DE60238780D1 - Depot formulierungen von iloperidone und einem sternförmigen polymer - Google Patents
Depot formulierungen von iloperidone und einem sternförmigen polymerInfo
- Publication number
- DE60238780D1 DE60238780D1 DE60238780T DE60238780T DE60238780D1 DE 60238780 D1 DE60238780 D1 DE 60238780D1 DE 60238780 T DE60238780 T DE 60238780T DE 60238780 T DE60238780 T DE 60238780T DE 60238780 D1 DE60238780 D1 DE 60238780D1
- Authority
- DE
- Germany
- Prior art keywords
- iloperidone
- star
- depot formulations
- term polymer
- polymer
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
- A61K9/1647—Polyesters, e.g. poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Neurology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Dermatology (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US33903601P | 2001-10-30 | 2001-10-30 | |
PCT/EP2002/012073 WO2003037337A1 (en) | 2001-10-30 | 2002-10-29 | Depot formulations of iloperidone and a star polymer |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60238780D1 true DE60238780D1 (de) | 2011-02-10 |
Family
ID=23327202
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60238780T Expired - Lifetime DE60238780D1 (de) | 2001-10-30 | 2002-10-29 | Depot formulierungen von iloperidone und einem sternförmigen polymer |
Country Status (12)
Country | Link |
---|---|
US (2) | US7767230B2 (de) |
EP (2) | EP1441727B1 (de) |
JP (1) | JP5067998B2 (de) |
CN (2) | CN1578664A (de) |
AT (1) | ATE493129T1 (de) |
BR (1) | BRPI0213564B8 (de) |
CA (1) | CA2463158C (de) |
CY (1) | CY1111357T1 (de) |
DE (1) | DE60238780D1 (de) |
ES (2) | ES2358416T3 (de) |
HK (2) | HK1068263A1 (de) |
WO (1) | WO2003037337A1 (de) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4848113B2 (ja) * | 1999-09-09 | 2011-12-28 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 血管新生血管に対するタキサンの陽イオン性リポソーム送達 |
CN1578664A (zh) * | 2001-10-30 | 2005-02-09 | 诺瓦提斯公司 | 伊潘立酮和星状聚合物的贮库制剂 |
GB0216416D0 (en) * | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
CA3113166A1 (en) | 2004-09-30 | 2006-04-13 | Vanda Pharmaceuticals Inc. | Methods for the administration of iloperidone |
US20100063093A1 (en) * | 2007-03-28 | 2010-03-11 | Curt Wolfgang | Methods for the administration of iloperidone |
DE102005051342A1 (de) * | 2005-10-25 | 2007-04-26 | Goldschmidt Gmbh | Verkapselung und kontrollierte Freisetzung biologisch aktiver Wirkstoffe mit enzymatisch abbaubaren hyperverzweigten Trägerpolymeren |
PL1940905T3 (pl) | 2005-10-25 | 2011-02-28 | Evonik Degussa Gmbh | Preparaty zawierające hiperrozgałęzione polimery |
KR20090029200A (ko) | 2006-05-22 | 2009-03-20 | 반다 파마슈티칼즈, 인코퍼레이티드. | 우울증 질환에 대한 치료 |
CN100460441C (zh) * | 2006-09-25 | 2009-02-11 | 南开大学 | 生物可降解星型结构聚乙丙交酯载药微球及其制备方法 |
EP2236546B1 (de) | 2006-10-31 | 2011-12-28 | Surmodics Pharmaceuticals, Inc. | Kugelförmige Polymer-Partikel |
WO2009036100A2 (en) * | 2007-09-10 | 2009-03-19 | Vanda Pharmaceuticals, Inc. | Prediction of qt prolongation based on snp genotype |
EP2222300B1 (de) | 2007-12-13 | 2014-06-11 | Vanda Pharmaceuticals Inc. | Verfahren und zusammensetzung zur behandlung eines zustands, der durch den serotonin-rezeptor vermittelt wird |
WO2009076663A1 (en) | 2007-12-13 | 2009-06-18 | Vanda Pharmaceuticals Inc. | Method and composition for treating an alpha adrenoceptor-mediated condition |
EP2453891A1 (de) | 2009-07-16 | 2012-05-23 | Vanda Pharmaceuticals Inc. | Verwendung eines melatoninagonisten zur behandlung von schlafstörungen, u.a. primärer insomnie |
BR112012015084A2 (pt) * | 2009-12-23 | 2017-03-07 | Lupin Ltd | composição farmacêutica de liberação lenta de iloperidone |
CN102311430A (zh) * | 2010-06-29 | 2012-01-11 | 大道隆达(北京)医药科技发展有限公司 | 伊潘立酮的新晶态及其制备方法 |
WO2012123963A2 (en) * | 2011-02-24 | 2012-09-20 | Megafine Pharma (P) Ltd. | A process for preparation of iloperidone and amorphous co- precipitate of iloperidone with pharmaceutically acceptable excipient |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
EP3620794A1 (de) | 2012-01-26 | 2020-03-11 | Vanda Pharmaceuticals Inc. | Bestimmung der circadianen rhythmik |
IN2014DN10691A (de) | 2012-05-18 | 2015-08-28 | Vanda Pharmaceuticals Inc | |
MX2015007909A (es) | 2012-12-18 | 2016-04-25 | Vanda Pharmaceuticals Inc | Tratamiento de trastornos del ritmo circadiano. |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
CN103599074A (zh) * | 2013-11-26 | 2014-02-26 | 重庆医药工业研究院有限责任公司 | 一种伊潘立酮缓释微球及其制备方法 |
CN104352443A (zh) * | 2014-10-21 | 2015-02-18 | 河北科技大学 | 伊潘立酮缓释微球及其制备方法 |
CN116211857A (zh) | 2015-02-17 | 2023-06-06 | 万达制药公司 | 用于治疗精神分裂症的伊潘立酮 |
US11071728B2 (en) | 2015-12-11 | 2021-07-27 | Vanda Pharmaceuticals Inc. | Treatment of schizophrenia |
MX2021006601A (es) * | 2018-12-04 | 2021-07-07 | Vanda Pharmaceuticals Inc | Administracion de iloperidona de liberacion lenta. |
US11607408B2 (en) | 2019-10-15 | 2023-03-21 | Vanda Pharmaceuticals Inc. | Method of treatment of schizophrenia |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CH656884A5 (de) * | 1983-08-26 | 1986-07-31 | Sandoz Ag | Polyolester, deren herstellung und verwendung. |
DE3511587A1 (de) | 1985-03-27 | 1986-10-02 | Schering AG, Berlin und Bergkamen, 1000 Berlin | Glykoester des estradiols und estriols |
US4886370A (en) | 1987-08-25 | 1989-12-12 | Nkk Corporation | Method for detecting a state of substance existing in pipe |
ES2076253T3 (es) * | 1989-05-19 | 1995-11-01 | Hoechst Roussel Pharma | N-(ariloxialquil)-heteroarilpiperidinas y -heteroarilpiperazinas, un procedimiento para su preparacion y su uso como medicamentos. |
US5364866A (en) | 1989-05-19 | 1994-11-15 | Hoechst-Roussel Pharmaceuticals, Inc. | Heteroarylpiperidines, pyrrolidines and piperazines and their use as antipsychotics and analetics |
US5776963A (en) | 1989-05-19 | 1998-07-07 | Hoechst Marion Roussel, Inc. | 3-(heteroaryl)-1- (2,3-dihydro-1h-isoindol-2-yl)alkyl!pyrrolidines and 3-(heteroaryl)-1- (2,3-dihydro-1h-indol-1-yl)alkyl!pyrrolidines and related compounds and their therapeutic untility |
US5538739A (en) | 1989-07-07 | 1996-07-23 | Sandoz Ltd. | Sustained release formulations of water soluble peptides |
AU636043B2 (en) | 1990-06-04 | 1993-04-08 | Schering Corporation | Method for preparing interferon alpha-2 crystals |
NZ276088A (en) * | 1993-11-19 | 1999-07-29 | Janssen Pharmaceutica Nv | [(1,2-benzisoxazol-3-yl)-1-piperidinyl-alkyl-6,7,8,9-tetrahydro-4h- pyrido[1,2-a]-pyrimidin-4-one derivatives (ie risperidone) |
HUP0002106A3 (en) | 1997-05-26 | 2001-11-28 | Akzo Nobel Nv | Aromatic sulfonates of trans-5-chloro-2,3,3a,12b-tetrahydro-2-methyl-1h-dibenz-[2,3:6,7]oxepino[4,5-c]pyrrole and pharmaceutical compositions containing it |
UA72189C2 (uk) | 1997-11-17 | 2005-02-15 | Янссен Фармацевтика Н.В. | Фармацевтична композиція, що містить водну суспензію субмікронних ефірів 9-гідроксирисперидон жирних кислот |
US5955459A (en) * | 1997-11-26 | 1999-09-21 | Neuromedica, Inc. | Fatty acid-antipsychotic compositions and uses thereof |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
DE19816070A1 (de) | 1998-04-09 | 1999-10-14 | Aventis Res & Tech Gmbh & Co | Retardtablette hergestellt aus linearen wasserunlöslichen Polysacchariden |
KR20010072878A (ko) * | 1998-10-16 | 2001-07-31 | 디르크 반테 | 인식을 개선하기 위한 아세틸콜린에스테라제 억제제와배합된 비정형 항정신병제 |
JP2003535106A (ja) | 2000-06-02 | 2003-11-25 | ノボ ノルディスク アクティーゼルスカブ | グルコース検知性インスリン誘導体からの、インスリンのグルコース依存性放出 |
US20050020632A1 (en) | 2001-08-31 | 2005-01-27 | Dominique Grimler | Optical isomers of an iloperidone metabolite |
CN1578664A (zh) * | 2001-10-30 | 2005-02-09 | 诺瓦提斯公司 | 伊潘立酮和星状聚合物的贮库制剂 |
GB0216416D0 (en) | 2002-07-15 | 2002-08-21 | Novartis Ag | Organic compounds |
-
2002
- 2002-10-29 CN CNA028214269A patent/CN1578664A/zh active Pending
- 2002-10-29 ES ES02785330T patent/ES2358416T3/es not_active Expired - Lifetime
- 2002-10-29 BR BRPI0213564A patent/BRPI0213564B8/pt not_active IP Right Cessation
- 2002-10-29 WO PCT/EP2002/012073 patent/WO2003037337A1/en active Application Filing
- 2002-10-29 CA CA2463158A patent/CA2463158C/en not_active Expired - Lifetime
- 2002-10-29 DE DE60238780T patent/DE60238780D1/de not_active Expired - Lifetime
- 2002-10-29 EP EP02785330A patent/EP1441727B1/de not_active Expired - Lifetime
- 2002-10-29 JP JP2003539681A patent/JP5067998B2/ja not_active Expired - Lifetime
- 2002-10-29 EP EP10009932.4A patent/EP2295058B1/de not_active Expired - Lifetime
- 2002-10-29 AT AT02785330T patent/ATE493129T1/de active
- 2002-10-29 ES ES10009932.4T patent/ES2436439T3/es not_active Expired - Lifetime
- 2002-10-29 CN CN2010102694146A patent/CN101912367A/zh active Pending
- 2002-10-30 US US10/283,989 patent/US7767230B2/en not_active Expired - Lifetime
-
2005
- 2005-01-14 HK HK05100401.8A patent/HK1068263A1/xx not_active IP Right Cessation
-
2010
- 2010-05-20 US US12/784,251 patent/US8815293B2/en not_active Expired - Lifetime
-
2011
- 2011-03-28 CY CY20111100327T patent/CY1111357T1/el unknown
- 2011-09-14 HK HK11109677.8A patent/HK1155381A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
ATE493129T1 (de) | 2011-01-15 |
US20100233217A1 (en) | 2010-09-16 |
HK1155381A1 (en) | 2012-05-18 |
CN101912367A (zh) | 2010-12-15 |
CN1578664A (zh) | 2005-02-09 |
JP5067998B2 (ja) | 2012-11-07 |
ES2436439T3 (es) | 2014-01-02 |
ES2358416T3 (es) | 2011-05-10 |
CA2463158A1 (en) | 2003-05-08 |
EP2295058B1 (de) | 2013-09-04 |
WO2003037337A8 (en) | 2004-05-13 |
BR0213564A (pt) | 2004-08-31 |
EP1441727B1 (de) | 2010-12-29 |
CY1111357T1 (el) | 2015-08-05 |
CA2463158C (en) | 2013-07-30 |
JP2005508975A (ja) | 2005-04-07 |
US8815293B2 (en) | 2014-08-26 |
EP1441727A1 (de) | 2004-08-04 |
EP2295058A1 (de) | 2011-03-16 |
BRPI0213564B1 (pt) | 2016-08-02 |
WO2003037337A1 (en) | 2003-05-08 |
BRPI0213564B8 (pt) | 2021-05-25 |
US7767230B2 (en) | 2010-08-03 |
US20030091645A1 (en) | 2003-05-15 |
HK1068263A1 (en) | 2005-04-29 |
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