HK1099300A1 - Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors - Google Patents

Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors

Info

Publication number
HK1099300A1
HK1099300A1 HK07106506.7A HK07106506A HK1099300A1 HK 1099300 A1 HK1099300 A1 HK 1099300A1 HK 07106506 A HK07106506 A HK 07106506A HK 1099300 A1 HK1099300 A1 HK 1099300A1
Authority
HK
Hong Kong
Prior art keywords
arylsulfonylheterocyclic
gamma
amines
substituted
secretase inhibitors
Prior art date
Application number
HK07106506.7A
Other languages
English (en)
Inventor
Hubert B Josien
John W Clader
Thomas A Bara
Ruo Xu
Hongmei Li
Dmitri Pissarnitski
Zhiqiang Zhao
Original Assignee
Schering Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Corp filed Critical Schering Corp
Publication of HK1099300A1 publication Critical patent/HK1099300A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/08—Bridged systems
HK07106506.7A 2004-06-30 2007-06-15 Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors HK1099300A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58401004P 2004-06-30 2004-06-30
PCT/US2005/023187 WO2006004880A2 (en) 2004-06-30 2005-06-28 Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors

Publications (1)

Publication Number Publication Date
HK1099300A1 true HK1099300A1 (en) 2007-08-10

Family

ID=35783342

Family Applications (1)

Application Number Title Priority Date Filing Date
HK07106506.7A HK1099300A1 (en) 2004-06-30 2007-06-15 Substituted n-arylsulfonylheterocyclic amines as gamma-secretase inhibitors

Country Status (14)

Country Link
US (3) US7763613B2 (zh)
EP (1) EP1789404B1 (zh)
JP (1) JP2008505100A (zh)
CN (2) CN101048393A (zh)
AR (1) AR050994A1 (zh)
AT (1) ATE461926T1 (zh)
CA (1) CA2570183A1 (zh)
DE (1) DE602005020156D1 (zh)
ES (1) ES2341560T3 (zh)
HK (1) HK1099300A1 (zh)
MX (1) MX2007000040A (zh)
PE (1) PE20060481A1 (zh)
TW (1) TWI297270B (zh)
WO (1) WO2006004880A2 (zh)

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* Cited by examiner, † Cited by third party
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MX2008009414A (es) 2006-01-20 2008-10-01 Schering Corp Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa.
PA8713501A1 (es) * 2006-02-07 2009-09-17 Wyeth Corp INHIBIDORES DE 11-BETA HIDROXIESTEROIDE DEHIDROGENASA - 11ßHSD1
US8389547B2 (en) 2006-04-26 2013-03-05 Yudith Garcia Piperidines and related compounds for the treatment of Alzheimer's disease
US20100226922A1 (en) * 2006-06-08 2010-09-09 Dorothea Maetzel Specific protease inhibitors and their use in cancer therapy
EP2089383B1 (en) 2006-11-09 2015-09-16 Probiodrug AG 3-hydr0xy-1,5-dihydr0-pyrr0l-2-one derivatives as inhibitors of glutaminyl cyclase for the treatment of ulcer, cancer and other diseases
JP5523107B2 (ja) 2006-11-30 2014-06-18 プロビオドルグ エージー グルタミニルシクラーゼの新規阻害剤
KR20090115951A (ko) 2007-03-01 2009-11-10 프로비오드룩 아게 글루타미닐 사이클라제 저해제의 신규 용도
US9656991B2 (en) 2007-04-18 2017-05-23 Probiodrug Ag Inhibitors of glutaminyl cyclase
AU2008312612B2 (en) * 2007-10-19 2013-11-28 Janssen Pharmaceutica, N.V. Piperidinyl and piperazinyl modulators of gamma-secretase
CN102695546B (zh) 2009-09-11 2014-09-10 前体生物药物股份公司 作为谷氨酰胺酰环化酶抑制剂的杂环衍生物
US20110190269A1 (en) * 2010-02-01 2011-08-04 Karlheinz Baumann Gamma secretase modulators
ES2586231T3 (es) 2010-03-03 2016-10-13 Probiodrug Ag Inhibidores de glutaminil ciclasa
DK2545047T3 (da) 2010-03-10 2014-07-28 Probiodrug Ag Heterocycliske inhibitorer af glutaminylcyclase (QC, EC 2.3.2.5)
WO2011131748A2 (en) 2010-04-21 2011-10-27 Probiodrug Ag Novel inhibitors
EP2686313B1 (en) 2011-03-16 2016-02-03 Probiodrug AG Benzimidazole derivatives as inhibitors of glutaminyl cyclase
AR091279A1 (es) 2012-06-08 2015-01-21 Gilead Sciences Inc Inhibidores macrociclicos de virus flaviviridae
PL3461819T3 (pl) 2017-09-29 2020-11-30 Probiodrug Ag Inhibitory cyklazy glutaminylowej
CN109705052B (zh) * 2019-01-25 2020-12-08 苏州大学 一种制备1,4-二氢噁嗪的方法

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JPH04247081A (ja) 1991-02-01 1992-09-03 Takeda Chem Ind Ltd ５員複素環酸アミド類
US5646167A (en) * 1993-01-06 1997-07-08 Ciba-Geigy Corporation Arylsulfonamido-substituted hydroxamix acids
ATE247090T1 (de) * 1996-02-02 2003-08-15 Hidaka Hiroyoshi Dr Isochinolinderivate und arzneimittel
IL140041A0 (en) * 1998-06-03 2002-02-10 Guilford Pharm Inc Multiple heteroatom containing heterocyclic ring compounds substituted with carboxylic acids and isosteres thereof
US6967196B1 (en) 1999-02-26 2005-11-22 Bristol-Myers Squibb Company Sulfonamide compounds and uses thereof
FR2802206B1 (fr) * 1999-12-14 2005-04-22 Sod Conseils Rech Applic Derives de 4-aminopiperidine et leur utilisation en tant que medicament
SE9904738D0 (sv) * 1999-12-22 1999-12-22 Astra Pharma Prod Novel compounds
JP2001261657A (ja) * 2000-03-17 2001-09-26 Yamanouchi Pharmaceut Co Ltd シアノフェニル誘導体
WO2001081308A2 (en) 2000-04-20 2001-11-01 Nps Allelix Corp. Aminopiperidines for use as glyt-1 inhibitors
US6589978B2 (en) 2000-06-30 2003-07-08 Hoffman-La Roche Inc. 1-sulfonyl pyrrolidine derivatives
BR0113989A (pt) 2000-09-25 2004-01-27 Actelion Pharmaceuticals Ltd Compostos, composições farmacêuticas, processo para a preparação de uma composição farmacêutica, e, uso de pelo menos um dos compostos
MXPA04001016A (es) * 2001-08-03 2004-05-27 Schering Corp Derivados de sulfonamida como inhibidores de la gamma secretasa.
KR20040019094A (ko) * 2001-08-03 2004-03-04 쉐링 코포레이션 신규한 감마 세크레타제 억제제
US7256186B2 (en) * 2002-02-06 2007-08-14 Schering Corporation Gamma secretase inhibitors
US20040171614A1 (en) 2002-02-06 2004-09-02 Schering-Plough Corporation Novel gamma secretase inhibitors
TW200302717A (en) * 2002-02-06 2003-08-16 Schering Corp Novel gamma secretase inhibitors
PE20050555A1 (es) 2003-05-13 2005-07-19 Schering Corp Compuestos con puente n-arilsulfonilpiperidina como inhibidores de la gamma-secretasa
JP4247081B2 (ja) 2003-09-24 2009-04-02 三菱電機株式会社 レーザアニール装置のレーザビーム強度モニタ方法とレーザアニール装置
CN1950358A (zh) * 2004-04-05 2007-04-18 先灵公司 新颖的γ分泌酶抑制剂
US20060035884A1 (en) * 2004-05-20 2006-02-16 Elan Pharmaceuticals, Inc. N-cyclic sulfonamido inhibitors of gamma secretase
MX2008009414A (es) * 2006-01-20 2008-10-01 Schering Corp Arilsulfonas carbociclicas y heterociclicas como inhibidores de gamma secretasa.

Also Published As

Publication number Publication date
WO2006004880A3 (en) 2007-03-08
US7998958B2 (en) 2011-08-16
JP2008505100A (ja) 2008-02-21
CN101048393A (zh) 2007-10-03
US20060040936A1 (en) 2006-02-23
TW200612928A (en) 2006-05-01
WO2006004880A2 (en) 2006-01-12
ES2341560T3 (es) 2010-06-22
AR050994A1 (es) 2006-12-13
EP1789404B1 (en) 2010-03-24
TWI297270B (en) 2008-06-01
CN101602741A (zh) 2009-12-16
DE602005020156D1 (de) 2010-05-06
US7763613B2 (en) 2010-07-27
US20100087425A1 (en) 2010-04-08
PE20060481A1 (es) 2006-06-19
MX2007000040A (es) 2007-03-07
ATE461926T1 (de) 2010-04-15
CA2570183A1 (en) 2006-01-12
US20100093695A1 (en) 2010-04-15
EP1789404A2 (en) 2007-05-30

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