HK1086257A1 - Diazepinoindole derivatives as kinase inhibitors - Google Patents
Diazepinoindole derivatives as kinase inhibitorsInfo
- Publication number
- HK1086257A1 HK1086257A1 HK06106153.4A HK06106153A HK1086257A1 HK 1086257 A1 HK1086257 A1 HK 1086257A1 HK 06106153 A HK06106153 A HK 06106153A HK 1086257 A1 HK1086257 A1 HK 1086257A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- kinase inhibitors
- diazepinoindole
- derivatives
- diazepinoindole derivatives
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/06—Peri-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/06—Peri-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US43939603P | 2003-01-09 | 2003-01-09 | |
PCT/IB2004/000026 WO2004063198A1 (en) | 2003-01-09 | 2004-01-05 | Diazepinoindole derivatives as kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1086257A1 true HK1086257A1 (en) | 2006-09-15 |
Family
ID=32713475
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06106153.4A HK1086257A1 (en) | 2003-01-09 | 2006-05-26 | Diazepinoindole derivatives as kinase inhibitors |
Country Status (35)
Country | Link |
---|---|
US (3) | US6967198B2 (hr) |
EP (2) | EP1585749B1 (hr) |
JP (1) | JP3990718B2 (hr) |
KR (1) | KR100697746B1 (hr) |
CN (1) | CN1759118B (hr) |
AP (1) | AP2048A (hr) |
AT (1) | ATE404564T1 (hr) |
AU (1) | AU2004203977B2 (hr) |
BR (1) | BRPI0406701A (hr) |
CA (1) | CA2512683C (hr) |
CR (1) | CR7899A (hr) |
CY (1) | CY1108408T1 (hr) |
DE (1) | DE602004015724D1 (hr) |
DK (1) | DK1585749T3 (hr) |
EA (1) | EA009337B1 (hr) |
EC (1) | ECSP055911A (hr) |
ES (1) | ES2309484T3 (hr) |
GE (1) | GEP20084367B (hr) |
HK (1) | HK1086257A1 (hr) |
HR (1) | HRP20050624A2 (hr) |
IL (1) | IL169082A (hr) |
IS (1) | IS7884A (hr) |
MA (1) | MA27703A1 (hr) |
MX (1) | MXPA05007352A (hr) |
NO (1) | NO20053775L (hr) |
NZ (1) | NZ540638A (hr) |
OA (1) | OA13017A (hr) |
PL (1) | PL378372A1 (hr) |
PT (1) | PT1585749E (hr) |
RS (1) | RS20050522A (hr) |
SI (1) | SI1585749T1 (hr) |
TN (1) | TNSN05176A1 (hr) |
UA (1) | UA80733C2 (hr) |
WO (1) | WO2004063198A1 (hr) |
ZA (1) | ZA200504674B (hr) |
Families Citing this family (41)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4745609B2 (ja) * | 2002-01-22 | 2011-08-10 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | グルココルチコイドレセプターのための非ステロイド性リガンド、その組成物および使用 |
ATE404564T1 (de) * | 2003-01-09 | 2008-08-15 | Pfizer | Diazepinoindolderivate als kinaseinhibitoren |
ATE464395T1 (de) * | 2005-02-18 | 2010-04-15 | Astrazeneca Ab | Verfahren zur bestimmung der reaktionsfähigkeit gegenüber chk1-inhibitoren |
AR056645A1 (es) | 2005-03-29 | 2007-10-17 | Icos Corp | Compuestos de urea sustituida inhibidores de enzimas chk1 . |
GB0510390D0 (en) * | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
EP1896040B1 (en) | 2005-06-29 | 2012-08-01 | Threshold Pharmaceuticals, Inc. | Phosphoramidate alkylator prodrugs |
CN101384614A (zh) * | 2005-08-15 | 2009-03-11 | 加利福尼亚大学董事会 | Vegf活化的fas配体 |
EP1942193A4 (en) | 2005-08-25 | 2010-10-27 | Ube Industries | PROCESS FOR PRODUCING OPTICALLY ACTIVE ACID (S OR R) -a-AMINO OR OPTICALLY ACTIVE ACID (S OR R) -a-AMINO ESTER |
EP1916896A4 (en) * | 2005-08-26 | 2010-08-11 | Univ California | NOT STEROID-antiandrogens |
MX2008012791A (es) * | 2006-04-04 | 2008-10-15 | Pfizer Prod Inc | Terapia de combinacion de (2r,z)-2-amino-2-ciclohexil-n-(5-(1-meti l-1h-pirazol-4-il)-1-oxo-2,6-dihidro-1h-[1,2]diazepinos[4,5,6-cd[ indol-8-il)acetamida. |
WO2007113647A1 (en) * | 2006-04-04 | 2007-10-11 | Pfizer Products Inc. | Polymorphic forms of (2r,z)-2-amino-2-cyclohexyl-n-(5-(1-methyl-1h-pyrazol-4υl)-1-oxo-2,6-dihydro-1h-[1,2]diazepino[4,5,6-cd]indol-8-yl)acetamide |
EP2086644A2 (en) * | 2006-11-17 | 2009-08-12 | Schering Corporation | Combination of an inhibitor of dna polymerase-alpha and an inhibitor of a checkpoint kinase for proliferative disorders |
US8158656B2 (en) * | 2008-05-16 | 2012-04-17 | Shenzhen Chipscreen Biosciences Ltd. | 2-indolinone derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
EP2328890B1 (en) * | 2008-08-06 | 2012-01-25 | Pfizer Inc. | 6 substituted 2-heterocyclylamino pyrazine compounds as chk-1 inhibitors |
EP2346881A1 (en) * | 2008-10-10 | 2011-07-27 | Priaxon AG | Novel compounds which modulate kinase activity |
US8314108B2 (en) | 2008-12-17 | 2012-11-20 | Eli Lilly And Company | 5-(5-(2-(3-aminopropoxy)-6-methoxyphenyl)-1H-pyrazol-3-ylamino)pyrazine-2-carbonitrile, pharmaceutically acceptable salts thereof, or solvate of salts |
US8663210B2 (en) | 2009-05-13 | 2014-03-04 | Novian Health, Inc. | Methods and apparatus for performing interstitial laser therapy and interstitial brachytherapy |
US8211901B2 (en) | 2009-05-22 | 2012-07-03 | Shenzhen Chipscreen Biosciences Ltd. | Naphthamide derivatives as multi-target protein kinase inhibitors and histone deacetylase inhibitors |
CN101906076B (zh) | 2009-06-04 | 2013-03-13 | 深圳微芯生物科技有限责任公司 | 作为蛋白激酶抑制剂和组蛋白去乙酰化酶抑制剂的萘酰胺衍生物、其制备方法及应用 |
JP5941981B2 (ja) | 2011-05-06 | 2016-06-29 | ザフゲン,インコーポレイテッド | 三環式スルホンアミド化合物ならびにその製造および使用方法 |
EP2793882A4 (en) * | 2011-12-22 | 2015-04-29 | Threshold Pharmaceuticals Inc | ADMINISTRATION OF HYPOXIA ACTIVATED DRUGS IN COMBINATION WITH CHK1 INHIBITORS FOR THE TREATMENT OF CANCER |
CN106220635B (zh) | 2011-12-31 | 2019-03-08 | 百济神州有限公司 | 作为parp抑制剂的稠合的四环或五环的二氢二氮杂*并咔唑酮 |
EP2797919B1 (en) | 2011-12-31 | 2017-03-29 | BeiGene, Ltd. | Fused tetra or penta-cyclic pyridophthalazinones as parp inhibitors |
CN102746211B (zh) * | 2012-06-27 | 2015-05-27 | 上海泰坦化学有限公司 | 一种取代吲哚-3-甲醛类化合物的制备方法 |
TWI633107B (zh) * | 2013-05-22 | 2018-08-21 | 開曼群島商百濟神州生物科技有限公司 | 作為parp抑制劑的稠合四或五環二氫二氮呯并咔唑酮 |
WO2015013579A1 (en) | 2013-07-26 | 2015-01-29 | Update Pharma Inc. | Compositions to improve the therapeutic benefit of bisantrene |
US10071109B2 (en) | 2013-11-06 | 2018-09-11 | Molecular Templates, Inc. | Predictive biomarker for hypoxia-activated prodrug therapy |
SG11201610500WA (en) | 2014-06-17 | 2017-01-27 | Vertex Pharma | Method for treating cancer using a combination of chk1 and atr inhibitors |
AU2016312011B2 (en) * | 2015-08-25 | 2021-02-04 | Beigene, Ltd. | Process for preparing Parp inhibitor, crystalline forms, and uses thereof |
CA3000684A1 (en) | 2015-09-30 | 2017-04-06 | Vertex Pharmaceuticals Incorporated | Method for treating cancer using a combination of dna damaging agents and atr inhibitors |
WO2018059437A1 (en) | 2016-09-27 | 2018-04-05 | Beigene, Ltd. | Treatment cancers using combination comprising parp inhibitors |
JP6541635B2 (ja) * | 2016-10-28 | 2019-07-10 | ベイジーン リミテッド | Parp阻害剤としての縮合四環式または縮合五環式ジヒドロジアゼピノカルバゾロン |
WO2018157794A1 (en) | 2017-02-28 | 2018-09-07 | Beigene, Ltd. | Crystalline forms of salts of fused tera or penta-cyclic dihydrodiazepinocarazolones, and uses thereof |
US11661581B2 (en) * | 2017-05-25 | 2023-05-30 | University Of Massachusetts | Use of CDK inhibitors to enhance growth and self-renewal of progenitor cells |
CA3073656C (en) * | 2017-09-22 | 2024-03-05 | Jubilant Epipad LLC | Heterocyclic compounds as pad inhibitors |
EP3461480A1 (en) | 2017-09-27 | 2019-04-03 | Onxeo | Combination of a dna damage response cell cycle checkpoint inhibitors and belinostat for treating cancer |
JP2022523028A (ja) * | 2019-01-25 | 2022-04-21 | ヌメディー, インコーポレイテッド | 特発性肺線維症を処置するための方法 |
CN114072410B (zh) * | 2019-08-01 | 2023-08-01 | 正大天晴药业集团股份有限公司 | 作为parp抑制剂吲哚并七元酰肟化合物 |
WO2021104461A1 (zh) | 2019-11-29 | 2021-06-03 | 南京明德新药研发有限公司 | 二氮杂吲哚类衍生物及其作为Chk1抑制剂的应用 |
WO2022011458A1 (en) * | 2020-07-13 | 2022-01-20 | Ontario Institute For Cancer Research (Oicr) | Nicotinamide phosphoribosyltransferase (nampt) inhibitor-conjugates and uses thereof |
JP2023537220A (ja) * | 2020-07-31 | 2023-08-31 | チア タイ ティエンチン ファーマシューティカル グループ カンパニー リミテッド | Parp阻害剤としてのインドロヘプタアシルオキシム類似体の結晶及びその製造方法 |
Family Cites Families (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9722320D0 (en) | 1997-10-22 | 1997-12-17 | Janssen Pharmaceutica Nv | Human cell cycle checkpoint proteins |
US6383744B1 (en) | 1998-07-10 | 2002-05-07 | Incyte Genomics, Inc. | Human checkpoint kinase |
JP2002526450A (ja) | 1998-09-18 | 2002-08-20 | スミスクライン・ビーチャム・コーポレイション | Chk1キナーゼ阻害物質 |
JP4093448B2 (ja) * | 1999-01-11 | 2008-06-04 | アグロン・ファーマシューティカルズ・インコーポレーテッド | ポリ(adp−リボース)ポリメラーゼの三環系阻害剤 |
ATE388226T1 (de) | 1999-08-27 | 2008-03-15 | Novartis Vaccines & Diagnostic | Chimerische antisense-oligonukleotide und zelltransfektions-zusammensetzungen davon |
ECSP003637A (es) | 1999-08-31 | 2002-03-25 | Agouron Pharma | Inhibidores triciclicos de poli (adp-ribosa) polimerasas |
US6670167B1 (en) | 1999-11-01 | 2003-12-30 | Agouron Pharmaceuticals, Inc. | Catalytic domain of the human effector cell cycle checkpoint protein kinase materials and methods for identification of inhibitors thereof |
ATE292677T1 (de) | 1999-09-22 | 2005-04-15 | Canbas Co Ltd | Zusammensetzungen und verfahren zur inhibierung vom zellulären g2-übergang und sensitisierung von zellen gegen dna-schädigenden wirkstoffe |
US6211164B1 (en) | 2000-03-10 | 2001-04-03 | Abbott Laboratories | Antisense oligonucleotides of the human chk1 gene and uses thereof |
US6887996B2 (en) * | 2000-12-01 | 2005-05-03 | Guilford Pharmaceuticals Inc. | Compounds and their use |
UA76977C2 (en) | 2001-03-02 | 2006-10-16 | Icos Corp | Aryl- and heteroaryl substituted chk1 inhibitors and their use as radiosensitizers and chemosensitizers |
ATE404564T1 (de) * | 2003-01-09 | 2008-08-15 | Pfizer | Diazepinoindolderivate als kinaseinhibitoren |
-
2004
- 2004-01-05 AT AT04700145T patent/ATE404564T1/de not_active IP Right Cessation
- 2004-01-05 SI SI200430830T patent/SI1585749T1/sl unknown
- 2004-01-05 CN CN2004800063838A patent/CN1759118B/zh not_active Expired - Fee Related
- 2004-01-05 MX MXPA05007352A patent/MXPA05007352A/es active IP Right Grant
- 2004-01-05 DK DK04700145T patent/DK1585749T3/da active
- 2004-01-05 CA CA2512683A patent/CA2512683C/en not_active Expired - Fee Related
- 2004-01-05 DE DE602004015724T patent/DE602004015724D1/de not_active Expired - Lifetime
- 2004-01-05 EP EP04700145A patent/EP1585749B1/en not_active Expired - Lifetime
- 2004-01-05 ES ES04700145T patent/ES2309484T3/es not_active Expired - Lifetime
- 2004-01-05 JP JP2006500278A patent/JP3990718B2/ja not_active Expired - Fee Related
- 2004-01-05 AU AU2004203977A patent/AU2004203977B2/en not_active Ceased
- 2004-01-05 NZ NZ540638A patent/NZ540638A/en unknown
- 2004-01-05 RS YUP-2005/0522A patent/RS20050522A/sr unknown
- 2004-01-05 WO PCT/IB2004/000026 patent/WO2004063198A1/en active IP Right Grant
- 2004-01-05 PT PT04700145T patent/PT1585749E/pt unknown
- 2004-01-05 AP AP2005003353A patent/AP2048A/xx active
- 2004-01-05 EP EP08155745A patent/EP1947102A1/en not_active Withdrawn
- 2004-01-05 OA OA1200500197A patent/OA13017A/en unknown
- 2004-01-05 EA EA200500893A patent/EA009337B1/ru not_active IP Right Cessation
- 2004-01-05 PL PL378372A patent/PL378372A1/pl not_active Application Discontinuation
- 2004-01-05 GE GEAP20048886A patent/GEP20084367B/en unknown
- 2004-01-05 BR BR0406701-0A patent/BRPI0406701A/pt not_active IP Right Cessation
- 2004-01-05 KR KR1020057012806A patent/KR100697746B1/ko not_active IP Right Cessation
- 2004-01-09 US US10/754,171 patent/US6967198B2/en not_active Expired - Fee Related
- 2004-05-01 UA UAA200506730A patent/UA80733C2/uk unknown
-
2005
- 2005-06-08 IL IL169082A patent/IL169082A/en not_active IP Right Cessation
- 2005-06-08 ZA ZA200504674A patent/ZA200504674B/en unknown
- 2005-06-09 IS IS7884A patent/IS7884A/is unknown
- 2005-07-07 HR HR20050624A patent/HRP20050624A2/hr not_active Application Discontinuation
- 2005-07-08 EC EC2005005911A patent/ECSP055911A/es unknown
- 2005-07-08 TN TNP2005000176A patent/TNSN05176A1/fr unknown
- 2005-07-08 CR CR7899A patent/CR7899A/es unknown
- 2005-07-08 MA MA28375A patent/MA27703A1/fr unknown
- 2005-07-22 US US11/187,089 patent/US7132533B2/en not_active Expired - Fee Related
- 2005-08-08 NO NO20053775A patent/NO20053775L/no unknown
-
2006
- 2006-05-26 HK HK06106153.4A patent/HK1086257A1/xx not_active IP Right Cessation
- 2006-06-23 US US11/426,132 patent/US7462713B2/en not_active Expired - Fee Related
-
2008
- 2008-10-13 CY CY20081101127T patent/CY1108408T1/el unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
PC | Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee) |
Effective date: 20150105 |