DE60301569T2 - Bestimmte 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazin verbindungen als inhibitoren der serin protease factor xa - Google Patents
Bestimmte 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazin verbindungen als inhibitoren der serin protease factor xa Download PDFInfo
- Publication number
- DE60301569T2 DE60301569T2 DE60301569T DE60301569T DE60301569T2 DE 60301569 T2 DE60301569 T2 DE 60301569T2 DE 60301569 T DE60301569 T DE 60301569T DE 60301569 T DE60301569 T DE 60301569T DE 60301569 T2 DE60301569 T2 DE 60301569T2
- Authority
- DE
- Germany
- Prior art keywords
- inhibitors
- cyclopropylglycinyl
- piperidin
- certain
- piperazine compounds
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D211/36—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D211/56—Nitrogen atoms
- C07D211/58—Nitrogen atoms attached in position 4
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
- C07C235/52—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US36852302P | 2002-04-01 | 2002-04-01 | |
| PCT/US2003/007794 WO2003084929A1 (en) | 2002-04-01 | 2003-03-24 | Certain 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazine compounds as inhibitors of the serine protease factor xa |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60301569D1 DE60301569D1 (de) | 2005-10-13 |
| DE60301569T2 true DE60301569T2 (de) | 2006-06-14 |
Family
ID=28791889
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60301569T Expired - Fee Related DE60301569T2 (de) | 2002-04-01 | 2003-03-24 | Bestimmte 1-(d-cyclopropylglycinyl)-4-(piperidin-4-yl)piperazin verbindungen als inhibitoren der serin protease factor xa |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US7166606B2 (de) |
| EP (1) | EP1492767B1 (de) |
| JP (1) | JP2005531529A (de) |
| KR (1) | KR20040094892A (de) |
| CN (1) | CN1288135C (de) |
| AT (1) | ATE303990T1 (de) |
| AU (1) | AU2003218147A1 (de) |
| BR (1) | BR0308870A (de) |
| CA (1) | CA2478340A1 (de) |
| CR (1) | CR7497A (de) |
| DE (1) | DE60301569T2 (de) |
| DK (1) | DK1492767T3 (de) |
| EA (1) | EA007300B1 (de) |
| EC (1) | ECSP045329A (de) |
| ES (1) | ES2248737T3 (de) |
| HK (1) | HK1070363A1 (de) |
| HR (1) | HRP20040900B1 (de) |
| IL (1) | IL164018A0 (de) |
| MX (1) | MXPA04009640A (de) |
| NO (1) | NO20044688L (de) |
| NZ (1) | NZ535402A (de) |
| PL (1) | PL373066A1 (de) |
| UA (1) | UA76849C2 (de) |
| WO (1) | WO2003084929A1 (de) |
| ZA (1) | ZA200407418B (de) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6834308B1 (en) | 2000-02-17 | 2004-12-21 | Audible Magic Corporation | Method and apparatus for identifying media content presented on a media playing device |
| US7363278B2 (en) | 2001-04-05 | 2008-04-22 | Audible Magic Corporation | Copyright detection and protection system and method |
| US8972481B2 (en) | 2001-07-20 | 2015-03-03 | Audible Magic, Inc. | Playlist generation method and apparatus |
| DE102014108210A1 (de) | 2014-06-11 | 2015-12-17 | Dietrich Gulba | Rodentizid |
| EP3541381B1 (de) | 2016-11-18 | 2022-12-28 | Merck Sharp & Dohme LLC | Faktor xiia inhibitoren |
| EP4070658A1 (de) | 2021-04-06 | 2022-10-12 | BIORoxx GmbH | Verwendung von blutgerinnungshemmenden verbindungen als rodentizide |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6262069B1 (en) | 1997-08-29 | 2001-07-17 | Protherics Molecular Design Limited | 1-amino-7-isoquinoline derivatives as serine protease inhibitors |
| EP1192135A2 (de) | 1999-06-14 | 2002-04-03 | Eli Lilly And Company | Inhibitoren von serin proteasen |
| AU5414000A (en) | 1999-06-14 | 2001-01-02 | Eli Lilly And Company | Compounds |
| GB0030304D0 (en) * | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030306D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030305D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| GB0030303D0 (en) | 2000-12-13 | 2001-01-24 | Lilly Co Eli | Compounds |
| TWI257389B (en) | 2001-06-12 | 2006-07-01 | Lilly Co Eli | Pharmaceutical compound |
| ATE384713T1 (de) * | 2001-07-26 | 2008-02-15 | Lilly Co Eli | 1-glycinyl-4-(1-methylpiperidin-4-yl)piperazine und -piperidine als faktor-xa-antagonisten |
-
2003
- 2003-03-24 NZ NZ535402A patent/NZ535402A/en unknown
- 2003-03-24 WO PCT/US2003/007794 patent/WO2003084929A1/en active IP Right Grant
- 2003-03-24 UA UA20041008649A patent/UA76849C2/uk unknown
- 2003-03-24 JP JP2003582128A patent/JP2005531529A/ja active Pending
- 2003-03-24 EP EP03714138A patent/EP1492767B1/de not_active Expired - Lifetime
- 2003-03-24 KR KR10-2004-7015486A patent/KR20040094892A/ko not_active Application Discontinuation
- 2003-03-24 ES ES03714138T patent/ES2248737T3/es not_active Expired - Lifetime
- 2003-03-24 EA EA200401290A patent/EA007300B1/ru not_active IP Right Cessation
- 2003-03-24 US US10/486,138 patent/US7166606B2/en not_active Expired - Fee Related
- 2003-03-24 CN CNB038074141A patent/CN1288135C/zh not_active Expired - Fee Related
- 2003-03-24 BR BR0308870-7A patent/BR0308870A/pt not_active IP Right Cessation
- 2003-03-24 IL IL16401803A patent/IL164018A0/xx unknown
- 2003-03-24 CA CA002478340A patent/CA2478340A1/en not_active Abandoned
- 2003-03-24 MX MXPA04009640A patent/MXPA04009640A/es active IP Right Grant
- 2003-03-24 AT AT03714138T patent/ATE303990T1/de not_active IP Right Cessation
- 2003-03-24 DE DE60301569T patent/DE60301569T2/de not_active Expired - Fee Related
- 2003-03-24 DK DK03714138T patent/DK1492767T3/da active
- 2003-03-24 PL PL03373066A patent/PL373066A1/xx unknown
- 2003-03-24 AU AU2003218147A patent/AU2003218147A1/en not_active Abandoned
-
2004
- 2004-09-15 ZA ZA200407418A patent/ZA200407418B/en unknown
- 2004-09-24 CR CR7497A patent/CR7497A/es unknown
- 2004-09-29 EC EC2004005329A patent/ECSP045329A/es unknown
- 2004-09-30 HR HR20040900A patent/HRP20040900B1/xx not_active IP Right Cessation
- 2004-10-29 NO NO20044688A patent/NO20044688L/no not_active Application Discontinuation
-
2005
- 2005-04-11 HK HK05103052A patent/HK1070363A1/xx not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005531529A (ja) | 2005-10-20 |
| US20050096328A1 (en) | 2005-05-05 |
| CN1288135C (zh) | 2006-12-06 |
| DE60301569D1 (de) | 2005-10-13 |
| MXPA04009640A (es) | 2005-01-11 |
| PL373066A1 (en) | 2005-08-08 |
| KR20040094892A (ko) | 2004-11-10 |
| UA76849C2 (uk) | 2006-09-15 |
| ES2248737T3 (es) | 2006-03-16 |
| NO20044688L (no) | 2004-10-29 |
| US7166606B2 (en) | 2007-01-23 |
| HRP20040900A2 (en) | 2004-12-31 |
| CR7497A (es) | 2005-01-17 |
| DK1492767T3 (da) | 2005-11-28 |
| ECSP045329A (es) | 2004-11-26 |
| EA007300B1 (ru) | 2006-08-25 |
| ZA200407418B (en) | 2005-09-15 |
| EP1492767A1 (de) | 2005-01-05 |
| AU2003218147A1 (en) | 2003-10-20 |
| IL164018A0 (en) | 2005-12-18 |
| EP1492767B1 (de) | 2005-09-07 |
| CN1642914A (zh) | 2005-07-20 |
| BR0308870A (pt) | 2005-01-04 |
| HK1070363A1 (en) | 2005-06-17 |
| CA2478340A1 (en) | 2003-10-16 |
| WO2003084929A1 (en) | 2003-10-16 |
| WO2003084929A8 (en) | 2004-05-21 |
| NZ535402A (en) | 2006-02-24 |
| ATE303990T1 (de) | 2005-09-15 |
| HRP20040900B1 (en) | 2006-02-28 |
| EA200401290A1 (ru) | 2005-02-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |