EA200700186A1 - Фармацевтическое соединение - Google Patents

Фармацевтическое соединение

Info

Publication number
EA200700186A1
EA200700186A1 EA200700186A EA200700186A EA200700186A1 EA 200700186 A1 EA200700186 A1 EA 200700186A1 EA 200700186 A EA200700186 A EA 200700186A EA 200700186 A EA200700186 A EA 200700186A EA 200700186 A1 EA200700186 A1 EA 200700186A1
Authority
EA
Eurasian Patent Office
Prior art keywords
pharmaceutical compound
phenylglycinyl
methylpiperidin
indole
piperazine
Prior art date
Application number
EA200700186A
Other languages
English (en)
Other versions
EA010307B1 (ru
Inventor
Джули Кей Буш
Original Assignee
Эли Лилли Энд Компани
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эли Лилли Энд Компани filed Critical Эли Лилли Энд Компани
Publication of EA200700186A1 publication Critical patent/EA200700186A1/ru
Publication of EA010307B1 publication Critical patent/EA010307B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1-(Индол-6-карбонил-D-фенилглицинил)-4-(1-метилпиперидин-4-ил)пиперазин D-тартрат образует стабильную кристаллическую соль и представляет собой ингибитор серинпротеазы, фактор Ха, полезный в лечении сердечно-сосудистых расстройств.
EA200700186A 2004-06-30 2005-06-13 Фармацевтическое соединение EA010307B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58359904P 2004-06-30 2004-06-30
PCT/US2005/020490 WO2006011955A1 (en) 2004-06-30 2005-06-13 1 (indole-6-carbonyl-d-phenylglycinyl) -4- (1-methylpiperidin-4-yl) piperazine d-tartrate

Publications (2)

Publication Number Publication Date
EA200700186A1 true EA200700186A1 (ru) 2007-06-29
EA010307B1 EA010307B1 (ru) 2008-08-29

Family

ID=35276192

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700186A EA010307B1 (ru) 2004-06-30 2005-06-13 Фармацевтическое соединение

Country Status (19)

Country Link
US (1) US20070249623A1 (ru)
EP (1) EP1763521A1 (ru)
JP (1) JP2008505075A (ru)
CN (1) CN1984903A (ru)
AR (1) AR049659A1 (ru)
AU (1) AU2005267579A1 (ru)
BR (1) BRPI0512245A (ru)
CA (1) CA2570634A1 (ru)
EA (1) EA010307B1 (ru)
EC (1) ECSP067105A (ru)
IL (1) IL179903A0 (ru)
MA (1) MA28842B1 (ru)
MX (1) MXPA06015112A (ru)
NO (1) NO20070486L (ru)
PE (1) PE20060480A1 (ru)
SV (1) SV2006002156A (ru)
TW (1) TW200603806A (ru)
WO (1) WO2006011955A1 (ru)
ZA (1) ZA200610091B (ru)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0616574D0 (en) * 2006-08-21 2006-09-27 Glaxo Group Ltd Compounds
CN107365304A (zh) * 2017-08-01 2017-11-21 齐宜涛 一种治疗心血管疾病的化合物及制备方法和应用

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UA51676C2 (ru) * 1995-11-02 2002-12-16 Пфайзер Інк. (-)Цис-6(S)-фенил-5(R)-[4-(2-пирРолидин-1-илетокси)фенил]-5,6,7,8-тетрагидронафталин-2-ол D-тартрат, способ его получения, способы лечения заболеваний поддающихся лечению агонистами эстрогена, и фармацевтическая композиция
GB9821058D0 (en) * 1998-09-28 1998-11-18 Univ Cardiff Chemical compound
JP2002539194A (ja) * 1999-03-15 2002-11-19 ノボ ノルディスク アクティーゼルスカブ 新規の（２ｒ，３ｒ，４ｒ）−３，４−ジヒドロキシ−２−ヒドロキシメチルピロリジンの塩
AU5414000A (en) * 1999-06-14 2001-01-02 Eli Lilly And Company Compounds
US6448293B1 (en) * 2000-03-31 2002-09-10 Pfizer Inc. Diphenyl ether compounds useful in therapy
GB0030304D0 (en) * 2000-12-13 2001-01-24 Lilly Co Eli Compounds
GB0019228D0 (en) * 2000-08-04 2000-09-27 Smithkline Beecham Plc Novel pharmaceutical
BR0209605A (pt) * 2001-05-14 2004-03-23 Pfizer Prod Inc Sais tartarato de 5,8,14-triazatetraciclo[10.3.1.0.²,¹¹.04,9]-hexadeca-2(11), 3,5,7,9-pentaeno
TWI257389B (en) * 2001-06-12 2006-07-01 Lilly Co Eli Pharmaceutical compound

Also Published As

Publication number Publication date
US20070249623A1 (en) 2007-10-25
IL179903A0 (en) 2007-05-15
JP2008505075A (ja) 2008-02-21
EA010307B1 (ru) 2008-08-29
ZA200610091B (en) 2008-02-27
MXPA06015112A (es) 2007-02-08
AU2005267579A1 (en) 2006-02-02
CN1984903A (zh) 2007-06-20
AR049659A1 (es) 2006-08-23
PE20060480A1 (es) 2006-07-13
SV2006002156A (es) 2006-02-15
CA2570634A1 (en) 2006-02-02
NO20070486L (no) 2007-01-25
EP1763521A1 (en) 2007-03-21
WO2006011955A1 (en) 2006-02-02
BRPI0512245A (pt) 2008-02-19
ECSP067105A (es) 2007-01-26
TW200603806A (en) 2006-02-01
MA28842B1 (fr) 2007-09-03

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU