HK1085461A1 - Compounds, compositions and methods of treatment for heart failure - Google Patents
Compounds, compositions and methods of treatment for heart failureInfo
- Publication number
- HK1085461A1 HK1085461A1 HK06105587.2A HK06105587A HK1085461A1 HK 1085461 A1 HK1085461 A1 HK 1085461A1 HK 06105587 A HK06105587 A HK 06105587A HK 1085461 A1 HK1085461 A1 HK 1085461A1
- Authority
- HK
- Hong Kong
- Prior art keywords
- heart failure
- treatment
- compositions
- compounds
- methods
- Prior art date
Links
- 206010019280 Heart failures Diseases 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 102000013602 Cardiac Myosins Human genes 0.000 abstract 1
- 108010051609 Cardiac Myosins Proteins 0.000 abstract 1
- 206010007559 Cardiac failure congestive Diseases 0.000 abstract 1
- 208000008253 Systolic Heart Failure Diseases 0.000 abstract 1
- 230000000747 cardiac effect Effects 0.000 abstract 1
- 230000003389 potentiating effect Effects 0.000 abstract 1
- 210000002235 sarcomere Anatomy 0.000 abstract 1
- 150000003672 ureas Chemical class 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C273/00—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C273/02—Preparation of urea or its derivatives, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups of urea, its salts, complexes or addition compounds
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/30—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by halogen atoms, or by nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/32—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms
- C07C275/34—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C275/36—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by singly-bound oxygen atoms having nitrogen atoms of urea groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with at least one of the oxygen atoms further bound to a carbon atom of a six-membered aromatic ring, e.g. N-aryloxyphenylureas
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
- C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
- C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/12—Oxygen or sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/40—Oxygen atoms
- C07D211/42—Oxygen atoms attached in position 3 or 5
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
- C07D213/65—One oxygen atom attached in position 3 or 5
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/70—Sulfur atoms
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D217/00—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems
- C07D217/02—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines
- C07D217/04—Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems with only hydrogen atoms or radicals containing only carbon and hydrogen atoms, directly attached to carbon atoms of the nitrogen-containing ring; Alkylene-bis-isoquinolines with hydrocarbon or substituted hydrocarbon radicals attached to the ring nitrogen atom
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hospice & Palliative Care (AREA)
- Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pyridine Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
- Indole Compounds (AREA)
- Quinoline Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US44018303P | 2003-01-14 | 2003-01-14 | |
US44013303P | 2003-01-14 | 2003-01-14 | |
US47608603P | 2003-06-04 | 2003-06-04 | |
US47651703P | 2003-06-05 | 2003-06-05 | |
US50137603P | 2003-09-08 | 2003-09-08 | |
PCT/US2004/001069 WO2004064730A2 (fr) | 2003-01-14 | 2004-01-14 | Composes, compositions et procedes |
Publications (1)
Publication Number | Publication Date |
---|---|
HK1085461A1 true HK1085461A1 (en) | 2006-08-25 |
Family
ID=32777326
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
HK06105587.2A HK1085461A1 (en) | 2003-01-14 | 2006-05-15 | Compounds, compositions and methods of treatment for heart failure |
Country Status (12)
Country | Link |
---|---|
US (3) | US7399866B2 (fr) |
EP (2) | EP1615878B1 (fr) |
JP (1) | JP4613157B2 (fr) |
KR (1) | KR20050100615A (fr) |
AT (1) | ATE552236T1 (fr) |
AU (1) | AU2004206860B2 (fr) |
CA (1) | CA2511970C (fr) |
ES (1) | ES2387909T3 (fr) |
HK (1) | HK1085461A1 (fr) |
MX (1) | MXPA05007513A (fr) |
NZ (1) | NZ540878A (fr) |
WO (1) | WO2004064730A2 (fr) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2001295986B2 (en) | 2000-10-20 | 2006-08-17 | Eisai R&D Management Co., Ltd | Nitrogenous aromatic ring compounds |
CA2511970C (fr) * | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Derives de l'uree utiles pour traiter l'insuffisance cardiaque |
WO2004080462A1 (fr) | 2003-03-10 | 2004-09-23 | Eisai Co., Ltd. | Inhibiteur de kinase c-kit |
AU2004228028B2 (en) | 2003-04-03 | 2009-12-10 | The Regents Of The University Of California | Improved inhibitors for the soluble epoxide hydrolase |
CN101337930B (zh) | 2003-11-11 | 2010-09-08 | 卫材R&D管理有限公司 | 脲衍生物的制备方法 |
EP1765311A4 (fr) | 2004-03-16 | 2009-04-29 | Univ California | Reduction de la nephropathie au moyen d'inhibiteurs d'hydrolase d'epoxyde soluble et d'epoxyeicosanoides |
AU2005264988B2 (en) | 2004-06-17 | 2011-09-22 | Cytokinetics, Inc. | Substituted urea derivatives for treating cardiac diseases |
US7176222B2 (en) * | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
JP4834553B2 (ja) | 2004-09-17 | 2011-12-14 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 医薬組成物 |
NZ554555A (en) | 2004-10-20 | 2011-09-30 | Univ California | Cyclohexyl-urea derivatives as improved inhibitors for the soluble epoxide hydrolase |
JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
US7538223B2 (en) * | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
JPWO2007052849A1 (ja) | 2005-11-07 | 2009-04-30 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質とc−kitキナーゼ阻害物質との併用 |
US7825120B2 (en) * | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
TW200808321A (en) | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
EP1959947A2 (fr) * | 2005-12-15 | 2008-08-27 | Cytokinetics, Inc. | Entites chimiques, compositions et procedes |
EP1959962A2 (fr) | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Entites chimiques, compositions et methodes |
US7989455B2 (en) * | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
TW200808723A (en) * | 2006-03-13 | 2008-02-16 | Univ California | Conformationally restricted urea inhibitors of soluble epoxide hydrolase |
CA2652442C (fr) | 2006-05-18 | 2014-12-09 | Eisai R & D Management Co., Ltd. | Agent antitumoral destine au cancer de la thyroide |
ES2558517T3 (es) * | 2006-08-02 | 2016-02-04 | Cytokinetics, Inc. | Ciertas entidades químicas, composiciones y métodos que comprenden imidazopirimidinas |
CN101511793B (zh) | 2006-08-28 | 2011-08-03 | 卫材R&D管理有限公司 | 针对未分化型胃癌的抗肿瘤剂 |
WO2008039794A1 (fr) * | 2006-09-25 | 2008-04-03 | Arete Therapeutics, Inc. | Inhibiteurs d'époxyde hydrolase soluble |
EP2079831A2 (fr) * | 2006-11-07 | 2009-07-22 | Keck Graduate Institute | Populations enrichies en cellules souches et cellules progénitrices, et procédé de production et d'utilisation de telles populations |
CA2676796C (fr) | 2007-01-29 | 2016-02-23 | Eisai R & D Management Co., Ltd. | Composition destinee au traitement d'un cancer de l'estomac de type indifferencie |
KR20100044251A (ko) * | 2007-08-15 | 2010-04-29 | 싸이토키네틱스, 인코포레이티드 | 특정 화학 물질, 조성물 및 방법 |
KR101513326B1 (ko) | 2007-11-09 | 2015-04-17 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 혈관 신생 저해 물질과 항종양성 백금 착물의 병용 |
JP5647125B2 (ja) * | 2008-09-05 | 2014-12-24 | アキュセラ インコーポレイテッド | 眼の疾患及び障害を治療する硫黄結合化合物 |
WO2012054093A2 (fr) | 2010-01-29 | 2012-04-26 | The Regents Of The University Of California | Inhibiteurs d'acyl pipéridine d'époxyde hydrolase soluble |
CN102858175A (zh) | 2010-02-22 | 2013-01-02 | 葛兰素史密斯克莱有限责任公司 | 作为脂肪酸合成酶抑制剂的三唑酮 |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
WO2011109441A1 (fr) * | 2010-03-01 | 2011-09-09 | Myrexis, Inc. | Composés et utilisations thérapeutiques associées |
US9221808B2 (en) | 2010-04-16 | 2015-12-29 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinase (ROCK) and methods of use |
CN102958523B (zh) | 2010-06-25 | 2014-11-19 | 卫材R&D管理有限公司 | 使用具有激酶抑制作用的组合的抗肿瘤剂 |
WO2012051595A1 (fr) | 2010-10-15 | 2012-04-19 | Cytopherx, Inc. | Cartouche de cytophérèse et son utilisation |
CN103402519B (zh) | 2011-04-18 | 2015-11-25 | 卫材R&D管理有限公司 | 肿瘤治疗剂 |
EP2714937B1 (fr) | 2011-06-03 | 2018-11-14 | Eisai R&D Management Co., Ltd. | Biomarqueurs pour la prédiction et l'estimation de la sensibilité de sujets atteints d'un cancer de la thyroïde et du rein vis-à-vis de composés lenvatinib |
AU2012364760B2 (en) * | 2012-01-09 | 2018-05-31 | Seastar Medical Inc. | Cartridge and method for increasing myocardial function |
US9409868B2 (en) | 2012-01-24 | 2016-08-09 | H. Lee Moffin Cancer Center and Research Institute, Inc. | Inhibitors of rho associated protein kinases (ROCK) and methods of use |
KR20150098605A (ko) | 2012-12-21 | 2015-08-28 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 퀴놀린 유도체의 비정질 형태 및 그의 제조방법 |
SG11201509278XA (en) | 2013-05-14 | 2015-12-30 | Eisai R&D Man Co Ltd | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
WO2015131299A1 (fr) * | 2014-03-04 | 2015-09-11 | 雅本化学股份有限公司 | Procédé de préparation et d'inversion chirale de 1-t-butoxycarbonyl-3-hydroxy pipéridine chirale |
WO2015142001A2 (fr) * | 2014-03-21 | 2015-09-24 | 충남대학교산학협력단 | Composé doté d'une action cardiotonique et composition pharmaceutique permettant de prévenir ou de traiter l'insuffisance cardiaque et contenant ledit composé |
KR101922542B1 (ko) * | 2014-03-21 | 2018-11-28 | 충남대학교산학협력단 | 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물 |
CR20160557A (es) * | 2014-05-29 | 2017-01-20 | Glaxosmithkline Ip Dev Ltd | Compuestos derivados de 1-(ciclopent-2-en-1-il)-3-(2-hidroxi-3-(arilsulfonil)fenil)urea como inhibidores cxcr2 |
IL302218B1 (en) | 2014-08-28 | 2024-06-01 | Eisai R&D Man Co Ltd | Methods for the production of lanvotinib and its derivatives in a high degree of purity |
JP6217866B2 (ja) | 2014-10-24 | 2017-10-25 | 小野薬品工業株式会社 | Kcnq2〜5チャネル活性化剤 |
DK3263106T3 (da) | 2015-02-25 | 2024-01-08 | Eisai R&D Man Co Ltd | Fremgangsmåde til undertrykkelse af bitterhed af quinolinderivat |
AU2015384801B2 (en) | 2015-03-04 | 2022-01-06 | Eisai R&D Management Co., Ltd. | Combination of a PD-1 antagonist and a VEGFR/FGFR/RET tyrosine kinase inhibitor for treating cancer |
US10858314B2 (en) | 2015-05-27 | 2020-12-08 | Kyorin Pharmaceutical Co., Ltd. | Urea derivative or pharmacologically acceptable salt thereof |
EP3311841B1 (fr) | 2015-06-16 | 2021-07-28 | PRISM BioLab Co., Ltd. | Agent anticancéreux |
KR101766731B1 (ko) | 2015-06-23 | 2017-08-10 | 충남대학교산학협력단 | 강심 활성을 갖는 크로메논 유도체 및 이를 포함하는 심부전의 예방 또는 치료용 약학 조성물 |
AU2017316908B2 (en) * | 2016-08-26 | 2020-11-19 | Sumitomo Chemical Company, Limited | 1-phenyl-3-carbamoyl urea compound, and use thereof |
KR20160108281A (ko) | 2016-09-06 | 2016-09-19 | 충남대학교산학협력단 | 강심 활성을 갖는 화합물 및 이를 함유하는 심부전 예방 또는 치료용 약학적 조성물 |
KR101954281B1 (ko) * | 2017-09-05 | 2019-03-05 | 한국외국어대학교 연구산학협력단 | 광학적으로 활성인 3-하이드록시피페리딘 또는 이의 유도체의 입체선택적 제조방법 |
CN111601798B (zh) | 2017-09-13 | 2023-08-11 | 美国安进公司 | 双酰胺肌节活化化合物及其用途 |
WO2019144041A1 (fr) | 2018-01-19 | 2019-07-25 | Cytokinetics, Inc. | Analogues de dihydrobenzofurane et d'inden en tant qu'inhibiteurs de sarcomes cardiaques |
US11964967B2 (en) | 2018-06-26 | 2024-04-23 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
US20210276991A1 (en) * | 2018-06-26 | 2021-09-09 | Cytokinetics, Inc. | Cardiac sarcomere inhibitors |
KR20210068422A (ko) | 2018-08-31 | 2021-06-09 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
US20220274969A1 (en) * | 2019-07-17 | 2022-09-01 | Cytokinetics, Inc. | Polymorphs of (r)-n-(5-(5-isopropyl-1,2,4-oxadiazol-3-yl)-2,3-dihydro-1h-inden-1-yl)-2-methyl-2h-tetrazole-5-carboxamide |
TW202138352A (zh) * | 2019-12-20 | 2021-10-16 | 美商愛彼特生物製藥股份有限公司 | 經取代之雙環及三環脲類及醯胺類、其類似物及使用其之方法 |
KR20240015622A (ko) | 2021-03-04 | 2024-02-05 | 싸이토키네틱스, 인코포레이티드 | 심장 근절 억제제 |
Family Cites Families (98)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NL254871A (fr) * | 1959-08-14 | |||
US3128280A (en) * | 1959-10-23 | 1964-04-07 | Searle & Co | 1-(alkoxylated/halogenated phenyl)-3-pyridylmethylureas |
US4078913A (en) * | 1970-04-08 | 1978-03-14 | Tetsuo Takematsu | Herbicidal 3-(2-phenylisopropyl)urea derivatives |
GB1339764A (en) | 1971-03-29 | 1973-12-05 | Ici Ltd | Pyridine derivatives |
US3939169A (en) | 1971-03-29 | 1976-02-17 | Imperial Chemical Industries Limited | Alkylene bis(pyridiniumareylene quaternary salts) |
US3994905A (en) * | 1974-04-11 | 1976-11-30 | Rohm And Haas Company | 3-Pyridylmethyl aryl urea rodenticides |
IE47458B1 (en) * | 1977-11-07 | 1984-03-21 | Leo Pharm Prod Ltd | Quinolylguanidine derivatives |
DE2928485A1 (de) * | 1979-07-14 | 1981-01-29 | Bayer Ag | Verwendung von harnstoffderivaten als arzneimittel bei der behandlung von fettstoffwechselstoerungen |
DE2942930A1 (de) * | 1979-10-24 | 1981-05-27 | Basf Ag, 6700 Ludwigshafen | Substituierte harnstoffe, deren herstellung und verwendung als herbizide |
DE3147879A1 (de) * | 1981-12-03 | 1983-06-16 | Basf Ag, 6700 Ludwigshafen | 1,3,5-triazinone, verfahren zu ihrer herstellung und ihre verwendung zur bekaempfung unerwuenschten pflanzenwuchses |
DE3271848D1 (en) * | 1981-12-03 | 1986-07-31 | Basf Ag | 1,3,5-triazinones, process for their preparation and their use in combating undesired plant growth |
US4672066A (en) * | 1985-04-22 | 1987-06-09 | Hoffmann-La Roche Inc. | Derivatives of 4-acetyl-3-hydroxy-2-alkyl-phenoxycarboxylic acids |
GB9027023D0 (en) | 1990-12-12 | 1991-01-30 | Wellcome Found | Anti-atherosclerotic aryl compounds |
US5162360A (en) * | 1991-06-24 | 1992-11-10 | Warner-Lambert Company | 2-heteroatom containing urea and thiourea ACAT inhibitors |
GEP20001968B (en) * | 1992-01-21 | 2000-03-05 | Glaxo Spa | Arilthio Compounds as Antibacterial and Antiviral Agents |
US6001860A (en) | 1992-05-28 | 1999-12-14 | Pfizer Inc. | N-aryl and N-heteroarylurea derivatives as inhibitors of acyl coenzyme A: Cholesterol acyl transferase (ACAT) |
GB9304920D0 (en) | 1993-03-10 | 1993-04-28 | Celltech Ltd | Chemical compounds |
US5547966A (en) * | 1993-10-07 | 1996-08-20 | Bristol-Myers Squibb Company | Aryl urea and related compounds |
JPH10510512A (ja) | 1994-10-04 | 1998-10-13 | 藤沢薬品工業株式会社 | 尿素誘導体とacat阻害剤としての用途 |
US5556969A (en) * | 1994-12-07 | 1996-09-17 | Merck Sharp & Dohme Ltd. | Benzodiazepine derivatives |
US5624937A (en) * | 1995-03-02 | 1997-04-29 | Eli Lilly And Company | Chemical compounds as inhibitors of amyloid beta protein production |
GB9504361D0 (en) | 1995-03-04 | 1995-04-26 | Glaxo Spa | Heterocyclic compounds |
US5972975A (en) | 1995-12-08 | 1999-10-26 | Merck & Co., Inc. | Substituted 2-aminopyridines as inhibitors of nitric oxide synthase |
US6005008A (en) * | 1996-02-16 | 1999-12-21 | Smithkline Beecham Corporation | IL-8 receptor antagonists |
US6174905B1 (en) | 1996-09-30 | 2001-01-16 | Mitsui Chemicals, Inc. | Cell differentiation inducer |
WO1998050346A2 (fr) * | 1997-04-18 | 1998-11-12 | Smithkline Beecham Plc | Derives d'acetamide et d'uree, procede de preparation et utilisation de ces derives dans le traitement des troubles du systeme nerveux central |
GB2324798B (en) * | 1997-05-01 | 1999-08-18 | Ici Plc | Open celled cellular polyurethane products |
ES2151467T3 (es) | 1997-05-23 | 2005-03-01 | Bayer Corporation | Arilureas para el tratamiento de enfermedades inflamatorias o inmunomoduladoras. |
AU7585598A (en) | 1997-05-23 | 1998-12-11 | Bayer Corporation | Raf kinase inhibitors |
US6750344B1 (en) | 1997-09-05 | 2004-06-15 | Isis Pharmaceuticals, Inc. | Amine compounds and combinatorial libraries comprising same |
AU9188698A (en) | 1997-11-05 | 1999-05-24 | Choongwae Pharma Corporation | Novel genipin derivative having liver protection activity |
CA2315715C (fr) | 1997-12-22 | 2010-06-22 | Bayer Corporation | Inhibition de la kinase p38 par des diphenyl-urees symetriques et dissymetriques |
WO1999032111A1 (fr) * | 1997-12-22 | 1999-07-01 | Bayer Corporation | Inhibition de l'activite de p38 kinase au moyen d'urees heterocycliques substituees |
CA2315717C (fr) * | 1997-12-22 | 2011-02-01 | Bayer Corporation | Inhibition de raf kinase au moyen d'urees heterocycliques substituees |
DE1049664T1 (de) | 1997-12-22 | 2001-05-03 | Bayer Ag | Hemmung der raf-kinase unter verwendung von symmetrisch und unsymmetrisch substituierten harnstoffen |
JP4405602B2 (ja) | 1998-04-16 | 2010-01-27 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | ヒストン脱アセチル化酵素阻害剤 |
CA2334298C (fr) | 1998-06-08 | 2008-01-08 | Schering Corporation | Antagonistes des recepteurs y5 neuropeptidiques |
US6329395B1 (en) | 1998-06-08 | 2001-12-11 | Schering Corporation | Neuropeptide Y5 receptor antagonists |
JP2000256194A (ja) | 1999-01-06 | 2000-09-19 | Mitsui Chemicals Inc | 核内レセプタ作動薬およびその効果増強剤 |
IL144144A0 (en) * | 1999-01-13 | 2002-05-23 | Bayer Ag | Omega-carboxy aryl substituted diphenyl ureas as p38 kinase inhibitors |
US7928239B2 (en) * | 1999-01-13 | 2011-04-19 | Bayer Healthcare Llc | Inhibition of RAF kinase using quinolyl, isoquinolyl or pyridyl ureas |
US6402960B1 (en) | 1999-03-01 | 2002-06-11 | The Regents Of The University Of California | Thiacrown polymers for removal of mercury from waste streams |
DE19921498A1 (de) | 1999-05-08 | 2000-11-16 | Clariant Gmbh | Verfahren zur Herstellung von wäßrigen Diazoniumsalzlösungen |
ATE312823T1 (de) * | 1999-07-09 | 2005-12-15 | Boehringer Ingelheim Pharma | Verfahren zur herstellung heteroarylsubstituierter ureaverbindungen |
WO2001025190A1 (fr) | 1999-10-01 | 2001-04-12 | Japan Energy Corporation | Nouveaux derives de diarylamide et utilisation de ces composes comme medicaments |
HN2001000008A (es) * | 2000-01-21 | 2003-12-11 | Inc Agouron Pharmaceuticals | Compuesto de amida y composiciones farmaceuticas para inhibir proteinquinasas, y su modo de empleo |
US6495337B1 (en) | 2000-03-29 | 2002-12-17 | Cytokinetics, Inc. | High throughput sarcomeric assay |
GB0015601D0 (en) | 2000-06-26 | 2000-08-16 | Ferring Bv | Novel antidiuretic agents |
GB0015904D0 (en) | 2000-06-28 | 2000-08-23 | Hoffmann La Roche | Inhibitors of HPV E1 helicase enzyme |
GB0017676D0 (en) | 2000-07-19 | 2000-09-06 | Angeletti P Ist Richerche Bio | Inhibitors of viral polymerase |
US6645990B2 (en) | 2000-08-15 | 2003-11-11 | Amgen Inc. | Thiazolyl urea compounds and methods of uses |
US20020173507A1 (en) | 2000-08-15 | 2002-11-21 | Vincent Santora | Urea compounds and methods of uses |
US6573264B1 (en) | 2000-10-23 | 2003-06-03 | Cv Therapeutics, Inc. | Heteroaryl alkyl piperazine derivatives |
US20030045552A1 (en) | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
MXPA03006666A (es) | 2001-01-25 | 2004-05-31 | Guilford Pharm Inc | Compuestos de union de ciclofilina carbociclicos trisubstituidos y su uso. |
JP2002220338A (ja) | 2001-01-26 | 2002-08-09 | Banyu Pharmaceut Co Ltd | ビアリールウレア化合物又はその塩を有効成分として含有するCdk4及び/又はCdk6阻害剤 |
GB0117950D0 (en) * | 2001-02-16 | 2001-09-19 | Aventis Pharma Inc | Novel heterocyclic urea derivatives andd their use as dopamine D3 receptor ligands |
DE10110749A1 (de) | 2001-03-07 | 2002-09-12 | Bayer Ag | Substituierte Aminodicarbonsäurederivate |
CA2443950C (fr) | 2001-04-20 | 2011-10-18 | Bayer Corporation | Inhibition de la kinase raf a l'aide d'urees de quinolyl, d'isoquinolyl ou de pyridyl |
WO2002092576A1 (fr) * | 2001-05-16 | 2002-11-21 | Boehringer Ingelheim Pharmaceuticals, Inc. | Derives de diaryluree utilisables en tant qu'agents anti-inflammatoires |
CA2453147A1 (fr) * | 2001-07-11 | 2003-01-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Methodes permettant de traiter des maladies induites par les cytokines |
DE10134482A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte Isoindole und ihre Verwendung |
AUPR688101A0 (en) | 2001-08-08 | 2001-08-30 | Luminis Pty Limited | Protein domains and their ligands |
US7297708B2 (en) | 2001-09-06 | 2007-11-20 | Bristol-Myers Squibb Company | Heteroaromatic substituted cyclopropane as corticotropin releasing hormone ligands |
EP1426360A4 (fr) | 2001-09-12 | 2006-04-12 | Kaken Pharma Co Ltd | Derive d'acide 2-phenyle-3-heteroarylpropionique ou son sel et medicaments le contenant |
TWI249515B (en) | 2001-11-13 | 2006-02-21 | Theravance Inc | Aryl aniline beta2 adrenergic receptor agonists |
WO2003059258A2 (fr) * | 2001-12-21 | 2003-07-24 | Cytokinetics, Inc. | Compositions et methodes permettant de traiter l'insuffisance cardiaque |
US20030207872A1 (en) | 2002-01-11 | 2003-11-06 | Bayer Corporation | Omega-carboxyaryl substituted diphenyl ureas as raf kinase inhibitors |
US7408067B2 (en) | 2002-01-17 | 2008-08-05 | Merck + Co., Inc. | Aza-cyclic compounds as modulators of acetylcholine receptors |
US7148236B2 (en) | 2002-01-17 | 2006-12-12 | Merck & Co., Inc. | Modulators of acetylcholine receptors |
JP4471262B2 (ja) | 2002-03-07 | 2010-06-02 | 株式会社エス・ディー・エス バイオテック | 置換イソキサゾールアルキルアミン誘導体及び農園芸用殺菌剤 |
US20050215605A1 (en) | 2002-03-28 | 2005-09-29 | Page Patrick N | Thiazolidine carboxamide derivatives as modulators of the prostaglandin f receptor |
TW200400035A (en) | 2002-03-28 | 2004-01-01 | Glaxo Group Ltd | Novel compounds |
EP1500643A4 (fr) | 2002-04-03 | 2007-03-28 | Dainippon Sumitomo Pharma Co | Derives de benzamide |
PE20040684A1 (es) | 2002-04-18 | 2004-10-05 | Schering Corp | Derivados de bencimidazol como antagonistas de histamina h3 |
EP1503996B1 (fr) | 2002-04-23 | 2008-12-24 | Bristol-Myers Squibb Company | Composes aryle cetone pyrrolo-triazine utiles comme inhibiteurs de kinase |
US20030236287A1 (en) * | 2002-05-03 | 2003-12-25 | Piotrowski David W. | Positive allosteric modulators of the nicotinic acetylcholine receptor |
AU2003229538A1 (en) | 2002-05-17 | 2003-12-02 | Lica Pharmaceuticals A/S | Aminoalkoxy-functional chalcones |
EP1539742B1 (fr) | 2002-06-24 | 2006-11-08 | Schering Corporation | Derives d'indole utilises en tant qu'antagonistes h3 d'histamine |
CA2744893A1 (fr) | 2002-06-27 | 2004-01-08 | Novo Nordisk A/S | Derives d'arylcarbonyle servant d'activateurs de glucokinase |
CA2493026C (fr) | 2002-07-31 | 2011-05-24 | Schering Aktiengesellschaft | Anthranylamidopyrimidines inhibant vegfr-2 et vegfr-3 |
GB0218147D0 (en) | 2002-08-05 | 2002-09-11 | Oxford Glycosciences Uk Ltd | Novel compounds |
AU2003262262A1 (en) | 2002-08-27 | 2004-03-19 | Kissei Pharmaceutical Co., Ltd. | Pyrazole derivatives, medicinal composition containing the same, and medicinal use thereof |
CA2498291C (fr) | 2002-09-10 | 2009-04-07 | Pfizer Products Inc. | Composes diazabicycliques utilises dans le traitement de troubles associes au snc |
EP1558203B1 (fr) | 2002-10-29 | 2007-05-09 | L'oreal | Composition capillaire contenant un compose styryl-pyrazole |
CA2511970C (fr) * | 2003-01-14 | 2012-06-26 | Cytokinetics, Inc. | Derives de l'uree utiles pour traiter l'insuffisance cardiaque |
US7557129B2 (en) * | 2003-02-28 | 2009-07-07 | Bayer Healthcare Llc | Cyanopyridine derivatives useful in the treatment of cancer and other disorders |
US20070020704A1 (en) | 2003-05-20 | 2007-01-25 | Scott Wilhelm | Diaryl ureas with kinase inhibiting activity |
AU2005264988B2 (en) | 2004-06-17 | 2011-09-22 | Cytokinetics, Inc. | Substituted urea derivatives for treating cardiac diseases |
US7176222B2 (en) | 2004-07-27 | 2007-02-13 | Cytokinetics, Inc. | Syntheses of ureas |
US7538223B2 (en) * | 2005-08-04 | 2009-05-26 | Cytokinetics, Inc. | Compounds, compositions and methods |
US20070208000A1 (en) * | 2005-12-15 | 2007-09-06 | Morgan Bradley P | Certain chemical entities, compositions and methods |
EP1959947A2 (fr) * | 2005-12-15 | 2008-08-27 | Cytokinetics, Inc. | Entites chimiques, compositions et procedes |
US7825120B2 (en) * | 2005-12-15 | 2010-11-02 | Cytokinetics, Inc. | Certain substituted ((piperazin-1-ylmethyl)benzyl)ureas |
TW200808321A (en) * | 2005-12-15 | 2008-02-16 | Cytokinetics Inc | Certain chemical entities, compositions and methods |
EP1959962A2 (fr) * | 2005-12-16 | 2008-08-27 | Cytokinetics, Inc. | Entites chimiques, compositions et methodes |
US7989455B2 (en) * | 2005-12-19 | 2011-08-02 | Cytokinetics, Inc. | Compounds, compositions and methods |
US7672247B2 (en) * | 2006-02-23 | 2010-03-02 | International Business Machines Corporation | Evaluating data processing system health using an I/O device |
-
2004
- 2004-01-14 CA CA2511970A patent/CA2511970C/fr not_active Expired - Lifetime
- 2004-01-14 MX MXPA05007513A patent/MXPA05007513A/es active IP Right Grant
- 2004-01-14 AU AU2004206860A patent/AU2004206860B2/en not_active Expired
- 2004-01-14 WO PCT/US2004/001069 patent/WO2004064730A2/fr active Application Filing
- 2004-01-14 ES ES04702228T patent/ES2387909T3/es not_active Expired - Lifetime
- 2004-01-14 EP EP04702228A patent/EP1615878B1/fr not_active Expired - Lifetime
- 2004-01-14 KR KR1020057013092A patent/KR20050100615A/ko not_active Application Discontinuation
- 2004-01-14 AT AT04702228T patent/ATE552236T1/de active
- 2004-01-14 US US10/541,596 patent/US7399866B2/en not_active Expired - Lifetime
- 2004-01-14 NZ NZ540878A patent/NZ540878A/en not_active IP Right Cessation
- 2004-01-14 EP EP11181477A patent/EP2397462A3/fr not_active Withdrawn
- 2004-01-14 JP JP2006500973A patent/JP4613157B2/ja not_active Expired - Fee Related
- 2004-07-14 US US10/890,829 patent/US7491826B2/en active Active
-
2006
- 2006-05-15 HK HK06105587.2A patent/HK1085461A1/xx not_active IP Right Cessation
-
2009
- 2009-01-05 US US12/348,786 patent/US20090176307A1/en not_active Abandoned
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WO2004064730A3 (fr) | 2005-03-24 |
MXPA05007513A (es) | 2005-09-21 |
WO2004064730A2 (fr) | 2004-08-05 |
NZ540878A (en) | 2008-06-30 |
EP1615878A2 (fr) | 2006-01-18 |
ATE552236T1 (de) | 2012-04-15 |
AU2004206860A1 (en) | 2004-08-05 |
EP2397462A2 (fr) | 2011-12-21 |
EP1615878B1 (fr) | 2012-04-04 |
EP1615878A4 (fr) | 2007-09-19 |
US7491826B2 (en) | 2009-02-17 |
CA2511970A1 (fr) | 2004-08-05 |
CA2511970C (fr) | 2012-06-26 |
JP2006515884A (ja) | 2006-06-08 |
EP2397462A3 (fr) | 2012-04-04 |
US20090176307A1 (en) | 2009-07-09 |
JP4613157B2 (ja) | 2011-01-12 |
US7399866B2 (en) | 2008-07-15 |
ES2387909T3 (es) | 2012-10-03 |
KR20050100615A (ko) | 2005-10-19 |
AU2004206860B2 (en) | 2010-03-18 |
US20050159416A1 (en) | 2005-07-21 |
US20060241110A1 (en) | 2006-10-26 |
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