HK1076029A1 - Injectable depot formulation comprising crystals of iloperidone - Google Patents

Injectable depot formulation comprising crystals of iloperidone

Info

Publication number
HK1076029A1
HK1076029A1 HK05108084A HK05108084A HK1076029A1 HK 1076029 A1 HK1076029 A1 HK 1076029A1 HK 05108084 A HK05108084 A HK 05108084A HK 05108084 A HK05108084 A HK 05108084A HK 1076029 A1 HK1076029 A1 HK 1076029A1
Authority
HK
Hong Kong
Prior art keywords
crystals
iloperidone
injectable depot
depot formulation
size
Prior art date
Application number
HK05108084A
Other languages
English (en)
Inventor
Dierk Wieckhusen
Alexandra Glausch
Markus Ahlheim
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=9940486&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1076029(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of HK1076029A1 publication Critical patent/HK1076029A1/xx

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Inorganic Chemistry (AREA)
  • Psychiatry (AREA)
  • Organic Chemistry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
HK05108084A 2002-07-15 2005-09-15 Injectable depot formulation comprising crystals of iloperidone HK1076029A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0216416.8A GB0216416D0 (en) 2002-07-15 2002-07-15 Organic compounds
PCT/EP2003/007619 WO2004006886A2 (en) 2002-07-15 2003-07-14 Injectable depot formulation comprising crystals of iloperidone

Publications (1)

Publication Number Publication Date
HK1076029A1 true HK1076029A1 (en) 2006-01-06

Family

ID=9940486

Family Applications (1)

Application Number Title Priority Date Filing Date
HK05108084A HK1076029A1 (en) 2002-07-15 2005-09-15 Injectable depot formulation comprising crystals of iloperidone

Country Status (16)

Country Link
US (5) US20050250813A1 (xx)
EP (1) EP1523335B1 (xx)
JP (2) JP5392961B2 (xx)
AT (1) ATE348635T1 (xx)
AU (1) AU2003281154B2 (xx)
CA (1) CA2492467C (xx)
CY (1) CY1106305T1 (xx)
DE (1) DE60310564T2 (xx)
DK (1) DK1523335T3 (xx)
ES (1) ES2279153T3 (xx)
GB (1) GB0216416D0 (xx)
HK (1) HK1076029A1 (xx)
NZ (1) NZ537598A (xx)
PT (1) PT1523335E (xx)
WO (1) WO2004006886A2 (xx)
ZA (1) ZA200410323B (xx)

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EP2479290B1 (en) 2004-09-30 2020-08-19 Vanda Pharmaceuticals Inc. Methods for the administration of iloperidone
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US8802855B2 (en) 2009-09-19 2014-08-12 Zhejiang Huahai Pharmaceutical Co., Ltd. Method for preparation of iloperidone and crystallization method thereof
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WO2011055188A1 (en) * 2009-11-05 2011-05-12 Orchid Chemicals And Pharmaceuticals Limited An improved process for the preparation of iloperidone
US20130004545A1 (en) * 2009-12-23 2013-01-03 Lupin Limited Slow release pharmaceutical compositions of iloperidone
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KR101936968B1 (ko) * 2010-10-18 2019-01-09 다이닛본 스미토모 세이야꾸 가부시끼가이샤 주사용 서방형 제제
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KR102317399B1 (ko) 2012-01-26 2021-10-26 반다 파마슈티칼즈, 인코퍼레이티드. 일주기 리듬 장애의 치료
JP2015508751A (ja) 2012-01-26 2015-03-23 イノテック ファーマシューティカルズ コーポレイション ［（２ｒ，３ｓ，４ｒ，５ｒ）−５−（６−（シクロペンチルアミノ）−９ｈ−プリン−９−イル）−３，４−ジヒドロキシテトラヒドロフラン−２−イル］メチルナイトレートの無水多形体及びその製造方法
CN102659771B (zh) * 2012-04-18 2013-11-27 吉林三善恩科技开发有限公司 一种伊潘立酮药物共晶及其制备方法
CN102633786B (zh) * 2012-04-18 2013-11-27 吉林三善恩科技开发有限公司 一种伊潘立酮药物共晶及其制备方法
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RU2748386C2 (ru) 2012-12-18 2021-05-25 Ванда Фармасьютиклз Инк. Лечение расстройств циркадного ритма
MX2015013234A (es) * 2013-03-15 2016-04-15 Inotek Pharmaceuticals Corp Formulaciones oftalmicas.
US11090285B2 (en) 2013-11-12 2021-08-17 Vanda Pharmaceuticals Inc Treatment of circadian rhythm disorders
US10376487B2 (en) 2013-11-12 2019-08-13 Vanda Pharmaceuticals Inc. Method of treatment
CN103599074A (zh) * 2013-11-26 2014-02-26 重庆医药工业研究院有限责任公司 一种伊潘立酮缓释微球及其制备方法
EP3258935B1 (en) 2015-02-17 2021-04-07 Vanda Pharmaceuticals Inc. Iloperidone for the treatment of schizophrenia
US11071728B2 (en) 2015-12-11 2021-07-27 Vanda Pharmaceuticals Inc. Treatment of schizophrenia
CN106831741B (zh) * 2016-12-28 2019-08-23 北京医药集团有限责任公司 一种伊潘立酮超细粉体的制备方法
US10935106B2 (en) * 2018-06-14 2021-03-02 Serapid, Inc. Block chain with monolithic links
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Also Published As

Publication number Publication date
AU2003281154A1 (en) 2004-02-02
NZ537598A (en) 2006-07-28
AU2003281154B2 (en) 2006-10-12
EP1523335B1 (en) 2006-12-20
DE60310564D1 (de) 2007-02-01
DK1523335T3 (da) 2007-01-29
US8227488B2 (en) 2012-07-24
US20090099232A1 (en) 2009-04-16
JP2011016849A (ja) 2011-01-27
CA2492467C (en) 2010-03-16
CA2492467A1 (en) 2004-01-22
JP5392961B2 (ja) 2014-01-22
ES2279153T3 (es) 2007-08-16
US8293765B2 (en) 2012-10-23
EP1523335A2 (en) 2005-04-20
JP5670698B2 (ja) 2015-02-18
PT1523335E (pt) 2007-02-28
ZA200410323B (en) 2006-06-28
ATE348635T1 (de) 2007-01-15
GB0216416D0 (en) 2002-08-21
US20050250813A1 (en) 2005-11-10
US20130012542A1 (en) 2013-01-10
DE60310564T2 (de) 2007-10-04
US8614232B2 (en) 2013-12-24
US20120156264A1 (en) 2012-06-21
WO2004006886A2 (en) 2004-01-22
JP2005533093A (ja) 2005-11-04
US20110212141A1 (en) 2011-09-01
WO2004006886A3 (en) 2004-02-19
CY1106305T1 (el) 2011-10-12

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