HK1106717A1 - Microparticles consisting of estradiol and cholesterol - Google Patents

Microparticles consisting of estradiol and cholesterol

Info

Publication number
HK1106717A1
HK1106717A1 HK08100366A HK08100366A HK1106717A1 HK 1106717 A1 HK1106717 A1 HK 1106717A1 HK 08100366 A HK08100366 A HK 08100366A HK 08100366 A HK08100366 A HK 08100366A HK 1106717 A1 HK1106717 A1 HK 1106717A1
Authority
HK
Hong Kong
Prior art keywords
estradiol
cholesterol
microparticles consisting
progesterone
particles
Prior art date
Application number
HK08100366A
Other languages
English (en)
Inventor
John Claude Savoir
Uribe Juan Angeles
Original Assignee
Skendi Finance Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33551788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1106717(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Skendi Finance Ltd filed Critical Skendi Finance Ltd
Publication of HK1106717A1 publication Critical patent/HK1106717A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
HK08100366A 2003-06-13 2008-01-10 Microparticles consisting of estradiol and cholesterol HK1106717A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US47793903P 2003-06-13 2003-06-13

Publications (1)

Publication Number Publication Date
HK1106717A1 true HK1106717A1 (en) 2008-03-20

Family

ID=33551788

Family Applications (4)

Application Number Title Priority Date Filing Date
HK07101862A HK1097735A1 (en) 2003-06-13 2007-02-15 Process for the manufacture of stable shaped particles consisting of estradiol and cholesterol
HK08100366A HK1106717A1 (en) 2003-06-13 2008-01-10 Microparticles consisting of estradiol and cholesterol
HK08103923.8A HK1109586A1 (en) 2003-06-13 2008-04-08 Slow release estradiol-progesterone formulation
HK11101525.9A HK1147426A1 (en) 2003-06-13 2011-02-16 Process for the manufacture of stable shaped particles consisting of estradiol and cholesterol

Family Applications Before (1)

Application Number Title Priority Date Filing Date
HK07101862A HK1097735A1 (en) 2003-06-13 2007-02-15 Process for the manufacture of stable shaped particles consisting of estradiol and cholesterol

Family Applications After (2)

Application Number Title Priority Date Filing Date
HK08103923.8A HK1109586A1 (en) 2003-06-13 2008-04-08 Slow release estradiol-progesterone formulation
HK11101525.9A HK1147426A1 (en) 2003-06-13 2011-02-16 Process for the manufacture of stable shaped particles consisting of estradiol and cholesterol

Country Status (24)

Country Link
US (2) US7589082B2 (xx)
EP (3) EP1820494B1 (xx)
JP (2) JP4956185B2 (xx)
CN (2) CN100594907C (xx)
AT (1) ATE454885T1 (xx)
AU (1) AU2004246870B2 (xx)
BR (1) BRPI0411335A (xx)
CA (2) CA2849228C (xx)
CY (1) CY1109967T1 (xx)
DE (1) DE602004025156D1 (xx)
DK (3) DK1820494T3 (xx)
EA (3) EA012783B1 (xx)
ES (3) ES2340422T3 (xx)
HK (4) HK1097735A1 (xx)
HU (1) HUE025147T2 (xx)
IL (2) IL172466A (xx)
MX (1) MX2008014654A (xx)
NO (1) NO341540B1 (xx)
OA (1) OA13307A (xx)
PL (3) PL1844765T3 (xx)
PT (3) PT1820494E (xx)
SI (3) SI1663161T1 (xx)
TW (1) TWI336623B (xx)
WO (1) WO2004110408A2 (xx)

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EP1820494B1 (en) 2003-06-13 2010-01-13 Skendi Finance, Ltd. Microparticles consisting of estradiol and cholesterol
WO2009128692A1 (es) * 2008-04-14 2009-10-22 Posi Visionary Solutions Llp Método y composición farmacéutica para lograr niveles plasmáticos de progesterona requeridos para diferentes indicaciones terapéuticas
UY33103A (es) * 2009-12-15 2011-07-29 Techsphere S A De C V Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico
US20120245552A1 (en) * 2011-03-23 2012-09-27 Pop Test Cortisol Llc Combination Therapy
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2016018993A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
ITUB20153652A1 (it) * 2015-09-16 2017-03-16 Fatro Spa Microsfere contenenti lattoni macrociclici antielminitici
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
AU2017239679A1 (en) * 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
ES2754370T3 (es) 2016-07-19 2020-04-17 Evonik Operations Gmbh Procedimiento para la alcoxicarbonilación de compuestos con insaturación etilénica con ligandos monofosfina
US11135229B2 (en) * 2018-11-29 2021-10-05 Insigna Inc. Cat and dog sterilization by estrogenic compounds
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

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Also Published As

Publication number Publication date
EP1663161A2 (en) 2006-06-07
ATE454885T1 (de) 2010-01-15
IL210851A0 (en) 2011-04-28
DE602004025156D1 (de) 2010-03-04
HK1109586A1 (en) 2008-06-13
MX2008014654A (es) 2009-03-09
CY1109967T1 (el) 2014-09-10
SI1663161T1 (sl) 2015-05-29
TW200514560A (en) 2005-05-01
CA2528545A1 (en) 2004-12-23
PL1844765T3 (pl) 2015-06-30
CN100594907C (zh) 2010-03-24
PL1663161T3 (pl) 2015-08-31
EA201201221A1 (ru) 2014-02-28
JP2011157386A (ja) 2011-08-18
EA026709B1 (ru) 2017-05-31
IL172466A (en) 2011-11-30
NO341540B1 (no) 2017-12-04
EA200600029A1 (ru) 2006-08-25
CA2528545C (en) 2014-08-12
PT1844765E (pt) 2015-05-20
WO2004110408A3 (en) 2005-04-14
EP1820494B1 (en) 2010-01-13
TWI336623B (en) 2011-02-01
EA200900451A1 (ru) 2009-12-30
BRPI0411335A (pt) 2006-07-25
EP1844765B1 (en) 2015-01-21
SI1820494T1 (sl) 2010-08-31
CA2849228C (en) 2016-09-20
ES2340422T3 (es) 2010-06-02
CA2849228A1 (en) 2004-12-23
SI1844765T1 (sl) 2015-05-29
AU2004246870A1 (en) 2004-12-23
CN1835737A (zh) 2006-09-20
ES2537551T3 (es) 2015-06-09
JP2006527263A (ja) 2006-11-30
CN101816662B (zh) 2015-01-28
EA018356B1 (ru) 2013-07-30
WO2004110408A2 (en) 2004-12-23
DK1820494T3 (da) 2010-05-25
HK1147426A1 (en) 2011-08-12
US7589082B2 (en) 2009-09-15
PT1820494E (pt) 2010-04-14
HUE025147T2 (hu) 2016-03-29
EP1820494A3 (en) 2007-09-19
HK1097735A1 (en) 2007-07-06
IL172466A0 (en) 2006-04-10
EP1663161B1 (en) 2015-01-14
EP1844765A1 (en) 2007-10-17
NO20060200L (no) 2006-01-13
PT1663161E (pt) 2015-05-13
JP4956185B2 (ja) 2012-06-20
IL210851A (en) 2016-05-31
OA13307A (en) 2007-04-13
US20050025827A1 (en) 2005-02-03
US8163722B2 (en) 2012-04-24
AU2004246870B2 (en) 2009-07-23
DK1844765T3 (en) 2015-04-27
PL1820494T3 (pl) 2010-07-30
DK1663161T3 (en) 2015-04-27
ES2537563T3 (es) 2015-06-09
EA012783B1 (ru) 2009-12-30
CN101816662A (zh) 2010-09-01
US20090081303A1 (en) 2009-03-26
EP1820494A2 (en) 2007-08-22

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Legal Events

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PC Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)

Effective date: 20190610