BR112017017608A2 - métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia. - Google Patents

métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia.

Info

Publication number
BR112017017608A2
BR112017017608A2 BR112017017608A BR112017017608A BR112017017608A2 BR 112017017608 A2 BR112017017608 A2 BR 112017017608A2 BR 112017017608 A BR112017017608 A BR 112017017608A BR 112017017608 A BR112017017608 A BR 112017017608A BR 112017017608 A2 BR112017017608 A2 BR 112017017608A2
Authority
BR
Brazil
Prior art keywords
schizophrenia
iloperidone
treating
symptom
maintain
Prior art date
Application number
BR112017017608A
Other languages
English (en)
Inventor
D Wolfgang Curt
H Polymeropoulos Mihael
Original Assignee
Vanda Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vanda Pharmaceuticals Inc filed Critical Vanda Pharmaceuticals Inc
Publication of BR112017017608A2 publication Critical patent/BR112017017608A2/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/42—Oxazoles
    • A61K31/423—Oxazoles condensed with carbocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia

Landscapes

  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Neurology (AREA)
  • Organic Chemistry (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

aspectos da invenção referem-se geralmente ao tratamento de esquizofrenia em um indivíduo e, mais especificamente, ao tratamento de um indivíduo com iloperidona, um metabolito de iloperidona, ou um sal farmaceuticamente aceitável do mesmo. em uma modalidade, a invenção provê um método de prevenção de recaída esquizofrênica em um indivíduo diagnosticado com esquizofrenia, o método compreendendo: administrar iloperidona ao indivíduo, um metabolito de iloperidona, ou um sal farmaceuticamente aceitável do mesmo em uma dose diária de entre cerca de 12 mg e cerca de 16 mg após um período no qual a esquizofrenia do indivíduo foi metabolizada.
BR112017017608A 2015-02-17 2016-02-17 métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia. BR112017017608A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562117173P 2015-02-17 2015-02-17
US201562172436P 2015-06-08 2015-06-08
PCT/US2016/018316 WO2016134049A1 (en) 2015-02-17 2016-02-17 Iloperidone for the treatment of schizophrenia

Publications (1)

Publication Number Publication Date
BR112017017608A2 true BR112017017608A2 (pt) 2018-05-08

Family

ID=55532275

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112017017608A BR112017017608A2 (pt) 2015-02-17 2016-02-17 métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia.

Country Status (10)

Country Link
US (2) US10441580B2 (pt)
EP (1) EP3258935B1 (pt)
JP (1) JP6885649B2 (pt)
KR (1) KR20170118830A (pt)
CN (2) CN116211857A (pt)
BR (1) BR112017017608A2 (pt)
CA (1) CA2976383C (pt)
ES (1) ES2870498T3 (pt)
HK (1) HK1248551A1 (pt)
WO (1) WO2016134049A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11214827B2 (en) * 2018-08-30 2022-01-04 Vanda Pharmaceuticals Inc. Genetic markers for enhancing efficacy of antipsychotic treatment with iloperidone
WO2024137439A1 (en) * 2022-12-19 2024-06-27 Vanda Pharmaceuticals Inc. Dosage regime of iloperidone for treating bipolar i disorder and schizophrenia

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050020632A1 (en) 2001-08-31 2005-01-27 Dominique Grimler Optical isomers of an iloperidone metabolite
JP5067998B2 (ja) 2001-10-30 2012-11-07 ノバルティス アーゲー イロペリドンおよび星形ポリマーのデポー製剤
GB0216416D0 (en) 2002-07-15 2002-08-21 Novartis Ag Organic compounds
ES2825949T3 (es) * 2004-09-30 2021-05-17 Vanda Pharmaceuticals Inc Métodos para administrar iloperidona
US20100063093A1 (en) 2007-03-28 2010-03-11 Curt Wolfgang Methods for the administration of iloperidone
US9328387B2 (en) * 2007-09-10 2016-05-03 Vanda Pharmaceuticals, Inc. Antipsychotic treatment based on SNP genotype
US9439906B2 (en) * 2007-12-19 2016-09-13 Janssen Pharmaceutica Nv Dosing regimen associated with long acting injectable paliperidone esters
WO2010132866A1 (en) 2009-05-15 2010-11-18 Vanda Pharmaceuticals Inc. Antipsychotic treatment based on drd2 or ankk1 snp genotype
CN104220074A (zh) * 2011-12-02 2014-12-17 大日本住友制药株式会社 鲁拉西酮新给药方案以及其用于治疗、预防和/或控制至少一种cns病症的用途
JP2015510893A (ja) 2012-03-14 2015-04-13 ヴァンダ ファーマシューティカルズ インコーポレイテッド 精神障害の治療における使用のためのイロペリドン代謝物
RU2667010C2 (ru) * 2012-08-21 2018-09-13 Сейдж Терапьютикс, Инк. Способы лечения эпилепсии или эпилептического статуса

Also Published As

Publication number Publication date
CN116211857A (zh) 2023-06-06
CA2976383C (en) 2023-05-23
JP2018505901A (ja) 2018-03-01
US20180021324A1 (en) 2018-01-25
EP3258935B1 (en) 2021-04-07
JP6885649B2 (ja) 2021-06-16
CA2976383A1 (en) 2016-08-25
EP3258935A1 (en) 2017-12-27
WO2016134049A1 (en) 2016-08-25
US10441580B2 (en) 2019-10-15
US10987346B2 (en) 2021-04-27
KR20170118830A (ko) 2017-10-25
US20190388412A1 (en) 2019-12-26
ES2870498T3 (es) 2021-10-27
CN107249586A (zh) 2017-10-13
HK1248551A1 (zh) 2018-10-19

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BR112017017608A2 (pt) métodos para tratamento de esquizofrenia ou um sintoma de esquizofrenia, para prevenir uma recaída esquizofrênica e para manter o efeito de iloperidona para esquizofrenia.
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Legal Events

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B07D Technical examination (opinion) related to article 229 of industrial property law [chapter 7.4 patent gazette]

Free format text: DE ACORDO COM O ARTIGO 229-C DA LEI NO 10196/2001, QUE MODIFICOU A LEI NO 9279/96, A CONCESSAO DA PATENTE ESTA CONDICIONADA A ANUENCIA PREVIA DA ANVISA. CONSIDERANDO A APROVACAO DOS TERMOS DO PARECER NO 337/PGF/EA/2010, BEM COMO A PORTARIA INTERMINISTERIAL NO 1065 DE 24/05/2012, ENCAMINHA-SE O PRESENTE PEDIDO PARA AS PROVIDENCIAS CABIVEIS.

B07E Notification of approval relating to section 229 industrial property law [chapter 7.5 patent gazette]
B06U Preliminary requirement: requests with searches performed by other patent offices: procedure suspended [chapter 6.21 patent gazette]
B350 Update of information on the portal [chapter 15.35 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B07A Application suspended after technical examination (opinion) [chapter 7.1 patent gazette]
B09B Patent application refused [chapter 9.2 patent gazette]