ATE518845T1 - Optische isomere eines iloperidon-metaboliten - Google Patents
Optische isomere eines iloperidon-metabolitenInfo
- Publication number
- ATE518845T1 ATE518845T1 AT02767454T AT02767454T ATE518845T1 AT E518845 T1 ATE518845 T1 AT E518845T1 AT 02767454 T AT02767454 T AT 02767454T AT 02767454 T AT02767454 T AT 02767454T AT E518845 T1 ATE518845 T1 AT E518845T1
- Authority
- AT
- Austria
- Prior art keywords
- optical isomers
- iloperidone metabolite
- fouoro
- isoxazol
- piperidin
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Hydrogenated Pyridines (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Cosmetics (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US31639001P | 2001-08-31 | 2001-08-31 | |
PCT/EP2002/009700 WO2003020707A1 (en) | 2001-08-31 | 2002-08-30 | Optical isomers of an iloperidone metabolite |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE518845T1 true ATE518845T1 (de) | 2011-08-15 |
Family
ID=23228843
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT02767454T ATE518845T1 (de) | 2001-08-31 | 2002-08-30 | Optische isomere eines iloperidon-metaboliten |
Country Status (10)
Country | Link |
---|---|
US (4) | US20050020632A1 (de) |
EP (2) | EP1425272B1 (de) |
JP (6) | JP2005504783A (de) |
AT (1) | ATE518845T1 (de) |
CY (2) | CY1112039T1 (de) |
DK (2) | DK2305656T3 (de) |
ES (2) | ES2398434T3 (de) |
HK (2) | HK1066536A1 (de) |
PT (2) | PT2305656E (de) |
WO (1) | WO2003020707A1 (de) |
Families Citing this family (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE60238780D1 (de) | 2001-10-30 | 2011-02-10 | Novartis Ag | Depot formulierungen von iloperidone und einem sternförmigen polymer |
IL164108A0 (en) | 2002-03-27 | 2005-12-18 | Glaxo Group Ltd | Quinoline derivatives and their useas 5-ht6 ligands |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
RS20060035A (en) | 2003-07-22 | 2008-08-07 | Arena Pharmaceuticals Inc., | Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto |
GB0322994D0 (en) * | 2003-10-01 | 2003-11-05 | Novartis Ag | Organic compounds |
ES2825949T3 (es) | 2004-09-30 | 2021-05-17 | Vanda Pharmaceuticals Inc | Métodos para administrar iloperidona |
US20100063093A1 (en) * | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
US20070262395A1 (en) | 2006-05-11 | 2007-11-15 | Gibbons Jasper S | Memory cell access devices and methods of making the same |
US8008144B2 (en) | 2006-05-11 | 2011-08-30 | Micron Technology, Inc. | Dual work function recessed access device and methods of forming |
JP2009538331A (ja) * | 2006-05-22 | 2009-11-05 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 抑うつ障害のための治療 |
US20150259747A1 (en) | 2007-03-29 | 2015-09-17 | Vanda Pharmaceuticals Inc. | Method of predicting a predisposition to qt prolongation |
EP2134873B1 (de) | 2007-03-29 | 2015-05-06 | Vanda Pharmaceuticals Inc. | Verfahren zur prognose einer prädisposition für qt-verlängerung |
US8198305B2 (en) | 2007-04-13 | 2012-06-12 | Concert Pharmaceuticals Inc. | 1,2-benzisoxazol-3-yl compounds |
WO2008144599A2 (en) | 2007-05-18 | 2008-11-27 | Vanda Pharmaceuticals Inc. | Genetic markers for efficacy of iloperidone in the treatment of psychotic symptoms |
JP5653753B2 (ja) | 2007-09-10 | 2015-01-14 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Snp遺伝子型に基づくqt延長の予測 |
EP2508177A1 (de) | 2007-12-12 | 2012-10-10 | Glaxo Group Limited | Kombinationen mit 3-phenylsulfonyl-8-piperazinyl-1yl-chinolin |
MX2010006521A (es) | 2007-12-13 | 2010-08-10 | Vanda Pharmaceuticals Inc | Metodo y composicion para el tratamiento de una condicion mediada por el receptor de serotonina. |
US8729100B2 (en) | 2007-12-13 | 2014-05-20 | Vanda Pharmaceuticals, Inc. | Method and composition for treating an alpha adrenoceptor-mediated condition |
US20110061014A1 (en) | 2008-02-01 | 2011-03-10 | Energyhub | Interfacing to resource consumption management devices |
US20110021538A1 (en) | 2008-04-02 | 2011-01-27 | Arena Pharmaceuticals, Inc. | Processes for the preparation of pyrazole derivatives useful as modulators of the 5-ht2a serotonin receptor |
US9126946B2 (en) | 2008-10-28 | 2015-09-08 | Arena Pharmaceuticals, Inc. | Processes useful for the preparation of 1-[3-(4-bromo-2-methyl-2H-pyrazol-3-yl)-4-methoxy-phenyl]-3-(2,4-difluoro-phenyl)urea and crystalline forms related thereto |
US7824986B2 (en) | 2008-11-05 | 2010-11-02 | Micron Technology, Inc. | Methods of forming a plurality of transistor gates, and methods of forming a plurality of transistor gates having at least two different work functions |
EP2416778B1 (de) | 2009-04-06 | 2016-03-02 | Vanda Pharmaceuticals Inc. | Verfahren zur vorhersagen der veranlagung zur qt verlängerung basierend auf abcc2 gensequenz oder produkte davon |
JP5881597B2 (ja) | 2009-04-06 | 2016-03-09 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Qt延長に対する素因を予測する方法 |
JP5692872B2 (ja) | 2009-04-06 | 2015-04-01 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Bai遺伝子の配列又はその産物に基づいてqt延長に対する素因を予測する方法 |
JP5800798B2 (ja) | 2009-04-06 | 2015-10-28 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | Kcnq1遺伝子の多型に基づいた治療方法 |
MX2012007365A (es) | 2009-12-23 | 2012-08-15 | Lupin Ltd | Composiciones farmaceuticas de liberacion lenta de iloperidona. |
US9000221B2 (en) | 2010-09-07 | 2015-04-07 | Symed Labs Limited | Processes for the preparation of 4′-[3-[4-(6-Fluoro-1 ,2-benzisoxazol-3-yl)piperidino]propoxy]-3′-methoxyacetophenone and intermediates thereof |
WO2012063269A2 (en) | 2010-11-12 | 2012-05-18 | Cadila Healthcare Limited | Process for preparing iloperidone |
JP2015510893A (ja) * | 2012-03-14 | 2015-04-13 | ヴァンダ ファーマシューティカルズ インコーポレイテッド | 精神障害の治療における使用のためのイロペリドン代謝物 |
BR112017017608A2 (pt) | 2015-02-17 | 2018-05-08 | Vanda Pharmaceuticals Inc | métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia. |
JP2018516992A (ja) | 2015-06-12 | 2018-06-28 | アクソファント サイエンシーズ ゲーエムベーハーAxovant Sciences Gmbh | レム睡眠行動障害の予防および処置のために有用なジアリールおよびアリールヘテロアリール尿素誘導体 |
BR112018000728A2 (pt) | 2015-07-15 | 2018-09-04 | Axovant Sciences Gmbh | resumo método para a profilaxia e/ou tratamento de alucinações visuais em um sujeito com necessidade do mesmo |
US11773118B2 (en) | 2019-02-21 | 2023-10-03 | Obi Pharma, Inc. | Methods of making high enantioselective secondary alcohols |
US11607408B2 (en) | 2019-10-15 | 2023-03-21 | Vanda Pharmaceuticals Inc. | Method of treatment of schizophrenia |
WO2023201182A1 (en) | 2022-04-13 | 2023-10-19 | Vanda Pharmaceuticals Inc. | Treatment of parkinson's disease and parkinson's disease psychosis |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4804663A (en) * | 1985-03-27 | 1989-02-14 | Janssen Pharmaceutica N.V. | 3-piperidinyl-substituted 1,2-benzisoxazoles and 1,2-benzisothiazoles |
US5158952A (en) * | 1988-11-07 | 1992-10-27 | Janssen Pharmaceutica N.V. | 3-[2-[4-(6-fluoro-1,2-benzisoxozol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9 tetrahydro-9-hydroxy-2-methyl-4H-pyrido [1,2-a]pyrimidin-4-one, compositions and method of use |
US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
DE69021645T2 (de) | 1989-05-19 | 1996-02-22 | Hoechst Roussel Pharma | N-(aryloxyalkyl)heteroarylpiperidine und -heteroarylpiperazine, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente. |
US5364866A (en) * | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
JPH05286868A (ja) | 1992-04-03 | 1993-11-02 | Kiyoshi Okawa | 制がん剤複合体およびそのスクリーニング法 |
US5889006A (en) * | 1995-02-23 | 1999-03-30 | Schering Corporation | Muscarinic antagonists |
CA2296104A1 (en) * | 1997-07-03 | 1999-01-14 | Asahi Kasei Kogyo Kabushiki Kaisha | Novel tricyclic compounds having saturated rings and medicinal compositions containing the same |
EP1551393A4 (de) | 2002-07-30 | 2010-06-16 | Peter Migaly | Kombinationstherapie gegen depression, prävention von suizid und verschiedener medizinischer und psychiatrischer erkrankungen |
-
2002
- 2002-08-30 JP JP2003524978A patent/JP2005504783A/ja not_active Withdrawn
- 2002-08-30 PT PT100099159T patent/PT2305656E/pt unknown
- 2002-08-30 ES ES10009915T patent/ES2398434T3/es not_active Expired - Lifetime
- 2002-08-30 AT AT02767454T patent/ATE518845T1/de active
- 2002-08-30 EP EP02767454A patent/EP1425272B1/de not_active Expired - Lifetime
- 2002-08-30 ES ES02767454T patent/ES2370634T3/es not_active Expired - Lifetime
- 2002-08-30 DK DK10009915.9T patent/DK2305656T3/da active
- 2002-08-30 PT PT02767454T patent/PT1425272E/pt unknown
- 2002-08-30 WO PCT/EP2002/009700 patent/WO2003020707A1/en active Application Filing
- 2002-08-30 EP EP10009915A patent/EP2305656B1/de not_active Expired - Lifetime
- 2002-08-30 DK DK02767454.8T patent/DK1425272T3/da active
- 2002-08-30 US US10/488,128 patent/US20050020632A1/en not_active Abandoned
-
2004
- 2004-11-30 HK HK04109446.7A patent/HK1066536A1/xx not_active IP Right Cessation
-
2009
- 2009-03-13 US US12/403,755 patent/US7977356B2/en active Active
- 2009-12-11 JP JP2009281094A patent/JP2010100633A/ja not_active Withdrawn
-
2011
- 2011-04-28 US US13/096,015 patent/US8314129B2/en active Active
- 2011-10-06 HK HK11110560.6A patent/HK1156309A1/xx not_active IP Right Cessation
- 2011-11-02 CY CY20111101053T patent/CY1112039T1/el unknown
-
2012
- 2012-10-26 US US13/661,609 patent/US20130296366A1/en not_active Abandoned
-
2013
- 2013-01-23 CY CY20131100058T patent/CY1113550T1/el unknown
- 2013-01-31 JP JP2013017050A patent/JP2013116905A/ja not_active Withdrawn
- 2013-07-08 JP JP2013142873A patent/JP2013227335A/ja active Pending
-
2015
- 2015-08-06 JP JP2015156358A patent/JP2015227368A/ja active Pending
- 2015-08-06 JP JP2015156359A patent/JP2015214577A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT2305656E (pt) | 2013-01-10 |
EP1425272B1 (de) | 2011-08-03 |
CY1113550T1 (el) | 2016-06-22 |
US20110201646A1 (en) | 2011-08-18 |
ES2370634T3 (es) | 2011-12-21 |
EP1425272A1 (de) | 2004-06-09 |
CY1112039T1 (el) | 2015-11-04 |
JP2013227335A (ja) | 2013-11-07 |
DK1425272T3 (da) | 2011-11-21 |
US7977356B2 (en) | 2011-07-12 |
ES2398434T3 (es) | 2013-03-19 |
JP2015214577A (ja) | 2015-12-03 |
JP2005504783A (ja) | 2005-02-17 |
ES2398434T8 (es) | 2017-10-09 |
JP2010100633A (ja) | 2010-05-06 |
HK1156309A1 (en) | 2012-09-07 |
JP2015227368A (ja) | 2015-12-17 |
US20090176739A1 (en) | 2009-07-09 |
EP2305656B1 (de) | 2012-10-24 |
EP2305656A1 (de) | 2011-04-06 |
US8314129B2 (en) | 2012-11-20 |
HK1066536A1 (en) | 2005-03-24 |
JP2013116905A (ja) | 2013-06-13 |
DK2305656T3 (da) | 2013-02-11 |
PT1425272E (pt) | 2011-10-19 |
WO2003020707A1 (en) | 2003-03-13 |
US20050020632A1 (en) | 2005-01-27 |
US20130296366A1 (en) | 2013-11-07 |
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