EA200401290A1 - НЕКОТОРЫЕ ПРОИЗВОДНЫЕ 1-(D-ЦИКЛОПРОПИЛГЛИЦИНИЛ)-4-(ПИПЕРИДИН-4-ИЛ)ПИПЕРАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ СЕРИНПРОТЕАЗЫ ФАКТОРА Xa - Google Patents

НЕКОТОРЫЕ ПРОИЗВОДНЫЕ 1-(D-ЦИКЛОПРОПИЛГЛИЦИНИЛ)-4-(ПИПЕРИДИН-4-ИЛ)ПИПЕРАЗИНА В КАЧЕСТВЕ ИНГИБИТОРОВ СЕРИНПРОТЕАЗЫ ФАКТОРА Xa

Info

Publication number
EA200401290A1
EA200401290A1 EA200401290A EA200401290A EA200401290A1 EA 200401290 A1 EA200401290 A1 EA 200401290A1 EA 200401290 A EA200401290 A EA 200401290A EA 200401290 A EA200401290 A EA 200401290A EA 200401290 A1 EA200401290 A1 EA 200401290A1
Authority
EA
Eurasian Patent Office
Prior art keywords
factor
inhibitors
serinproteasis
cyclopropilglycinyl
piperidin
Prior art date
Application number
EA200401290A
Other languages
English (en)
Other versions
EA007300B1 (ru
Inventor
Майкл Роберт Уайли
Гэри Лоувелл Инджел
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200401290A1 publication Critical patent/EA200401290A1/ru
Publication of EA007300B1 publication Critical patent/EA007300B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D211/56—Nitrogen atoms
    • C07D211/58—Nitrogen atoms attached in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Соединения формулы (I), в которых R представляет собой атом водорода, или атом фтора, или их фармацевтически приемлемые соли являются ингибиторами фактора Xa, применимыми при лечении тромботических заболеваний.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401290A 2002-04-01 2003-03-24 Некоторые производные 1-(d-циклопропилглицинил)-4-(пиперидин-4-ил) пиперазина в качестве ингибиторов серинпротеазы фактора ха EA007300B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US36852302P 2002-04-01 2002-04-01
PCT/US2003/007794 WO2003084929A1 (en) 2002-04-01 2003-03-24 Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa

Publications (2)

Publication Number Publication Date
EA200401290A1 true EA200401290A1 (ru) 2005-02-24
EA007300B1 EA007300B1 (ru) 2006-08-25

Family

ID=28791889

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200401290A EA007300B1 (ru) 2002-04-01 2003-03-24 Некоторые производные 1-(d-циклопропилглицинил)-4-(пиперидин-4-ил) пиперазина в качестве ингибиторов серинпротеазы фактора ха

Country Status (25)

Country Link
US (1) US7166606B2 (ru)
EP (1) EP1492767B1 (ru)
JP (1) JP2005531529A (ru)
KR (1) KR20040094892A (ru)
CN (1) CN1288135C (ru)
AT (1) ATE303990T1 (ru)
AU (1) AU2003218147A1 (ru)
BR (1) BR0308870A (ru)
CA (1) CA2478340A1 (ru)
CR (1) CR7497A (ru)
DE (1) DE60301569T2 (ru)
DK (1) DK1492767T3 (ru)
EA (1) EA007300B1 (ru)
EC (1) ECSP045329A (ru)
ES (1) ES2248737T3 (ru)
HK (1) HK1070363A1 (ru)
HR (1) HRP20040900B1 (ru)
IL (1) IL164018A0 (ru)
MX (1) MXPA04009640A (ru)
NO (1) NO20044688L (ru)
NZ (1) NZ535402A (ru)
PL (1) PL373066A1 (ru)
UA (1) UA76849C2 (ru)
WO (1) WO2003084929A1 (ru)
ZA (1) ZA200407418B (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6834308B1 (en) 2000-02-17 2004-12-21 Audible Magic Corporation Method and apparatus for identifying media content presented on a media playing device
US7363278B2 (en) 2001-04-05 2008-04-22 Audible Magic Corporation Copyright detection and protection system and method
US8972481B2 (en) 2001-07-20 2015-03-03 Audible Magic, Inc. Playlist generation method and apparatus
DE102014108210A1 (de) 2014-06-11 2015-12-17 Dietrich Gulba Rodentizid
US11014920B2 (en) 2016-11-18 2021-05-25 Merck Sharp & Dohme Corp. Factor XIIa inhibitors
EP4070658A1 (de) 2021-04-06 2022-10-12 BIORoxx GmbH Verwendung von blutgerinnungshemmenden verbindungen als rodentizide

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000077027A2 (en) 1999-06-14 2000-12-21 Tularik Limited Serine protease inhibitors
AU8875798A (en) 1997-08-29 1999-03-22 Proteus Molecular Design Ltd Meta-benzamidine derivatives as serin protease inhibitors
EP1192132B1 (en) 1999-06-14 2005-09-07 Eli Lilly And Company Serine protease inhibitors
GB0030303D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030304D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030305D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0030306D0 (en) 2000-12-13 2001-01-24 Lilly Co Eli Compounds
TWI257389B (en) 2001-06-12 2006-07-01 Lilly Co Eli Pharmaceutical compound
ES2298386T3 (es) * 2001-07-26 2008-05-16 Eli Lilly And Company 1-glicinil-4-(1-metilpiperidin-4-il)piperazinas y -piperidinas como antagonistas del factor xa.

Also Published As

Publication number Publication date
KR20040094892A (ko) 2004-11-10
HRP20040900A2 (en) 2004-12-31
WO2003084929A1 (en) 2003-10-16
NZ535402A (en) 2006-02-24
ES2248737T3 (es) 2006-03-16
DE60301569D1 (de) 2005-10-13
EP1492767B1 (en) 2005-09-07
ATE303990T1 (de) 2005-09-15
IL164018A0 (en) 2005-12-18
UA76849C2 (ru) 2006-09-15
DE60301569T2 (de) 2006-06-14
CA2478340A1 (en) 2003-10-16
DK1492767T3 (da) 2005-11-28
US7166606B2 (en) 2007-01-23
EP1492767A1 (en) 2005-01-05
MXPA04009640A (es) 2005-01-11
ECSP045329A (es) 2004-11-26
CR7497A (es) 2005-01-17
EA007300B1 (ru) 2006-08-25
AU2003218147A1 (en) 2003-10-20
JP2005531529A (ja) 2005-10-20
BR0308870A (pt) 2005-01-04
US20050096328A1 (en) 2005-05-05
PL373066A1 (en) 2005-08-08
CN1642914A (zh) 2005-07-20
NO20044688L (no) 2004-10-29
HRP20040900B1 (en) 2006-02-28
CN1288135C (zh) 2006-12-06
WO2003084929A8 (en) 2004-05-21
HK1070363A1 (en) 2005-06-17
ZA200407418B (en) 2005-09-15

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): RU