DK2305656T3 - Optiske isomerer of en iloperidonmetabolit - Google Patents
Optiske isomerer of en iloperidonmetabolitInfo
- Publication number
- DK2305656T3 DK2305656T3 DK10009915.9T DK10009915T DK2305656T3 DK 2305656 T3 DK2305656 T3 DK 2305656T3 DK 10009915 T DK10009915 T DK 10009915T DK 2305656 T3 DK2305656 T3 DK 2305656T3
- Authority
- DK
- Denmark
- Prior art keywords
- optical isomers
- iloperidone metabolite
- fouoro
- isoxazol
- piperidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Cosmetics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31639001P | 2001-08-31 | 2001-08-31 | |
EP02767454A EP1425272B1 (en) | 2001-08-31 | 2002-08-30 | Optical isomers of an iloperidone metabolite |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2305656T3 true DK2305656T3 (da) | 2013-02-11 |
Family
ID=23228843
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02767454.8T DK1425272T3 (da) | 2001-08-31 | 2002-08-30 | Optiske isomerer af en iloperidon-metabolit |
DK10009915.9T DK2305656T3 (da) | 2001-08-31 | 2002-08-30 | Optiske isomerer of en iloperidonmetabolit |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK02767454.8T DK1425272T3 (da) | 2001-08-31 | 2002-08-30 | Optiske isomerer af en iloperidon-metabolit |
Country Status (10)
Country | Link |
---|---|
US (4) | US20050020632A1 (da) |
EP (2) | EP2305656B1 (da) |
JP (6) | JP2005504783A (da) |
AT (1) | ATE518845T1 (da) |
CY (2) | CY1112039T1 (da) |
DK (2) | DK1425272T3 (da) |
ES (2) | ES2398434T3 (da) |
HK (2) | HK1066536A1 (da) |
PT (2) | PT1425272E (da) |
WO (1) | WO2003020707A1 (da) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5067998B2 (ja) | 2001-10-30 | 2012-11-07 | ノバルティス アーゲー | イロペリドンおよび星形ポリマーのデポー製剤 |
KR101020399B1 (ko) | 2002-03-27 | 2011-03-08 | 글락소 그룹 리미티드 | 퀴놀린 유도체 및 5-ht6 리간드로서의 그의 용도 |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
BRPI0412263B1 (pt) | 2003-07-22 | 2019-10-15 | Arena Pharmaceuticals, Inc. | Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição |
GB0322994D0 (en) * | 2003-10-01 | 2003-11-05 | Novartis Ag | Organic compounds |
CA3113166A1 (en) | 2004-09-30 | 2006-04-13 | Vanda Pharmaceuticals Inc. | Methods for the administration of iloperidone |
US20100063093A1 (en) * | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
US20070262395A1 (en) | 2006-05-11 | 2007-11-15 | Gibbons Jasper S | Memory cell access devices and methods of making the same |
US8008144B2 (en) | 2006-05-11 | 2011-08-30 | Micron Technology, Inc. | Dual work function recessed access device and methods of forming |
US20090306137A1 (en) * | 2006-05-22 | 2009-12-10 | Wolfgang Curt D | Treatment for depressive disorders |
US20150259747A1 (en) | 2007-03-29 | 2015-09-17 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation |
WO2008121899A2 (en) | 2007-03-29 | 2008-10-09 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation |
US8198305B2 (en) | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
EP2152917B1 (en) | 2007-05-18 | 2016-03-23 | Vanda Pharmaceuticals Inc. | Genetic markers for efficacy of iloperidone in the treatment of psychotic symptoms |
WO2009036100A2 (en) | 2007-09-10 | 2009-03-19 | Vanda Pharmaceuticals, Inc. | Prediction of qt prolongation based on snp genotype |
EP2254564A1 (en) | 2007-12-12 | 2010-12-01 | Glaxo Group Limited | Combinations comprising 3-phenylsulfonyl-8-piperazinyl-1yl-quinoline |
PL2222300T3 (pl) | 2007-12-13 | 2015-02-27 | Vanda Pharmaceuticals Inc | Sposób i skład preparatu do leczenia chorób z udziałem receptorów serotoniny |
MX2010006520A (es) | 2007-12-13 | 2010-11-30 | Vanda Pharmaceuticals Inc | Metodo y composicion para el tratamiento de una condicion mediada por alfa-adrenoceptor. |
US20110061014A1 (en) | 2008-02-01 | 2011-03-10 | Energyhub | Interfacing to resource consumption management devices |
WO2009123714A2 (en) | 2008-04-02 | 2009-10-08 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
US7824986B2 (en) | 2008-11-05 | 2010-11-02 | Micron Technology, Inc. | Methods of forming a plurality of transistor gates, and methods of forming a plurality of transistor gates having at least two different work functions |
WO2010117941A1 (en) | 2009-04-06 | 2010-10-14 | Vanda Pharmaceuticals, Inc. | Method of predicting a predisposition to qt prolongation based on abcc2 gene sequence or product thereof |
US9074255B2 (en) | 2009-04-06 | 2015-07-07 | Vanda Pharmaceuticals, Inc. | Method of predicting a predisposition to QT prolongation |
EP2417267B1 (en) | 2009-04-06 | 2016-08-17 | Vanda Pharmaceuticals Inc. | Method of treatment based on polymorphisms of the kcnq1 gene |
JP5692872B2 (ja) | 2009-04-06 | 2015-04-01 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Bai遺伝子の配列又はその産物に基づいてqt延長に対する素因を予測する方法 |
EP2515863A2 (en) | 2009-12-23 | 2012-10-31 | Lupin Limited | Slow release pharmaceutical compositions of iloperidone |
WO2012032532A1 (en) * | 2010-09-07 | 2012-03-15 | Symed Labs Limited | "processes for the preparation of 4'-[3-[4-(6-fluoro-1,2-benzisoxazol-3-yl)piperidino]propoxy]-3'-methoxyacetophenone and intermediates thereof" |
WO2012063269A2 (en) | 2010-11-12 | 2012-05-18 | Cadila Healthcare Limited | Process for preparing iloperidone |
AU2013232014B2 (en) * | 2012-03-14 | 2016-06-16 | Vanda Pharmaceuticals Inc. | An iloperidone metabolite for use in the treatment of psychiatric disorders |
ES2870498T3 (es) | 2015-02-17 | 2021-10-27 | Vanda Pharmaceuticals Inc | Iloperidona para el tratamiento de esquizofrenia |
RU2017145976A (ru) | 2015-06-12 | 2019-07-15 | Аксовант Сайенсиз Гмбх | Производные диарил- и арилгетероарилмочевины, применимые для профилактики и лечения нарушения поведения во время REM-фазы сна |
KR20180064373A (ko) | 2015-07-15 | 2018-06-14 | 엑소반트 사이언시즈 게엠베하 | 신경퇴행성 질환과 관련된 환각의 예방 및 치료에 유용한 5-ht2a 세로토닌 수용체의 조절자로서의 다이아릴 및 아릴헤테로아릴 우레아 유도체 |
WO2020172506A1 (en) * | 2019-02-21 | 2020-08-27 | Obi Pharma Inc. | Methods of making high enantioselective secondary alcohols |
US11607408B2 (en) | 2019-10-15 | 2023-03-21 | Vanda Pharmaceuticals Inc. | Method of treatment of schizophrenia |
WO2023201182A1 (en) | 2022-04-13 | 2023-10-19 | Vanda Pharmaceuticals Inc. | Treatment of parkinson's disease and parkinson's disease psychosis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
EP0402644B1 (en) * | 1989-05-19 | 1995-08-16 | Hoechst-Roussel Pharmaceuticals Incorporated | N-(aryloxyalkyl)heteroarylpiperidines and -heteroarylpiperazines,a process for their preparation and their use as medicaments |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
JPH05286868A (ja) | 1992-04-03 | 1993-11-02 | Kiyoshi Okawa | 制がん剤複合体およびそのスクリーニング法 |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
EP0997458A4 (en) * | 1997-07-03 | 2003-03-05 | Asahi Chemical Ind | NOVEL TRICYCLIC COMPOUNDS HAVING SATUROUS CORES AND MEDICINAL COMPOSITIONS CONTAINING THEM |
EP1551393A4 (en) | 2002-07-30 | 2010-06-16 | Peter Migaly | COMBINATION OF THERAPY FOR DEPRESSION, PREVENTION OF SUICIDE AND VARIOUS MEDICAL AND PSYCHIATRIC DISORDERS |
-
2002
- 2002-08-30 JP JP2003524978A patent/JP2005504783A/ja not_active Withdrawn
- 2002-08-30 PT PT02767454T patent/PT1425272E/pt unknown
- 2002-08-30 DK DK02767454.8T patent/DK1425272T3/da active
- 2002-08-30 DK DK10009915.9T patent/DK2305656T3/da active
- 2002-08-30 ES ES10009915T patent/ES2398434T3/es not_active Expired - Lifetime
- 2002-08-30 EP EP10009915A patent/EP2305656B1/en not_active Expired - Lifetime
- 2002-08-30 EP EP02767454A patent/EP1425272B1/en not_active Expired - Lifetime
- 2002-08-30 ES ES02767454T patent/ES2370634T3/es not_active Expired - Lifetime
- 2002-08-30 US US10/488,128 patent/US20050020632A1/en not_active Abandoned
- 2002-08-30 PT PT100099159T patent/PT2305656E/pt unknown
- 2002-08-30 AT AT02767454T patent/ATE518845T1/de active
- 2002-08-30 WO PCT/EP2002/009700 patent/WO2003020707A1/en active Application Filing
-
2004
- 2004-11-30 HK HK04109446.7A patent/HK1066536A1/xx not_active IP Right Cessation
-
2009
- 2009-03-13 US US12/403,755 patent/US7977356B2/en active Active
- 2009-12-11 JP JP2009281094A patent/JP2010100633A/ja not_active Withdrawn
-
2011
- 2011-04-28 US US13/096,015 patent/US8314129B2/en active Active
- 2011-10-06 HK HK11110560.6A patent/HK1156309A1/xx not_active IP Right Cessation
- 2011-11-02 CY CY20111101053T patent/CY1112039T1/el unknown
-
2012
- 2012-10-26 US US13/661,609 patent/US20130296366A1/en not_active Abandoned
-
2013
- 2013-01-23 CY CY20131100058T patent/CY1113550T1/el unknown
- 2013-01-31 JP JP2013017050A patent/JP2013116905A/ja not_active Withdrawn
- 2013-07-08 JP JP2013142873A patent/JP2013227335A/ja active Pending
-
2015
- 2015-08-06 JP JP2015156358A patent/JP2015227368A/ja active Pending
- 2015-08-06 JP JP2015156359A patent/JP2015214577A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
EP1425272B1 (en) | 2011-08-03 |
EP2305656A1 (en) | 2011-04-06 |
WO2003020707A1 (en) | 2003-03-13 |
ATE518845T1 (de) | 2011-08-15 |
JP2015214577A (ja) | 2015-12-03 |
JP2013227335A (ja) | 2013-11-07 |
US20110201646A1 (en) | 2011-08-18 |
ES2370634T3 (es) | 2011-12-21 |
HK1066536A1 (en) | 2005-03-24 |
US20130296366A1 (en) | 2013-11-07 |
JP2010100633A (ja) | 2010-05-06 |
ES2398434T8 (es) | 2017-10-09 |
EP1425272A1 (en) | 2004-06-09 |
CY1112039T1 (el) | 2015-11-04 |
ES2398434T3 (es) | 2013-03-19 |
US20050020632A1 (en) | 2005-01-27 |
US20090176739A1 (en) | 2009-07-09 |
US7977356B2 (en) | 2011-07-12 |
JP2015227368A (ja) | 2015-12-17 |
PT2305656E (pt) | 2013-01-10 |
CY1113550T1 (el) | 2016-06-22 |
JP2005504783A (ja) | 2005-02-17 |
HK1156309A1 (en) | 2012-09-07 |
JP2013116905A (ja) | 2013-06-13 |
US8314129B2 (en) | 2012-11-20 |
EP2305656B1 (en) | 2012-10-24 |
PT1425272E (pt) | 2011-10-19 |
DK1425272T3 (da) | 2011-11-21 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK2305656T3 (da) | Optiske isomerer of en iloperidonmetabolit | |
RU2361860C2 (ru) | Новые замещенные 3-сера-индолы | |
RS50624B (sr) | Monohidrohloridna so 1-[3-[3-(4-hlorofenil)propoksi]propil]piperidina | |
NO20051965D0 (no) | Nye piperidinderivater for anvendelse ved behandling av kemokinmedierte sykdomstilstander. | |
NO20065327L (no) | Fremgangsmate for fremstilling av derivarer av 5-'4-(2-hydroksy-propyl)-3,5-dihydro-3H'1, 2,4(triazin-2-yl)-benzamid. | |
NO2015002I2 (no) | Ataluren (3-[5-(2-fluorfenyl)-[ 1,2,4]oksadiazol-3-yl]-benzosyre) og farmasøytisk akseptable salter og solvater derav | |
NO20071193L (no) | Fluorsubstituerte sykloalkanoindoler og deres anvendelse som prostaglandin D2-reseptorantagonister | |
PE20080360A1 (es) | Derivados 4-bencilftalazinona 2-sustituidos como antagonistas de histaminas h1 y h3 | |
NO20076498L (no) | Derivater av 4-(2-amino-1-hydroksyetyl)fenol som agonister av den betta2-adrenerge reseptoren | |
NO20073366L (no) | 1,6-substituert (3R,6R)-3-(2,3-dihydro-1H-inden-2-yl)-2,5-piperazindionderivater som oksytocinreceptorantagonister for behandling av for tidlige veer, dysmenorri og endometriose | |
RS54608B1 (en) | CGRP RECEPTOR ANTAGONITY | |
ATE347550T1 (de) | Polymorph von 4-(2-(4-(1-(2-ethoxyethyl)-1h- benzimidazol-2-yl)-1-piperidinyl)ethyl)-alpha, alpha-dimethylbenzolessigsäure | |
WO2007066163A3 (en) | Optically active carbamates, process for preparation thereof and use thereof as pharmaceutical intermediates | |
NO20054225L (no) | Benzamid-derivater som oksytocin-agonister og vasopressin-antagonister | |
JP2013510155A5 (da) | ||
DE602006010329D1 (de) | Verfahren zur herstellung eines indolon-derivats | |
HK1070363A1 (en) | Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serineprotease factor xa | |
DE602004009079D1 (de) | Carbostyril-derivative zur beschleunigten speichelabsonderung | |
DE60013751D1 (de) | Optisch aktive 3-((2-piperazinyl-phenyl)methyl)-1-(4-(trifluoromethyl)-phenyl)-2-pyrrolidinone als selektive 5-HT1D Rezeptor Antagonisten | |
NO20070972L (no) | Benzyloksyderivater som MAOB-inhibitorer | |
UY31400A1 (es) | Composiciones farmaceuticas | |
HN2005000205A (es) | Compuestos terapeuticos | |
SE0102809D0 (sv) | Novel compounds | |
DK1631291T3 (da) | Anvendelse af tyrosinkinaseinhibitorer til behandling af diabetes | |
DE60115428D1 (de) | Benzoesäureester mit antiplasmideffekt |