PL1844765T3 - Formulacja estradiol-progesteron o spowolnionym uwalnianiu - Google Patents

Formulacja estradiol-progesteron o spowolnionym uwalnianiu

Info

Publication number
PL1844765T3
PL1844765T3 PL07008938T PL07008938T PL1844765T3 PL 1844765 T3 PL1844765 T3 PL 1844765T3 PL 07008938 T PL07008938 T PL 07008938T PL 07008938 T PL07008938 T PL 07008938T PL 1844765 T3 PL1844765 T3 PL 1844765T3
Authority
PL
Poland
Prior art keywords
slow release
estradiol
progesterone
progesterone formulation
release estradiol
Prior art date
Application number
PL07008938T
Other languages
English (en)
Inventor
John Claude Savoir
Uribe Juan Angeles
Original Assignee
Skendi Finance Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=33551788&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PL1844765(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Skendi Finance Ltd filed Critical Skendi Finance Ltd
Publication of PL1844765T3 publication Critical patent/PL1844765T3/pl

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/565—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol
    • A61K31/568—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone
    • A61K31/569—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids not substituted in position 17 beta by a carbon atom, e.g. estrane, estradiol substituted in positions 10 and 13 by a chain having at least one carbon atom, e.g. androstanes, e.g. testosterone substituted in position 17 alpha, e.g. ethisterone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063—Periodont
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1688—Processes resulting in pure drug agglomerate optionally containing up to 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/12—Drugs for genital or sexual disorders; Contraceptives for climacteric disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/30—Oestrogens
PL07008938T 2003-06-13 2004-06-10 Formulacja estradiol-progesteron o spowolnionym uwalnianiu PL1844765T3 (pl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US47793903P 2003-06-13 2003-06-13
EP20040736545 EP1663161B1 (en) 2003-06-13 2004-06-10 Slow release estradiol-progesterone formulation
EP20070008938 EP1844765B1 (en) 2003-06-13 2004-06-10 Slow release estradiol-progesterone formulation

Publications (1)

Publication Number Publication Date
PL1844765T3 true PL1844765T3 (pl) 2015-06-30

Family

ID=33551788

Family Applications (3)

Application Number Title Priority Date Filing Date
PL07008938T PL1844765T3 (pl) 2003-06-13 2004-06-10 Formulacja estradiol-progesteron o spowolnionym uwalnianiu
PL07008942T PL1820494T3 (pl) 2003-06-13 2004-06-10 Mikrocząstki składające się z estradiolu i cholesterolu
PL04736545T PL1663161T3 (pl) 2003-06-13 2004-06-10 Formulacja estradiol-progesteron o powolnym uwalnianiu

Family Applications After (2)

Application Number Title Priority Date Filing Date
PL07008942T PL1820494T3 (pl) 2003-06-13 2004-06-10 Mikrocząstki składające się z estradiolu i cholesterolu
PL04736545T PL1663161T3 (pl) 2003-06-13 2004-06-10 Formulacja estradiol-progesteron o powolnym uwalnianiu

Country Status (24)

Country Link
US (2) US7589082B2 (pl)
EP (3) EP1820494B1 (pl)
JP (2) JP4956185B2 (pl)
CN (2) CN100594907C (pl)
AT (1) ATE454885T1 (pl)
AU (1) AU2004246870B2 (pl)
BR (1) BRPI0411335A (pl)
CA (2) CA2849228C (pl)
CY (1) CY1109967T1 (pl)
DE (1) DE602004025156D1 (pl)
DK (3) DK1820494T3 (pl)
EA (3) EA012783B1 (pl)
ES (3) ES2340422T3 (pl)
HK (4) HK1097735A1 (pl)
HU (1) HUE025147T2 (pl)
IL (2) IL172466A (pl)
MX (1) MX2008014654A (pl)
NO (1) NO341540B1 (pl)
OA (1) OA13307A (pl)
PL (3) PL1844765T3 (pl)
PT (3) PT1820494E (pl)
SI (3) SI1663161T1 (pl)
TW (1) TWI336623B (pl)
WO (1) WO2004110408A2 (pl)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1820494B1 (en) 2003-06-13 2010-01-13 Skendi Finance, Ltd. Microparticles consisting of estradiol and cholesterol
WO2009128692A1 (es) * 2008-04-14 2009-10-22 Posi Visionary Solutions Llp Método y composición farmacéutica para lograr niveles plasmáticos de progesterona requeridos para diferentes indicaciones terapéuticas
UY33103A (es) * 2009-12-15 2011-07-29 Techsphere S A De C V Formulacion farmaceutica parenteral en suspension, de liberacion sostenida, en dosis baja y ultra baja, en terapia hormonal en el sindrome climaterico
US20120245552A1 (en) * 2011-03-23 2012-09-27 Pop Test Cortisol Llc Combination Therapy
US9301920B2 (en) 2012-06-18 2016-04-05 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
ES2885523T3 (es) 2011-11-23 2021-12-14 Therapeuticsmd Inc Formulaciones y terapias de reposición hormonal de combinación naturales
US10806740B2 (en) 2012-06-18 2020-10-20 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
US10806697B2 (en) 2012-12-21 2020-10-20 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US20130338122A1 (en) 2012-06-18 2013-12-19 Therapeuticsmd, Inc. Transdermal hormone replacement therapies
US20150196640A1 (en) 2012-06-18 2015-07-16 Therapeuticsmd, Inc. Progesterone formulations having a desirable pk profile
US11266661B2 (en) 2012-12-21 2022-03-08 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10568891B2 (en) 2012-12-21 2020-02-25 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US9180091B2 (en) 2012-12-21 2015-11-10 Therapeuticsmd, Inc. Soluble estradiol capsule for vaginal insertion
US10471072B2 (en) 2012-12-21 2019-11-12 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US10537581B2 (en) 2012-12-21 2020-01-21 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
US11246875B2 (en) 2012-12-21 2022-02-15 Therapeuticsmd, Inc. Vaginal inserted estradiol pharmaceutical compositions and methods
AU2015264003A1 (en) 2014-05-22 2016-11-17 Therapeuticsmd, Inc. Natural combination hormone replacement formulations and therapies
WO2016018993A1 (en) 2014-07-29 2016-02-04 Therapeuticsmd, Inc. Transdermal cream
US10328087B2 (en) 2015-07-23 2019-06-25 Therapeuticsmd, Inc. Formulations for solubilizing hormones
ITUB20153652A1 (it) * 2015-09-16 2017-03-16 Fatro Spa Microsfere contenenti lattoni macrociclici antielminitici
US10286077B2 (en) 2016-04-01 2019-05-14 Therapeuticsmd, Inc. Steroid hormone compositions in medium chain oils
AU2017239679A1 (en) * 2016-04-01 2018-10-18 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
WO2017173071A1 (en) 2016-04-01 2017-10-05 Therapeuticsmd, Inc. Steroid hormone pharmaceutical composition
ES2754370T3 (es) 2016-07-19 2020-04-17 Evonik Operations Gmbh Procedimiento para la alcoxicarbonilación de compuestos con insaturación etilénica con ligandos monofosfina
US11135229B2 (en) * 2018-11-29 2021-10-05 Insigna Inc. Cat and dog sterilization by estrogenic compounds
US11633405B2 (en) 2020-02-07 2023-04-25 Therapeuticsmd, Inc. Steroid hormone pharmaceutical formulations

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3800038A (en) * 1972-04-21 1974-03-26 Biolog Concepts Inc Uterine administraton of eutectic solid solutions of steroid hormones in a steroidal lipid carrier
GB1367608A (en) 1973-03-09 1974-09-18 Biolog Concepts Inc Oral pharmaceutical dosage form
US4218255A (en) 1976-08-30 1980-08-19 University Of Dayton Porous ceramic carriers for controlled release of proteins, polypeptide hormones, and other substances within human and/or other mamillian species and method
US4180560A (en) * 1976-10-26 1979-12-25 Syntex Corporation Inert core implant pellet
JPS5799562A (en) 1980-12-12 1982-06-21 Nippon Shinyaku Co Ltd Preparation of microcrystal
US5023092A (en) 1988-06-16 1991-06-11 Ici Americas Inc. Mannitol having gamma sorbitol polymorph
IT1230566B (it) 1988-10-17 1991-10-28 Vectorpharma Int Farmaci poco solubili supportati su sostanze polimeriche in forma atta all'aumento della velocita' di dissoluzione
US5252334A (en) 1989-09-08 1993-10-12 Cygnus Therapeutic Systems Solid matrix system for transdermal drug delivery
FR2663223B1 (fr) 1990-06-14 1994-12-02 Af Aplicaciones Far Lab Forme galenique parenterale.
FR2663224B1 (fr) * 1990-06-14 1995-01-20 Applicationes Farmaceuticas Sa Forme galenique parenterale.
IE71203B1 (en) 1990-12-13 1997-02-12 Akzo Nv Low estrogen oral contraceptives
IE62665B1 (en) 1990-12-17 1995-02-22 Akzo Nv Contraceptive regimen
US5874063A (en) 1991-04-11 1999-02-23 Astra Aktiebolag Pharmaceutical formulation
SE9101090D0 (sv) * 1991-04-11 1991-04-11 Astra Ab Process for conditioning of water-soluble substances
US5211952A (en) * 1991-04-12 1993-05-18 University Of Southern California Contraceptive methods and formulations for use therein
DE4130173A1 (de) 1991-09-11 1993-03-18 Bayer Ag Pharmazeutische zubereitungen mit einer speziellen kristallmodifikation des 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridindicarbonsaeure-isopropyl-(2-methoxyethyl)-esters
SE9301171D0 (sv) * 1993-04-07 1993-04-07 Ab Astra Pharmaceutical composition containing lipophilic drugs
TW360548B (en) 1993-04-08 1999-06-11 Powderject Res Ltd Products for therapeutic use
FR2747042B1 (fr) * 1996-04-05 1998-06-05 Besins Iscovesco Lab Medicament a base de progesterone et d'oestradiol
US5762956A (en) 1996-04-24 1998-06-09 Rutgers, The State University Of New Jersey Transdermal contraceptive delivery system and process
EP0888790A1 (en) 1997-07-04 1999-01-07 PowderJect Research Limited Drug particle delivery device
US6287693B1 (en) 1998-02-25 2001-09-11 John Claude Savoir Stable shaped particles of crystalline organic compounds
US6117446A (en) * 1999-01-26 2000-09-12 Place; Virgil A. Drug dosage unit for buccal administration of steroidal active agents
CZ306435B6 (cs) * 2000-12-14 2017-01-25 Ortho-Mcneil Pharmaceutical, Inc. Steroidní hormonální přípravek a způsob jeho přípravy
US20020151508A1 (en) * 2001-02-09 2002-10-17 Schering Corporation Methods for treating proliferative diseases
EP1820494B1 (en) 2003-06-13 2010-01-13 Skendi Finance, Ltd. Microparticles consisting of estradiol and cholesterol

Also Published As

Publication number Publication date
EP1663161A2 (en) 2006-06-07
ATE454885T1 (de) 2010-01-15
IL210851A0 (en) 2011-04-28
DE602004025156D1 (de) 2010-03-04
HK1109586A1 (en) 2008-06-13
MX2008014654A (es) 2009-03-09
CY1109967T1 (el) 2014-09-10
SI1663161T1 (sl) 2015-05-29
TW200514560A (en) 2005-05-01
CA2528545A1 (en) 2004-12-23
CN100594907C (zh) 2010-03-24
PL1663161T3 (pl) 2015-08-31
EA201201221A1 (ru) 2014-02-28
JP2011157386A (ja) 2011-08-18
EA026709B1 (ru) 2017-05-31
IL172466A (en) 2011-11-30
NO341540B1 (no) 2017-12-04
EA200600029A1 (ru) 2006-08-25
CA2528545C (en) 2014-08-12
PT1844765E (pt) 2015-05-20
WO2004110408A3 (en) 2005-04-14
EP1820494B1 (en) 2010-01-13
TWI336623B (en) 2011-02-01
EA200900451A1 (ru) 2009-12-30
BRPI0411335A (pt) 2006-07-25
EP1844765B1 (en) 2015-01-21
SI1820494T1 (sl) 2010-08-31
CA2849228C (en) 2016-09-20
ES2340422T3 (es) 2010-06-02
CA2849228A1 (en) 2004-12-23
SI1844765T1 (sl) 2015-05-29
AU2004246870A1 (en) 2004-12-23
CN1835737A (zh) 2006-09-20
ES2537551T3 (es) 2015-06-09
JP2006527263A (ja) 2006-11-30
CN101816662B (zh) 2015-01-28
EA018356B1 (ru) 2013-07-30
WO2004110408A2 (en) 2004-12-23
DK1820494T3 (da) 2010-05-25
HK1147426A1 (en) 2011-08-12
US7589082B2 (en) 2009-09-15
PT1820494E (pt) 2010-04-14
HUE025147T2 (hu) 2016-03-29
EP1820494A3 (en) 2007-09-19
HK1097735A1 (en) 2007-07-06
IL172466A0 (en) 2006-04-10
EP1663161B1 (en) 2015-01-14
EP1844765A1 (en) 2007-10-17
NO20060200L (no) 2006-01-13
PT1663161E (pt) 2015-05-13
JP4956185B2 (ja) 2012-06-20
IL210851A (en) 2016-05-31
OA13307A (en) 2007-04-13
US20050025827A1 (en) 2005-02-03
HK1106717A1 (en) 2008-03-20
US8163722B2 (en) 2012-04-24
AU2004246870B2 (en) 2009-07-23
DK1844765T3 (en) 2015-04-27
PL1820494T3 (pl) 2010-07-30
DK1663161T3 (en) 2015-04-27
ES2537563T3 (es) 2015-06-09
EA012783B1 (ru) 2009-12-30
CN101816662A (zh) 2010-09-01
US20090081303A1 (en) 2009-03-26
EP1820494A2 (en) 2007-08-22

Similar Documents

Publication Publication Date Title
HK1109586A1 (en) Slow release estradiol-progesterone formulation
HK1064921A1 (en) Sustained release formulations of oxymorphone
TW200806318A (en) Uses of anti-insulin-like growth factor I receptor antibodies
HK1059564A1 (en) Indanylderivatives for treating airway diseases
JP2002523375A5 (pl)
NZ516347A (en) Indanyl-substituted benzenecarboxamides, process for their preparation, their use as a medicament and pharmaceutical formulations containing them
IL195723A (en) Use of p53 inhibitors for the preparation of medicament
ZA200408649B (en) Opthamological use of roflumilast for the treatment of diseases of the eye
AU2001273945A1 (en) 8beta-substituted-11beta-pentyl- and 11beta-hexyl-estra-1,3,5(10)-triene derivatives
GB9917822D0 (en) Nmda antagonist
HUT62192A (en) Process for producing pharmaceutical compositions comprising tomoxetine and suitable for treating diseases of lower urinary tract
EG24584A (en) Method for the preparation of a pharmaceutical composition comprising 5-aminosalicylic acid for use in treatment of uicerative colitis and crohn's disease
HUP0002533A2 (hu) Asztmaellenes gyógyszerhatóanyagok új kombinációja
WO2003104253A3 (de) 9-alpha-substituierte estratriene als selektiv wirksame estrogene
HUP0302984A2 (hu) Buprenorphin felhasználása vizeletinkontinencia kezelésére alkalmas gyógyszerkészítmény előállítására
MXPA02012957A (es) Formulacion nueva.
WO2004073627A3 (en) Novel therapeutic method and compositions for topical administration
HUP0201875A3 (en) Use of antiprogestagens for preparing pharmaceutical compositions for contraception in combined therapy