sl) Visokokoncentrirane formulacije protitelesa in proteinov
GB0325391D0 (en) Human monoclonal antibodies

Legal Events

Date Code Title Description
PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20191208